4.Comparison of the effect of gatifloxacin and levofloxacin for treating acute bacterial infection
Chinese Journal of Primary Medicine and Pharmacy 2013;20(11):1622-1624
Objective To compare the effect of gatifloxacin and levofloxacin for treating acute bacterial infection.Methods According to the digital table,228 patients with respiratory or urinary tract infections were randomly divided into group A and group B,114 cases in each group.Group A was given gatifloxacin 200mg,adding 5% glucose injection 100ml intravenous drip injection twice daily; Group B was treated with levofloxacin 200mg,by adding 5% glucose injection 100ml intravenous infusion twice daily.The treatment course lasted 7-14 days.The clincal effect,bacterial clearance rate and adverse reactions of the two groups were observed.Results The cure rate and total effective rate of group A was 68.4%,93.0%,respectively,which of group B was 66.7%,90.3%,respectively,the differences were statistically significant (x2 =0.184,0.213,all P >0.05).The bacterial clearance rate and bacterial drug sensitivity test sensitivity was 89.4%,78.8%,respectively,which of group B was 77.2%,70.3 %,respectively,the differences were all statistically significant (x2 =4.812,4.236,all P < 0.05).The incidence rate of adverse reactions of group A was 7.0%,which of group B was 6.1%,there was no statistically significant difference (x2 =0.672,P >0.05).Conclusion Gatifloxacin has better effect and lower adverse reactions in the treatment of acute bacterial respiratory or urinary tract infections,and there is no significant difference compared with levofloxacin treatment,and it is worthy of clinical application.
5.Application effect of clinical pathways in children pneumonia patients:a meta-analysis
Chongqing Medicine 2013;(23):2735-2739
Objective To systematically evaluate the application effect of clinical pathways in children pneumonia patients by u-sing the system analysis .Methods Published RCT in children pneumonia patients were searched and screened in CNKI ,VIP ,CBM-disc and Wanfang datebase under present standards .The quality of the included studies were evaluated and statistical analyzed by RevMan5 .0 software .Results Total 17 literatures including 2 717 cases were eligible to the criteria (1 359 in clinical pathways group and 1 358 in control group)altogether .The system analysis showed there were significant difference between the clinical path-way group and the traditional treatment group in grasp of health knowledge [RR=1 .30 ,95% CI(1 .17 -1 .44) ,P<0 .01] ,rate of patients ,satisfaction[RR=1 .17 ,95% CI(1 .13 -1 .21) ,P<0 .01] ,length of hospital stay [WMD= -2 .90 ,95% CI(-3 .93 - -1 .86) ,P<0 .01] ,hospitalization expenses[WMD= -620 .02 ,95% CI(-838 .99 - -401 .04) ,P<0 .01] ,the body temperature to restore normal time[WMD= -1 .67 ,95% CI(-2 .10- -1 .23) ,P<0 .01] ,lung sound disappear time[WMD= -1 .80 ,95% CI(-2 .15- -1 .45) ,P<0 .01] .Conclusion Clinical pathways is superior compared with the traditional treatment for children pneumo-nia patients ,be worthy of spread in clinical .
6.Different brand automatic instrument of coagulation test results contrast analysis
China Medical Equipment 2014;(12):59-61
Objective: Based on the same clinical laboratory automatic blood coagulation analyzer method comparison of different brands. Discuss different between blood coagulation analyzer test results are comparable or check whether the deviation of the results in the permitted range. Method:collecting 112 cases of fresh plasma specimens, using ACL ADVANCE and Sysmex CA7000 two kinds of blood coagulation analyzer, respectively prothrombin time (PT), activated partial prothrombin time (APTT), thrombin time (TT) and fibrinogen (FIB), and compare the results, to medical decision level of judging system error detection system for clinical result, and calculate the two blood coagulation instrument testing results of the correlation coefficient and linear regression equation. Results:the ACL ADVANCE and Sysmex CA7000 blood coagulation analyzer test of PT, APTT, TT and FIB result comparison, there were no statistically significant difference (t=0.974, t=0.649, t=0.765, t=1.163;P>0.05), the correlation coefficient respectively;Medical decision level of system error were less than half the total margin of error. Conclusion:to the ACL ADVANCE as standard test system, Sysmex CA7000 determination results have clinical acceptability, two blood coagulation test results with good correlation. Should be conducted on a regular basis in the same laboratory coagulation analyzer compares different experiments, to ensure the comparability of the same in the laboratory test results.
7.Treatment of 50 Cases of Cervical Spondylopathy by Acupuncture plus Tuina
Journal of Acupuncture and Tuina Science 2005;3(1):36-38
According to the syndrome differentiation, 50 cases of cervical spondylopathy were treated by puncturing the distal acupoints and performing massage manipulation on the local affected area. After 2 courses of treatment, 35 cases were cured, 8 cases were markedly effective, 6 cases were improved,1 case was ineffective.
8.Critical Discourse Analysis in Doctor-patient Discourse in Chinese Medical Clinic
Chinese Medical Ethics 2015;(1):8-12
Critical Discourse Analysis ( CDA) attempts to uncover the inequality in social reality and the way language presents power and ideology through the analysis of language features. Systemic functional linguistics ( SFL) focuses on the dialectical relationship between language and society and has been considered an important approach and theoretical basis to CDA. Doctors in Chinese medical clinic follow the Four Diagnostic Methods, within which the inquiry diagnosis strongly shows the fact that doctor and patient clash over the ideology and strug-gle for the power via language. The study carries out CDA on doctor-patient discourse in Chinese medical clinic within the theoretical framework of SFL from four aspects including nominalization, classification, transitivity and mood, which verifies that the language is the product of asymmetric power between doctor and patient. It is hoped that the paper would provide insight into CDA on doctor-patient discourse and would be of theoretical meaning.
9.Analysis of the results of antinuclear antibody and anti-ENA antibodies for 297 patients of autoimmune diseases with IIF and biochip technology
International Journal of Laboratory Medicine 2015;(12):1735-1736
Objective To analyze the clinical features and significance of the samples which the expression of ANA is positive and the expression of anti‐ENA antibody is negative .Methods Detect ANA and anti‐ENA antibody of all the 297 samples by indi‐rect immunofluorescence method and biological chip technology ,repectively .And analyze the fluorescence karyotype of ANA posi‐tive specimens with double‐blind method .Screen the samples which anti‐ENA antibody express negative from ANA positive sam‐ples .Compare and analyze the fluorescent karyotype .Results Of all the 297 samples ,74 cases were positive for ANA ,the positive rate was 24 .9% (74/297) .The majority of patterns were speckled pattern (43 cases ,58 .1% ) ,cytoplasmic granular pattern (9 ca‐ses ,12 .2% ) ,and antibody to centromere antigen(9 cases ,12 .2% ) ,respectively .In 74 cases of ANA positive specimens ,ENA anti‐body the negative rate of ENA antibody is 17 .6% (13/74) .Of the 13 cases ,the most frequently occurred pattern was the speckled pattern(11 cases ,84 .6% ) ,the rate of cytoplasmic granular pattern and antibody to centromere antigen was 7 .7% (1/13) respec‐tively .Conclusion In the serum samples which express ANA positive and ENA antibody negative ,the rate of speckled pattern is significantly higher than the other patterns ,and far more than the rate of speckled pattern in the samples which express ENA anti‐body and ANA positive (52 .5% ) (chi‐square= 5 .018 ,P< 0 .05) ,with statistical significance .We consider the speckled pattern samples be in favour of discovering new antibodys of this kind of serum sample .
10.Clinical analysis of umbilical cord blood stem cell transplantation in the treatment of decompensated hepatic cirrhosis
Chinese Journal of Primary Medicine and Pharmacy 2014;(5):655-657
Objective To observe the clinical effect of umbilical cord blood stem cell transplantation in the treatment of decompensated hepatic cirrhosis .Methods The umbilical cord blood of healthy puerperal women was collected,and stem cells were isolated and injected into liver through hepatic artery to treat 20 patients withdecompensated cirrhosis.Blood,liver function,coagulation changes ,indicators of clinical symptoms and adverse events were observed after transplantation 1 week,2 weeks,4 weeks and 8 weeks.Results 1 week after transplantation ,the fatigue,loss of appetite situation were improved in more than 80% patients,but the changes were not significant ( t=0.88,0.80, 0.20,0.23,0.56,all P>0.05).2 weeks after transplantation,the bloating of 60% patients was improved,ALB in-creased significantly(t=2.03,P<0.05).After 4 weeks,the bloating of 70%patients relieved,50%of patients with ascites subsided.ALB,ALT,PT were significantly improved (t=3.84,P <0.01;t =1.75,3.02,all P<0.05);8 weeks later,75%of patients with ascites subsided .Except for AST was not obvious ,other indicators were improved significantly(t=2.20,2.22,5.93,all P<0.05).Except for one case had low fever ,there were no other adverse reac-tions.Conclusion Cord blood stem cell transplantation in the treatment of decompensated cirrhosis can achieve a certain short-term treatment effects , especially in increasing the level of ALB and reducing PT , could resume liver damage and has relatively high security at the same time .