Objective To study the longitudinal change of Migraine patient′s condition ,quality of life and disability ;analyze the evolution of the relationship between headache frequency ,pain intensity ,medication and treatment efficacy .Methods Continuous registration of migraine patients ,using WHO-DAS Ⅱ to assess the disability ,using MSQ2 .1 to assess the health-related quality of life ,using headache diary to record the patient′s condition .Results Compared the conditions of before and after treatment ,the aver-age level of pain ,acute drug using and headache frequency ,were significantly improved .The three dimensions′scores of MSQ2 .1 were decreased .Conclusion In this study ,significant improvement were found in some of the disability and health-related quality of life .Continuity of treatment has an important role to improve health-related quality of life of patients and reduce disability .

Objective:To investigate the influence of different routes of administration on vaccine efficiency of peptide-pulsed dendritic cells(DC).Methods:Immunization of syngeneic C57BL/6 mice with bone marrow-derived murine DC pulsed with SIINFEKL, a MHC class Ⅰ-restricted peptide from chicken ovalbumin(OVA) sited at 257-264 amino acid residuals were performed via subcutaneous(s.c.), intramuscular(i.m.), intravenous(i.v.), and intraperitoneal(i.p.) administration, respectively. Seven days later the mice were sacrificed and the splenocytes were prepared to analyze antigen-specific CTL lysis for target cells and IFN-?-producting CD8+T lymphocytes using in vivo CTL assay and intracellular cytokine staining(ICS), respectively.Results:The results from in vivo CTL assay showed that the CTL lysis activities were 37.3%?7.3%, 10.8%?2.3%, 56.9%?3.6% and 61.0%?4.2% via s.c., i.m., i.v., and i.p. administration, respectively. Similarly, ICS showed that IFN-?-producting cells in total CD8+T lymphocytes were 0.43%?0.09%, 0.85%?0.12%, 0.76%?0.14% and 0.15%?0.04%, respectively.Conclusion:Different routes of administration has an obvious influence on vaccine efficiency of peptide-pulsed DC. The i.p. immunization with DC elicites the strongest CTL lysis activity, i.v. immunization is next, and s.c., in particular i.m. is the worst, suggesting that i.p. administration may be a safe and effective route for immunization with peptide-pulsed DC against cancers in a mice model.

OBJECTIVE:To investigate the effects of Shuxuetong injection on related indexes of patients with acute myocardial infarction (AMI).METHODS:The data of 156 AMI patients were analyzed retrospectively,and then divided into control group (65 cases) and observation group (91 cases) according to therapy plan.Control group received routine treatment.Observation group was additionally given Shuxuetong injection 6 mL added into 5％ Glucose injection 250 mL intravenously,once a day,on the basis of control group.Both groups were given treatment for 5 d.The incidence of vascular recanalization,recanalization time,the incidence of reocclusion as well as LVEF,APTT,PT,FIB,the occurrence of adverse cardiovascular events before and after treatment as well as the occurrence of ADR were observed in 2 groups.RESULTS:The incidence of reocclusion and adverse cardiovascular events in observation group was significantly lower than control group,with statistical significance (P＜0.05).There was no statistical significance in the incidence of vascular recanalization,recanalization time or the incidence of ADR between 2 groups (P＞0.05).After treatment,the levels of LVEF,APTT and PT in 2 groups were significantly higher than before treatment,and the observation group was significantly higher than the control group.The levels of FIB in 2 groups were significantly lower than before treatment,and the observation group was significantly lower than the control group,with statistical significance (P＜0.05).CONCLUSIONS:Based on routine treatment,Shuxuetong injection can reduce the incidence of reocclusion,improve cardiac function and reduce the incidence of adverse cardiovascular events without increasing the occurrence of ADR.

Eighty percent of patients with chronic pancreatitis were presented with symptoms of intractable pain.Patients with chronic pancreatitis were at risk of losing the endocrine and exocrine function of the pancreas as the advance of the disease.The main objective of surgical management of chronic pancreatitis includes pain alleviation and pancreatic endocrine and exocrine function improvement.This paper analyzes the strategics of surgical procedure selcction and thc time,indication for surgical intervention.

The differential diagnosis of inguinal and scrotal emergencies in children is difficult and misdiagnosis might be associated with danger or even mortality.Early diagnosis and proper treatment are very important and explorational surgery should be carried out when diagnosis is in doubt.

This paper analyzed the thoughts of Chinese traditional medical ethics through discussing the four aspects: philanthropy and salvation, incorruptibility and uphold justice, proficient in medicine, scholarly and re-fined. It proposed that moral cultivation is very important, which is the basic premise of medical profession.

Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerged human coro-navirus causing serious respiratory syndrome. The etiological and epidemiological characteristics of MERS along with the recent advances in MERS will be briefly described in this review.

Virtual reality technology is a kind of information technology,which can achieve the interaction between the users and the virtual environment by using relevant devices.This article introduces the application and validity of virtual reality technology in surgery of orthopedics,general surgery,neurosurgery and urology surgery and surgical training.It discusses the advantages and disadvantages and development prospects of the virtual reality technology in the field of surgery and surgical training as well.

With the development of Quality Education, more and more students have gained knowledge by interact. There is close relationship between immunology and clinical medicine, which leads immunology to becoming one of the required subjects. Based on the characteristics of effect, Web Problem -Based Learning is utilized to reform the teaching model of immunology, which will provide some new ideas for immunology teaching method.

The incidence of cervical cancer is the first place in gynecological malignant tumors in China. About 500,000 new cases accounts for 5% of all new cancer patients appeared per year all over the world.How to prolong the progression free survival and overall survival of patients with cervical carcinoma is a very important issue in the field of gynecology.So it is very important to take effective treatment.This paper reviewed the research progress of cervical carcinoma treatment in recent years,including surgical treatment,chemotherapy drugs thera?py,angiogenesis inhibitors targeted therapy,immunization therapy.