1.Mosapride Accelerates the Delayed Gastric Emptying of High-Viscosity Liquids: A Crossover Study Using Continuous Real-Time 13C Breath Test (BreathID System).
Yasunari SAKAMOTO ; Yusuke SEKINO ; Eiji YAMADA ; Hidenori OHKUBO ; Takuma HIGURASHI ; Eiji SAKAI ; Hiroshi IIDA ; Kunihiro HOSONO ; Hiroki ENDO ; Takashi NONAKA ; Tamon IKEDA ; Koji FUJITA ; Masato YONEDA ; Tomoko KOIDE ; Hirokazu TAKAHASHI ; Ayumu GOTO ; Yasunobu ABE ; Eiji GOTOH ; Shin MAEDA ; Atsushi NAKAJIMA ; Masahiko INAMORI
Journal of Neurogastroenterology and Motility 2011;17(4):395-401
BACKGROUND/AIMS: The administration of liquid nutrients to patients is often accompanied by complications such as gastroesophageal reflux. To prevent gastroesophageal reflux, high-viscosity liquid meals are used widely, however, it still remains controversial whether high-viscosity liquid meals have any effect on the rate of gastric emptying. The present study was conducted with the aim of determining whether high-viscosity liquid meals had any effect on the rate of gastric emptying and mosapride might accelerate the rate of gastric emptying of high-viscosity liquid meals. METHODS: Six healthy male volunteers underwent 3 tests at intervals of > 1 week. After fasting for > 8 hours, each subject received one of three test meals (liquid meal only, high-viscosity liquid meal [liquid meal plus pectin] only, or high-viscosity liquid meal 30 minutes after intake of mosapride). A 13C-acetic acid breath test was performed, which monitored the rate of gastric emptying for 4 hours. Using the Oridion Research Software (beta version), breath test parameters were calculated. The study parameters were examined for all the 3 test conditions and compared using the Freidman test. RESULTS: Gastric emptying was significantly delayed following intake of a high-viscosity liquid meal alone as compared with a liquid meal alone; however, intake of mosapride prior to a high-viscosity liquid meal was associated with a significantly accelerated rate of gastric emptying as compared with a high-viscosity liquid meal alone. CONCLUSIONS: This study showed that high-viscosity liquid meals delayed gastric emptying: however, mosapride recovered the delayed rate of gastric emptying by high-viscosity liquid meals.
Benzamides
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Breath Tests
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Cross-Over Studies
;
Fasting
;
Gastric Emptying
;
Gastroesophageal Reflux
;
Humans
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Male
;
Meals
;
Morpholines
;
Pectins
Result Analysis
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