The formula of the skin cream containing the extracts of Centella asiatica (L.) Urb. and Curcuma longa L. - the two medicinal plants available in Vietnam – was established by means of experimental design and computer – aided optimization. At first, the formulae were designed by varying the amounts of their ingredients such as Polawax, cetostearyl alcohol, Tween 80 and Span. Then, the Oil-in-Water emulsion – type creams were manufactured by using the PUC VIKOSATOR emulsor. Next, the resulted products were evaluated for their physics – chemical parameters including the melting point, the extrudability and the number of the Oil particles. After that, the multiple – objective optimization was performed by the CAD/Chem artificial intelligence software, which is the unification of neural networks, fuzzy logic and genetic algorithms. At the end, the optimized formula was strictly evaluated by both hypothetical tests and experimental trials. In drug quality control, the investigation of skin cream was proven to meet its ointment requirements.
Cookery ; Chemistry ; Pharmaceutical ; Plants, Medicinal