1.Diagnostic accuracy of neuropsychological tests for classification of dementia
Takuya Yagi ; Daisuke Ito ; Daisuke Sugiyama ; Satoko Iwasawa ; Hajime Tabuchi ; Mika Konishi ; Machiko Araki ; Naho Saitoh ; Yoshihiro Nihei ; Masaru Mimura ; Norihiro Suzuki
Neurology Asia 2016;21(1):47-54
Although numerous studies have shown that each neuropsychological test is effective for diagnosing
mild cognitive impairment (MCI) or Alzheimer’s disease (AD), studies comparing diagnostic accuracies
of various neuropsychological tests are relatively rare and practical cutoff values are not available. The
present study aimed to investigate the validity of neuropsychological tests and develop cutoff values
for each in differentiating healthy control (HC), MCI and AD groups. A total of 84 HC, 187 with
MCI and 195 with AD were evaluated by the selected seven neuropsychological tests using receiver
operating characteristic (ROC) curve analysis. Logical Memory (LM) delayed recall (cutoff, 7) and
Rey Auditory Verbal Learning Test (RAVLT) delayed recall (cutoff, 6) were effective for differentiating
HC from MCI. To distinguish MCI and AD, Rey Osterrieth Complex Figure Test (ROCFT) 3 mindelayed
recall (cutoff, 6) and LM immediate recall (cutoff, 4) were excellent. Delayed recall of verbal
materials, as indexed by LM and RAVLT was sensitive for discriminating MCI from HC. Handling
visual memory traces, as indexed by ROCFT and immediate verbal information by LM were sensitive
for differentiating MCI and AD.
Alzheimer Disease
;
Dementia
;
Neuropsychological Tests
2.Body composition changes following chemotherapy for testicular germ cell tumor: obesity is the long-term problem.
Yuki TAKAI ; Sei NAITO ; Hidenori KANNO ; Atsushi YAMAGISHI ; Mayu YAGI ; Toshihiko SAKURAI ; Hayato NISHIDA ; Takuya YAMANOBE ; Tomoyuki KATO ; Norihiko TSUCHIYA
Asian Journal of Andrology 2022;24(5):458-462
Metabolic syndrome is a long-term complication of systemic chemotherapy for testicular germ cell tumor (TGCT). It is believed to be caused by secondary hypogonadism or toxic medicines because of orchidectomy followed by systemic chemotherapy. In this study, changes in the body composition of patients over time were quantitatively analyzed up to 24 months after chemotherapy. This study retrospectively analyzed 44 patients with TGCT who underwent chemotherapy at our institution from January 2008 to December 2016. Subcutaneous and visceral fat areas and psoas and skeletal muscle areas were measured by computed tomography before and immediately after chemotherapy as well as 3 months, 6 months, 12 months, and 24 months after chemotherapy. The subcutaneous and visceral fat indices and psoas and skeletal muscle indices were calculated as each area divided by body height squared. The total fat area had already significantly increased 3 months after the initiation of chemotherapy (P = 0.004). However, it did not return to prechemotherapeutic levels even at 24 months after chemotherapy. The skeletal muscle area was significantly decreased at the end of chemotherapy (P < 0.001); however, the value returned to baseline within 12 months. In multivariable analysis, the prechemotherapeutic skeletal muscle index and number of chemotherapy cycles were independently associated with the reduction of skeletal muscle at the end of chemotherapy (P = 0.001 and P = 0.027, respectively). In patients with TGCT, skeletal muscle mass decreased during chemotherapy and recovered within 12 months, whereas fat mass progressively increased from the initiation of chemotherapy until 24 months after chemotherapy.
Body Composition
;
Body Mass Index
;
Humans
;
Male
;
Muscle, Skeletal
;
Neoplasms, Germ Cell and Embryonal
;
Obesity
;
Retrospective Studies
;
Sarcopenia
;
Testicular Neoplasms
3.Report on Workshops at the 55th Annual Conference
Yuko TAKEDA ; Shizuma TSUCHIYA ; Takuya SAIKI ; Takami MAENO ; Rintaro IMAFUKU ; Yasushi MATSUYAMA ; Machiko YAGI ; Makoto KIKUKAWA ; Haruo OBARA ; Michio SHIIBASHI ; Mariko NAKAMURA ; Akiteru TAKAMURA ; Kazuya NAGASAKI ; Shizuko KOBAYASHI ; Jun TSURUTA ; Yuka MIYACHI ; Hiroshi NISHIGORI
Medical Education 2023;54(4):406-409