In their infant years, physically handicapped children have a tendency to develop infections, otitis media, tonsillitis and acute sinusitis repeatedly because their physical development is retarded and metabolism poor.
A combination of shosaiko-to and Shokenchu-to were prescribed to a 3-year-old boy with Down's syndrome. and a 2-year-old boy with cerebral palsy. They caught fewer colds, stopped contracting infections, and digestive symptoms were ameliorated. When the sho, or Kampo diagnostic procedure, was followed in the administration of the above combination or other Kampo formulas during infection remission, they were effective in improving weak constitutions.
When a combination of Shosaiko-to and Keishikashakuyaku-to were prescribed for a mantally handicapped 14-year-old boy who suffered from frequent colds and acute sinusitis, good results were obtained. Although the patient's physical development was normal, he became weak due to his poor basic physical habits, such as snacking, which arose from his retarded mental development.

Organochlorine insecticides (BHC, DDT, etc) have been used in massive quatities in Japan. But in 1971, the goverment put a ban on their use as insecticides. We continued the residue analyses of organochlorine insecticide in human bodies from 1971 to 1982. This paper deals with the results of our residue analyses from 1980-1982. In paralel, We have also continued to analyze the residue of PCB.
(1) A total of 264 specimens have been analyzed for human mother milk, the adipose tissue, the liver, the kidney and the spleen.
(2) β-BHC and pp'-DDE were detected from all of these specimens.
(3) Over a span 12 years, the decrease of total-DDT was smaller than that of β-BHC.
(4) In the adipose tissue, there were no signs of a decrease in total DDT.
(5) PCB was detected from all specimens of mother milk, the adipose tissue and the liver.
It is conceivable that the pollution of human bodies by BHC, DDT. PCB, and other chemicals will last for a long time.
There is a need to keep constant surveillance over the tendency of these chemicals in the environment and human bodies.

“DOKAKONSAN IN KINKI YORYAKU” in the original is limited to the usage of women whose menses recur twice a month and of men whose genitals are swollen and painful.
Judging from “YAKUSEI and YAKUNO” of four kinds of ingredients, we recognize the herb is effective against the syndrome, “KEISHITOSHO” easily caught by the Japanese, accompanyed with “KETSUNETSU” and “CHINKYU-OKETSU”.
We got remarkably effective results, after we made the chart of the symptoms at a radorgraph from the point of view of “KOHO” (the ancient school), “HOSHO-ITCHI”, on the basis of six factors, “KI”, “KETSU”, “SUI”, “HI-I”, and “KAN and NETSU”, and administered the herb for 50 cases equivalent to the factors by “TANPO” (a single dose), “KAHO”, or “GAPPO”.
The herb is administered to a broad range, that is, both sex from infants to the aged.
The indications are firstly musculus skeleti connective tissue symptoms and each field of symptoms excluding sensorial symptoms and blood dyscrasia.
Observing the process that “KESSHO” is changed into “KANKETSU” through “OKETSU” and the medicine, “KUOKETSU-ZAI”, the removal medicine, “DOKAKONSAN” can be a unique herb to be effective against the begining stage of “KANKETSU” and to be “ZANRYU-OKETSU KAIJYOZAI” after the administration of “KANKETSU CHINKYU OKETSUZAI”.

Objective : To get first-hand information on and understand MEDWatch, a newly created program of the US FDA, on safety information reporting and management.
Design and Method : Through a visit to the FDA office by Japanese members of the ICH M1 (Medical Terminology) Expert Working Group (EWG) and other concerned experts, and discussion with relevant FDA staffs.
Results and Conclusion : (1) The MEDWatch program was introduced in June 1993, to accelerate the spontaneous reporting of adverse events (AE) to FDA by developing a single Adverse Event Reporting Form, i.e., FDA 3500, for (1) drugs, (2) biologics (except vaccine), (3) medical devices, (4) food, and (5) veterinary medicines; (2) Five responsible sectors in FDA have been working together to develop a smooth flow of information from health care professionals and industries; (3) The remarkable result from the development of this new program is the increased reporting of serious AE; (4) Much efforts have been exerted by FDA on the education of health professionals through various health societies and through publications; (5) Some of the issues which remain unresolved include database integration of NDA and PMS information; (6) Advocacy of the AE concept and importance of reporting thereof by health care professionals and the use of simple, easy-to-fill-out form is recommended in Japan.

A 68-year-old man underwent percutaneous transluminal coronary angioplasty (PTCA) to left anterior descending artery (LAD) seg 7 after acute anteroseptal myocardial infarction 8 years previously. He was admitted because of syncope attack due to sustained ventricular tachycardia and subsequent fibrillation. He was treated medically in the ICU after cardiopulmonary resuscitation. Medical treatment with amiodarone and lidocaine was not successful and he was transferred to our hospital for surgical treatment of malignant ventricular tachycardia (VT) associated with left ventricular aneurysm and acute cholecystitis that occurred during admission. Left ventriculogram showed left ventricular aneurysm (ejection fraction: 35%) without any significant coronary lesions. The patient successfully underwent a Dor operation (left ventriculoplasty), double encircling endocardial cryoablation without endocardial resection, and preoperative and intraoperative endocardial mapping. Cholecystectomy was simultaneously performed after complete closure of the median chest incision. The recurrence of VT was never recognized clinically or electrophysiologically. The extended encircling endocardial cryoablation without endocardial resection and preoperative and intraoperative electrophysiological study, was a simple and effective method for ventricular tachycardia.

Aim: AS stated in the past reports that approx, 75% of hralthy adulte have experienced it, headache is a symptom often experienced in the crinical peactice of acupuncture.
Effects of acupunctural therapy against headache hace already been reported in many cases, but few reports hace been published so far on the use of acupunctural stimulation for the purpose of diagnosis. In the past 15 years, we used the acupunctural stimulation dor diagnosis of tinnitus and headache and ecaluated the meanings of uts use.
In the present study, we examind the cases whose pains could be reproduced by the acupunctula stimulation in the patients with pain who were introduced to us for diagnosis from the Department of otorhinolaryngology of our hospital.
Ptients and method: Of the patients with pain as the chige complaints whise diagmoses were requested to the Oriental Medicine clinic from the Department of Otorhinolaryngology of Showa University since April 1982 up until October 1990, thise whi complained of facial pain were subjected to our diagnosis, previding that they had no abnormalities in the otorhinolaryngological and ophthalmological checks.
A stainless steel needle (50mm Mo. 20) was usedfor theusting into block points of greater occiptal nerce and the possible relationship between the pain and the sense of reacting sense was examind at the time of thrusting.
Results: 1) It could be reconfirmed that the reacting sensation was produced deep in the inner part and in the epicanthal area of eyes by the neadle thrusting to block points of the greater occipital berce. 2) Ammong the patients who had been teated nefor against trigeminal neuralgia or what were claimed to be pains of eyes of buknown causes, there were cases withe pains coincidental with pathological symptoms such a manner that the reacting sensation by the neadle thrusting (1) resembled the nature of the pain and (2) wads coincidental with that of the affected regions, and (3) the pain could be reproduced by the acupunctural stimulatiom in synchronization with the acupuncturalhandling of the neadle. 3) The efficary of the acupunctueal treatments was higher in those whose pains could be reproducedby the acupunctueal stimulation.
Summaary: The stimulations to the block points of the greater occipital berve caused reacting sessation deep in the inner part of eyes. By utilizing this sensation for diagnostic purposes, sone cases could be properly diagnosed. On the ground of these fundungs it can be claimed that the acupunctueal stimulation according to the method in our present study would be one of the useful methods for cheeck of the pain and also for therapeutic treatment in view of the therapeutic meanings of the findings described in the subparagraphe of (1) through (3) in the paragraph 2) and in the paragraph 3) of the above-mentioned “Results”.

The incidence of fluorosis, believed to arise from the burning of coal, has been frequently reported in the highlands in the southern part of China. With a lot of rain and a climate of low temperature, the hilly region produces coal and inhabitants use it as a fuel for cooking and heating. The fossil fuel used by them is mostly powdery. It is mixed with dirt and rolled up into bolls. In that way,the people make the briquettes that burn a long time.Ordinary houses have no chimneys to belch forth smoke, so that it stagnates indoors for a while. Soot and smoke, before flowing out via the openings in the roof shingle of the loft, spoils farm produce stored there. Because the smoke contains high concentrations of fluoride derived from coal and dirt, it is believed that eating farm produce exposed to the smoke is one of the major factors for fluoride poisoning. Many researchers have thus far analyzed farm products for fluoride content and confirmed that high levels of fluoride were contained in their samples.In the present study, we measured fluoride concentrations in some samples of corn and capsicum produced in a rural area of Sichuan, China on one hand and on the other examined the water-solubility of fluoride. Furthermore, screening tests for chronic endemic dental fluorosis were performed on students to survey the fluoride contamination in the past as compared with the present state.Incidentally, indoor air-borne fluoride concentrations in this area averaged out at0.047mg F/m3 (15 times as high as the mean in a community that was free of fluoride contamination). The fluoride content of the drinking water from a spring in the nearby hill, measured with use of a fluoride-specific electrode method,was within the range from 0.2 to 0.3μg/ml.
Fluorides ; Fluoride measurement ; China ; Coal ; Levels

We report the findings in a 75-year-old woman who was given diagnosis of rupture of the internal thoracic artery (ITA) and was successfully treated by coil embolization. The patient suddenly felt chest pain, and a chest CT revealed a mediastinal hematoma. She was suspected to have an acute aortic dissection, and therefore transferred to our hospital. Upon careful examination, a CT showed a hematoma in the superior mediastunum and the extravasation of the left internal thoracic artery. Emergency coil embolization was thus performed to stop the bleeding. After the embolization, no further hemorrhaging was observed. The patient was uneventfully discharged in a healthy state 2 weeks later. Rupture of the internal thoracic artery is rare. However, it is important to include this potential disease in the differential diagnosis when encountering a patient presenting with an atraumatic mediastinal hematoma.

An 88-year-old woman presented at a local hospital with a left femoral pulsatile mass. CT revealed saccular aneurysms with irregular intima in the descending thoracic aorta, the right common femoral artery and the left superficial femoral artery. They were 60 mm, 30 mm, and 25 mm in diameter, respectively. After referral to our hospital, multiple inflammatory aneurysms were strongly suspected by detailed examinations. Endovascular treatment including thoracic endovascular aortic repair and surgical replacement were performed by two-stage operations. After steroid therapy was started postoperatively, her c-reactive protein (CRP) value decreased. Nevertheless, the thoracic aortic aneurysm enlarged and she died due to hemorrhage. Multiple inflammatory aneurysms are extremely rare. We consider that appropriate steroid therapy and close follow-up are most important.