1.Familial Aortic Dissection: A Report of Four Cases in Two Families.
Satoru Tobinaga ; Hidetoshi Akashi ; Takayuki Fujino ; Shuji Fukunaga ; Shinsuke Hayashi ; Tomokazu Kosuga ; Koji Akasu ; Seiji Onitsuka ; Hideki Sakashita ; Shigeaki Aoyagi
Japanese Journal of Cardiovascular Surgery 2001;30(3):161-164
There are rare reports of families with multiple members with aortic dissection in the absence of Marfan syndrome. We encountered four cases of aortic dissection in two families. The aortic dissection occurred in the mother and child of the first family and in sisters of the second family. All cases had systemic hypertension preoperatively and presented Stanford type A aortic dissection. All of them were operated successfully. None of them showed the characteristics of connective tissue disease affecting the skeletal, ocular, and cardiovascular system. However, many members of the two families had systemic hypertension and histopathological examination of the aorta showed cystic medial necrosis in all of the four cases. The present study suggests that the familial aortic dissection may be caused by weakness of the aortic wall related to heredity and systemic hypertension.
2.Repeatedly Recurrent Colon Cancer Involving the Appendiceal Orifice after Endoscopic Piecemeal Mucosal Resection: A Case Report.
Masau SEKIGUCHI ; Takahisa MATSUDA ; Shigeki SEKINE ; Taku SAKAMOTO ; Takeshi NAKAJIMA ; Ryoji KUSHIMA ; Takayuki AKASU ; Yutaka SAITO
The Korean Journal of Gastroenterology 2013;61(5):286-289
Local recurrence after endoscopic piecemeal mucosal resection (EPMR) for colorectal tumors is a crucial issue. However, such recurrence is usually detected within one year and cured with additional endoscopic treatment, which makes EPMR acceptable. Herein, we report a rare case of repeatedly recurrent colon cancer involving the appendiceal orifice after EPMR, which was not cured with additional endoscopic treatments. A 67-year-old man was referred to us for endoscopic treatment of a 25 mm cecal tumor spreading to the appendiceal orifice in May 2002. The tumor was resected with EPMR, showing well differentiated intramucosal adenocarcinoma with a positive lateral cut margin of tubular adenoma. Endoscopic surveillance was conducted and the first local recurrence was detected in August 2006. Although we resected it endoscopically, the second local recurrence was found in September 2007 and we removed it with endoscopic resection again. However, the third local recurrence was detected in March 2008. Although endoscopic resection was performed also for the third recurrence, curative resection was not achieved. In February 2009, laparoscopic assisted colectomy was performed and histopathological examination showed well differentiated adenocarcinoma with deep submucosal invasion. This case is important in considering indication for endoscopic resection in colorectal tumors involving the appendiceal orifice.
Adenocarcinoma/*diagnosis/pathology/surgery
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Aged
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Appendiceal Neoplasms/complications
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Colectomy
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Colonic Neoplasms/*diagnosis/pathology/surgery
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Colonoscopy
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Humans
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Intestinal Mucosa/pathology
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Male
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Neoplasm Recurrence, Local
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Recurrence