A study was conducted to assess gender differences of body fat distribution (i. e., total body fat mass, subcutaneous fat mass, and internal fat mass) in a homogeneous group of Japanese children. Body composition was estimated in 141 boys and 139 girls (aged 3-6 yr) using bioelectrical impedance analysis (BIA) . All subjects were apparently healthy. Determinations of impedance were made using a four-terminal impedance analyzer (TP-95 K, Toyo Physical, Inc., Fukuoka) . The lean body mass (LBM) was calculated using the equation of Kushuner et al. (1992) and Goran et al. (1993) . Total body fat mass (TFM) was calculated as the difference between body weight and LBM. The subcutaneous fat mass (SFM) was calculated using a modification of the equation derived by Skerjl et al. (1953) . The internal fat mass (IFM) was calculated as the difference between TFM and SFM. From ages 3 through 6 years, the mean LBM increased with age in boys and girls, but showed no significant gender differences. There were also no obvious gender differences in TFM and IFM within the same age range. Percentage body fat decreased in both sexes until the age of approximately 5-yr, and then increased again slightly at 6 yr, although it showed no significant differences between the sexes. The gender-specific pattern of fat accumulation during childhood was characterized by an almost steady increase of SFM in girls. These differences were independent of gender differences in physical characteristics.

OBJECTIVE: We conducted a retrospective, multi-institutional, collaborative study to accumulate cases of neuroendocrine carcinoma of the endometrium, to clarify its clinicopathologic features, treatment, prognosis and prognostic factors to collate findings to establish future individualized treatment regimens. To our knowledge, this is the largest case study and the first study to statistically analyze the prognosis of this disease. METHODS: At medical institutions participating in the Kansai Clinical Oncology Group/Intergroup, cases diagnosed at a central pathologic review as neuroendocrine carcinoma of the endometrium between 1995 and 2014 were enrolled. We retrospectively analyzed the clinicopathologic features, treatment, prognosis and prognostic factors of this disease. RESULTS: A total of 65 cases were registered from 18 medical institutions in Japan. Of these, 42 (64.6%) cases were diagnosed as neuroendocrine carcinoma of the endometrium based on the central pathological review and thus included in the study. Advanced International Federation of Gynecology and Obstetrics stages (stage III and IV) and pure type small cell neuroendocrine carcinoma cases had a significantly worse prognosis. Upon multivariate analysis, only histologic subtypes and surgery were significant prognostic factors. Pure type cases had a significantly worse prognosis compared to mixed type cases and complete surgery cases had a significantly better prognosis compared to cases with no or incomplete surgery. CONCLUSION: Our findings suggest that complete surgery improves the prognosis of neuroendocrine carcinoma of the endometrium. Even among cases with advanced disease stages, if complete surgery is expected to be achieved, clinicians should consider curative surgery to improve the prognosis of neuroendocrine carcinoma of the endometrium.
Carcinoma, Large Cell ; Carcinoma, Neuroendocrine ; Carcinoma, Small Cell ; Endometrial Neoplasms ; Endometrium ; Female ; Gynecology ; Japan ; Medical Oncology ; Multivariate Analysis ; Obstetrics ; Prognosis ; Retrospective Studies