1.Cancer Chemoprevention by Ginseng in Mouse Liver and Other Organs.
Hoyoku NISHINO ; Harukuni TOKUDA ; Tsunehiro II ; Manabu TAKEMURA ; Masashi KUCHIDE ; Motohiro KANAZAWA ; Xiao Yang MOU ; Ping BU ; Junko TAKAYASU ; Mari ONOZUKA ; Mitsuharu MASUDA ; Yashiko SATOMI ; Takao KONOSHIMA ; Naoki KISHI ; Masaki BABA ; Yoshihito OKADA ; Toru OKUYAMA
Journal of Korean Medical Science 2001;16(Suppl):S66-S69
Oral administration of red ginseng extracts (1% in diet for 40 weeks) resulted in the significant suppression of spontaneous liver tumor formation in C3H/He male mice. Average number of tumors per mouse in control group was 1.06, while that in red ginseng extracts-treated group was 0.33 (p<0.05). Incidence of liver tumor development was also lower in red ginseng extracts-treated group, although the difference from control group was not statistically significant. Anti-carcinogenic activity of white ginseng extracts, besides red ginseng extracts, was also investigated. In the present study, the administration of white ginseng extracts was proven to suppress tumor promoter-induced phenomena in vitro and in vivo. It is of interest that oral administration of the extracts of Ren-Shen-Yang- Rong-Tang, a white ginseng-containing Chinese medicinal prescription, resulted in the suppression of skin tumor promotion by 12-o-tetradecanoylphorbol-13-acetate in 7,12-dimethylbenz[a]anthracene-initiated CD-1 mice. These results suggest the usefulness of ginseng in the field of cancer prevention.
Animal
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Anticarcinogenic Agents/*pharmacology
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Female
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Liver Neoplasms, Experimental/*prevention & control
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Male
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Mice
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Mice, Inbred C3H
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*Panax
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Plant Extracts/pharmacology
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Plant Roots
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Skin Neoplasms/*prevention & control
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