1.Factors related to serum total cholesterol.
Yang Ju TAK ; Seun Mi YOO ; Belong CHO ; Yun Mi SONG ; Taiwoo YOO ; Bong Yul HUH
Journal of the Korean Academy of Family Medicine 1992;13(12):935-942
No abstract available.
Cholesterol*
2.The clinical usefulness of CEA in breast cancer.
Ho Tak NAM ; Min Hyuk LEE ; Ik Soo KIM ; Kyung Bal HUH
Journal of the Korean Cancer Association 1993;25(4):514-519
No abstract available.
Breast Neoplasms*
;
Breast*
3.A comparison of reminder models for increasing compliance forcervical cancer screening in a family practice setting.
Eun Kyeong JEONG ; Yang Ju TAK ; Yun Mi SONG ; Taiwoo YOO ; Bong Yul HUH ; Chang Yeop KIM
Journal of the Korean Academy of Family Medicine 1992;13(2):117-124
No abstract available.
Compliance*
;
Early Detection of Cancer*
;
Family Practice*
;
Humans
4.The Overxpression of p53 in gestational Trophoblastic Disease and Normal Human Placenta.
Sung Ook WHANG ; Jong Hyeok KIM ; Jooryung HUH ; Yong Man KIM ; Young Tak KIM ; Joo Hyun NAM ; Jung Eun MOK
Korean Journal of Gynecologic Oncology and Colposcopy 1997;8(3):300-314
Mutations in the tumor suppressor p53 gene are the most frequently observed genetic lesions in human cancers. It seems that wild type p53 does significant role on growth and differentiation of normal cells, Mutations and allelic loss of the p53 gene are thought to be a cause of tumor development and to be correlated with the prognostic factors in various human cancers such as breast, ovary and lung cancer. Mutant p53 proteins have a prolonged half-life and can be detected by immunohistochemistry. In case of GTD(gestational trophoblastic disease), although the mutation of p53 gene mutation was revealed to be very rare, the overexpression of p53 in immunohistochemical staining has been reported in wide range of discrepancy and its role or prognostic significance in GTD is uncertain. This study is performed to define the status of p53 overexpression in GTD and to evaluate the correlations between p53 overexpression and prognostic factors of GTD. THE RESULTS WERE AS FOLLOWS: 1. p53 overexpression was detected in none of normal placental tissue, in 58.3%(14/24) of hydatidiform mole, in 15%(6/8) of invasive mole, in 75%(3/4) of choriocarcinoma, and in 100%(1/1) of placental site trophoblastic tumor, and showed significant difference between normal placenta and GTD. We could not find any difference of the p53 overexpression between benign group(H-mole) of GTD and malignant one(invasive mole, choriocarcinoma, and placental site trophoblastic tumor) 2. In H-mole, low-risk group showed significantly higher prevalence of p53 overexpression than high-risk group did. In malignant group, there is no difference in the prevalence of p53 overexpression between early(FIGO stage I) and late(II- IV)stage-diseases, but the prevalence of p53 overexpression of low-risk group is slightly higher than that of high-risk group although we failed to find statistical significance. In conclusion, the high prevalence of p53 overexpression in GTD suggests that p53 may have a certain role in the pathogenesis of GTD or at least represent generalized DNA damage or genetic instability of GTD. And the higher prevalence of p53 overexpression in low-risk group suggests that accumulation of wild-type p53 may be related with favorable prognosis in GTD.
Breast
;
Choriocarcinoma
;
DNA Damage
;
Female
;
Genes, p53
;
Gestational Trophoblastic Disease*
;
Half-Life
;
Humans*
;
Hydatidiform Mole
;
Hydatidiform Mole, Invasive
;
Immunohistochemistry
;
Loss of Heterozygosity
;
Lung Neoplasms
;
Ovary
;
Placenta*
;
Pregnancy
;
Prevalence
;
Prognosis
;
Trophoblastic Tumor, Placental Site
;
Trophoblasts
5.DNA Ploidy Heterogeneity in Primary an Metastatic Lesion of Epithelial Ovarian Cancer.
Jong Hyeok KIM ; Joo Hyun NAM ; Joo Ryung HUH ; Yong Man KIM ; Young Tak KIM ; Jung Eun MOK
Korean Journal of Obstetrics and Gynecology 1997;40(1):170-180
Tumor DNA content measured by flow cytometry may be a predictor in the prognosis of epithelial ovarian cancer, but the results have been inconsistent. It is recognized that these conflicting results are at least partly due to the variation of DNA content between the samples from the same patient(i.e., intratumoral DNA heterogeneity). The purposes of this retrospective study were to investigate the frequency and the nature of DNA heterogeneity in epithelial ovarian cancer and to evaluate the prognostic significance of DNA heterogenetiy itself. Thirty-two patients with stage II to IV epithelial ovarian cancer who were managed at Asan Medical Center between May 1993 and April 1996 were analysed. Measurements of the nuclear DNA content were performed on samples from primary and metastatic lesion using paraffin embedded archival tissues by Epics(Coulter Inc.) flow cytometry. In two cases, the metastatic tumor was minute and did not reveal a separable peak on repeated examination. DNA heterogeneity was defined as different ploidy pattern or difference of the DNA indices than 0.15 between primary and metastatic tumors. DNA heterogeneity was found in 11 cases(36.7%), and the number of cases with homogeneous diploid and that with homogeneous aneuploid tumor were 5(16.7%) and 14(46.7%) respectively. In evaluation of prognostic significance of DNA heterogeneity using correlation with serum CA 125 level after second course of chemotherapy and residual tumor size after cytoreductive surgery among these three groups, the patients with DNA heterogeneity were considered to show intermediate prognosis between those with homogeneous diploid and homogeneous aneuploid tumor. In conclusion, DNA heterogeneity in epithelial ovarian cancer is considerable in frequency and may have prognostic value.
Aneuploidy
;
Chungcheongnam-do
;
Diploidy
;
DNA*
;
Drug Therapy
;
Flow Cytometry
;
Humans
;
Neoplasm, Residual
;
Ovarian Neoplasms*
;
Paraffin
;
Ploidies*
;
Population Characteristics*
;
Prognosis
;
Retrospective Studies
6.Primary transitional cell carcinoma of the fallopian tube: A case report.
Jong Hyeok KIM ; Jooryung HUH ; Yong Man KIM ; Young Tak KIM ; Joo Hyun NAM ; Jung Eun MOK
Korean Journal of Gynecologic Oncology and Colposcopy 1997;8(1):82-88
No abstract available.
Carcinoma, Transitional Cell*
;
Fallopian Tubes*
;
Female
7.The Study of the Changes of Myocardial Histology and Left Ventricular Function according to the Total Doses of Doxorubicin in Rabbits.
Jeong Hwa CHOI ; Hee Ju PARK ; Young Tak LIM ; Bong Seon KIM ; Eun Young HUH
Journal of the Korean Pediatric Society 2001;44(12):1395-1403
PURPOSE: We'd like to evaluate the relationship between the degree of cardiac damage and that of cardiac function according to the total injected dose of doxorubicin. METHODS: 12 rabbits(body weight : 2.0-3.2 kg) were used and 30 mg/m2/week of doxorubicin hydrochloride was injected intravenously. The cardiac function was checked under anesthesia, after which the thorax was opened and cardiac samples were evaluated with light and electron microscopics. RESULTS: Regardless of total injected dose of doxorubicin, there was no difference between the general appearance, sizes and thickness of both atria and ventricles of doxorubicin injected rabbits and those of normal control. The rabbits with total cumulative dose <180 mg/m2 showed no differences with the rabbits of normal control in the cardiac histology. The rabbits with cumulative doses of 210 mg/m2 had an increased number of vacuoles in the interspaces of the myofibrils and glucogen granules in myocytes. The rabbits with the cumulative dose of 240 mg/m2 had focal necrosis and degeneration of myocytes with fibrous cells infiltration. The rabbits with cumulative doses of 300 mg/m2 demonstrated severe and diffuse degenerations with markedly decreased numbers of myocytes and increased intracellular vacuoles. All the rabbits with total cumulative doses <240 mg/m2 showed no difference in the aortic pressure, left ventricular(LV) maximal dP/dt and left ventricular end diastolic pressure(LVEDP) compared to normal control. The rabbit with total cumulative doses of 300 mg/m2 showed no difference in the aortic pressure and LV maximal dP/ dt, but revealed significantly elevated LVEDP compared to normal control. CONCLUSION: These results showed doxorubicin induced cardiotoxicity is dose related and may be certain at total cumulative dose >200 mg/m2, although cardiac function is normal.
Anesthesia
;
Arterial Pressure
;
Doxorubicin*
;
Muscle Cells
;
Myofibrils
;
Necrosis
;
Rabbits*
;
Thorax
;
Vacuoles
;
Ventricular Function, Left*
8.Clinical Study of Ten Cases of Continuous Spinal Anesthesia for Total Hip Replacement.
Kyung Hang CHO ; Ok Young SHIN ; Tak HUH ; Doo Ik LEE ; Kyu Suk SUH ; Sang Ho JIN
Korean Journal of Anesthesiology 1978;11(1):34-38
This study was primarily undertaken to assess the value of continuous spinal anesthesia for total hip replacements (Charnley's low friction arthroplasty), which had been done under the Filtered Air Flow System for the prevention of wound contamination due to long term exposure. The results were as follows: 1. Preoperative diagnosis was in 4 cases hip joint tuberculosis,in 2 cases avascular necreosis, in 2 cases femur fracture, and in 2 cases osteoarthritis of the hip joint. 2. Average blood loss was 2, 800 ml for a one side operation and 5, 000 ml for a bilateral one. Overall average blood loss with continuous spinal anesthesia was 2, 600 ml and with general anesthesia was 1, 725 ml, and with amount of difference being 1. 175 ml more in the spinal anesthesia group (p<0. 025). 3. In 4 eases (40%) the hypotensive range was over 30% of the preoperative level, but recovery occurred soon after administration of Effortil. 4. Practically management of a patient with continuous spinal anesthesia is easier' thai with general anesthesia for total hip replacement, with fieeing of the anesthesio1ogist'a hands for better care of the patient during anesthesia.
Anesthesia
;
Anesthesia, General
;
Anesthesia, Spinal*
;
Arthroplasty, Replacement, Hip*
;
Asian Continental Ancestry Group
;
Diagnosis
;
Etilefrine
;
Femur
;
Friction
;
Hand
;
Hip Joint
;
Humans
;
Osteoarthritis
;
Wounds and Injuries
9.Quantitative Pathologic Variables as Prognostic Factors in Epithelial Ovarian Cancer.
Jong Hyeok KIM ; Jooryung HUH ; Chang Won KOH ; Jun Hee NA ; Bong Hee KIM ; Yong Man KIM ; Young Tak KIM ; Joo Hyun NAM ; Jung Eun MOK
Korean Journal of Gynecologic Oncology and Colposcopy 1997;8(3):279-290
No abstract available.
Ovarian Neoplasms*
;
Prognosis
10.Primary Clear Cell Carcinoma of the Ovary ; An Analysis of 9 Cases with Review of the Literature.
Jung Eun MOK ; Ji Yoon JUNG ; Jun Hee NA ; Jong Hyeok KIM ; Bong Hee KIM ; Joor Rung HUH ; Yong Man KIM ; Young Tak KIM ; Joo Hyun NAM
Korean Journal of Obstetrics and Gynecology 1998;41(12):3016-3022
Clear cell carcinoma of the ovary is a clinicopathologic entity with distinct morphologic characteristics and known to be associated with poor prognosis irrespective of stage and prognostic benefits of chemotherapy have not been evidently demonstrated. This represents 2-3.6% of all ovarian malignancies. From October, 1991 to January, 1998, nine patients with primary clear cell carcinoma of the ovary treated in the deptartment of Gynecology and Obstetrics, University of Ulsan, Asan Medical Center were identified, and clinical and histologic review(including architectural pattern, mitotic activity, nuclear grading) was performed retrospectively. The age of the patients ranged from 30 to 67 year(mean+S.D.; 46.0+11.8) and the mean parity was 1.2 (+1.3). Five(55.6%) of nine patients had elevated level of CA 125. The size of the tumors varied from 3 cm to 20 cm with the mean maximal diameter of 12.1 (+6.3) cm. The FIGO stages of the patients were IC(6 cases, 66.7%), IIC (2 cases, 22.2%) and IV(1 case, 11.1%). All patients except one were treated by total abdominal hysterectomy and bilateral salpingoophorectomy with or without omentectomy and pelvic lymph node dissection. All except two were received postoperative chemotherapy with regimens such as CEC (cyclophosphamide + epirubicin + carboplatin), TC(taxol + carboplatin), CC(cyclophosphamide + carboplatin) or CAP (cyclophosphamide + adriamycin + cisplatin). The mean follow-up duration was 14.6 (+ 8.6) months and 8 patients were free of disease and one patient with stage IV disease died of disease during postoperative chemotherapy(4 months after surgery).
Chungcheongnam-do
;
Doxorubicin
;
Drug Therapy
;
Epirubicin
;
Female
;
Follow-Up Studies
;
Gynecology
;
Humans
;
Hysterectomy
;
Lymph Node Excision
;
Obstetrics
;
Ovary*
;
Parity
;
Prognosis
;
Retrospective Studies
;
Ulsan