Objective To investigate the cause, prevention and the treatment of postoperative complication of the placement of percutaneous portcatheter system Methods Retrospective analysis of 18 cases with different postoperative complications of the placement of percutaneous portcatheter system. Results 18 patients developed different postoperative complications, including skin necrosis in 2 cases(discard to use 2 cases), incision infection in 3 cases(discard to use 2 cases), incision split in 3 cases(discard to use 1 case), pipe obstruction in 4 cases(discard to use 1 case), pipe moving in 3 cases, incision hemorrhage in 2 cases, pump inversion in 1 case. After all, 12 cases of complicafions were cured. Conclusions Skin necrosis and incision infection are serious postoperative complication of the placement of percutaneous portcatheter system that lead to discard the percutaneous portcatheter system discard to use.