No abstract available.
Birds* ; Chiroptera* ; Hantavirus Infections* ; Hantavirus* ; Korea* ; Seroepidemiologic Studies*

Various devices have been introduced in the field of orthopaedic surgery for the treatment of fractures and dislocations. Widely used among these are metallic nails and pins. A rare complication is the migration of such intermal fixation devices from their original sites of insertion. Examples of migration have been shown in cases for which devices like Kirschner wire and Steinmann pin were used. Acromio-clavicular joint dislocation gives us another good example. Kuntscher nail has beenin worldwide use for the treatment of femoral shaft fractures since the original work of Kuntscher in 1940. Yet few cases were reported, for migration & Kuntscher nail. We, recently had an experience of proximal migration of a Kuntscher nail in a femoral shaft fractnre which was markedly comminuted. The case is presented here with references.
Dislocations ; Femur ; Joints

No abstract available.
Humans ; Quintuplets*

The present study was undertaken to investigate the effect of acute administration of ethanol on production of cytokines such as IL-1j3, IL-2, IL-6, IL-10 and TNF-a, induction of penicillin V-induced active fatal anaphylaxis, and resistence to Salmonel/a typhimurium infection in mice. Ethanol administration into mice was performed by intraperitoneal injection of 0.5 ml of 20 % ethanol for 3 consecutive days before induction of cytokines with lipopolysaccharide (LPS), Con A or Salmone/la injection. Serum levels of cytokines were measured by ELISA. It was found that ethanol administration significantly inhibited both the serum levels of all cytokines examined and the resistance of mice to S. typhimurium. However, ethanol administration failed to prevent penicillin-induced fatal anaphylaxis. Taken together, the present results may need new insights in the diagnosis and treatment of various immunologically-mediated diseases.
Anaphylaxis* ; Animals ; Cytokines* ; Diagnosis ; Enzyme-Linked Immunosorbent Assay ; Ethanol ; Injections, Intraperitoneal ; Interleukin-10 ; Interleukin-2 ; Interleukin-6 ; Interleukins ; Mice* ; Penicillin V* ; Penicillins* ; Salmonella Infections* ; Salmonella*

BACKGROUND: Korea is, known to be an endemic area of viral hepatitis B, and 5-6% of population are carriers. Immunization can reduce the spread of hepatitis B infection. Hower, not all people respond to hepatitis B immunsation. 5-15% of primary vaccinees fail to be immunized. After revaccination, only 37.5 44% of the primary failures elicit antibody response. Recent studies have reported that it is effective to inject a double dose vaccination in immunocompromsed patients. In some country, they recommend that neonate whode mother is HBV carrier shoud receive double dose vaccination. This study documented the results of double dose vaccintion only once to nonrsponders toward the HBV immunzation. METHODS: Healthy nonresponders to Hepatitis B immunization were recuited from Sep. 1995 to Aug. 1996. Subjects with their AST/ALT level over 40, or over 65 years old were excluded. They were received 2ml of plasma-derived vaccine(Hepavax-B) intramuscularly in the deltoid muscle. Anti-HBs antibody testing were performed at 1 to 3 months after vaccintion. RESULTS: 17 healthy nanreponders to Hepatitis B immunization(male 10, female 7) were included. Their mean ages were 47(32 to64), AST/ALT level 20/19(16 to 28/11 to 35), smoking 4.3pys(1 to 7). Seroconversion occured in 13 of them(76.5%). CONCLUSIONS: Nonresponders to Hepatitis B vaccintion respond well to double dose vaccination once.
Aged ; Antibody Formation ; Deltoid Muscle ; Female ; Hepatitis B* ; Hepatitis* ; Humans ; Immunization ; Immunization, Secondary ; Infant, Newborn ; Korea ; Mothers ; Smoke ; Smoking ; Vaccination*

Capsaicin, the pungent principle of hot peppers, is a neurotoxin that depletes unmyelinated primary sensory neurons (polymodal nociceptors) of neuropeptides like tachykinins. However, the role of capsaicin-sensitive sensory nerve in the production of cytokines, penicillin V (PEV)-induced active fatal anaphylaxis and other immune responses is not yet fully established. Neonatal mice were pretreated s.c. with a single injection of 10 ug of capsaicin per mouse in volume of 20 ul within 5 days of age. Using 5-8 week old mice pretreated as neonates with capsaicin, the capsaicin- pretreated and vehicle-treated control mice were examined for various parameters of immune responses described above. For the induction of active fatal anaphylaxis with PEV, 8 week old mice pretreated as neonates and age-matched capsaicin- untreated control mice were sensitized i.p. with 500 ug of PEV-ovalbumin conjugate plus 2*10(9) B. pertussis and 1.0 mg alum and challenged i.v. with PEV-bovine serum albumin conjugate 14 days later. It was found that neonatal capsaicin-pretreatment significantly enhanced contact hypersensitivity to TNCB and hemagglutination response to SRBC, but significantly inhibited the proliferation response of rnurine splenocyte to Con A and LPS. Interestingly, neonatal capsaicin pretreatment significantly inhibited the intensity of PEV-induced active fatal anaphylaxis and decreased the mortality due to anaphylactic shock. It also significantly inhibited LPS- induced production of cytokines such as TNF-a, IL-1B, IL-6, IL-10, and IL-12. The capsaicin-pretreatment also resulted in an inhibition of the activation of NF-kB. Taken together, these data showed for the first time that neonatal capsaicin-pretreatment significantly inhibited an antibiotic (PEV)-induced anaphylaxis and production of various cytokines, and suggest that capsaicin-sensitive primary sensory nerve may play an important regulatory role in active fatal anaphylaxis and cytokine production, thus potentially presenting tools for immune intervention. In particular, the data presented also indicated the possibility to selectively down-modulate cytokine production and NF-kB activation may offer a broad application for therapeutic intervention in neuroimmunological diseases and other pathological situations.
Anaphylaxis ; Animals ; Capsaicin* ; Cytokines ; Denervation* ; Dermatitis, Contact ; Hemagglutination ; Humans ; Infant, Newborn ; Interleukin-10 ; Interleukin-12 ; Interleukin-6 ; Mice ; Mortality ; Neuropeptides ; NF-kappa B ; Penicillin V ; Sensory Receptor Cells ; Serum Albumin ; Tachykinins ; Whooping Cough

No abstract available.
Anaphylaxis* ; Animals ; Hypersensitivity* ; Immunoglobulin E* ; Interferons* ; Mice*

No abstract available.
Child* ; Humans ; Rheumatic Fever*

Congenital biliary atresia is the commonest cause of prolonged obstructive jaundice in the neonatal period, and is due to the pathologic closure of a major portion or segment of the biliary tree. The neonate with prolonged obstructive jaundice poses a diagnostic dilemma that may be insoluble by routine clinical and laboratory studies. This applies particularly to the most common entities, neonatal hepatitis and biliary atresia. We esperienced one case of congenital biliary atresia associated with ectopic pancreatic tissue in 23 day-old female which was confirmed by autospy. Literature about congenital biliary atresia were reviewed.
Biliary Atresia* ; Biliary Tract ; Female ; Hepatitis ; Humans ; Infant, Newborn ; Jaundice, Obstructive

BACKGROUND: The purpose of this study was to compare the Physical Activity Recall (Stanford 7-days physical activity recall)with the Triaxial accelerometer (RT3)to assess physical activity in young adults. METHODS: Thirty-seven subjects wore the RT3 for 24 hours and then completed the physical activity recall. The Stanford 7-Day Recall records hours of sleep, light-, moderate-, hard-and very hard levels of physical activity. RESULTS: The total energy expenditure per day for the Stanford 7-day recall and RT3 was 2381.29 +/-594.93 kcal/day and 2232.97 +/-398.32 kcal/day,respectively, and showed high correlation (r=0.821).The activity energy expenditure per day for the Stanford 7-day recall and RT3 was 836.21+/-290.59 kcal/day and 509.83+/-181.57 kcal/day,respectively,and showed less high but significant correlation (r=0.327).When compared by sex, the total energy expenditure was significantly correlated in men (r=0.572)and the activity energy expenditure in women (r=0.484). CONCLUSION: The Stanford 7-day recall and the RT3 was highly correlated in the total energy expenditure and significantly correlated in the activity energy expenditure. Therefore,it may be used reciprocally to assess physical activity.
Energy Metabolism ; Female ; Humans ; Male ; Motor Activity* ; Young Adult