Testicular involvement in male patients with leprosy is well documented and may be associated with impotence, sterility and gynecomastia. Testicular histology shows atrophy of the seminiferous tubules with hypertropy and clumping of Leydig cells and hyalinization of the small and medium sized vessels. The hormonal functions of the testes have been studied by a number of workers, usually in patients with testicular atrophy and gynecomastia. In these particular patients, androgens are generally diminished while gonadotropins are increased. The pathogenesis of testicular damage is uncertain, though Wall and Wright(1974) found that testicular germinal cell antibodies were present in 75% of lepromatous, and postulated that :autoirnmunity, Erythema Nodosum Leprosum imrnune complex damage and direct invasion by Mycobacterium leprae may all be contributory.
Androgens ; Antibodies ; Atrophy ; Erectile Dysfunction ; Erythema Nodosum ; Gonadotropins ; Gynecomastia ; Humans ; Hyalin ; Infertility ; Leprosy ; Leydig Cells ; Male ; Mycobacterium leprae ; Seminiferous Tubules ; Testis

No abstract available.
Gerbillinae

No abstract available.
Animals ; Ethanol* ; Killer Cells, Natural* ; Mice* ; Rats*

Intracavernosal self injection therapy is now being widely used to treat patients with erectile dysfunction. However, there is a large number of patients who gives up the self injection program due to the fear of needle or injection. Therefore, the less invasive route of drug administration is highly recommended. We investigated the efficacy of intraurethral instillation of PGE1 solution in comparison with the trimix intracavernosal injection. A total of 24 patients have been observed with either injection of trimix (11 patients), or intraurethral instillation of PGE1 (13 patients). All patients were evaluated with the penile doppler ultrasonography before 5,15,30 and 45 minutes after the drug administration. Penile length and circumference were measured before and after intraurethral administration of PGE1. Ten out of 11 patients (91%) showed positive response in trimix group and nine of 13 patients (69.2%) in PGE1 group. Mean length and circumference of penile shaft before and after the pharmacologic erection test showed significant difference in PGE1 group. The mean peak systolic velocity at 30 minutes was 28.5% 10.53 cm/sec in Trimix group and 28.2 t8.47 cm/sec in PGE, group (p=0.4773). The mean end diastolic velocity at 30 minutes was 8.4 5.23 cm/sec in Trimix group and 8.2=4.21 cm/sec in PGE1 group (p=0.4689). With the intraurethral administration of PGE1, urethral pain and irritation were the noticeable complications but systemic side effect was not noticed In conclusion, PGE1 intraurethral instillation can be satisfactorily used for the patients with erectile dysfunction of psychogenic, less prominent organic and neurogenic origin, although the effect of intraurethral instillation of PGE1 is obviously less than that of Trimix intracavernosal injection.
Alprostadil* ; Erectile Dysfunction* ; Humans ; Male ; Needles ; Prostaglandins E ; Ultrasonography, Doppler

No abstract available.
Animals ; Fibroblasts* ; Fluorouracil* ; Rats*

Currently, the cell surface antigen A,B,O(H) is thought to be an important indicator of malignant potential in bladder carcinoma. Herein, we performed SRCA test in 54 bladder carcinoma for detection of such an isoantigen, comparing the SRCA result to its tumor grade and stage. Also, various significances including the clinical application of SRCA test for the management of the bladder carcinoma were discussed. The results were as follows: 1. Of 54 patients, 34 patients were low stage(0-A) and low grade(1-2). 2. There is a significant correlation between tumor grade and SRCA test: Of 38 patients with low grade. 19 patients were SRCA positive, but of 16 patients with high grade. all were SRCA negative. 3. There is a significant correlation between tumor stage and SRCA test: Of 36 patients with low stage, 18 patients were SRCA positive, but of 18 patients with high stage(above B1), only one patient was SRCA positive. 4. There is a high possibility of false-negative results in detecting O(H) isoantigen: Of 36 patients with low stage, 6 patients were blood group 0 who were all SRCA negative. but 30 patients with other blood groups showed variable SRCA results. 5. There is a considerable correlation between tumor recurrence and SRCA result: Of 20 patients who were followed more than one year after initial TUR, 8 patients were SRCA positive, of these 4 patients were recurred, but 9 patients of 12 patients with SRCA negative were recurred.
Antigens, Surface* ; Blood Group Antigens ; Humans ; Isoantigens ; Recurrence ; Urinary Bladder*

No abstract available.
Quality of Life* ; Surveys and Questionnaires*

Acquired perforating disease(APD) is characterized by hyperkeratotic papules with transepidermal elimination of degenerated material and is associated with renal disease and/or diabetes. Particular attention has been directed to transepidermal elimination because the articles on perforating diseases among patients with chronic renal failure and/or diabetes have been increasingly reported. We describe four patients with chronic renal failure and/or diabetes whose skin biopsy specimens showed transepidermal elimination.
Biopsy ; Humans ; Kidney Failure, Chronic* ; Skin

A clinical observation was made on 43 cases of genitourinary tract tuberculosis who were admitted to National Police Hospital during the period from January 1981 through December 1987. Following results were obtained. 1. Incidence of genitourinary tract tuberculosis was 2.3% of all patients. Male to female ratio was 2:1 and most common incidence was in the 4th decade. 2. Most common symptoms were those of vesical symptoms such as frequency(49%) and hematuria(37 %). 3. Previous tuberculosis histories were noted in 14 cases(32.2%) most of which were pulmonary tuberculosis. 4. Laboratory findings of urine were in order of pyuria(60%), hematuria(51 %), proteinuria (47%) and positive AFB in concentrated sediments(30%). 5. Excretory urographic findings were nonvisualization(41%), deformity of the ureter(28 %), delayed visualization(l7%) and caliectasis(17%). 6. Cystoscopic findings were active lesion of cystitis in 7 cases, deformed ureteral orifice in 7 cases, contracted bladder in 1 case and unremarkable in 2 cases. 7. Patients were managed by chemotherapy in 16 cases(37%), nephrectomy with chemotherapy in 12 cases(28%), epididymectomy with chemotherapy in 14 cases(33%) and ureteral reimplantation in 1 case. The short course chemotherapy using INH, rifampin and pyrazinamide was tried in 7 cases with good result and no recurrence during maximum 1 year follow-up period.
Congenital Abnormalities ; Cystitis ; Drug Therapy ; Female ; Follow-Up Studies ; Humans ; Incidence ; Male ; Nephrectomy ; Police ; Proteinuria ; Pyrazinamide ; Recurrence ; Replantation ; Rifampin ; Tuberculosis* ; Tuberculosis, Pulmonary ; Ureter ; Urinary Bladder

No abstract available.
DNA Fingerprinting* ; DNA* ; Oligonucleotide Probes* ; Polymerase Chain Reaction*