The incidence of ectopic thyroid is about 7%-10%. It generally appears in the midline due to abnormal migration. Rarely, ectopic thyroid is located at the heart, the mediastium, the lungs, the pancreas or adrenal glands. The authors report the case of a 36 years old, female patients who presents with symptoms of dysponia (hot potato speech) due to abnormal mass at the base of the tongue. Ultrasound detects no thyroid gland at the normal site. At the base of the tongue, there is an hypoechoic mass without hypervascularity on color Doppler, which is suspected for ectopic thyroid tissue. Then Tc99m sodium pertechnetate scanning shows thyroid tissue of the base of the tongue and there is no thyroid tissue in the normal location.
Thyroid Gland ; Tongue

Phytochemical investigation of Kandelia candel resulted in the isolation of six triterpenes (1 - 5) and two glyceryl glycosides (6 and 7) and their structures were determined by comparing the spectroscopic data with those of reported values. In present study, we described the inhibitory effects of fractions and isolated compounds from K. candel on pro-inflammatory cytokines (IL-12 p40, IL-6, and TNF-alpha) production in lipopolysaccharide (LPS) stimulated bone marrow-derived dendritic cells (BMDCs). Results indicated that compounds 3, 6, and 7 showed potent inhibition on IL-6 production (IC50 values at less than 0.5 microM, respectively). Meanwhile, compounds 6 and 7 exhibited strong inhibitory effects on the production of TNF-alpha (IC50 values of 1.7 +/- 0.1 and 5.5 +/- 0.2 microM). Compounds 1 and 3 were also showed the inhibitory effects on IL-12 p40 production (IC50 values of 8.9 +/- 0.4 and 3.3 +/- 0.1 microM, respectively).
Cytokines ; Dendritic Cells ; Glycosides* ; Interleukin-12 ; Interleukin-6 ; Rhizophoraceae* ; Triterpenes* ; Tumor Necrosis Factor-alpha