A case of pigmented villondular synovitis is reported in a 32 years old woman, who exhibited bulbulous supra-patellar bulging with dull pain on the right knee joint. Aspiration yielded thick purplish brown effusion from the knee joint and roentgenologically negative. Synovectomy through two seperate para-patellar incision were carried out, and no recurrence of symptom was demonstrable in 2 years post-operative follow-up. A brief summary of literatures is Submitted.
Female ; Follow-Up Studies ; Humans ; Knee Joint ; Recurrence ; Synovitis ; Synovitis, Pigmented Villonodular

No abstract available.
Gestational Age* ; Mortality

Experiments were performed in mice (Balb/C) to support the basic efficacy of the human immunoglobulin (IgG) preparation. The antibacterial activity of IgG purified from human sera was examined with or without the quinolone agent, ciprofloxacin (CPFX), against Pseudomonas aeruginosa isolated from clinical specimens. Results were as follows: Antibacterial activities in terms of percentage of survivors, after administration of Ps. aeruginosa into mouse intraperitoneal cavity were in the following order, single IgG group, CPFX administration after IgG pretreatment group, IgG and CPFX combined administration group and CPFX alone group. The number of living bacteria was monitored in blood and liver tissue of mice infected with Ps. aeruginosa and treated by IgG administration. The increase of living bacteria in liver was more drastic than that in blood. Leukocytosis was observed in mice injected with IgG, excluding those only with ciprofloxacin, after 8 hours of administration to see a decrease to normal number of bacteria after 18 hours. No significant difference was noticed between pretreatment group and post treatment group. In vitro susceptibility test of IgG against Ps. aeruginosa, minimal inhibitory concentration (MIC) was 250 µg/ml, resistant to IgG, regardless of a combined administration with CPFX. In vitro test revealed that the IgG itself did not have anti-Ps. aeruginosa activity.
Animals ; Bacteria ; Ciprofloxacin* ; Humans ; Immunoglobulin G ; Immunoglobulins* ; In Vitro Techniques ; Leukocytosis ; Liver ; Mice ; Pseudomonas aeruginosa* ; Pseudomonas* ; Survivors

PURPOSE: The postpubertal males with unilateral cryptorchidism undergo orchiectomy rather than orchiopexy, which is based on the various reports in its effect on fertility and predisposition to testicular cancer. We reviewed retrospectively the clinical features and histopathological findings of orchiectomized testes and investigated the role of orchiectomy in the postpubertal unilateral cryptorchidism. MATERIALS AND METHODS: We reviewed 42 patients with postpubertal unilateral cryptorchidism who underwent orchiectomy from 1986 to 1998, retrospectively. Patient`s age ranged from 15 to 47 years(mean 26.4). The cryptorchid testes were palpable in 33 cases(79%) and impalpable in 9 cases(21%). We classified cryptorchid testes histopathologically into 2 broad groups of specimens with no spermatogenesis(severe atrophy and/or Sertoli cell-only syndrome) and specimens displaying spermatogenesis(maturation arrest, hypospermatogenesis). In 38 cases of all orchiectomized specimens, testicular volume was calculated by Lambert`s formula. RESULTS: Histopathology showed maturation arrest in 8 cases(19%) while 34 cases(81%) had severe atrophy and/or Sertoli cell-only syndrome. No case of carcinoma in situ or cancer was found in testicular tissue. The location of the cryptorchid testes was the prepubic area in 13(31%), inguinal canal in 23(55%), and abdomen in 6(14%). There was a statistically significant difference in the relationship between the presence and absence of spermatogenesis in cryptorchid testes and the anatomical levels of descent(p<0.05). There was no statistically significant difference in the relationship between testicular volume and the location of cryptorchid testes, between testicular volume and patient`s age(p>0.05). CONCLUSIONS: Currently, orchiectomy is mostly advocated for a postpubertal unilateral cryptorchid testis because of the risk of future malignancy. But we consider that orchiopexy is a valuable modality of treatment for postpubertal unilateral cryptorchid testis, especially located at prepubic area, after performing testis biopsy and then periodic follow-up is required.
Abdomen ; Atrophy ; Biopsy ; Carcinoma in Situ ; Cryptorchidism* ; Fertility ; Humans ; Inguinal Canal ; Male ; Orchiectomy* ; Orchiopexy ; Retrospective Studies ; Sertoli Cell-Only Syndrome ; Spermatogenesis ; Testicular Neoplasms ; Testis

No abstract available.
Congenital Hypothyroidism* ; Diagnosis* ; Prognosis*

The enzyme complex 3beta-hydroxysteroid dehydrogenase (3beta-HSD) is involed in the biosynthesis of all classes of active steroids. It has been known that the enzymatic activity of 3beta-HSD is present not only in the classical steroido-genic tissues, but also in many peripheral tissues. This study was performed to investigated of 3beta-HSD immunore-activity in the rat cardiovascular tissues such as the ventricle, atrium, aortic arch, and abdominal aorta. Immunoblot analyses and immunohistochemical studies were performed using polyclonal antibodies raised against purified human placental 3beta-HSD. We identified 43 and 37KDa bands in the ventricle and atrum, whereas only 37KDa band was observed in the aortic arch and abdominal aorta. Immunostaining for 3beta-HSD was detected in the ventricular and atrial cardiocytes. The intensity of staining was much higher in the atrial cardiocytes than in the ventricular cardiocytes. Immunostaining was also found in the smooth muscles of aortic arch and abdominal aorta.
Animals ; Antibodies ; Aorta, Abdominal ; Aorta, Thoracic ; Cardiovascular System* ; Humans ; Muscle, Smooth ; Oxidoreductases ; Rats* ; Steroids

Invasive mole is a malignant form of hydatidiform mole and can be seen occasionally. It invades the myometrium, adjacent structures and metastasizes distantly. It can initially appear with symptoms of the respiratory, genitourinary system, or rarely intraperitoneal hemorrhage. However, reports of invasive mole initially presenting symptom of brain metastasis is rare and is occasionally found at autopsy. We report a case of invasive mole which had metastasized to the brain and lung and initially presented with symptoms of brain metastasis.
Animals ; Autopsy ; Brain* ; Female ; Hemorrhage ; Hydatidiform Mole ; Hydatidiform Mole, Invasive* ; Lung ; Mice ; Myometrium ; Neoplasm Metastasis* ; Pregnancy ; Urogenital System

The gene for tyrosinase has been mapped to the long arm of chromosome 11 at 11q14-21. The gene is at least 50Kb in length and its coding region is divided into five exons. Until now several mutations of the tyrosinase gene have been identifed in patient with typical oculocutaneous albinism (OCA) who are responsible for tyrosinase negative OCA. It may be possible to determine the types of OCA by measuring the hairbulb tyrosinase activity. Hairbulb tyrosinase activity was examined in a Korean albino to determine the type of OCA. And also tyrosinase assay was carried out in normally pigmented individuals and all members of a Korean albino's family to examine the tyrosinase activities. Five exons of tyrosinase gene from a Korean albino were amplified by polymerase chain reaction. Each amplified exon segments were independently subcloned and DNA sequences of clones were determined. The results obtained were as follows : 1. A Korean albino had no measurable hairbulb tyrosinase activity and was identified as type IA (tyrosinase negative) oculocutaneous albinism. 2. Normally pigmented individuals had different ranges of hairbulb tyrosinase activity. 3. A Korean albino had two single base insertions within exon V (between 337bp and 338bp, 353bp and 354bp) of tyrosinase gene. These insertional mutations might disrupt tyrosinase function and were associated with a total lack of melanin biosynthesis.
Albinism* ; Albinism, Oculocutaneous ; Arm ; Base Sequence ; Chromosomes, Human, Pair 11 ; Clinical Coding ; Clone Cells ; Exons ; Humans ; Melanins ; Monophenol Monooxygenase* ; Polymerase Chain Reaction

OBJECTIVES: SCC Ag(Squamous cell carcinoma antigen) is so far the most useful tumor marker in assisting clinical diagnosis of cervical cancer and follow-up after therapy. Elevated levels of cytokeratin 19-fragments(CYFRA 21-1) have recently been detected in large proportion of patients with non small cell cancer of the lung, and in particular those with squamous cell carcinoma. This study is to assess the clinical efficacy of CYFRA 21-1 with SCC Ag as the clinicopathologic parameter in cervical cancer. METHOD: Retrospective analysis of the serum tumor markers CYFRA 21-1 & SCC Ag in eighty cervical cancer patients was performed. RESULTS: Cut off values for SCC Ag & CYFRA 21-1 were 1.94 ng/ml, 3.11 ng/ml respectively. Using the cut-off point, the sensitivity, specificity, positive predictive value(PPV), and negative predictive value(NPV) of serum SCC were 55, 95, 97, 46%, respectively. Serum CYFRA 21-1 showed a sensitivity of 45%, specificity of 91%, PPV of 87%, and NPV of 55%. The combination of SCC and CYFRA 21-1 increased the sensitivity to 62%, with a specificity, PPV, and NPV of 72, 75, 58%. Serum levels of both markers were compared with tumor stage, lesion size and were significantly related. In FIGO stage Ib-IIa, the serum levels of SCC Ag & CYFRA were 2.2+/-3.9, 2.5+/-3.6 ng/ml and in FIGO stage IIb-IV, 12.2+/-15.2, 10.8+/-11.2 ng/ml. In < or =4cm of lesion size the serum levels of SCC Ag & CYFRA were 3.3+/-9.0, 4.5+/-7.6 ng/ml and in >4cm of lesion size, 11.8+/-11.9, 7.7+/-9.3 ng/ml. CONCLUSION: These data seems to show that serum CYFRA 21-1 may be of additional value in assessing the state of disease in some patients with cervical cancer. The prediction of recurrent cervical cancer with SCC Ag were improved by the combination with CYFRA 21-1 but further investigation is needed.
Carcinoma, Squamous Cell ; Diagnosis ; Follow-Up Studies ; Humans ; Keratins ; Retrospective Studies ; Sensitivity and Specificity ; Small Cell Lung Carcinoma ; Biomarkers, Tumor ; Uterine Cervical Neoplasms*

No abstract available.
Vagina*