Sonozaki syndrome is an exceptionally rare chronic rheumatic disorder characterized by pustulosis on the palms and soles, as well as arthritis and osteitis. This syndrome belongs to the category of spondyloarthritis, which includes psoriatic arthritis. Pustules are concentrated on the palms and soles, whereas arthro-osteitis predominantly affects the sternoclavicular and costochondral joints. This report presents the case of a 32-year-old man with a 2-month history of worsening anterior chest wall pain and pustular eruptions on the palms and soles.

Sonozaki syndrome is an exceptionally rare chronic rheumatic disorder characterized by pustulosis on the palms and soles, as well as arthritis and osteitis. This syndrome belongs to the category of spondyloarthritis, which includes psoriatic arthritis. Pustules are concentrated on the palms and soles, whereas arthro-osteitis predominantly affects the sternoclavicular and costochondral joints. This report presents the case of a 32-year-old man with a 2-month history of worsening anterior chest wall pain and pustular eruptions on the palms and soles.

Sonozaki syndrome is an exceptionally rare chronic rheumatic disorder characterized by pustulosis on the palms and soles, as well as arthritis and osteitis. This syndrome belongs to the category of spondyloarthritis, which includes psoriatic arthritis. Pustules are concentrated on the palms and soles, whereas arthro-osteitis predominantly affects the sternoclavicular and costochondral joints. This report presents the case of a 32-year-old man with a 2-month history of worsening anterior chest wall pain and pustular eruptions on the palms and soles.

Sonozaki syndrome is an exceptionally rare chronic rheumatic disorder characterized by pustulosis on the palms and soles, as well as arthritis and osteitis. This syndrome belongs to the category of spondyloarthritis, which includes psoriatic arthritis. Pustules are concentrated on the palms and soles, whereas arthro-osteitis predominantly affects the sternoclavicular and costochondral joints. This report presents the case of a 32-year-old man with a 2-month history of worsening anterior chest wall pain and pustular eruptions on the palms and soles.

Sonozaki syndrome is an exceptionally rare chronic rheumatic disorder characterized by pustulosis on the palms and soles, as well as arthritis and osteitis. This syndrome belongs to the category of spondyloarthritis, which includes psoriatic arthritis. Pustules are concentrated on the palms and soles, whereas arthro-osteitis predominantly affects the sternoclavicular and costochondral joints. This report presents the case of a 32-year-old man with a 2-month history of worsening anterior chest wall pain and pustular eruptions on the palms and soles.

OBJECTIVE: The authors demonstrate neuroprotective effects of antioxidant in reperfusion injury using ischemic rat model and evaluate the clinical eligibility of this agent to ischemic cerebrovascular diseases. METHODS: Rat model was made according to Longa method. Thirty-six Sprague-Dawley rats were used and were equally divided into three groups;A) treated subcutaneously with D,L-6,8-Thioctic acid 30 minutes before occlusion, B) within one hour after occlusion, and C) with vehicle only. Neurologic examination was performed immediately and 24 hours after reperfusion. Twenty-four hours after reperfusion, brains were extracted and stained with 2% 2,3,5-Triphenyltetrazolim chloride in 2mm-thickness section. Then, fixed sections were digitalized and used for infarct area calculation. RESULTS: There was no significant statistical difference in recorded hemodynamic and physiologic parameters between three groups. The neurologic status taken immediately following reperfusion were A) 2.67+/-0.492, B) 2.75+/-0.452, and C) 2.83+/-0.389, and were improved to A) 1.67+/-0.898, B) 1.92+/-0.900, and C) 2.08+/-0.793 just before sacrificing. However, there was no statistically significant difference between three groups. Mean volume of cerebral infarction was A) 9.5+/-1.67%, B) 10.4+/-1.58%, and C) 11.3+/-1.12% with no significant difference. Any specific correlation between the neurologic status and the mean infarction volume was not observed. CONCLUSION: Any single agent does not seem to reduce the infarction volume holistically, therefore, the incoming therapeutic target should be the development of versatile neuroprotective agents or the selection of preexisting synergistic compounds without compromising patients' safety.
Animals ; Brain ; Cerebral Infarction* ; Hemodynamics ; Infarction ; Models, Animal* ; Neurologic Examination ; Neuroprotective Agents ; Rats* ; Rats, Sprague-Dawley ; Reperfusion ; Reperfusion Injury

PURPOSE: We hoped to evaluate the possibility of substitution of the local anesthesia for the spinal anesthesia in hemorrhoidectomy. METHODS: We did Milligan-Morgan hemorrhoidectomy under local anesthesia for the sixty- eight patients from January 1998 to December 2005. These patients were compared with seventy-nine patients of spinal anesthesia, sampled with similar gender, age, a surgeon, retrospectively. We used a mixture of 0.5% lidocaine and 1:200,000 epinephrine into perianal skin and intersphincteric space. RESULTS: The male-to-female ratio was 1:1 in local anesthesia group and 1:0.84 in spinal anesthesia group. The mean age was 50 and 46 respectively. The number of excised pile was 3.9 and 3.8 respectively. The frequency of the analgegics injected within first 24 hours was 1.79 and 2.70 respectively (P=0.001). The frequency of the urinary catheterization was 0.07 and 0.69 respectively (P < 0.001). The first bowel movement after surgery was 1.2 days and 1.6 days respectively. The hospital stay was 6.4 days and 8.1 days respectively (P=0.06). CONCLUISIONS: Local anesthesia is simple, safe and effective in the hemorrhoidectomy.
Anesthesia, Local* ; Anesthesia, Spinal ; Epinephrine ; Hemorrhoidectomy* ; Hope ; Humans ; Length of Stay ; Lidocaine ; Retrospective Studies ; Skin ; Urinary Catheterization ; Urinary Catheters

PURPOSE: The aim of this study was to detail clinical experiences with a new type of tension-free herniorrhaphy using the Prolene Hernia System (PHS) and analyze the system' usefulness. METHODS: We reviewed 48 cases of herniorrhaphy using PHS and 45 cases of conventional herniorrhaphy retrospectively by reviewing the medical records of patients undergoing either procedure between January 2000 and February 2005. RESULTS: There was no significant difference in the operation time (P=0.054) or the length of hospital stay (P=0.138) between the groups. However, the need for analgesic therapy in the PHS group was less than in the control group (P= 0.008). There were no serious postoperative complications, but wound complications occurred more often in the PHS group (6 seromas and 2 hematomas), and urinary retention occurred more frequently in the control group. The recurrence rate in the control group was 2.2% (1/45), but there were no recurrences in the PHS group for 46 months. CONCLUSION: Herniorrhaphy using the PHS is safe and effective as conventional surgery. It can be carried out under local anesthesia more easily, and it is less painful than the conventional surgery. We suggest that the PHS be widely adopted as a method of tension-free herniorrhaphy.
Anesthesia, Local ; Hernia ; Hernia, Inguinal ; Herniorrhaphy ; Humans ; Hydrogen-Ion Concentration ; Length of Stay ; Medical Records ; Polypropylenes ; Postoperative Complications ; Recurrence ; Retrospective Studies ; Seroma ; Urinary Retention

Merkel cell carcinoma is a rapidly growing malignant neuroendocrine tumor with a high rate of recurrence and metastasis for which wide excision is recommended. About 10 cases of spontaneous regression have been reported in the world. We report a case of Merkel cell carcinoma which showed spontaneous regression. The patient was a 68-year-old woman with a two-month history of a rapidly enlarging dusky red tumor on her right cheek. Microscopically, the tumor cells were uniform with round to oval shaped nucleus and scanty cytoplasm, and showed trabecular arrangement. Ultrastructually, dense core neurosecretory granules 100 to 200nm in diameter were found in the cytoplasm of tumor cells. As far as we know, this is the first case of the spontaneous regression of the tumor in the country.
Aged ; Carcinoma, Merkel Cell* ; Cheek ; Cytoplasm ; Female ; Humans ; Neoplasm Metastasis ; Neuroendocrine Tumors ; Recurrence

Sebaceous trichofolliculoma, which is a variant of trichofolliculoma, is a rare disease that clinically show a centrally depressed lesion usually singly on the nose, and histologically a centrally located cavity, lined by squamous epithelium, with numerous sebaceous lobules connected to them. We describe a case of sebaceous trichofolliculoma in a 27-year-old woman who had several brown papules on the nose. We think that this is the first report of sebaceous trichofolliculloma in Korean literature.
Adult ; Epithelium ; Female ; Humans ; Nose ; Rare Diseases