Intraductal papillary mucinous neoplasms of the bile ducts (IPMNs-B) are uncommon lesions that are characterized by innumerable papillary fronds that contain fine vascular cores, enriched mucin production and bile duct dilatation. IPMNs-B are histologically similar to intraductal papillary mucinous neoplasms of the pancreas and they are occasionally associated with hepatolithiasis. IPMNs-B are considered to be relatively low-grade malignancy and they merit consideration for aggressive surgery. Thus, early and precise diagnosis is important to maximize patient survival. From July 2002 to March 2006, we identified four patients with IPMNs-B at our hospital. In three patients, intrahepatic or extrahepatic bile duct stones were associated with their condition. Computed tomography and magnetic resonance cholangiography were done in all four cases and this demonstrated marked dilatation of the biliary tree. Endoscopic retrograde cholangiography was done in two cases and a large amount of mucin that was draining from the patulous orifice of the duodenal papilla was seen on endoscopy. However, two cases were initially misdiagnosed as intrahepatic cholangiocarcinoma or choledochal cyst with intrahepatic bile duct stones. All the cases underwent ipsilateral hemihepatectomy with caudate lobectomy. Histologically, one case showed to be adenoma, one case was borderline and two cases were invasive adenocarcinoma.
Adenocarcinoma ; Adenoma ; Bile Ducts* ; Bile Ducts, Extrahepatic ; Bile Ducts, Intrahepatic ; Bile* ; Biliary Tract ; Cholangiocarcinoma ; Cholangiography ; Choledochal Cyst ; Diagnosis ; Dilatation ; Endoscopy ; Humans ; Mucins* ; Pancreas

No abstract available.
Lymphoma* ; Thyroid Gland*

PURPOSE: Neonatal jaundice is one of the most common problems in our country leading to hospitalization. Agar is low cost, low risk, and easily fed orally; it can bind bilirubin in the intestine, decreasing its enterohepatic circulation, thereby decreasing serum bilirubin levels. At present, however, the effectiveness of agar in the prevention and treament of neonatal jaundice is quite conflicting and controversy. Recently we have read Caglayan's 'Superiority of Oral Agar and Phototherapy Combination in the Treatment of Neonatal Hyperbilirubinemia'. The result was very hopeful and attractive enough, and which gave us a motivation to study if it was really of value. METHODS: From May 1995 to April 1996, a total 50 term neonates admitted in nursery of Dong-Eui Medical Center with the capillary serum bilirubin levels greater than 10mg/ dl were enrolled in the study. Those with pathologic causes and breast fed infants were all excluded. The neonates were randomly devided into two groups; 25 of conventional phototherapy alone (P group) and 25 of oral agar plus conventional phototherapy combination (A+P group). The study was terminated when the capillary serum bilirubins were decreased to 8mg/dl. Pastagar B (Pasteur Institute 64946) 500mg in 10ml distilled water were fed four times a day using 10ml syringes prior to bottle feeding. Capillary serum bilirubin levels were measured daily at 10:00 a.m. with heel pad samples. Daily stool frequency and adverse effects of treatment were observed closely. RESULTS: 1) The decrement of the serum bilirubin levels at first 24 hours of therapy was significantly different between P and A+P groups showing as 1.7+/-1.2 and 2.4+/-1.0mg/dl respectively (p<0.05). 2) Mean time for bilirubin to decrease to 8mg/dl was shorter in A+P group than in P group showing as 45.7+/-20.8 and 57.5+/-32.3 hours each other, but those differences were statistically insignificant (p>0.05). 3) No adverse effects such as rashes or abdominal pains were observed during treatment. Differences of mean stool frequency were significant between P and A+P groups showing as 3.7+/-1.2 and 4.7+/-2.0 times per day respectively (p<0.05). CONCLUSION: The agar plus conventional phototherapy combination was superior to conventional phototherapy alone at first 24 hours of therapy in neonatal hyperbilirubinemia, but further more careful researches would be necessary for using it routinely in the treatment of neonatal hyperbilirubinemia in future.
Abdominal Pain ; Agar* ; Bilirubin ; Bottle Feeding ; Breast ; Capillaries ; Enterohepatic Circulation ; Exanthema ; Heel ; Hope ; Hospitalization ; Humans ; Hyperbilirubinemia, Neonatal* ; Infant ; Infant, Newborn ; Intestines ; Jaundice, Neonatal ; Motivation ; Nurseries ; Phototherapy* ; Syringes ; Water

No abstract available.
Anemia* ; Bone Marrow Transplantation* ; Bone Marrow*

Hemangioma is one of the most common congenital tumors in the region of the face and neck. Although histologically benign, these facial masses are clinically malignant for their deforming and inexorable growth, especially in so-called cavernous hemangioma. Today, hemagiomas have been treated by various methods; steroids, electrocoagulation, injection of sclerosing agent, cryotherapy, radiation therapy, laser therapy, and surgical treatment, etc. The response of treatment varies with the types, surgical skills, regions of hemangioma, the age of patient, but the appropriate method of the treatment has not been yet established. In the case of massive hemangioma, which involves most part of the face and neck, we prefer surgical treatment and consistently obtain better result than other treatment modalities. Wide excision and proper reconstruction of the face helps the patient for their better life aesthetically and functionally.
Cryotherapy ; Electrocoagulation ; Hemangioma* ; Hemangioma, Cavernous ; Humans ; Laser Therapy ; Neck* ; Steroids

This article is the case report of primary gastric malignant lymphoma which was diagnosed by laparatomy. A 24-year-old male was admitted because of epigastric pain and general weakness, He was taken by gastrofiberoscopy with biopsy, upper gastrointestinal series, ultrasonogram, and abdominal computerized tomogram. Endoseopic pieture demonstrated whitish to yellowish exudate in the ulcer base and the surround.ing mucosal elevation in the poterior wall of the antrum and lower body. In the X-ray and endoseapic findings, the lesion was considered as Borrmann III type carcinoma, but on the second endoscopic biopsy gastric lymphoma was suapected. Reaected stomach revealed an irregular ulceration with the surrounding mucosal elevation with a size of 5X7X10cm at the pasterior wall of the antrum. Bridging folds were observed on the surrounding elevated mucosa of the lesion. Histologically, the lesion was diagnosed as malignant lymphoma (poorly differentiated lymphocytic).
Biopsy ; Exudates and Transudates ; Humans ; Lymphoma* ; Male ; Mucous Membrane ; Stomach ; Ulcer ; Ultrasonography ; Young Adult

The present study was designed to investigate the interposed joint capsule at the femorotibial space following meniscectomy which could contribute to the regeneration of meniscus. Thirty two rabbits were used for this study. The anterior half of the medial meniscus was resected and the joint capsule was cut transversely 4mm above the joint line. It was reflected and interposed at the meniscectomized site. Gross findings at 2, 6, 8, and 12 weeks were recorded, respectively. Hematoxylin-Eosin(H-E) and safranin-O staining were done for histological and histochemical study, respectively. The results were as follows : 1 . With tile passage of time, interposed joint capsules looked like normal meniscus in shape, and the surface was glistening. 2. At 12 weeks, the width and thickness of interposed tissue were gradually decreased until it became normal size (P>0.05). 3. Histologically(H-E stain), the interposed tissue consisted of dense connective tissue with fibrocyte at 2 weeks. The interposed tissue changed to wedge shape and consisted of dense connective tissue with fibrocyte and prolifelated synovial cells at 6 weeks. Immature chondrocytes appeared at the lower portion and fat cells appeared at the upper portion of the tissue at 8 weeks. The fat cells disappeared and more mature chondrocyte were found in the central portion of interposed tissue at 12 weeks after operation. 4. Histochemical study(safranin-O stain) showed the interstitial tissue was not stained at 2 and 6 weeks, but glycosaminoglycan synthetic activity increased in the newly formed chondrocytes at postoperative 8 weeks and 12 weeks. From these results, the interposed capsule at the femorotibial space could be a substitute material for postmeniscectomy patients.
Adipocytes ; Chondrocytes ; Connective Tissue ; Humans ; Joint Capsule* ; Joints* ; Menisci, Tibial ; Rabbits* ; Regeneration

Gastric neuroendocrine tumor is an uncommon entity, and it constitutes less than 1% of all neuroendocrine tumors and less than 2% of all gastric neoplasms. Regardless of its origin, approximately 75% of the patients with neuroendocrine tumors will develop liver metastasis. We report here on two cases of primary neuroendocrine tumor with hepatic metastasis. A 37-year-old-man presented with chronic and intermittent abdominal pain in the epigastric area. He was diagnosed with gastric neuroendocrine tumor together with hepatic metastasis, based on the imaging studies and the octreotide scan. Subtotal gastrectomy and right hemihepatectomy was done and the patient was discharged on the postoperative 15th day without any complication. Another 41-year-old man presented with abdominal discomfort and a RUQ palpable mass. He was diagnosed with hepatocellular carcinoma based on the abdominal computerized tomography (CT). However, we incidentally found a gastric mass in the operating field and subtotal gastrectomy was then done. The pathologic report was large cell neuroendocrine carcinoma. The patient was discharged on the postoperative 19th day without any complication.
Abdominal Pain ; Adult ; Carcinoid Tumor ; Carcinoma, Hepatocellular ; Carcinoma, Neuroendocrine ; Gastrectomy ; Humans ; Liver ; Neoplasm Metastasis* ; Neuroendocrine Tumors* ; Octreotide ; Stomach Neoplasms

Nickel and chromium are two major metals used in the alloys of most orthodontic appliances. But these metals are known to cause hypersensitivity, dermatitis, and asthma. In addition, a significant carcinogenic and mutagenic potential has been demonstrated for compounds containing these metals. The purpose of this study was to find out how much nickel and chromium was released from orthodontic appliances, and which factors would influence the release. The simulated orthodontic appliances were constructed for a half of a mandibular arch and incubated in 0.05% NaCl solution at 37degrees C. Nickel and chromium release was quantified with an Inductively Coupled Plasma (ICP) spectroanalyzer. The results were as follows : 1. From simulated orthodontic appliances, nickel was released 9.83-70.0microgram/day but the release of chromium was not detectable in limit of 10ppb. 2. The amount of nickel release was significantly different between the types of appliances. 3. The galvanic condition increased the amount of nickel release, which was not statistically significant. 4. The sand blasting increased the amount of nickel release, which was also not statistically significant.
Alloys ; Asthma ; Chromium* ; Dermatitis ; Hypersensitivity ; Metals ; Nickel* ; Orthodontic Appliances* ; Plasma ; Silicon Dioxide

No abstract available.
Gene Expression* ; Humans* ; Insulin-Like Growth Factor I* ; Thyroid Gland*