1.Internal Carotid Artery Aneurysms Arising from the Medial Wall of the Communicating Segment of the Internal Carotid Artery: Case Report.
Jong Won LEE ; Jong Sik SUK ; Jung Taek KWON ; Byung Kook MIN
Journal of Korean Neurosurgical Society 2000;29(10):1352-1356
No abstract available.
Aneurysm*
;
Carotid Artery, Internal*
2.Minimally Invasive Spine Surgery: Techniques, Technologies, and Indications
Jiwon PARK ; Dae-Woong HAM ; Byung-Taek KWON ; Sang-Min PARK ; Ho-Joong KIM ; Jin S. YEOM
Asian Spine Journal 2020;14(5):694-701
Over the past few decades, interest in minimally invasive spine surgery (MISS) has increased tremendously due to its core principle of minimizing approach-related injury while providing outcomes similar to traditional open spine procedures. With technical and technological advancements, MISS has expanded its utility not only to simple spinal stenosis, but also to complex spinal pathologies such as metastasis, trauma, or adult spinal deformity. In this article, we review the techniques and technology in MISS and discuss the indications, benefits, and limitations of MISS.
3.Herpes Simplex virus thymidine kinase gene therapy delivered by retroviral or adenoviral vector in mouse model of lewis lung carcinoma.
Hee Chung KWON ; Jae Min JEONG ; Jung Hyeon KIM ; Yong Ho HAM ; Ji Sook SEO ; Ki Ho CHANG ; Min KIM ; Han Soo LEE ; Choon Taek LEE
Tuberculosis and Respiratory Diseases 2000;49(3):298-309
BACKGROUND: The antitumor effects of herpes simplex virus thymidine kinase(HSV-tk) and ganciclovir(GCV) strategies for cancer gene therapy have a the following advantages:1) a direct cytotoxicity to HSV-tk modified cancer cells by GCV 2) a cell death by the local transfer of toxic metabolites from the HSV-tk modified cells to nearby unmodified tumor cells(bystander effect), and 3) in vivo bystander effect such as antitumor-immunity. Retroviral and adenoviral sequences can silence transgene expression in cells and mice. In this study, we investigated the above described advantages of HXV-tk/GCV strategy in Lewis lung cell and mouse lung cancer model using retroviral vector and adenoviral vector. Also, we observed whether the expression of a silenced gene can be reactivated by treating cell with butyrate. METHODS: Retrovirus-HSV-tk and adenovirus-HSV-tk vectors were used for the transduction of Lewis lung carcinoma(LLC) cells. The change of HSV-tk expression by butyrate was measured by Western blot.The antitumor activities containing bystander effect were observed in vivo(by MTT assay) and in vivo tumor models of various combinations of LLC and LLC-tk. RESULTS: 1. Butyrate induced the enhancement of HSV-tk expression from adenovirally transduced cells but not from retrovirally transduced cells. 2. Both retrovirus-HSV-tk and adenovirus-HSV-tk vectors with GCV treatment were effective for killing of tumor cell in vitro and suppression of LLC tumorigenicity. Bystander effect was responsible for killing of mixture of LLC-tk and LLC in vitro and in vivo-tumorigenicity model. CONCLUSION: Butyrate could augment adenoviral vector seems to be an effective approach for lung cancer therapy.
Adenoviridae
;
Animals
;
Butyrates
;
Bystander Effect
;
Carcinoma, Lewis Lung*
;
Cell Death
;
Genes, Neoplasm
;
Genetic Therapy*
;
Herpes Simplex*
;
Homicide
;
Lung
;
Lung Neoplasms
;
Mice*
;
Phosphotransferases*
;
Retroviridae
;
Simplexvirus*
;
Thymidine
;
Transgenes
;
Zidovudine*
4.Two Cases of Fournier's Gangrene.
Hyun Jo KWON ; Mi Yeon KIM ; Young Min PARK ; Hyung Ok KIM ; Seong Taek OH
Korean Journal of Dermatology 2006;44(1):127-129
Fournier's gangrene is a form of necrotizing fasciitis of the perineal, genital or perianal region due to perianal infection, urinary tract infection or local trauma. Even though many patients may present with minor skin lesions in the early stages of the disease, the natural course of this necrotizing disease is rapid progression of gangrene, eventually resulting in sepsis and death. Therefore, rapid and accurate diagnosis is the most important factor for a successful outcome. We report two cases of Fournier's gangrene in a 21-year-old and 24-year-old male, both of whom commonly presented with painful swelling and tenderness of the scrotum. Although one man showed a rapidly-spreading erythema and induration to the flank and lateral chest, they were both successfully treated with early antibiotic therapy and surgical drainage.
Diagnosis
;
Drainage
;
Erythema
;
Fasciitis, Necrotizing
;
Fournier Gangrene*
;
Gangrene
;
Humans
;
Male
;
Scrotum
;
Sepsis
;
Skin
;
Thorax
;
Urinary Tract Infections
;
Young Adult
5.A Case of Using Open-Close Valve during One Lung Ventilation: A case report.
Na Ra CHUNG ; Taek Min KWON ; Byung Hoon YOO ; Jun Heum YON
Korean Journal of Anesthesiology 2005;49(2):256-258
One lung ventilation for thoracic surgery may reduce arterial oxygen saturation by ventilation-perfusion mismatching and by increasing intrapulmonary shunting. We experienced a 52 year old male patient with a lung abscess, who showed arterial desaturation after one-lung ventilation. The authors tried to increase arterial oxygen saturation by applying positive end-expiratory pressure (PEEP) and continuous positive airway pressure (CPAP) to dependent and nondependent lung, respectively. However, arterial oxygen saturation did not increase. So, we applied partial differential lung ventilation using an open-close valve designed by the authors, and arterial oxygen saturation increased rapidly. The advantages of the open-close valve are its straightforward use and ease of manipulation. We report a case involving the use of this open-close valve in a desaturated patient during one lung ventilation.
Continuous Positive Airway Pressure
;
Humans
;
Lung
;
Lung Abscess
;
Male
;
Middle Aged
;
One-Lung Ventilation*
;
Oxygen
;
Positive-Pressure Respiration
;
Thoracic Surgery
;
Ventilation
6.Cytokine Induction of Intercellular Adhesion Molecule-1(ICAM-1) Expression on Human Glioblastoma Cell Line, U-251 MG, U-373 MG.
Jong Won LEE ; Jung Taek KWON ; Byung Kook MIN ; Seung Won PARK ; Young Baeg KIM ; Sung Nam HWANG ; Jong Sik SUK ; Duck Young CHOI
Journal of Korean Neurosurgical Society 2000;29(4):477-484
No abstract available.
Cell Line*
;
Glioblastoma*
;
Humans*
7.Growth Suppression by Adenovirus-mediated Gene Transfer of p16/INK4a in Glioma Cell Lines.
Mi Suk KIM ; Hee Chung KWON ; Hee Seog KANG ; In Chul PARK ; Chang Hun RHEE ; Chang Min KIM ; Choon Taek LEE ; Seok Il HONG ; Seung Hoon LEE
Journal of Korean Neurosurgical Society 2000;29(4):471-476
No abstract available.
Cell Line*
;
Glioma*
8.Pregnancy associated with kyphoscoliosis.
Kyung Ik KWON ; Dong Ho NAM ; Chun Gun LIM ; Min Yon LEE ; Suk Kyung YANG ; Jong In KIM ; Taek Hoon KIM ; Young Wook SUH
Korean Journal of Perinatology 1993;4(4):543-547
No abstract available.
Pregnancy*
9.CT Findings of Spontaneous Subarachnoid Hemorrhage of Unknown Cause.
Il Kwon YANG ; Kyung Sub SHINN ; Hee Jeong RO ; Myung Hee CHUNG ; Kyu Ho CHOI ; Han Jin LEE ; Seog Min PARK ; Taek Geun KIM
Journal of the Korean Radiological Society 1994;30(3):401-404
PURPOSE: Spontaneous subarachnoid hemorrhage(S-SAH) is a relatively rare disease with good clinical course and prognosis. The purpose of this study is to evaluate the cisternal blood distribution on CT in patient with S-SAH. MATERIALS AND METHODS: Out of 406 patients with subarachnoid hemorrhage on brain CT scan, 11 patients confirmed to be S-SAH by angiography and clinical follow-up were examined. We analysed the CT findings of these 11 cases retrospectively. RESULTS: Five patients had only perimesencephalic distribution of hemorrhage:the prepontine, the interped- uncular, and the suprasellar cisterns were involved in 4 cases each, the basal sylvian cistern in 3 cases, and the ambient cistern in 2 cases. The quadrigeminal and a portion of the lateral sylvians were also involved in 1 case each. Six patients revealed cisternal hemorrhage extending beyond the perimesencephalic cistern into the ventricles, cortical sulci, and lateral sylvian fissure. Intraventricular hemorrhage was noted in 3 cases of these 6 patients. CONCLUSION: Our study suggests that uncomplicated clinical course and normal anglographic finding are more important than CT distribution of cisternal hemorrhage in diagnosing S-SAH.
Angiography
;
Brain
;
Follow-Up Studies
;
Hemorrhage
;
Humans
;
Prognosis
;
Rare Diseases
;
Retrospective Studies
;
Subarachnoid Hemorrhage*
;
Tomography, X-Ray Computed
10.A Case of Femoral Artery Pseudoaneurysm Treated with Compression Guided by Color Doppler Ultrasound.
Bon Kwon KU ; Han Soo KIM ; Choong Won KO ; Min Kyung SONG ; Sung Taek CHUNG ; Joon Han SHIN ; Seung Jea TAHK ; Byung il CHOI
Korean Circulation Journal 1995;25(1):119-123
Pseudoaneurysm is one of the undesirable complications of interventional cardiology procedures involving peripheral puncture site. Nowadays, it is not uncommon as a consequences of more complex interventional preocedures, larger catheters and prolonged anticoagulation treatment. Surgical repair has been mainstay of treatment for pesudoaneurysm. However, sucessful closures of pseudoaneurysms have been reported recently by using direct compression guided by color doppler ultrasound. We report a case of pseudoaneurysm in femoral artery, which was developed at the right inguinal puncture site in 38 year old male patient with unstabel angina who had received continuous intravenous infusion of heparin and had undergone coronary angiography treated successfully with direct compression guided by color doppler ultrasound.
Adult
;
Aneurysm, False*
;
Cardiology
;
Catheters
;
Coronary Angiography
;
Femoral Artery*
;
Heparin
;
Humans
;
Infusions, Intravenous
;
Male
;
Punctures
;
Ultrasonography*