1.Cutaneous Leishmaniasis Treated with Metronidazole and Cryotherapy.
Young Hoon YOON ; Miri KIM ; Shin Taek OH ; Baik Kee CHO ; Hyun Jeong PARK
Korean Journal of Dermatology 2015;53(7):576-578
No abstract available.
Cryotherapy*
;
Leishmaniasis, Cutaneous*
;
Metronidazole*
2.A Case of Furuncular Cutaneous Myiasis by Dermatobia hominis.
Young Hoon YOON ; Miri KIM ; Shin Taek OH ; Baik Kee CHO ; In Yong LEE ; Hyun Jeong PARK
Korean Journal of Dermatology 2015;53(7):570-571
No abstract available.
Myiasis*
3.Radiation-Induced Proctitis in Rat and Role of Nitric Oxide.
Mison CHUN ; Seunghee KANG ; Yoon Mi JIN ; Young Taek OH ; Hoon Jong KIL ; Byoung Ok AHN ; Tae Young OH
The Journal of the Korean Society for Therapeutic Radiology and Oncology 2001;19(3):265-274
PURPOSE: Proctitis is one of acute complications encountered when radiotherapy was applied to the pelvis. Radiation-induced proctitis represents similar microscopic findings that are observed in inflammatory bowel disease (IBD). Nitric oxide (NO) plays an important role in the inflammatory process and many data suggest a close relationship between NO production and gastrointestinal inflammation. This study was aimed to establish the optimal radiation dose for radiation-induced proctitis in rat and to find a relationship between radiation proctitis and NO production. MATERIALS AND METHODS: Female Wistar rats, weighing from 150 to 220 g, received various doses(10-30 Gy) of radiation to the rectum. On the 5th and 10th day after irradiation, rectal specimens were evaluated grossly and microscopically. In addition, the degree of NO production by irradiation dose was evaluated by study with NOS expression and nitrite production in the irradiated rectal tissue. To evaluate relationship between radiation proctitis and NO, we administered aminoguanidine, iNOS inhibitor and L-arginine, substrate of NOS to rats from 2 days before to 7 days after the irradiation. RESULTS: There were obvious gross and histological changes after 17.5 Gy or higher radiation dose but not with 15 Gy or less radiation dose. Twenty Gy or higher dose of radiation caused Grade 4 damage in most of rectal specimens which were more likely to be related to the late complications such as fibrosis, rectal bleeding and rectal obstruction. A single fraction of 17.5 Gy to the rat rectum is considered to be an optimal dose to produce commonly experienced proctitis in the clinic. The result demonstrated that severity of microscopic damage of rectal mucosa from irradiation significantly correlated with iNOS overexpression. However, administration of iNOS inhibitor or substrate of iNOS did not influence the degree of rectal damage. CONCLUSION: A single fraction of 17.5 Gy irradiation to the rat rectum considered to be an optimal dose for radiation induced proctitis model. These results indicated that an excess production of NO contributes to pathogenesis of radiation-induced proctitis in part but was not the direct cause of rectal damage.
Animals
;
Arginine
;
Female
;
Fibrosis
;
Hemorrhage
;
Humans
;
Inflammation
;
Inflammatory Bowel Diseases
;
Models, Animal
;
Mucous Membrane
;
Nitric Oxide Synthase
;
Nitric Oxide*
;
Pelvis
;
Proctitis*
;
Radiotherapy
;
Rats*
;
Rats, Wistar
;
Rectum
4.Hypernatremia and Intraventricular Hemorrhage in Very Low Birth Weight Infants (<1,250 g).
Soo Ho LEE ; Cheol Hwan SO ; Seung Hoon KEUM ; Seung Taek YOO ; Doo Young CHOI ; Yeon Kyun OH
Journal of the Korean Society of Neonatology 2011;18(1):89-95
PURPOSE: Hypernatremia most frequently occurs in the immature newborn and be severe in association with intraventricular hemorrhage (IVH). This study examined the frequency, onset and risk factors of hypernatremia, and the relationship between hypernatremia and IVH in very low birth weight (VLBW; <1,250 g) infants. METHODS: We retrospectively reviewed the medical records of 55 VLBW infants admitted between January 2006 and December 2009 to the neonatal intensive care unit of Wonkwang University Hospital and who survived over 7 days. Serum sodium concentration, sodium intake, fluid and weight loss, as suggested risk factors of hypernatremia, and the incidence of IVH were evaluated. The infants were divided into a hypernatremia group (> or =150 mEq/L) and nonhypernatremia group, and were compared. RESULTS: Incidence of hypernatremia in the VLBW infants was 52.7%, and mean starting time of hypernatremia was 2.8+/-1.3 days. There were no differences in the sodium and fluid intake between the two groups. Weight loss at day 3 after birth was significantly higher in the hypernatremia compared to the nonhypernatremia group (P<0.05); thereafter weight loss was non-significantly higher. The incidence of IVH in VLBW infants was 38.2%, and the difference between the two groups was not significant. CONCLUSION: Hypernatremia occurs commonly in VLBW infants and is most commonly caused by weight loss in the early days after birth. Incidence of IVH is not likely influenced by hypernatremia with marginally elevated sodium concentration.
Hemorrhage
;
Humans
;
Hypernatremia
;
Incidence
;
Infant
;
Infant, Newborn
;
Infant, Very Low Birth Weight
;
Intensive Care, Neonatal
;
Medical Records
;
Parturition
;
Retrospective Studies
;
Risk Factors
;
Sodium
;
Weight Loss
5.The Effects of Intraperitoneal Carbon Dioxide Insufflation and Head-down Tilt Position on Intracranial Pressure.
Hoo Jeon LEE ; Taek Hoon OH ; Sun Gyoo PARK
Korean Journal of Anesthesiology 1996;31(2):140-149
BACKGROUND: The laparoscopy requires CO2 insufflation and posture changes for operational convenience. However, above circumstances affect the cardiopulmonary systems significantly. And then intracranial pressure (ICP) may be also influenced. METHODS: To ascertain the changes of ICP, an experimental study was performed, in which the parameters of hemodynamic status, arterial blood gas components and ICP were measured from twelve cases of Korean mongrel dogs. Pneumoperitoneum was produced by CO2 insufflation(15 mmHg) and then posture was altered from horizontal to head-down tilt of 20, 30 and 40 degree*. The measurements were obtained before (control), after CO2 insufflated horizontal position at 20, 40 and 60 minute in CO2 insufflated tilt** and CO2 deflated horizontal***. RESULTS: MAP and HR were not related to the insufflated time and degree of tilt. CVP and PCWP were significantly increased after CO2 insufflated tilt (p<0.01), but returned to control after deflated supine. PaCO2 was not significantly changed after CO2 insufflated supine, but grdually increased with degree of tilt and time (p<0.01). ICP was increased at 40 and 60 minute of 20degree, and at 20 minute of 30degree(p<0.05), then markedly increased at 40 and 60 minute of 30degree, and at 20, 40 and 60 minute of 40degreetilt (p<0.01). The increment of ICP was parallel with time and degree of tilt. But, ICP was returned to control after deflated supine. CONCLUSIONS: ICP was increased significantly during laparoscopy in head-down tilt, although it was reversible. Therefore, the patient must be given special attention during laparoscopy in whom the increment of ICP may be harmful.
Animals
;
Carbon Dioxide*
;
Carbon*
;
Dogs
;
Head-Down Tilt*
;
Hemodynamics
;
Humans
;
Insufflation*
;
Intracranial Pressure*
;
Laparoscopy
;
Pneumoperitoneum
;
Posture
6.The Association of Interleukin-4 Promoter Gene and Receptor alpha Gene Polymorphisms with Atopic Dermatitis.
Shin Taek OH ; Min Suk LEE ; Jung Soo KIM ; Hoon HAN ; Bo Kyung KOH ; Jin Wou KIM
Korean Journal of Dermatology 2004;42(7):815-820
BACKGROUND: Several investigators have linked the interleukin-4(IL-4) gene nearby markers located on chromosome 5 to atopy and demonstrated that the T allele of a polymorphism in the IL-4 gene promoter region -590C/T is associated with elevated levels of total serum IgE. IL-4 receptor alpha gene has been also reported to be involved in the development of atopy. Recently, the R allele of a polymorphism in the IL-4 receptor alpha gene (IL4R*A) has been reported to be associated with atopy. OBJECTIVE: The purpose of our study is to investigate the association of IL-4 promoter gene C-590T polymorphism and receptor alpha gene (-1902) IL4R*A polymorphism with atopic dermatitis in Korea. MATERIAL AND METHODS: Seventy one Korean patients with atopic dermatitis and one hundred and sixty six normal subjects participated in this study with the analysis of polymorphism of IL-4 promoter (-590C/T) gene and IL-4 receptor alpha(-1902) gene by using PCR-SSCP. RESULTS: The frequency of IL-4 promoter (-590) genotypes (T/T, T/C, C/C), genes (T, C), alleles (T, C) did not show any significant difference between atopic dermatitis patients and normal controls (p>0.05). There were weak associations in the frequency of IL-4 receptor alpha(-1902) genotypes (IL4R*G/IL4R*G) and genes (IL4R*A) in patients of atopic dermatitis and normal controls (p=0.05). But, the frequency of IL-4 receptor alpha(-1902) genotypes (IL4R*A/IL4R*G, IL4R*A/IL4R*A), genes (IL4R*G), alleles (IL4R*A, IL4R*G) did not show any significant difference between atopic dermatitis patients and normal controls (p>0.05). CONCLUSION: These data show that IL-4 promoter polymorphism (-590C/T) and IL-4 receptor alpha polymorphism (-1902) IL4R*A are not associated with atopic dermatitis in Korean. It is suggested that the difference between our results and previous reports means racial difference, cooperation of -590C/T or IL4R*A polymorphism with the other gene, and the existence of another polymorphism.
7.A Clinical Study of 21 Cases of Washboard Nail.
Ji Hoon CHUN ; Jung Eun KIM ; Shin Taek OH ; Hyun Jeong PARK ; Baik Kee CHO
Korean Journal of Dermatology 2009;47(12):1353-1358
BACKGROUND: Washboard nail most commonly involves the thumbnail or great toenail. As its name implies, it resembles a washboard with a series of evenly spaced ridges across the nail. A central depression can be seen as well. This can develop as the result of repeated habitual trauma to the proximal nail fold by the other fingers or by biting the nailplate. Thus, it is also called habit tic deformity or traumatic nail dystrophy. Although it is known to be not uncommon, there have been no studies on this with a sufficient number of cases and long term follow up. OBJECTIVE: This study was conducted to provide a better understanding of washboard nail and to estimate the outcome of it. METHODS: We reviewed all the medical records and clinical photographs of 21 patients who had been diagnosed with washboard nail at our department between July 2000 and July 2009. RESULTS: The male to female ratio was 1:1.3. The patients' ages varied from 6 to 68 years, with an average of 25.4 years. The mean duration at the first visit was 4.4 years. The most common involved site was both thumbnails. Predisposing factors were found in 42.9% of the patients, which included nail picking or onychophagia. The treatment options were primarily intralesional triamcinolone injection and topical steroid. If the patient had the habitual tic, we educated them to restrain it. The follow up periods varied from 1 to 32 months with a mean of 7.9 months. Among the 14 patients with adequate follow up, 50% of these patients showed clinical improvement. CONCLUSION: This study demonstrated the clinical features of washboard nail. Physicians should closely observe the nail changes and long-term follow up is needed to determine the therapeutic response of patients with washboard nail.
Bites and Stings
;
Congenital Abnormalities
;
Depression
;
Female
;
Fingers
;
Follow-Up Studies
;
Humans
;
Male
;
Medical Records
;
Nail Biting
;
Nails
;
Tics
;
Triamcinolone
8.Clinical Evaluation of Ovarian Tumors associated with Pregnancy.
Jeong Wook SEO ; Jeong Hoon RHO ; Kwan Young OH ; Mi Hye PARK ; Eun Kyung KIM ; Yun Seok YANG ; In Taek HWANG ; Ji Hak JUNG ; Joon Sook PARK
Korean Journal of Obstetrics and Gynecology 2000;43(9):1551-1556
No abstract available.
Pregnancy*
9.A Case of Hemolytic Disease of Newborn due to Anti-JKa.
Cheol Hwan SO ; Se Hoon YOON ; Dong Sup KIM ; Seung Taek YU ; Yeon Kyun OH
Korean Journal of Perinatology 2012;23(1):5-8
The Kidd system of blood group is clinically significant since the anti-Kidd antibody can cause immediate or delayed hemolytic transfusion reactions as well as hemolytic disease of newborn (HDN). In contrast to the hemolytic activity of Kidd antibodies in incompatible transfusion, the severity of HDN varies but usually tends to be a benign clinical course with favorable outcomes. And severe HDN due to anti-JKa incompatibility is a rare, which is still not reported in Korea. We experienced a newborn with severe jaundice to be detected within 24 hours from birth due to anti-JKa incompatibility. The laboratory data on admission indicated hemoglobin 13.2 g/dL, reticulocyte 4.08%, total bilirubin 18.7 mg/dL, and direct and indirect antiglobulin tests were positive (2+/2+). But, there are no ABO and Rh (D) incompatibilities between the mother and newborn. Maternal serum was found to contain an antibody that recognized JKa , and also seen in neonate. This patient completely recovered with intensive phototherapy without exchange transfusion. We report this case with a brief review of relevant literature.
Antibodies
;
Bilirubin
;
Blood Group Incompatibility
;
Coombs Test
;
Erythroblastosis, Fetal
;
Hemoglobins
;
Humans
;
Infant, Newborn
;
Jaundice
;
Korea
;
Mothers
;
Parturition
;
Phototherapy
;
Reticulocytes
10.A Case of Hemolytic Disease of Newborn due to Anti-JKa.
Cheol Hwan SO ; Se Hoon YOON ; Dong Sup KIM ; Seung Taek YU ; Yeon Kyun OH
Korean Journal of Perinatology 2012;23(1):5-8
The Kidd system of blood group is clinically significant since the anti-Kidd antibody can cause immediate or delayed hemolytic transfusion reactions as well as hemolytic disease of newborn (HDN). In contrast to the hemolytic activity of Kidd antibodies in incompatible transfusion, the severity of HDN varies but usually tends to be a benign clinical course with favorable outcomes. And severe HDN due to anti-JKa incompatibility is a rare, which is still not reported in Korea. We experienced a newborn with severe jaundice to be detected within 24 hours from birth due to anti-JKa incompatibility. The laboratory data on admission indicated hemoglobin 13.2 g/dL, reticulocyte 4.08%, total bilirubin 18.7 mg/dL, and direct and indirect antiglobulin tests were positive (2+/2+). But, there are no ABO and Rh (D) incompatibilities between the mother and newborn. Maternal serum was found to contain an antibody that recognized JKa , and also seen in neonate. This patient completely recovered with intensive phototherapy without exchange transfusion. We report this case with a brief review of relevant literature.
Antibodies
;
Bilirubin
;
Blood Group Incompatibility
;
Coombs Test
;
Erythroblastosis, Fetal
;
Hemoglobins
;
Humans
;
Infant, Newborn
;
Jaundice
;
Korea
;
Mothers
;
Parturition
;
Phototherapy
;
Reticulocytes