1.Lumbar Spinal Epidural Lipomatosis: Two Cases Report.
Byeong Yeon SEONG ; Chan Ji PARK ; Sung Jun PARK ; Sang Wook KIM ; Taek Gun LEE
Journal of Korean Society of Spine Surgery 1998;5(2):333-341
STUDY DESIGN: We report two cases of symptomatic spinal epidural lipomatosis (SEL) associated with long-term use of steroid medication OBJECTIVES: The purpose of this study was to assess the clinical characteristics, diagnosis and treatment of symptomatic spinal epidural lipomatosis. SUMMARY OF LITERATURE REVIEW: Spinal epidural lipomatosis is a condition in which excess adipose tissue is deposited circumferentially about the spinal cord in the epidural space. It can present neurologic symptoms including back pain, radiculopathy or cauda equina. Magnetic resonance imaging is the most helpful dignostic means and should be used initially if suspected. Treatment is decompressive laminectomy and debulking of fat. MATERIALS AND METHODS: Two cases of lumbar epidural lipomatosis with neurologic symptoms were discussed and evaluated by physical examination, postmyelography CT and MRI. RESULTS: Two cases were treated with decompressive laminectomy and debulking of fat. Increased accumulation of the fatty tissue was seen predominently in posterior and posterolateral epidural space of the spinal canal, displacing and compressing the lumbar spinal cord anteriorly. Both gross and histologic evaluation revealed overgrowth of unencapsulated normal appearing fat consistent with spinal epidural lipomatosis. One case was demonstrated gradual improvement in symtoms after operation but the other was died due to medical problems. CONCLUSION: The authors reviewed the literature and reported the results of operative treatment of patients with lumbago, radicular pain and intermitent claudication caused by epidural lipomatosis of lumbar spine and degenerative spinal stenosis.
Adipose Tissue
;
Back Pain
;
Cauda Equina
;
Diagnosis
;
Epidural Space
;
Humans
;
Laminectomy
;
Lipomatosis*
;
Low Back Pain
;
Magnetic Resonance Imaging
;
Neurologic Manifestations
;
Physical Examination
;
Radiculopathy
;
Spinal Canal
;
Spinal Cord
;
Spinal Stenosis
;
Spine
2.A Phase II Trial of Combination Chemotherapy with Cisplatin & Etoposide in Small Cell Lung Cancer.
Eun Mee CHEON ; Hyung Gun KIM ; Tae Young SON ; Young Jin YUH ; Sang Goo LEE ; Choon Taek LEE ; Young Hwan KIM ; Jhin Oh LEE ; Tae Woong KANG
Tuberculosis and Respiratory Diseases 1994;41(6):632-643
BACKGROUND: The objective responses of cisplatin and etoposide (PVP) combination chemotherapy as second-line therapy following CAV was high (40~50%) and, in several reports, PVP yields survival results that are at least as good as those obtained with cyclophosphamide or doxorubicin-based regimens and with less host-related toxicity in chemotherapy-naive patients. We conducted a phase II study to evaluate the effect of a combination of cisplatin and etoposide as a first-line therapy in patients with small cell lung cancer. METHODS: Sixty-one previously untreated small cell lung cancer patients with measurable lesion(s) received cisplatin(30 mg/m2 IV, day 1~3) and etoposide(100 mg/m2 IV, day 1~3). In patients with limited disease, after completion of 6 cycles of PVP chemotherapy, chest and prophylatic brain irradiation was performed in case of complete responder, chest irradiation only in partial responder. RESULTS: 1) Of 55 evaluable patients, 13(24%) had a complete response and 29(53%) had a partial response. 2) The median survival time was 55.8 weeks for all patients(N=55), 61.1 weeks for limited disease(N=31), 51.3 weeks for extensive disease(N=24). 3) The response duration was 29.1 weeks for responders(N=42). 4) There was no significant prognostic factors iufluencing response rates. 5) The toxicity was tolerable and there was no treatment-related deaths. CONCLUSION: The PVP combination chemotherapy as a first-line therapy was effective and well-tolerated in patients with small cell lung cancer.
Brain
;
Cisplatin*
;
Cyclophosphamide
;
Drug Therapy
;
Drug Therapy, Combination*
;
Etoposide*
;
Humans
;
Small Cell Lung Carcinoma*
;
Thorax
3.Pharmacological Prevention of Post-Anesthetic Shivering: Clonidine Vs Meperidine: A Meta-Analysis of Randomized-Controlled Trials.
Sang Kee MIN ; Won Oak KIM ; Yong Taek NAM ; Sang Gun HAN ; Sung Jung LEE ; Young Seok LEE
Korean Journal of Anesthesiology 1999;37(1):63-72
BACKGROUND: Post-operative shivering is one of the potential complications for any surgical patient. Its incidence varies from 5% to 65%, and many preventive and treatment modalities have been reported. For the effective prevention of post-anesthetic shivering by using intravenous clonidine or meperidine, randomized controlled studies were reviewed. The overall incidence of shivering after clonidine or meperidine administration, and the anti-shivering effect of clonidine and meperidine were evaluated. METHODS: DATA SOURCES: Medline search from 1978 to March 1998. DATA SELECTION: We selected studies that had investigated the preventive anti-shivering effect of intravenous clonidine or meperidine by randomized controlled trials. Ten clinical trials were evaluated. RESULTS: The pooled odd ratio of the patients who received clonidine was 0.32 (95% confidence interval, 0.22~0.47) and it seemed to be effective. But these studies showed little evidence of significant homogeneity (P=0.01). In the subgroup analysis, the pooled odd ratio of group A (early administration or intra-operative infusion group) was 0.47 (95% CI 0.31~0.72) evidenced effectiveness but failed to prove homogeneity (P=0.047). But group B (the late intra-operative administration group) had a pooled odd ratio of 0.10 (95% CI 0.05~0.22) and showed homogeneity (P=0.98). In meperidine trials, the pooled odd ratio was 0.20 (95% CI 0.07~0.55). CONCLUSION: We present quantitative evidence based on a meta-analysis of pooled effect size from randomized trials that clonidine is more beneficial for the prevention of post-anesthetic shivering and more effective than meperidine when it is administrated during later period of surgery.
Clonidine*
;
Information Storage and Retrieval
;
Humans
;
Incidence
;
Meperidine*
;
Shivering*
4.Pregnancy associated with kyphoscoliosis.
Kyung Ik KWON ; Dong Ho NAM ; Chun Gun LIM ; Min Yon LEE ; Suk Kyung YANG ; Jong In KIM ; Taek Hoon KIM ; Young Wook SUH
Korean Journal of Perinatology 1993;4(4):543-547
No abstract available.
Pregnancy*
5.Diagnosis of headaches in dental clinic.
Hye Jin LEE ; Young Gun KIM ; Seong Taek KIM
Journal of Dental Rehabilitation and Applied Science 2016;32(2):102-108
Headache disorders, one of most common disease in general population, have been developed according to many versions of international classifications. The primary headaches are those in which no consistently identified organic cause can be determined. It is divided into the following categories: (1) migraine, (2) tension-type headache, (3) cluster headache and other trigeminal autonomic cephalalgias, (4) other primary headaches. This review described a diagnosis of primary headache disorders based on International Classification of Headache Disorders (ICHD)-3 beta criteria.
Classification
;
Cluster Headache
;
Dental Clinics*
;
Diagnosis*
;
Headache Disorders
;
Headache Disorders, Primary
;
Headache*
;
Migraine Disorders
;
Temporomandibular Joint Disorders
;
Tension-Type Headache
;
Trigeminal Autonomic Cephalalgias
6.A Case of Systemic Arterialization of the Lung without Sequestration.
Hyun Ju HONG ; Gun Min PARK ; Yong Il HWANG ; Choon Taek LEE ; Chul Gyu YOO ; Sung Koo HAN ; Young Soo SHIM ; Young Whan KIM
Tuberculosis and Respiratory Diseases 2001;50(3):373-377
An anomalous systemic arterial supply to the normal basal segments of the left lower lobe without sequestration is a rare congenital anomaly. It differs from classical bronchopulmonary sequestration in that the involver lung retains a normal connection to the bronchial tree, although some place this entity exists within the broad framework of pulmonary sequestration. We experienced a case of a woman who presented with a nodular lesion on a chest X-ray. Contrast-enhanced CT diagnosed her as having an anomalous systemic arterial supply to the normal basal segments of the left lower lobe. This case is reported with a brief literature review.
Bronchopulmonary Sequestration
;
Female
;
Humans
;
Lung*
;
Thorax
;
Tomography, X-Ray Computed
;
Trees
7.Bilateral Femoral Neck Stress Fracture in Child: A Case Report.
Gun Woo LEE ; Kyung Soon PARK ; Taek Rim YOON ; Eshnazarov Kamolhuja ESHNAZAROVICH
Hip & Pelvis 2016;28(3):169-172
A femoral neck stress fracture in child is rare, particularly in bilateral case. It is easy to miss initially or may be misdiagnosed. The authors experienced a case of bilateral femoral neck stress fracture in a 10-year-old boy with bilateral hip. The patient was successfully healed by conservative treatment. We report this rare case with a review of the literature. A femoral neck stress fracture should be included in the differential diagnosis in children who present with sustained hip or groin pain.
Child*
;
Diagnosis, Differential
;
Femur Neck*
;
Fractures, Stress*
;
Groin
;
Hip
;
Humans
;
Male
8.Clinical Characteristics of Pulmonary Histiocytosis X.
Yong Il HWANG ; Gun Min PARK ; Jae Joon YIM ; Chul Gyu YOO ; Choon Taek LEE ; Young Whan KIM ; Sung Koo HAN ; Young Soo SHIM
Tuberculosis and Respiratory Diseases 2001;51(4):346-353
BACKGROUND: Pulmonary Langerhans cell histiocytosis forms part of a spectrum of diseases that are characterized by a monoclonal proliferation and infiltration of organs by Langerhans cells. Several organ systems may be involved in Langerhans cell histiocytosis, including the lungs, bone, skin, pituitary gland, liver, lymph nodes and thyroid. Pulmonary histiocytosis X represents 2.8% of interstitial lung disease. Here we present the clinical, radiological, therapeutic aspects of pulmonary histiocytosis X. METHOD: Fourteen cases of biopsy-proven pulmonary histiocytosis X patients who were diagnosed in Seoul National University Hospital during the period from January 1990 to December 1998 were analyzed retrospectively. RESULT: There were 12 men and 2 women in this study. The initial presenting symptoms were dyspnea, cough, chest pain, which was associated with the pneumothorax, and chest radiography abnormalities. Only 8 patients (57%) were smokers. There were 5 patients with extra-pulmonary histiocytosis (pituitary, bone, skin). Eight patients had received the chemotherapy. There were no mortalities and only one patient experienced an aggravation of symptom during the follow-up period. CONCLUSION: In contrast to previous reports from other countries, the patients with pulmonary histiocytosis X in this study presented with several different clinical characteristics, such as a male predominance, relatively low smoker's rate, and a better prognosis.
Chest Pain
;
Cough
;
Drug Therapy
;
Dyspnea
;
Female
;
Follow-Up Studies
;
Histiocytosis
;
Histiocytosis, Langerhans-Cell*
;
Humans
;
Langerhans Cells
;
Liver
;
Lung
;
Lung Diseases, Interstitial
;
Lymph Nodes
;
Male
;
Mortality
;
Pituitary Gland
;
Pneumothorax
;
Prognosis
;
Radiography
;
Retrospective Studies
;
Seoul
;
Skin
;
Thorax
;
Thyroid Gland
9.Comparison of Outcomes of Total Hip Arthroplasty between Patients with Ankylosing Spondylitis and Avascular Necrosis of the Femoral Head.
Sun Ho LEE ; Gun Woo LEE ; Young Jun SEOL ; Kyung Soon PARK ; Taek Rim YOON
Clinics in Orthopedic Surgery 2017;9(3):263-269
BACKGROUND: The objective of this study was to compare clinical and radiological outcomes of total hip arthroplasty (THA) between ankylosing spondylitis (AS) of the hip joint and avascular necrosis (AVN) of the femoral head. METHODS: Thirty patients (30 hips) underwent cementless THA for AS between 2003 and 2012. They were compared to 30 patients (30 hips) who underwent the same procedure for AVN of the femoral head. Each group was matched for age and gender, and both groups had similar preoperative demographic characteristics. All cases were followed for minimum 4 postoperative years. Clinical evaluation was based on operation time, intraoperative blood loss, quantity of postoperative drainage, Harris Hip Score (HHS), and range of motion (ROM). Radiological results were evaluated by acetabular cup anteversion and inclination, femoral stem orientation, pre- and postoperative leg length discrepancy, and postoperative complications. RESULTS: The operation time was significantly longer in the AS group (120.2 ± 26.2 min) than in the AVN group (79.5 ± 11.1 min). The volume of postoperative drainage was significantly greater in the AS group (764.5 ± 355.4 mL vs. 510.5 ± 195.6 mL). Preoperative HHS was lower in the AS group (55.6 ± 13.8 vs. 59.2 ± 2.8). Similarly, postoperative HHS was significantly lower in the AS group (92.8 ± 2.7 vs. 97.4 ± 2.6). The arc of ROM was improved from 146.5°± 13.2° preoperatively to 254.7°± 17.2° postoperatively in the AS group and from 182.6°± 15.5° to 260.4°± 13.7° in the AVN group. Implant position and postoperative leg length discrepancy were not different between the groups. However, three cases of heterotopic ossification was observed in the AS group, whereas only 1 case was found in the AVN group. One deep infection and one aseptic stem loosening were found in the AS group, whereas none was observed in the AVN group. CONCLUSIONS: Cementless THA showed satisfactory clinical and radiological results in both groups, despite the longer operation time, larger blood loss volume, and lower HHS score of the AS group. Our findings suggest that cementless THA is an effective and reliable treatment for both AS and AVN.
Acetabulum
;
Arthroplasty, Replacement, Hip*
;
Drainage
;
Head*
;
Hip
;
Hip Joint
;
Humans
;
Leg
;
Necrosis*
;
Ossification, Heterotopic
;
Postoperative Complications
;
Range of Motion, Articular
;
Spondylitis, Ankylosing*
10.Expression of COX-2 and IDO by Uteroglobin Transduction in NSCLC Cell Lines.
Gun Min PARK ; Sang Min LEE ; Jae Joon YIM ; Seok Chul YANG ; Chul Gyu YOO ; Choon Taek LEE ; Sung Koo HAN ; Young Soo SHIM ; Young Whan KIM
Tuberculosis and Respiratory Diseases 2009;66(4):274-279
BACKGROUND: Uteroglobin (UG) is a secretary protein that has strong immunomodulatory properties, and which is synthesized in most epithelia including lung tissue. Overexpression of UG is associated with decreased expression of cyclooxygenase (COX)-2 and suppression of cancer cell growth. Indoleamine 2,3-dioxygenase (IDO) catalyzes tryptophan along the kynurenine pathway, and both the reduction in local tryptophan and the production of tryptophan metabolites contribute to the immunosuppressive effects of IDO. METHODS: In this study, we investigated the pattern of expression of COX-2 and IDO, and the effect of UG transduction in the expression of COX-2 and IDO in several non-small cell lung cancer cell lines, especially A549. RESULTS: Both COX-2 and IDO were constitutionally expressed in A549 and H460 cells, and was reduced by UG transduction. In A549 cells, the slightly increased expression of COX-2 and IDO with the instillation of interferon-gamma (IFN-gamma) was reduced by UG transduction. However, the reduced expression of COX-2 and IDO by UG transduction was not increased with IFN-gamma instillation in A549 cells. In both the A549 COX-2 sense and the A549 COX-2 anti-sense small interfering RNA (siRNA)-transfected cells, IDO was expressed; expression was reduced by UG transduction, irrespective of the expression of COX-2. CONCLUSION: The results suggest that the anti-proliferative function of UG may be associated with the immune tolerance pathway of IDO, which is independent of the COX-2 pathway.
Carcinoma, Non-Small-Cell Lung
;
Cell Line
;
Constitution and Bylaws
;
Cyclooxygenase 2
;
Immune Tolerance
;
Indoleamine-Pyrrole 2,3,-Dioxygenase
;
Interferon-gamma
;
Kynurenine
;
Lung
;
Prostaglandin-Endoperoxide Synthases
;
RNA, Small Interfering
;
Tryptophan
;
Uteroglobin