1.A Case of Atypical Maxillary Sinusitis Accompanied with Papillon-Lefevre Syndrome.
Korean Journal of Otolaryngology - Head and Neck Surgery 2013;56(7):456-459
Papillon-Lefevre syndrome (PLS) is an extremely rare autosomal recessive disorder characterized by palmoplantar keratoderma and periodontitis and occuring with an estimated incidence of 1-4 cases per million. Patients with PLS are highly susceptible to infection. The etiology of an infective susceptibility is unknown; however, an association with defects in neurophil dysfunction, insufficient lymphocyte response to pathogens, defects in monocyte functions and impairment of NK cell cytotoxic function has been suggested. To our knowledge, this is the first case report of atypical maxillary sinusitis accompanied by PLS, and we represent the case with a review of the related literatures.
Humans
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Incidence
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Keratoderma, Palmoplantar
;
Killer Cells, Natural
;
Lymphocytes
;
Maxillary Sinus
;
Maxillary Sinusitis
;
Monocytes
;
Papillon-Lefevre Disease
;
Periodontitis
2.Adherence of Helicobacter pylori to areas of type II intestinal metaplasia in Korean gastric mucosa.
Tae Jung JANG ; Jung Ran KIM ; Dong Hoon KIM
Yonsei Medical Journal 1999;40(4):392-395
The aim of this study was to examine whether Helicobacter pylori (H. pylori) attaches to areas of intestinal metaplasia in Korean patients. Gastric biopsy specimens with intestinal metaplasia from 8 gastric cancers, 24 gastric ulcers, 11 duodenal ulcers, and 57 chronic gastritis were examined. The specimens were stained with periodic acid-Schiff/alcian blue pH 2.5 and high-iron diamine/alcian blue pH 2.5 to identify the subtype of intestinal metaplasia, and then immunohistochemical stain was done with rabbit anti-H. pylori polyclonal antibody. In 17 patients, H. pylori attached to areas of type II intestinal metaplasia. All areas of intestinal metaplasia showing adherence contained sialomucin, and H. pylori was not detected in the areas of intestinal absorptive cells and sulfomucin-containing metaplastic cells.
Adult
;
Aged
;
Bacterial Adhesion/physiology*
;
Female
;
Gastric Mucosa/pathology*
;
Gastric Mucosa/microbiology*
;
Helicobacter pylori/physiology*
;
Human
;
Intestines/pathology*
;
Intestines/microbiology*
;
Korea
;
Male
;
Metaplasia
;
Middle Age
3.2 Cases of Reduction of Orbital Floor Fracture Using Fibrin Glue for Securing Bioresorbable Panel.
Taejung PARK ; Boyoung KIM ; Kibeom BAE
Journal of Rhinology 2014;21(1):51-54
Many surgical methods for the reconstruction of orbital floor fractures have been reported, and theseinclude transorbital, transantral and transnasal endoscopic approaches, among others. The choice of surgical approach and materials for the reduction of orbital blowout fractures depends on the surgeon's experience and preference. For the cases of large orbital floor fractures, reduction has beenperformed most frequently through the transantral approach, and the herniated orbital tissue generally has been supported by asilastic block, silastic tube or urethral balloon catheter. However, the transantral approach has significant drawbacks that includethe requirement of removal surgery, displacement of materials, and inflammation of the maxillary sinus. To overcome these negative effects, the authors used fibrin glue tosecure the reduction through the transantral approach in two cases of patients with orbital floor fractures.
Catheters
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Fibrin Tissue Adhesive*
;
Humans
;
Inflammation
;
Maxillary Sinus
;
Orbit*
;
Orbital Fractures
4.The Expression of Pigment Epithelium-Derived Factor in Bladder Transitional Cell Carcinoma.
Tae Jung JANG ; Sung Woo KIM ; Kyung Seop LEE
Korean Journal of Pathology 2012;46(3):261-265
BACKGROUND: Pigment epithelium-derived factor (PEDF) is an anti-angiogenic factor. The purpose of this study is to examine the involvement of PEDF in the angiogenesis and biological behavior of bladder transitional cell carcinoma (TCC). METHODS: We examined the expression of PEDF in 99 bladder TCCs and ten non-neoplastic tissues, and evaluated microvessel density (MVD). RESULTS: The positive immunoreactivity for PEDF was seen in normal urothelium in 60% (6/10) and TCC in 13% (13/99). The PEDF expression had a significant correlation with MVD, i.e., a low MVD in 42% (5/12), a middle MVD in 11% (8/76) and a high MVD 0% (0/11) of tumors. The PEDF expression was not significantly correlated with the differentiation and invasion of TCC, but the degree of MVD was significantly higher in both high grade TCC and the pT2 tumors. CONCLUSIONS: The degree of PEDF expression is significantly higher in normal bladder urothelium than bladder TCC; it is inversely correlated with the angiogenesis; and it is not related to the differentiation and progression of TCC. It can therefore be concluded that bladder TCC would initially occur if there is a lack of the PEDF expression.
5.The Expression of Pigment Epithelium-Derived Factor in Bladder Transitional Cell Carcinoma.
Tae Jung JANG ; Sung Woo KIM ; Kyung Seop LEE
Korean Journal of Pathology 2012;46(3):261-265
BACKGROUND: Pigment epithelium-derived factor (PEDF) is an anti-angiogenic factor. The purpose of this study is to examine the involvement of PEDF in the angiogenesis and biological behavior of bladder transitional cell carcinoma (TCC). METHODS: We examined the expression of PEDF in 99 bladder TCCs and ten non-neoplastic tissues, and evaluated microvessel density (MVD). RESULTS: The positive immunoreactivity for PEDF was seen in normal urothelium in 60% (6/10) and TCC in 13% (13/99). The PEDF expression had a significant correlation with MVD, i.e., a low MVD in 42% (5/12), a middle MVD in 11% (8/76) and a high MVD 0% (0/11) of tumors. The PEDF expression was not significantly correlated with the differentiation and invasion of TCC, but the degree of MVD was significantly higher in both high grade TCC and the pT2 tumors. CONCLUSIONS: The degree of PEDF expression is significantly higher in normal bladder urothelium than bladder TCC; it is inversely correlated with the angiogenesis; and it is not related to the differentiation and progression of TCC. It can therefore be concluded that bladder TCC would initially occur if there is a lack of the PEDF expression.
6.Application and effectiveness of a nutrition education program based on the 2020 Dietary Reference Intakes for Koreans for undergraduates in Gyeongsangnam-do and Gyeonggi-do
Mijoo CHOI ; Hyein JUNG ; Nayoung KIM ; Sangah SHIN ; Taejung WOO ; Eunju PARK
Journal of Nutrition and Health 2023;56(6):730-741
Purpose:
The 2020 Dietary Reference Intakes for Koreans (KDRIs) serves as a foundation for daily nutrient and energy recommendations aiming to enhance public health and prevent chronic diseases. They act as guidelines for maintaining proper nutrition and overall health.Using KDRIs is crucial for promoting healthier lifestyles and making informed dietary choices. Thus, this study explores the influence of a nutrition education program, based on the 2020 KDRIs, on the nutrition knowledge and dietary habits of undergraduates in Gyeongsangnam-do and Gyeonggi-do.
Methods:
The nutrition education program, designed with diverse instructional materials, was executed across a wide range of universities. The education group (n = 75) engaged in the program for a 6-week instructional period, while the control group (n = 53) underwent the survey without participating in the education program. Nutrition Quotient (NQ) and knowledge assessments were administered to both groups immediately before and after the instructional period.
Results:
Within the education group, the nutrition education program positively impacted responses to NQ practice items, including knowledge of nutrition, daily intake, and portion sizes (p < 0.05). In contrast, there were no significant differences between the before and after responses of the control group for most survey items. Post-program evaluations showed significantly higher self-assessment scores and increased satisfaction levels (p < 0.05), with the satisfaction rate for the education program using the 2020 KDRIs reaching 99.2%.
Conclusion
This study has demonstrated the positive impact of an effective nutrition education program. However, there is a need for the continuous development and implementation of nutrition education programs to sustain these outcomes and further enhance the nutritional education experience.
7.The Development of an Automatic Thyroid Cancer Staging, Prognosis Predicting and Follow-Up Strategy Suggesting Calculator with Concurrent Data Input Process.
Taejung PARK ; Hyeongsin LEE ; Seongwon KIM ; Bugyeong KIM ; Hyosang PARK ; Hyeongu LEE ; Daeseok SHIN ; Nakyeong KIM ; Kangdae LEE
Korean Journal of Otolaryngology - Head and Neck Surgery 2015;58(6):407-412
BACKGROUND AND OBJECTIVES: It takes considerable time and effort to make decisions about management and follow up for the thyroid cancer. Also there are risks of incorrectness or confusion on the part of thyroid specialists. We developed a thyroid cancer calculator that does automatic thyroid cancer staging, prognosis predicting and suggesting follow-up strategies in order to reduce the burden of thyroid specialists who have to memorize a lot of guidelines and statistics, and to give consistency to the treatment plan. MATERIALS AND METHOD: An automatic thyroid cancer calculator was developed by using a computer program called 'Qt 5.2 version', based on patient demographics, diagnosis, treatment, and follow-up status. This partly cited the history of prior thyroid cancer or other cancer registration, and focused on the specification of differentiated thyroid cancer. RESULTS: The program consisted of survival, recurrence and, dynamic re-stratification with follow-up. The patient registration form consisted of identification number, name and operation date, and patients needed to enter their thyroid cancer status, including clinical and pathologic information after registration. The entered information could be easily accessed in a few seconds. The program helped to update patient's current status, promptly collect data for clinical studies of thyroid cancers and provide better patient care. This program was simple, convenient and time-saving for users as it specifically contained important thyroid cancer items. CONCLUSION: Although this program is still in its primitive stage, the Kosin thyroid calculator reduces the workload of thyroid specialists and prevents the loss of clinical data. Furthermore, it could be a useful tool for the management and research of thyroid cancer.
Demography
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Diagnosis
;
Follow-Up Studies*
;
Humans
;
Neoplasm Staging
;
Patient Care
;
Prognosis*
;
Recurrence
;
Specialization
;
Thyroid Gland
;
Thyroid Neoplasms*
8.Expression of Cyclin D1, Cyclin E, p21Cip1 and p27Kip1 in Chemically Induced Rat Mammary Tumor Treated with Tamoxifen and Transforming Growth Factor-1.
Tae Jung JANG ; Jae Hum PARK ; Mee Yon CHO ; Ki Kwon KIM ; Jung Ran KIM
Korean Journal of Pathology 2001;35(2):151-157
BACKGROUND: Tamoxifen (TAM) inhibits the action of estrogen by binding to estrogen receptors, and also has non-estrogen receptor mediated cytostatic activities. Transforming growth factor-1 (TGF-1) inhibits the proliferation of many other cell types, such as epithelial, hematopoietic and endothelial cells. METHODS: We investigated the effects of tamoxifen on the growth of 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary tumors and the expression of cyclin D1, cyclin E, p21Cip1, and p27Kip1 by performing immunohistochemistry and Western blot analysis, and studied whether TGF-1 injection amplified the effects of TAM. When tumor size reached between 10-15 mm in the largest dimension, the rats were divided into 3 groups: DMBA-control group (n=12), DMBA-TAM group (n=14) and DMBA-TAM plus TGF-1 group (n=5). RESULTS: The consecutive administration of TAM markedly decreased the tumor development compared with the DMBA-control group. The DMBA-TAM and DMBA-TAM plus TGF-1 groups showed decreased expression of bromodexoyuridine, cyclin D1, cyclin E, and p21Cip1 when compared with those of the DMBA-control group. On the other hand, the labeling index of p27Kip1 was higher in the DMBA-TAM plus TGF-1 group than in the DMBA-control group. CONCLUSION: TAM suppresses tumor development, which may be associated with down-expression of cyclin D1 and cyclin E, and overexpression of p27Kip1, and addition of TGF-1 does not influence tumor development treated by TAM.
Animals
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Blotting, Western
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Breast
;
Cell Cycle
;
Cyclin D1*
;
Cyclin E*
;
Cyclins*
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Endothelial Cells
;
Estrogens
;
Hand
;
Immunohistochemistry
;
Rats*
;
Receptors, Estrogen
;
Robenidine
;
Tamoxifen*
;
Transforming Growth Factor beta
9.A Sudden Unexpected Death in an Epileptic with Cerebral Cavernous Angioma.
Jong Pil PARK ; Taejung KWON ; Yu Hoon KIM ; Hyoung Joong KIM
Korean Journal of Legal Medicine 2010;34(1):38-42
Cerebral cavernous angioma is a rare form of vascular malformations which is histologically composed of closely-packed, thin-walled blood vessels without neural tissue intervened. One of the most common symptoms is seizure, which is usually well-controlled by medication or surgery and known to be rarely intractable or fatal. Because sudden, unexpected death in epilepsy patients reveals generally its unclear death mechanism and negative autopsy finding in forensic pathology practice, particular attention should be paid. We recently experienced an autopsy case of 32-year-old woman who had suffered from epilepsy and showed cerebral cavernous angioma on autopsy. We report this case with literature review.
Adult
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Autopsy
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Blood Vessels
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Caves
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Central Nervous System
;
Epilepsy
;
Female
;
Forensic Pathology
;
Hemangioma
;
Hemangioma, Cavernous
;
Humans
;
Seizures
;
Vascular Malformations
10.Hyperventilation Induced Nystagmus in Patient with Vestibular Schwannoma : A Case Report.
Yoon Jeong CHANG ; Geun Ho LEE ; Chang Min LEE ; Young Mok SONG ; Chung Ku RHEE ; Jae Il KIM
Journal of the Korean Balance Society 2004;3(1):177-179
When doctors evaluate the complaints of dizziness, they often perform a series of clinical tests to look for the evidence of a vestibular dysfunction. A useful procedure is to ask the patient to take deep breaths and observe the gaze behind Frenzel goggles. If hyperventilation-induced nystagmus(HIN) is detected, it is the evidence for an underlying vestibular imbalance. The authors evaluated nystagmus with electronystagmography after hyperventilation for 50 seconds. Brain imaging was performed to search the responsible lesion for dizziness. Brain MRI revealed a brain tumor suggesting vestibular schwannoma in the left cerebellopontine angle. After hyperventilation, dizziness and the right beating horizontal nystagmus with Alexander law could be detected. By precisely measuring the HIN, we determined that inputs arising from the horizontal semicircular canal were mainly responsible. The contralaterality of the direction of the horizontal component of the nystagmus was detected. We suggest that clinicians should routinely check the nystagmus after hyperventilation, when they evaluate patients complaining of dizziness.
Brain
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Brain Neoplasms
;
Cerebellopontine Angle
;
Dizziness
;
Electronystagmography
;
Eye Protective Devices
;
Humans
;
Hyperventilation*
;
Jurisprudence
;
Magnetic Resonance Imaging
;
Neuroimaging
;
Neuroma, Acoustic*
;
Nystagmus, Pathologic
;
Semicircular Canals