1.Three Cases of Familial Benign Chronic Pemphigus.
Korean Journal of Dermatology 1979;17(5):379-383
Familial Renign Chronic Femphigus(FRCP) is rare, persistent and vesicobullous genodermatoai. Three casee of FRCP with typical clinical and histapathological findings are reported. The first case of FBCP was 27-year-oId man who had recurrent episodes of grou vesicles and rust with miId pruritue at the posterior neck, in both axillae and in inguinal area for 10 years. The second case was 49-year-old woman with skin lesions of recurrent persistent. vesicles, pustules on the erythematous skin, crust and lichenification on the flexural area of extrimeties, axillae, ingumal and neck area for 10 yeara. The third case was 49-year-old male patient who had recurrent pruritic grouped vesicles with crust on the neck and axillary area. In all three patients, skin eruptions usually began and or aggravated in the spring or summer and tend to heal spontaneously in the autumn and winter and showed positive Nikolsky sign. The only one case of the reported three casea had familiaI history of skin lesions similar to FRCP. Histopat,holag;ic finding of biopsy specimens from the vesicular eruption showed auprabasal vesiculation with acantholysis, lacunae and villi formation in all 3 cases.
Acantholysis
;
Axilla
;
Biopsy
;
Female
;
Humans
;
Male
;
Middle Aged
;
Neck
;
Pemphigus, Benign Familial*
;
Skin
2.Two Cases of Monochromatic Green Argon Laser Photocoagulation for Choroidal Neovascular Membrane in High Myopes.
Sheen Chull JOH ; Young Tae CHUNG
Journal of the Korean Ophthalmological Society 1986;27(4):657-666
High myopia, often called malignant, pathologic or degenerative myopia, involves a progressive elongation of globe, accompanied by degenerative changes of the retina and choroid. Continued stretching and degeneration of the choroid causes eyes with severe myopia to develop breaks in Bruch's membrane which, called lacquer cracks, and permits neovascular proliferation from the choriocapillaris into the subretinal pigment epithelial space. Neovascularization associated with severe myopia deteriorates central visual acuity due to exudation and/or hemorrhage. Laser photocoagulation therapy is useful in treating neovascular membrane outside the foveal avascular zone or extending to the edge of the perifoveal capillary network. We have evaluated three patients with macular hemorrhage which associated with high myopic choroidal degeneration. Subretinal neovascular membrane was detected by fluorecein angiography and was treated with monochromatic Argon green laser photocoagulation in two patients indicated. The visual acuities were improved. But one patient who had macular hemorrhage involving both foveas could not be treated with laser photocoagulation. Then his visual acuity severly decreased. We give our experiences with the review of other papers in this report.
Angiography
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Argon*
;
Bruch Membrane
;
Capillaries
;
Choroid*
;
Hemorrhage
;
Humans
;
Lacquer
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Light Coagulation*
;
Membranes*
;
Myopia
;
Myopia, Degenerative
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Retina
;
Visual Acuity
3.Detection of genital herpes infection by culturing herpes simplex virus and immunofluorecent stain.
Korean Journal of Obstetrics and Gynecology 1992;35(9):1324-1336
No abstract available.
Herpes Genitalis*
;
Herpes Simplex*
;
Simplexvirus*
4.Total Hyphema Treated with Ocutome.
Young Tae CHUNG ; Tae Jun KIM ; Youn Hee CHUNG
Journal of the Korean Ophthalmological Society 1982;23(3):879-882
Author have experienced 3 cases of intractable total traumatic hyphema on conservative medical treatment and have good results after surgical management by using Model 800(A) Ocutome vitrectomy instrument. For evacuation of blood clot in anterior chamber. The conclusion were as follow; 1. We experienced no significant intraoperative complication. 2. All 3 cases achieved intraocular presure controls in early post operative state and these controls were sustained till now without any antiglaucomatous agent. 3. Good final visual acuity was obtained in pure total hyphema in which there was no other associated intraocular injury at the time of trauma.
Anterior Chamber
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Hyphema*
;
Intraoperative Complications
;
Visual Acuity
;
Vitrectomy
5.Antitumorigenic activities of linoleic acid detected by in situ hybridization on transplanted tumors in mice.
Tae Hyong RHEW ; Seong Mi PARK ; Hae Young CHUNG ; Kun Young PARK ; Jae Chung HAH
Journal of the Korean Cancer Association 1992;24(4):493-503
No abstract available.
Animals
;
In Situ Hybridization*
;
Linoleic Acid*
;
Mice*
6.Antitumor effect of ursolic acid against inbred hepatoma in CBA/J mouse.
Jae Chung HAH ; Tae Hyong RHEW ; Eun Sang CHOE ; Hae Young CHUNG ; Kun Young PARK
Journal of the Korean Cancer Association 1992;24(6):790-794
No abstract available.
Animals
;
Carcinoma, Hepatocellular*
;
Mice*
7.A Clinical Study of Ankle Fractures
Chil Soo KWON ; Kwang Yoon SEO ; Young Koo LEE ; Tae Young CHUNG ; Joon Wha CHUNG
The Journal of the Korean Orthopaedic Association 1978;13(3):399-408
The authors have reviewed 71 cases (70 patients) of the ankle fractures that were treated through the admission in Orthopedic Department, Paik Foundation Hospital, from June 1972 to April 1978. The average duration of the follow-up waa 15 months. The summary of the results were as follows; 1. Of the 71 cases, male was 54 cases and female 17 cases. The average age of the patients was 32. 2. The main cause of the injuries was traffic accident, and the other causes were sliding down and falling from a height, industrial accident, and sports injury in order. 3. By the classification of Lauge-Hansen, the pronation-external rotation and,supination-adduction types were commoner than the other types. 4. Open reduction was performed in 48 cases, and closed reduction in 23 cases. 5. The average duration of the cast immobilization after the closed reduction was 8 weeks, and that of the open reduction was 6 weeks. 6. The result of the treatment was better in those cases of the open reduction than that of, the closed reduction. 7. The good clinical results could be achieved by obtaining the anatomical position of the talus in the mortise and the reduction was achieved more satisfactorily when the key role of the lateral malleolus in complete reduction was well understood.
Accidental Falls
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Accidents, Occupational
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Accidents, Traffic
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Ankle Fractures
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Ankle
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Athletic Injuries
;
Classification
;
Clinical Study
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Female
;
Follow-Up Studies
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Humans
;
Immobilization
;
Male
;
Orthopedics
;
Talus
8.A Case of Xanthoma Tuberosum.
Young Ja CHOI ; Kyung Sool KWON ; Tae An CHUNG
Korean Journal of Dermatology 1980;18(1):101-105
A 43 year-old Korean male has had multiple, grouped, asymptomatic, yellowish brown flat papules and nodules on the knees, elbows, buttocks, palms and soles for 3 years. Small yeIlowish, discrete papules first appeared on the right palm and left elbow, and gradually increased in size and number and spread to knees, buttocks and soIes. Physical examination revealed normal except for the skin lesions and no familial occurrence was noted. Gross finding of the serum was turbid, more or less creamy and paper electrophoresis revealed marked increase of prebetalipoprotein, increase of betalipoprotein and alphalipoprotein and absence of chylomicron, suggesting type III or type IV hyperlipoproteinemia. Serem choleterol was 200mg% and fasting blood sugar was 115.0mg%. with normal glucose tolerance test. Histopathology showed many aggregates of foam cells on H-E stain and many lipid droplets in the dermis on Sudan red stain. Based on the clinical and histopathological findings and lipoprotein analysis by the paper electrophoresis, the patient was diagnosed as type IV hyperlipoproteinemia with xanthoma tuberosum.
Adult
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Blood Glucose
;
Buttocks
;
Dermis
;
Elbow
;
Electrophoresis, Paper
;
Fasting
;
Foam Cells
;
Glucose Tolerance Test
;
Humans
;
Hyperlipoproteinemia Type IV
;
Knee
;
Lipoproteins
;
Male
;
Physical Examination
;
Skin
;
Sudan
;
Xanthomatosis*
9.The Effect of Minizide(R) in the Hypertensive Patients.
Jong Seong KIM ; Tae Seong KIM ; Young Sun CHUNG
Korean Circulation Journal 1980;10(1):37-42
The effect of Minizide(R) (prazosine 1mg and polythiazide 0.5mg) was studied in 34 hypertensive patients (female 16 cases, male 18 cases) at the Department of Internal Medicine, Paik Hospital, In-Je Medical College between July, 1979 and August 1980 for 14 months. The patients didn't take the any drugs for one week before the clinical trial with Minizide(R), and thereafter they took minizide 1 tablet 3 times daily for 2 weeks. The blood pressure was checked before and after the trial in the supine and standing position. The results were as followings: 1) The systolic blood pressure before the treatment with Minizide in the supine position was 196+/-24mmHg and in the standing position 188+/-22mmHg. The systolic blood pressure after the treatment with minizide in the supine position was 148+/-16mmHg and in the standing position 139+/-9mmHg. 2) The diastolic blood pressure before the treatment with minizide in the supine position was 118+/-11mmHg, and in the standing position 113+/-10mmHg. The diastolic blood pressure after the treatment with minizide in the supine position was 87+/-6mmHg and in the standing position 84+/-5mmHg. 3) There was no significant orthostatic hypotension after the 34 patients. 4) There was no changes of laboratory findings after the treatment. 5) 3 of 34 hypertensive patients after the treatment complained of headache, 3 palpitation, 2 edema, 2 drowsiness, and 1 fatigability and 1 patient complained of weakness.
Blood Pressure
;
Edema
;
Headache
;
Humans
;
Hypotension, Orthostatic
;
Internal Medicine
;
Male
;
Polythiazide
;
Sleep Stages
;
Supine Position
10.Ultrastructural Changes in the Exocrine and Endocrine Cells of Rat Pancreas in Endotoxin Shock.
Kun Young KWON ; Chai Hong CHUNG ; Tae Joong SOHN
Korean Journal of Pathology 1985;19(3):255-289
This study was carried out to investigate the morphological changes in the exocrine and endocrine glands of rat pancreas treated with endotoxin. Thirty-five male Sprague-Dawley rats, maintained on a stock diet, weight 200.0 gm. average. were divided into two experimental groups. Group 1. Control group. Five rats. Intraperitoneal infections of 0.3 ml normal saline only. Group 2. Endotoxin-treated group. Thirty rats. 7.6 mg of endotoxin per kg. of body weight was administered intraperitoneally. Each of 5 experimental animal was sacrificed 30 minutes, 1, 2, 4, 6 and 8 hours after endotoxin treatment, followed by examinations of histochemical, light and electron microscopy of both transmission and scanning modes. The results were as follows: A. Light microscopic findings: A mild interstitial edema and hyperemia were noted 1-hour after endotoxin treatment. Cytoplasmic vacuolization at 2-hour level(2-hours after endotoxin administration), diminished staining quality of both endocrine and exocrine cells at 6-hour level. B. Electron microscopic examination: a. Transmission electron microscopy. The acinar cells of pancreas showed a mildly increased pre-lysosome at 30-minute level. At 1-hour level, appearance of secondary lysosome was noted in addition to the findings of mitochondrial swelling and decreased cristae; disarray and vacuolization of the RER; vacuolar change of Golgi apparatus. At 6-hour level, post-lysosomes. The changes in the endocrine glands were similar to the findings of exocrine glands just described with time lag of 1 to 2 hours. The endothelial cells of capillaries show swelling and pinocytotic vesicle formation, protrusion of the cytoplasmic processes into the capillary lumen and increased heterochromatin at 1-hour level. These findings became more prominent as time lapses. The lumen of the endothelium tends to be narrowed, filled with fibrin and other blood cell components which later terminated with occasional complete occlusion by the formation of thrombi. b. Histochemical study: Primary lysosomes of the control group revealed a strong reaction of the acid phosphatase whereas the endotoxin treated group with less reactivity limited in the peripheral zones of the lysosomes. Secondary lysosomes with partial reactions. However, the pre-lysosomes and post-lysosomes failed to demonstrate any acid phosphatase activity at all. c. Scanning electron microscopy. The endothelial cells of the capillaries, arterioles and venules demonstrated increased microvillous activity, broad bled formation, cytoplasmic protrusion into the luminal spaces and microthrombi formation at 1-hour level. Six-hour level onward there noted a junctional disruption and partial detachment from the subendothelium of the wall. It can be concluded, therefore: When the endotoxin enters the blood stream, it elicits endothelial injury followed by both exudation with resultant edema of the surrounding tissue and concomitant vascular occlusions due to thrombosis. This vascular occlusion, in turn, causes ischemic degenerative change of the cells of exocrine and endocrine glands of the pancreas which are followed by digestions of degradational materials from the injured cells through the lysosomal phagocytic system. Besides the above pathogenetic pathway, one can not rule out the possibility of the direct effects of the endotoxin to the cells of exocrine and endocrine cells of the pancreas also so rendered.
Male
;
Humans
;
Rats
;
Animals