Purpose: The study aimed to identify which digital biomarkers are collected and which specific devices are used according to vulnerable and susceptible individual characteristics in a living-lab setting. Materials and Methods: A literature search, screening, and appraisal process was implemented using the Web of Science, Pubmed, and Embase databases. The search query included a combination of terms related to “digital biomarkers,” “devices that collect digital biomarkers,” and “vulnerable and susceptible groups.” After the screening and appraisal process, a total of 37 relevant articles were obtained. Results: In elderly people, the main digital biomarkers measured were values related to physical activity. Most of the studies used sensors. The articles targeting children aimed to predict diseases, and most of them used devices that are simple and can induce some interest, such as wearable device-based smart toys. In those who were disabled, digital biomarkers that measured location-based movement for the purpose of diagnosing disabilities were widely used, and most were measured by easy-to-use devices that did not require detailed explanations. In the disadvantaged, digital biomarkers related to health promotion were measured, and various wearable devices, such as smart bands and headbands were used depending on the purpose and target. Conclusion As the digital biomarkers and devices that collect them vary depending on the characteristics of study subjects, researchers should pay attention not only to the purpose of the study but also the characteristics of study subjects when collecting and analyzing digital biomarkers from living labs.

No abstract available.
Weight Gain*

The clinical and pathological features of a paraganglioma arising in the cauda equina is described and compared with previous reports. The right microscopic fetures were similar to those of paragangliomas from other sites, with a 'Zellballen' pattern of cells containing arzyrophil granules. Immunohistocytochemical stains for neurone specific enolase, S-100 protein, cytokeratin were positive, but stains for glial fibrillary acidic protein were negative. Electron microscopy showed densely staining membrane-bound granules, cilia like structures and fibros bodies in the cytoplasm. The last two features only occur in paragangliomas from this site. The pathological findings suggest that paragangliomas in this site arise from pre-existing paraganglia, possibly of the visceral autonomic group.

Three cases of giant pituitray adenoma are reported. Two cases were operated by transsphenoidal approach and a case by transcranial approach. Transsphenoidal approach showed satisfactory results despite of marked suprasellar extension of tumors. We report rare giant pituitary adenomas with review of relevant literatures.
Adenoma ; Pituitary Neoplasms*

OBJECTIVE: Breast cancer is one of the most common cancers affecting women. Both physicians and patients have concerned about breast cancer survivability. Many researchers have studied the breast cancer survivability applying artificial nerural network model (ANN). Usually ANN model outperformed in classification of breast cancer survivability than other models such as logistic regression, Bayesian network (BN), or decision tree models. However, physicians in the fields hesitate to use ANN model, because ANN is a black-box model, and hard to explain the classification result to patients. In this study, we proposed a hybrid model with a degree of the accuracy and interpretation by combining the ANN for accuracy and BN for interpretation. METHODS: We developed an artificial neural network, a Bayesian network, and a hybrid Bayesian network model to predict breast cancer prognosis. The hybrid model combined the artificial neural network and the Bayesian network to obtain a good estimation of prognosis as well as a good explanation of the results. The National Cancer Institute's SEER program public-use data (1973-2003) were used to construct and evaluate the proposed models. Nine variables, which are clinically acceptable, were selected for input to the proposed models' nodes. A confidence value of the neural network served as an additional input node to the hybrid Bayesian network model. Ten iterations of random subsampling were performed to evaluate performance of the models. RESULTS: The hybrid BN model achieved the highest area under the curve value of 0.935, whereas the corresponding values of the neural network and Bayesian network were 0.930 and 0.813, respectively. The neural network model achieved the highest prediction accuracy of 88.8% with a sensitivity of 93.7% and a specificity of 85.4%. The hybrid Bayesian network model achieved a prediction accuracy of 87.2% with a sensitivity of 93.3% and a specificity of 83.1%. The results of the hybrid Bayesian network model were very similar to the neural network model. CONCLUSION: In the experiments, the hybrid model and the ANN model outperformed the Bayesian network model. The proposed hybrid BN model for breast cancer prognosis predictin may be useful for clinicians in the medical fields, as the model provides both high degree of performance inherited from ANN and good explanation power from BN.
Breast Neoplasms* ; Classification ; Decision Trees ; Female ; Humans ; Logistic Models ; Neural Networks (Computer) ; Prognosis* ; SEER Program ; Sensitivity and Specificity

OBJECTIVES: To discern in advanced uterine cervical cancer whether the hyperfractionation is more effective in tumor control and in reducing radiation complication rates than the simple fractionation. METHODS: We retrospectively reviewed the medical records of 184 patients with advanced cervical cancer at our hospitals from January 2000 to December 2004. All patients were treated with radiation, 114 patients with simple fractionation, and 70 patients with hyperfractionation. RESULTS: Mean age was 55.4 years at baseline study. Complications were occurred in 90 patients of the 184 patients who treated with radiation therapy. Of these, 48 patients suffered from gastrointestinal complications, 24 patients suffered from genitourinary complications and 18 patients had both complications. Complications were occurred in 72 cases in simple fractionation group and 40 cases in hyperfractionation group. 77 patients had acute complications and 13 patients had chronic complications. There was no statistically significant difference between two groups (P = 0.772). Mild complication were occurred in 75 patients and severe complication were occurred in 15 patients, there was no statistically significant difference in two groups (P = 0.495). 66 patients had gastrointestinal complications and 42 patients had genitourinary complications, there was no statistical significance in two groups (P = 0.910). CONCLUSION: Many complications were occurred in patients who treated with radiation therapy, but there was no statistically significant survival and complication difference in two groups. Further research is needed.
Humans ; Medical Records ; Retrospective Studies ; Uterine Cervical Neoplasms

The wrist joint is composed of midcarpal, radiocarpal and distal radioulnar joints. It is difficult to analyze the motion of these joints by the simple roentgenogram. We reconstructed three dimensional images of the wrist and distal radius from computerized tomogram using a new interactive graphics software written in Pascal and Turbo Graphic. There were 10 normal wrists in neutral position, and two normal and one abnormal wrists in ulnar-radial deviation and one normal wrist in flexion-extension were analyzed in this study. For simplification, the images were reformatted for the scaphoid, the proximal carpal row, the distal carpal row and the distal radius. We established the three dimensional references for wrist by defining the Z axis as the long axis of radius, the X axis as a line which is in horizontal plane and parallel to the anterior cortex of distal radius about 2 cm proximal to the articular surface and the Y axis as the automatically defined line perpendicular to both X and Z axes. We measured the angles between the X-axis and the reference lines of scaphoid and each carpal rows. The scaphoid was internally rotated by 60,0 degrees from X axis, the proximal carpal row by 7.0 degrees and the distal carpal row by 25.6 degrees each. There was only minimal change in the angles during the ulnar and radial deviation. The pattern of angles in abnormal wrist was different from those in normal wrists. In flexion-extension, the angle of distal carpal row was changed significantly, which means there was some error in selecting the reference line of distal carpal row as an axis of motion, or in measuring the angles, or it can be suggested that there is some rotational motion of distal carpal row on the Z axis. The proximal poles of the scaphoid and the triquetrum were displaced ventrally during flexion and dorsally during extension.
Imaging, Three-Dimensional ; Joints ; Radius ; Wrist Joint ; Wrist

PURPOSE: The aim of the present study was to evaluate the effect of Bio-Oss on bone formation in terms of healing period and type of membrane so that determine the most suitable condition for implant fixation in grafted maxilla. MATERIAL AND METHOD: Forty-five biopsy specimens from graft site were evaluated. Sinus lift was performed in the patients with reduced alveolar bone height(less than 5mm). The specimen was taken at the time of implant fixation, which was performed at least 5 months after the sinus lift procedure. All specimens were stained with HandE and Trichrome staining and evaluated histomorphometrically. RESULT: The results showed that Bio-Oss particle was in direct contact with newly formed bone in all cases. In the present study, the amount of newly formed bone and the residual bone substitute material were not statistically different according to various membrane and different healing period. There was no difference between the histological feature of the specimen of 5 and 31 months. No statistical significance was detected between male and female. CONCLUSION: The result implies that Bio-Oss does not seem to be resorbed over time regardless of the type of the membranes. The further investigation is needed to clarify this issue with the extended period of follow-up.
Biopsy ; Bone Substitutes ; Female ; Follow-Up Studies ; Hand ; Humans ; Male ; Maxilla ; Maxillary Sinus* ; Membranes* ; Osteogenesis ; Transplants

Asian Continental Ancestry Group ; Child ; Diagnosis ; Female ; Fever ; Fever of Unknown Origin ; Histiocytic Necrotizing Lymphadenitis ; Humans ; Lymph Nodes ; Lymphatic Diseases ; Lymphoma ; Neck ; Rare Diseases ; Young Adult

A three-year-old female beaver (Castor canadensis) was referred to the Veterinary Teaching Hospital of Chungbuk National University. It had been raised in the Cheong-ju zoo and had a history of malocclusion caused by improper feeding. General anesthesia was induced, and preoperative intraoral dental radiographs of the rostal maxillary and mandibular dentition were taken and lateral and ventrodorsal extraoral radiographs of the cheek teeth were also taken. The radiographs were negative for apical pathology and revealed a normal appearance of the cheek teeth. The lesion was likely to be related to the excessive length of the maxillary and mandibular incisors. Odontoplasty was performed to reduce overgrowth of the crowns of the incisors. Sequential transverse sections were removed until the crown was reduced by approximately its original length. The pulp chamber was not approached during the operation, as confirmed by postoperative intraoral radiographic evaluation of the incisors. Recovery from anesthesia was uneventful and the beaver returned to normal masticatory activities immediately after the operation.
Animals ; Animals, Zoo ; Female ; Incisor/pathology/*surgery ; Malocclusion/pathology/surgery/*veterinary ; Rodentia/*surgery