1.Comparison of Gadolinium Polylysine and Gadopentetate in Contrast Enhanced MR Imaging of IVlyocardial Ischemia-Reperfusion in Cats.
Jung Hee LEE ; Tae Hwan LIM ; Tae Keun LEE ; Chi Woong MUN
Journal of the Korean Radiological Society 1995;33(1):59-65
PURPOSE: To assess the signal enhancement by gadolinium-DTPA-polylysine (Gd-polylysine) as compared to gadopentetate (Gd-DTPA) in MR imaging of heart that have undergone ischemia-reperfusion, and to estimate the extent of myocardial damage covered bythe MR signal enhancement. MATERIALS AND METHODS: A series of contrast enhanced cardiac MR images were obtained from 17 cats subjected to a 90 minutes of occlusion of the left anterior descending coronary artery (LAD) followed by a 90 minutes of raperfusion. Time courses of changes in the signal intensity (Sl) of the ischemic area were measu red in Gd-polylysine group (8 cats) and Gd- DTPA group (9 cats). The size of U R signal enhanced area was then compared to the sizes of infarction and the area at risk revealed byTTC histochemical staining. RESULTS: Maximum Sis were obtained at 60 minutes and 30 minutes after injection of the contrast material, respectively for Gd-polylysine group and Gd-DTPA group. Signal enhancement was stronger and persistent for a longer period in Gd-polylysine group than in GD-DTPA group. Sizes of the enhanced area, the infarction, and the area at risk were about 30%, 15%, and 50% of the total left ventricle (LV) area; the difference between the groups was statistically insignificant. CONCLUSION: Gd-polylysine can be used better for a blood pool marker than Gd-DTPA in MR imaging of myocardial ischemia, due to its strong and persistent signal enhancement. The MR signal enhanced area includes both the infarcted area and a portion of the area at risk.
Animals
;
Cats*
;
Coronary Vessels
;
Gadolinium DTPA
;
Gadolinium*
;
Heart
;
Heart Ventricles
;
Infarction
;
Magnetic Resonance Imaging*
;
Myocardial Ischemia
;
Pentetic Acid
;
Polylysine*
2.A case of isolated ACTH deficiency.
Tae Yong SON ; Myung Shik LEE ; Jhin Oh LEE ; Tae Woong KANG
Journal of Korean Society of Endocrinology 1991;6(4):367-370
No abstract available.
Adrenocorticotropic Hormone*
3.In vitro 31P NMR spectroscopic assessment of the endurance and recovery capacity of skeletal muscle: comparison between the sedentaries and canoe athletes.
Tae Hawn LIM ; Tae Keun LEE ; Ki Hong SEONG ; Chi Woong MUN ; Sang Tae KIM ; Myung Jin SHIN
Journal of the Korean Radiological Society 1992;28(5):776-782
In vivo 31P NMR spectroscopic study of forearm wrist flexor muscles was performed in two groups of volunteers composed respectively of 6 sedentaries and 6 canoe athletes. A continuous isometric contraction of endurance exercises was adopted in oder to assess the endurance capacity and recovery potential of skeletal muscles. Differences in high energy phosphorus metabolism between the sedentaries and athletes were evaluated with and emphasis on the intracellular pH and Pi/PCr ratio as indicators of high energy phosphorus metabolism. There were no differences of baseline pH and Pi/PCr ratio between the two groups. The athletes sustained the exercise at more acidic intracellular pH and at a higher Pi/PCr ratio of intracellular conditions for an all-out than did the sedentaries. The recovery rate of pH showed no difference between the two groups. There was a tendency of faster recovery of Pi/PCr in athletes showing half recovery time(T1/2) of 39.0±3.0 seconds as compared to that of sedentaries (55.7±7.5 seconds). The recovery rate of Pi/PCr as a function of Pi/PCr ratio at a given period of time was significantly faster in athletes than in sedentaries (P<0.001). The correlation coefficient of the recovery rate of Pi/PCr against the Pi/PCr ratio was 0.985 and 0.914 respectively for the athletes and sedentaries. The pH and the Pi/PCR ratio at an all-out state can be used as indicators of endurance capacity and the recovery rate of Pi/PCr, as a reovery potential of skeletal muscles.
Athletes*
;
Exercise
;
Forearm
;
Humans
;
Hydrogen-Ion Concentration
;
In Vitro Techniques*
;
Isometric Contraction
;
Metabolism
;
Muscle, Skeletal*
;
Muscles
;
Phosphorus
;
Volunteers
;
Wrist
4.A Case of Blue Rubber Bleb Nevus Syndrome.
Woong Jae LEE ; Tae Won KIM ; Ki Beom SUHR ; Jeung Hoon LEE ; Jang Kyu PARK
Korean Journal of Dermatology 1998;36(6):1139-1142
The blue rubber bleb nevus syndrome(CRBNS) is a rare disorder characterized by distinctive vascular malformations of the skin and gastrointestinal tract. The syndrome is associated commonly with iron deficiency anemia due to gastrointestinal bleeding. Most cases are sporadic, although a few have been reported with autosomal dominant inheritance. We report a case with clinical characteristics of the blue rubber bleb nevus syndrome. The patient had typical skin manifestations of the BRBNS and chronic iron deficiency anemia. However, we could not find any gastrointestinal vascular malformations radiologically.
Anemia, Iron-Deficiency
;
Blister*
;
Gastrointestinal Tract
;
Hemorrhage
;
Humans
;
Nevus*
;
Rubber*
;
Skin
;
Skin Manifestations
;
Vascular Malformations
;
Wills
5.A Case of Coats' Disease.
Yong Tae KIM ; Tae Soo LEE ; Seong Tack RHEE ; Woong Bin LEE
Journal of the Korean Ophthalmological Society 1972;13(4):270-274
A case of Coats' disease in 15 years old boy was presented with some clinical observation. This is a rare unilateral retinal disorder with hemorrhagic and exudative properties affecting otherwise healthy young boys. A brief review of literatures has also been described.
Adolescent
;
Humans
;
Male
;
Retinaldehyde
6.A Case of Sick Sinus Syndrome Derived in Elderly Patient on Hemodialysis.
Jong Dae BONG ; Gki Boem BOO ; Doo Sun SIM ; Tae Woong LEE
Journal of the Korean Geriatrics Society 2004;8(4):247-251
Sick sinus syndrome comprises a variety of conditions involving sinus node dysfunction and commonly affects elderly persons. Though sudden cardiac death accounts for as much as 15% of all cause mortality in uremia, requiring permanent cardiac pacing in end-stage renal disease hemodialysed patients are very few. Most cases of sick sinus syndrome are idiopathic, and the cause can be multifac- torial. A-V conducton defects were attributed to extensive metastatic calcifications, involving the cardiac skeleton, conservative to severe hyperparathyroidism and inadvertent use of calcitriol and calcium carbonate as phosphate binders. If optimal hemodialysis is provided, benefits of permanent pacing are equal in uremic or non uremic patients and pacemaker implantation should be instituted. We report a case of sick sinus syndrome derived in elderly patient on hemodialysis.
Aged*
;
Calcitriol
;
Calcium Carbonate
;
Death, Sudden, Cardiac
;
Humans
;
Hyperparathyroidism
;
Kidney Failure, Chronic
;
Mortality
;
Renal Dialysis*
;
Sick Sinus Syndrome*
;
Skeleton
;
Uremia
7.A Case of Behcet's Disease Associated with Intestinal Ulcers.
Eun Kyoung LEE ; Doo Hee YOON ; Tae Yoon KIM ; Chung Won KIM ; Woong Sik AHN
Korean Journal of Dermatology 1997;35(3):575-578
Behcets disease is a chronic systemic disease of unknown etiology, which is characterized by the recurrent orogenital ulcers, eye involvement and skin manifestations. In addition to the major symptoms, it includes arthritis, vasculitis, neurologic manifestations and gastrointestinal lesions. We report a case of Behcets disease associated with intestinal ulcers. The patient, a 45-year-old female, who had been treated under the diagnosis of Behcets disease for 4 years, presented with swallowing difficulty, vaginal discharge and persistent right lower abdominal pain. Colonoscopic examination showed multiple ulcers on the ileocecal region which is reported as the most common site of gastrointestinal Behcets disease. Gastrointestinal evaluation can be useful in diagnosis of Behcets disease, especially in a patient with gastrointestinal symptoms.
Abdominal Pain
;
Arthritis
;
Deglutition
;
Diagnosis
;
Female
;
Humans
;
Middle Aged
;
Neurologic Manifestations
;
Skin Manifestations
;
Ulcer*
;
Vaginal Discharge
;
Vasculitis
8.Discriminating Power of MCV and RDW in Anemia.
Ga Young LEE ; Tae Jin PARK ; Ean Ju LIM ; Seung Woong GWAK
Journal of the Korean Academy of Family Medicine 1997;18(1):39-45
BACKGROUND: The red cell distribution width(RDW) has been reported to be of value in discriminating iron deficiency anemia(IDA) from the anemia of the other causes(non-IDA). The combination of a low MCV and a high RDW may indicate iron deficiency anemia. The purpose of this study was to discriminate IDA from anemia, using automated blood cell count alone. METHODS: We collected 139 cases of anemia in outpatients, with 80 cases of IDA and 59 cases of anemia due to other causes, from July 1995 to September 1996 in department of family medicine, Pusan Paik hospital. RESULTS: The sex distribution was 39(28.1%) in male, 100(71.9%) in female. The age distribution was 15 to 79 year. The hemoglobin level and MCV in IDA(9.5+/-1.6g/dl, 77.5+/-8.9fl) was significantly lower than those in non-IDA(10.1+/-1.5g/dl, 87.6+/-10.5fl)(P=0.042, P<0.001, respectively). And mean RDW in IDA(16.9+/-3.3%) was significantly higher than that in non-IDA(15.1+/-3.2%)(P<0.001). In discriminating IDA from anemia, we drew receiver operating characteristic curves (ROC curves) with each value of MCV and RDW. The cut-off value of MCV was 83fl, and in that value, the sensitivity and specificity were 75.9% and 72.9%, respectively. The cut-off value of RDW was 14.3%, and the sensitivity and specificity were 78.2% and 57.6 %, respectively. We combined each value of MCV with RDW, the cut off value were 83fl of MCV and 14.3% of RDW, and the sensitivity and specificity were 76.3% and 71.3%, respectively. CONCLUSIONS: The sensitivity and specificity of MCV, RDW and combination of MCV and RDW were not so high in discriminating IDA from the anemia of the other causes in ambulatory patients.
Age Distribution
;
Anemia*
;
Anemia, Iron-Deficiency
;
Blood Cell Count
;
Busan
;
Female
;
Humans
;
Iron
;
Male
;
Outpatients
;
ROC Curve
;
Sensitivity and Specificity
;
Sex Distribution
9.28-year old Polycythemia Vera patient presenting with Cerebral Infarction.
Ho Suk OH ; Myung Ju AHN ; Hee Tae KIM ; Woong Soo LEE
Korean Journal of Medicine 2002;62(4):482-483
No abstract available.
Adult*
;
Cerebral Infarction*
;
Humans
;
Polycythemia Vera*
;
Polycythemia*
10.Distribution of Human Papillomavirus 52 and 58 Genotypes, and Their Expression of p16 and p53 in Cervical Neoplasia.
Tae Eun KIM ; Hwal Woong KIM ; Kyung Eun LEE
Korean Journal of Pathology 2014;48(1):24-29
BACKGROUND: This study investigates the prevalence of human papillomavirus (HPV) 52 and 58 genotypes among women residing in Busan, and the expression of p16 and p53 proteins in cervical neoplasia with HPV 52 and 58 infections. METHODS: A total of three hundred fifteen cases were analyzed using the HPV DNA chip test for HPV genotypes, and of these, we retrospectively examined p16 and p53 expression in 62 cases of cervical tissues infected with HPV 52 and 58 using immunohistochemistry. RESULTS: HPV 52 and 58 genotypes were identified in 62 (54.9%) out of 113 high-risk, HPV-infected cases. Of the cases examined, there were 19 single HPV 52 infections (16.8%), 23 single HPV 58 infections (20.4%), 4 multiple HPV 52 infections (3.5%), and 16 multiple HPV-58 infections (14.2%). Immunoreactivity of p16 and p53 was observed in 41 (66.1%) and 23 (37.1%) of the 62 cases of cervical neoplasia infected with HPV 52 and 58 genotypes, respectively. CONCLUSIONS: This study demonstrates a high prevalence of HPV 52 and 58 genotypes, in addition to HPV 16, among high-risk strains of cervical neoplasia in Korea. These findings suggest that development of more vaccines would be beneficial for the prevention of the various HPV genotypes.
Busan
;
Cyclin-Dependent Kinase Inhibitor p16
;
Female
;
Genotype*
;
Human papillomavirus 16
;
Humans*
;
Immunohistochemistry
;
Korea
;
Oligonucleotide Array Sequence Analysis
;
Prevalence
;
Retrospective Studies
;
Tumor Suppressor Protein p53
;
Vaccines