The authers observed one case of typical poikilodermatomyositis who was 47 year old female. The poikiIodermatomyositis is a rare disease which is a variant of dermatomyositis and has never been reported in Korea. This patient complained of a weakness of left lower leg and tingling sensation of both fingers since one year ago, And she has a difficulty of both finger flexion since 20 days ago. The skin lesions revealed mottled dark brownish pigmentation, hardness, scattered atrophic patches and telangiectasia in the lesion on the left lower leg since one year ago. The same skin changes appeared on the thigh, lower abdomen and upper chest on 4 months ago. Histopathologically, a biopsy was performed from the skin of lower leg, the skin shows typical poikiloderma, i.e. the epidermis shows moderate atrophy of the stratum malpighii, flattened rete ridges and hydropic degeneration of the hasal cells. The dermis is edematous and a band like dense lymphocytic cellular infiltration. And the muscIe biopsy from gastrocnemius muscle shows dermatomyositis finding which the muscle bundles are edematous and degenerative. Many inflammatory cells present between muscle bundles but there is no suppurative change. Diagnosis was confirmed by clinical appearance, histopathologically and other laboratory studies. The patient was markedly improved by the prednisolone 80 mg and vasculat (vascular dilatator) 100 mg daily.
Abdomen ; Atrophy ; Biopsy ; Bryophyta ; Dermatomyositis ; Dermis ; Diagnosis ; Epidermis ; Female ; Fingers ; Hardness ; Humans ; Korea ; Leg ; Middle Aged ; Muscle, Skeletal ; Pigmentation ; Prednisolone ; Rare Diseases ; Sensation ; Skin ; Telangiectasis ; Thigh ; Thorax

The authers observed one case of typical poikilodermatomyositis who was 47 year old female. The poikiIodermatomyositis is a rare disease which is a variant of dermatomyositis and has never been reported in Korea. This patient complained of a weakness of left lower leg and tingling sensation of both fingers since one year ago, And she has a difficulty of both finger flexion since 20 days ago. The skin lesions revealed mottled dark brownish pigmentation, hardness, scattered atrophic patches and telangiectasia in the lesion on the left lower leg since one year ago. The same skin changes appeared on the thigh, lower abdomen and upper chest on 4 months ago. Histopathologically, a biopsy was performed from the skin of lower leg, the skin shows typical poikiloderma, i.e. the epidermis shows moderate atrophy of the stratum malpighii, flattened rete ridges and hydropic degeneration of the hasal cells. The dermis is edematous and a band like dense lymphocytic cellular infiltration. And the muscIe biopsy from gastrocnemius muscle shows dermatomyositis finding which the muscle bundles are edematous and degenerative. Many inflammatory cells present between muscle bundles but there is no suppurative change. Diagnosis was confirmed by clinical appearance, histopathologically and other laboratory studies. The patient was markedly improved by the prednisolone 80 mg and vasculat (vascular dilatator) 100 mg daily.
Abdomen ; Atrophy ; Biopsy ; Bryophyta ; Dermatomyositis ; Dermis ; Diagnosis ; Epidermis ; Female ; Fingers ; Hardness ; Humans ; Korea ; Leg ; Middle Aged ; Muscle, Skeletal ; Pigmentation ; Prednisolone ; Rare Diseases ; Sensation ; Skin ; Telangiectasis ; Thigh ; Thorax

Intraspinal neurenteric cysts are rare congenital lesions that results from abnormal separation of germ layers in the third week of embryonic development, which may cause spinal compression. Although, the diagnosis of neurenteric cyst was very difficult prior to operation, MRI has proven to be a useful imaging modality in detection, localization and characterization of intraspinal neurenteric cysts. We recently experienced intraspinal neurenteric cyst in two patients who presented with progerssive quadriparesis. Myelography, CT myelography and MRI were taken and complete excision was performed. The MRI findings are presented and the literature is reviewed.
Diagnosis ; Embryonic Development ; Female ; Germ Layers ; Humans ; Magnetic Resonance Imaging* ; Myelography ; Neural Tube Defects* ; Pregnancy ; Quadriplegia

One case of malignant acanthosis nigricans associated with internal malignany and oral florid papilloma has been presented and reviewed the subject of malignant acanthosis nigricans. The patient who was 34 year old man had been affected generalixed dark brownish hyperpigmentation with papillomatoses especially on forehead, neck, axillae, umbilical area, anogenital area, webs of fingers, palms and soles. And characteristically it was associated with severe florid papilloma on mucous membrane such as buccal mucosa, lip and glans penis. Histopathologically, internal malignancy was confirmed metastatic adenocarcinoma of stomach after autopsy, although previous biopsy finding was squamous cell carcinoma when explorative laparatomy was done. The response to Bleomycin, new antibiotic anticancer drug, followed by intravenous injection is good and satisfying. But the patient died due to sudden pulmonary hemorrhage which are serious side effect of Bleomycin.
Acanthosis Nigricans* ; Adenocarcinoma ; Adult ; Autopsy ; Axilla ; Biopsy ; Bleomycin ; Carcinoma, Squamous Cell ; Fingers ; Forehead ; Hemorrhage ; Humans ; Hyperpigmentation ; Injections, Intravenous ; Lip ; Male ; Mouth Mucosa ; Mucous Membrane ; Neck ; Papilloma* ; Penis ; Stomach

Genes of cancer-associated testis antigens (CTAs) are expressed in various cancer tissues. In order to use CTAs as cancer diagnosis marker, we developed molecular method for detection of CTAs transcripts in tissue. In order to know the applicability of DNA of cancer-associated testis antigens (CTAs) on cancer diagnosis, molecular diagnostic methods for detection of gene expression of melanoma antigen gene (MAGE), GAGE, and B melanoma antigen (BAGE) was studied. After comparing DNA sequences of CTAs, S1/AS1 and S2/AS2, GAGE-S/ GAGE-AS, and BAGE-S/BAGE-AS primers were designed for the detection of MAGEs, GAGEs and BAGEs, respectively. The gene expression of CTAs in cancer cell lines, head and neck cancer tissues, ovary cancer tissue, and peritoneal cells of gastric cancer patients were investigated by reverse transcription-polymerase chain reaction (RT-PCR) using these primers. The MAGEs, GAGEs and BAGE genes were expressed in 8/8 (100%), 5/8 (62.5%) and 1/8 (12.5%) of head and neck cancer tissues, respectively. The gene expression of MAGEs were also detected in 8/10 (80%) of ovary cancer tissues and in 9/10 (90%) of peritoneal cells of gastric cancer patients in RT-PCR test using S1/AS1 primers. The results of this study suggest that molecular diagnosis method using CTAs genes, especially RT-PCR using S1/AS1 primer combination, is useful for diagnosis of cancer and it will be used for the prediction of cancer progression or regression and metastasis in future.
Base Sequence ; Cell Line ; Diagnosis* ; DNA ; Gene Expression ; Head and Neck Neoplasms ; Humans ; Melanoma ; Neoplasm Metastasis ; Ovarian Neoplasms ; Pathology, Molecular ; Stomach Neoplasms ; Testis*

No abstract available.
Animals ; Cats* ; Reflex*

PURPOSE: Spiculation pathologically correlated with irregular fibrosis, localized lymphatic spread of tumor, or an infiltrative growth pattern of tumor, and the spiculation was Observed in malignant mass. But the spiculation was also observed in benign mass, particularly in tuberculoma. We retrospectively reviewed the length of spiculation under the hypothesis that the length of spiculation could be one of differential diagnostic points between lung cancer and tuberculoma. MATERIALS AND METHODS: We studied thirty seven patients (27 men and 10 women) ranging in age from 35 to 80 years (mean, 60 years). Analysis of spiculation included (a) the number of spicules (b) the mean length of spicules (c) the mean length of the longest spicule (d) the percentage of the mean length of spicules to the longest diameter of mass (e) the percentage of the mean length of spicules to the shortest dia, meter of mass. RESULTS: The mean length of spicules of tuberculoma was 13.8 mm (S. D. 6.7) and that of lung cancer was 5.7 mm (S. D. 3.5). The percentage of the mean length of spicules to the longest diameter of tuberculoma was 63.6% and that of lung cancer was 13.7%. The percentage of the mean length of spicules to the shortest diameter of tuberculoma was 90.4% and that of lung cancer w~s 18.3%. CONCLUSION: It is hard to differentiate lung cancer from tuberculoma on the basis of the spiculation being present or not, but we suggest that the longer spiculation be more highly suggestive of tuberculoma rather than lung cancer. The length of spiculation may help us differentiate lung cancer from tuberculoma.
Fibrosis ; Humans ; Lung Neoplasms ; Lung* ; Male ; Retrospective Studies ; Tuberculoma*

No abstract available.

Male breast cancer is a rare disease, representing approximately 1% of breast cancer and less than 1.5% of malignant tumors occurring in men. We report a case of cuaneous metastasis of male breast cances. a 64-year-old male who presented with multiple nodules and erythematous plaque on the right anterior chest and enlargement of the right axillary lymplinodes. The histopathologic findings of the nodule showed atypical tumor cells with a somew eat gland-like pattern. The cells showed potive reactions in PAS, DPAS and alcian blue stains, and also positive for estrogen and roiesterone receptors. Biopsy specimens taken from the plaque showed cellular arrangement in show line, referred to as Indian filing, between thiclenecin collagen bundles. He was treated not, tamoxifen, 5-fluorouracil, adriamycin, cyclophosphamide and megestrol acetate. 5 months after nitiation of the treatment, the skin lesions were improved vvith a decreased number and size or dules and decreased intensity of erythema.
Alcian Blue ; Biopsy ; Breast ; Breast Neoplasms ; Breast Neoplasms, Male* ; Collagen ; Coloring Agents ; Cyclophosphamide ; Doxorubicin ; Erythema ; Estrogens ; Fluorouracil ; Humans ; Male ; Male* ; Megestrol Acetate ; Middle Aged ; Neoplasm Metastasis* ; Rare Diseases ; Skin ; Tamoxifen ; Thorax

No abstract available.
Female ; Laparoscopy* ; Methotrexate* ; Pregnancy ; Pregnancy, Ectopic*