No abstract available.
Hantaan virus* ; Hemorrhagic Fever with Renal Syndrome*

No abstract available.
Atrophy* ; Brain*

Adenocarcinoma in situ (AIS) of the cervix is a rare disease. Seventeen patients with this disease seen at the Keimyung University Dongsan Medical Center are reported, with a review of their clinical characteristics and pathologic data. Their median age was 49 years. Cervical cytology showed that all contained abnormal cells. In our series all cases were combined with other cervical epithelial precancerous and cancerous lesion. 6 cases of AIS were combined with invasive adenocarcinoma of the cervix. Cone biopsy margins were examined in 15 patients, and predicted the presence or absence of disease in twelve of 14 hysterectomy specimens. But their prediction was low accuracy.
Adenocarcinoma* ; Biopsy ; Cervix Uteri* ; Conization ; Female ; Humans ; Hysterectomy ; Rare Diseases

Adenocarcinoma in situ (AIS) of the cervix is a rare disease. Seventeen patients with this disease seen at the Keimyung University Dongsan Medical Center are reported, with a review of their clinical characteristics and pathologic data. Their median age was 49 years. Cervical cytology showed that all contained abnormal cells. In our series all cases were combined with other cervical epithelial precancerous and cancerous lesion. 6 cases of AIS were combined with invasive adenocarcinoma of the cervix. Cone biopsy margins were examined in 15 patients, and predicted the presence or absence of disease in twelve of 14 hysterectomy specimens. But their prediction was low accuracy.
Adenocarcinoma* ; Biopsy ; Cervix Uteri* ; Conization ; Female ; Humans ; Hysterectomy ; Rare Diseases

Appropriate control of diet and water intake is important for maintaining normal blood pressure, fluid and electrolyte homeostasis in the body. It is relatively understood that the amount of sodium and potassium intake directly affects blood pressure and regulates ion transporters; Na and K channel functions in the kidney. However, little is known about whether diet and water intake regulates Aquaporin (AQP) function. AQPs, a family of aquaporin proteins with different types being expressed in different tissues, are important for water absorption by the cell. Water reabsorption is a passive process driven by osmotic gradient and water permeability is critical for this process. In most of the nephron, however, water reabsorption is unregulated and coupled to solute reabsorption, such as AQP1 mediated water absorption in the proximal tubule. AQP2 is the only water channel founded so far that can be regulated by hormones in the kidney. AQP2 expressed in the apical membrane of the principal cells in the collecting tubule can be regulated by vasopressin (antidiuretic hormone) controlling the final volume of urine excretion. When vasopressin binds to its receptor on the collecting duct cells, it stimulates the translocation of AQP2 to the membrane, leading to increased water absorption via this AQP2 water channel. However, some studies also indicated that the AQP2 is also been regulated by vasopressin independent mechanism. This review is focused on the regulation of AQP2 by diet and the amount of water intake on salt and water homeostasis.
Absorption ; Aquaporin 2* ; Arginine Vasopressin ; Blood Pressure ; Diet* ; Drinking* ; Homeostasis ; Humans ; Ion Transport ; Kidney ; Membranes ; Nephrons ; Osmolar Concentration ; Permeability ; Potassium ; Sodium ; Vasopressins ; Water*

Inversion injury of the lateral ankle ligaments is very common. Few studies, however, have focused on avulsion fracture of the lateral ankle ligaments. A fracture producing a small fragment usually avulsed from lateral malleolus and may be easily misdiagnosed as a sprain because the fragment is superimposed on the lateral malleolus and goes undetected on early radiographs, especially in skeletally immature patients. We present a case of isolated avulsion fracture of the talar attachment of the anterior talofibular ligament in 13-year-old male patient. Diagnosis was confirmed by computed tomography and avulsed fragment was fixed to original talar footprint with suture anchors. A high level of suspicion must be maintained to obtain an accurate diagnosis of avulsion fracture in inversion ankle injury because of the high incidence in children and to prevent recurrent instability.
Adolescent ; Animals ; Ankle ; Ankle Injuries ; Child ; Humans ; Incidence ; Ligaments ; Male ; Sprains and Strains ; Suture Anchors

Recently world wide web is popular and the role of homepage is getting important. So the number of homepages about medicine or medical institute is increasing among homepages made in Korea, but the homepages are made by the specialist - homepage developer - not by medical personnel. Homepage specialists can promise the specialty, quality of the homepage itself, but medical personnels in the institute are better and ideal in the practical, economical aspect and in the content of information. Authors made homepage of Hallym medical center and its hospitals from September first, 1996 to December 31, 1996 only by their own work. The characteristics of this homepage are various structure and forms of 6 hospitals under the proper homogeneity, easy link or connectivity among 6 hospitals and central institute, and getting faster speed by proper restriction of large multimedia data considering present basal structure of internet. The targets of this homepage are medical personnels, students, patients, members of this institute and public. In the future foreigners are considered as targets. In conclusion, homepage of medical institute can be made somewhat effectively an d economically by its own medical personnels without the aid of homepage specialist and this first trial can be popular and participation of medical personnels to this work will be increased.
Emigrants and Immigrants ; Humans ; Internet ; Korea ; Multimedia ; Specialization

Background and objectives: Carvedilol is a cardiovascular drug, beta- and alpha1-adrenoceptor antagonist, currently approved for the treatment of hypertension, angina, congestive heart failure by FDA. Carvedilol has been shown to attenuate oxygen free radical-initiated lipid peroxidation and to inhibit neointimal formation of aorta following vascular injury by balloon angioplasty. We have investigated the effect of carvedilol on DNA synthesis of vascular smooth muscle cells (VSMC) stimulated by platelet-derived growth factor (PDGF)-BB. MATERIALS AND METHOD: Rat aortic smooth muscle cells were obtained by the combined collagenase and elastase methods. Cells between the 4th and 8th passages were used for the experiments. Incorporated radioactivity of [3H]-thymidine was measured by liquid scintillation spectrometry. RESULTS: PDGF-BB (1 nM) increased [3H]-thymidine incorporation about 70-100% over basal value in cultured VSMC. PDGF-stimulated increase in DNA synthesis was significantly suppressed by simultaneous administration of carvedilol. In contrast, propranolol did not significantly affect 3[H]-thymidine uptake in rat aortic VSMC. CONCLUSION: The present study demonstrate that carvedilol significantly inhibits the proliferation of vascular smooth muscle cell in our condition. These results indicate that carvedilol may be effective in the treatment of cardiovascular diseases principally associated with abnormal vascular smooth muscle growth.
Angioplasty, Balloon ; Animals ; Aorta ; Cardiovascular Diseases ; Cell Proliferation ; Collagenases ; DNA ; Heart Failure ; Hypertension ; Lipid Peroxidation ; Muscle, Smooth, Vascular* ; Myocytes, Smooth Muscle ; Oxygen ; Pancreatic Elastase ; Platelet-Derived Growth Factor ; Propranolol ; Radioactivity ; Rats ; Spectrum Analysis ; Vascular System Injuries

Transurethral resection syndrome (TURS) is one of the complications of endoscopic transurethral operation with irrigation fluid. TURS comprehensively refer to several clinical symptoms and signs caused by intravascular absorbtion of irrigation fluid, hypertension, bradycardia, arrhythmia, respiratory distress, hypotension, confusion, blindness, seizure, coma, hyponatremia, and hypoosmolarity. TURS is mainly known as the complication of the transurethral resection of prostate (TURP), and rarely found in the procedures such as transurethral resection of bladder tumor (TUR-BT), hysteroscopy, cystoscopy, and arthroscopy. Only a few cases of TURS after TUR-BT have been reported. The patients on maintenance hemodialysis were restricted in the amount of water intake for volume control. They were susceptible to the absorption of irrigation fluid during TUR-BT since they had anuria. We hereby report the 2 cases maintenance hemodialysis patients who were led to TURS after TUR-BT.
Absorption ; Anuria ; Arrhythmias, Cardiac ; Arthroscopy ; Blindness ; Bradycardia ; Coma ; Cystoscopy ; Drinking ; Humans ; Hypertension ; Hyponatremia ; Hypotension ; Hysteroscopy ; Kidney Failure, Chronic ; Renal Dialysis ; Seizures ; Transurethral Resection of Prostate ; Urinary Bladder ; Urinary Bladder Neoplasms

BACKGROUND AND OBJECTIVES: The octapeptide hormone of the renin-angiotensin system, angiotensin ii, regulates a wide variety of physiological responses including salt and water balance, blood pressure, and vascular tone. Contradictory results have been reported regarding the effects of angiotensin ii on vascular smooth mu-scle cell (VSMC) proliferation. The aim of the present study was to investigate the direct effect of angiotensin ii on the growth of VSMC. MATERIALS AND METHOD: Rat aortic smooth muscle cells were obtained by the combined collagenase and elastase methods. Cells between the 4th and 8th passages were used for the experiments. Cultures were treated daily for 3 days with either angiotensin ii alone or angiotensin ii with equimolar concentrations of saralasin. Incorporated radioactivity of [3H]thymidine and [14C]phenylalanine was measured by liquid scintillation spectrometry. RESULTS: Angiotensin ii increased [14C]phenyalanine incor-poration about 20-30%, and saralasin completely blocked the stimulation by angiotensin ii. However, there was no significant increase in [3H]thymidine incorporation by angiotensin ii stimulation in this study. CONCLUSION: These results suggest that angiotensin ii alone induces cellular hypertrophy but has no detectable mitogenic activity in cultured rat aortic VSMC.
Angiotensin II* ; Angiotensins* ; Animals ; Blood Pressure ; Collagenases ; Hypertrophy ; Muscle, Smooth, Vascular* ; Myocytes, Smooth Muscle ; Pancreatic Elastase ; Radioactivity ; Rats ; Renin-Angiotensin System ; Saralasin ; Spectrum Analysis