No abstract available.
Anterior Temporal Lobectomy* ; Seizures*

No abstract available.
Lipomatosis*

PURPOSE: To evaluate the usefulness of laser cystectomy for the treatment of patients with dacryocystitis and sump syndrome. METHODS: Thirteen patients (13 eyes) diagnosed with acute or chronic dacryocystitis, and nine patients (9 eyes) who developed sump syndrome after dacryocystorhinostomy from 2005 to 2006 underwent laser cystectomy and endonasal dacryocystorhinostomy. RESULTS: Pain and swelling around the orbit improved immediately after the operation in patients with acute dacryocystitis, and all symptoms of sump syndrome disappeared by 1 month postoperatively. Epiphora reduced in all patients. During the follow-up period, functional nasolacrimal duct obstruction occurred in one eye and membranous obstruction developed in two eyes. In these two eyes with membranous obstruction, revisional surgery was performed successfully. No recurrence of dacryocystitis was noticed. CONCLUSIONS: Laser cystectomy with endonasal dacryocystorhinostomy is a simple and effective treatment modality for patients with dacryocystitis and sump syndrome that minimizes the risk of recurrence.
Cystectomy ; Dacryocystitis ; Dacryocystorhinostomy ; Eye ; Follow-Up Studies ; Humans ; Lacrimal Apparatus Diseases ; Nasolacrimal Duct ; Orbit ; Postcholecystectomy Syndrome ; Recurrence

In order to study the effects of welding fume on ventilatory function, forced expiratory spirogram was performed on 563 male workers exposed to welding fume in motor vehicles industry and 589 male control workers. Ventilatory indices such as forced vital capacity (FVC), forced expiratory volume in one second (FEV(1)), the ratio of one-second forced expiratory volume to forced vital capacity (FEV(1)%= FEV(1)/FVC) and maximal mid-expiratory flow(MMF) were obtained by analyzing forced expiratory spirogram which were measured by Vitalograph in standing position. The results were as follows: 1. Mean values of FVC, FEV(1), FEV(1)%, and MMF expressed as percent of the predicted were significantly lower in exposure group than in control group. 2. No significant differences for mean ventilatory indices were demonstrated between smokers and nonsmokers both in exposure group and control group. However, mean MMF of welders tended to reduce in smokers (77.4 %) than in nonsmokers (82.4 %). 3. In exposure group mean FEV(1) was significantly lower in more than 20 years than those of control group. However, mean MMF, FEV(1)% were significantly reduced with increasing exposure duration compared to control group, indicating 90.8 %; and 62.2 % of the predicted in more than 20 years group. 4. In exposure group workers with obstructive ventilatory impairment (7.5 %) was markedly higher than that with restrictive ventilatory impairment (2.0 %). 5. In exposure group the proportion of workers with low ventilatory indices was' the highest in MMF (26.8 %), and followed by FEV(1)(11.9 %), FEV(1)%(7.6 %) and FVC (2.1 %) in descending order. Workers with low MMF and PEV^% were significantly increased with increasing exposure duration compared to control group, indicating 64.3 % and 32.1 % in above 20 years group. With the above considerations in mind it suggested that the exposure to welding fume be associated with reduced pulmonary function and obstructive ventilratory impairment, increasing exposure duration be associated with reduced pulmonary function, and MMF be the most sensitive index in the evaluation of venfcilatory impairments of workers exposed to welding fume.
Forced Expiratory Volume ; Humans ; Male ; Motor Vehicles ; Respiratory Function Tests ; Vital Capacity ; Welding*

No abstract available.
Adenocarcinoma* ; Cervix Uteri* ; Fallopian Tubes* ; Female

Diffuse idiopathic skeletal hyperostosis (DISH) is a systemic bone-forming disease, and its pathogenesis remains unknown. Moreover, the incidence of DISH increases with age. DISH may be an age-related disorder that occurs more frequently in degenerative spines than in healthy spines. Most patients with DISH of the cervical spine are asymptomatic; however, mechanical compression of the esophagus by the cervical spine can induce dysphagia, hoarseness, and dyspnea. In most cases, dysphagia progresses slowly. Most cases of postoperative dysphagia after anterior cervical spine surgery occurred within 1 month, and most patients recovered spontaneously. Severe dysphagia is relatively uncommon. Here, we report a case of acute-onset dysphagia with DISH that occurred immediately after anterior cervical discectomy. We should consider the possibility of dysphagia occurring immediately after anterior cervical discectomy in patients with DISH, even in those without dysphagia before surgery. Furthermore, surgical treatment for severe postoperative dysphagia associated with DISH may be a good option.

The majority of neurocritically ill patients have disorders of consciousness. Both level and content of consciousness should be assessed repeatedly throughout the course of patient care. In this review, we describe the definition and diagnostic criteria for disorders of consciousness, and the neurological examination and standardized neurobehavioral assessment tools as methods of assessing consciousness. Next, we will discuss neurophysiological and neuroimaging tests as tools for assessing consciousness: automated quantitative pupillometry, electroencephalogram, evoked potentials, brain imaging, functional near-infrared spectroscopy, and biomarkers. We discuss the clinical utility of each assessment tool and the importance of a multimodal approach in the diagnosis, treatment, and prognostication of disorders of consciousness.

PURPROSE: The objectives of this study is to evaluate the role of microsatellite instability(MI) and p53 gene inactivation in transitional cell carcinoma(TCC) of the bladder. MATERIALS AND METHODS: Total 31 cases of TCC patients, not treated with radiation or anticancer chemotherapy, were included in this study. Fifteen out of 31 patients were superficial and 16 were invasive TCC according to pathologic stage, while 16 were low grade and 15 were high grade TCC according to Ash grading system. The presence of MI was investigated in 3 loci of 9p site(D9S162, IFNA, D9S1747), and 6 loci of 17p site(D17S261, D17S513, D17S654, D17S695, D17S796, TP53) using a method based on the polymerase chain reaction(PCR). And the p53 point mutations were detected using polymerase chain reaction-single stranded conformation polymorphism (PCR-SSCP) analysis. The p53 protein overexpression was determined by immunohistochemical stain using DO-7 primary antibody on formalin fixed, paraffin embedded tissue sections. RESULTS: On MI analysis, altered band pattern were detected in 16 of 31 case(51.6%) in 9p region and 15 of 31 cases(48.4%) in 17p region. MI of the 9p region showed no association with tumor grade or stage. MI of the 17p site also showed no difference between superficial and invasive tumor group, but were higher in high grade(73.3%) than low grade tumor group(25.0%). On PCR-SSCP analysis, total 8 mutations were found in 6 cases(19.4%) and 4 of 8 mutations(50%) were at exon 8. On immunohistochemical staining, p53 nuclear overexpressions were found in 18 cases(58.1%) and more common in high grade and invasive tumor group(p<0.05). Fifteen out of 18 cases(83.3%) showed MI of the 9p or 17p regions. CONCLUSIONS: These results suggest that the p16 alterations may occur in the early stage of tumorigenesis and p53 alterations are more associated with high grade/invasive tumor. And DNA mismatch repair system may play an important role in tumorigenesis of bladder tumor. MI analysis can be a useful method to detect early genetic alterations in transitional cell carcinoma of the bladder.
Carcinogenesis ; Carcinoma, Transitional Cell* ; DNA Mismatch Repair ; Drug Therapy ; Exons ; Formaldehyde ; Genes, p53 ; Humans ; Incidence* ; Microsatellite Instability* ; Microsatellite Repeats* ; Paraffin ; Point Mutation* ; Urinary Bladder Neoplasms ; Urinary Bladder*

BACKGROUND: Germline mutations in the breast cancer-associated genes BRCA1 and BRCA2 confer susceptibility and a lifetime risk of breast. Several morphological and clinical features have been attributed to hereditary tumors. However, in sporadic breast cancer, the interrelationship between the loss of heterozygosity (LOH) of these loci and clinical features remains to be fully elucidated. METHODS: Microdissected paraffin-embedded tissue blocks of 48 cases of surgically resected breast carcinoma were investigated to identify the LOH of BRCA1 and BRCA2 using microsatellite markers. RESULTS: Of 48 cases, 22 (45.9%) exhibited LOH at BRCA1 locus while in 29 out of 48 (60.4%) cases LOH was observed for the BRCA2 region. There was no significant correlation between LOH at BRCA1/2 and the patient's age, tumor size, histologic grade or lymph node metastasis. When comparing the frequency of LOH with the expression of several prognostic factors, such as p53, c-erb B2 protein, estrogen and progesterone receptor using immunohistochemical stain, there was only correlation with LOH at BRCA2 and the progesterone receptor. CONCLUSIONS: Our results suggest that allelic deletion play a role to the development of sporadic breast cancers.
Breast Neoplasms* ; Breast* ; Estrogens ; Germ-Line Mutation ; Loss of Heterozygosity* ; Lymph Nodes ; Microsatellite Repeats ; Neoplasm Metastasis ; Paraffin* ; Receptors, Progesterone

No abstract available.
Meningioma* ; Paragonimiasis*