Author presented the clinical evaluation for 21 eyes or patients diagnosed as having retinal detachment due to retinal breaks. These cases were patients who visited this clinic since 1968 to 1970. 10 of these eyes were operated upon. Followings were evaluated. 1. Incidence of retinal detachment due to retinal breaks was approximately 0.17% of the total out patients in our clinic. 2. The age distribution ranged from 11 to 59 years old with two thirds of patients being under 30 years old and in sex difference male seemed to be more prevalent. 3. The intraocular pressure of affected eyes was hypotensive in approximately 76.1% of the cases. 4.50% of the eyes contained retinal dialysis and majority of retinal breaks were found to be in the inferior temporal quadrant. 5. The extent of detachment was limited to one or two quadrants in 56.1% of the eyes and 33.3% of the eyes involved macula. 6. The period of detachment from onset was durated six months or more in 33.3% of the eyes. 7. In 33.3% of the eyes, there was a history of direct ocular trauma, but the correlation between truma and site predilection was not significant. 8. The result of operations, such as lamellar scleral resection, buckling and Arruga's encirclage for these 10 eyes was successful in all cases but an eye of serious postoperative complication, endophthalmitis, resulted in evisceration.
Adult ; Age Distribution ; Dialysis ; Endophthalmitis ; Humans ; Incidence ; Intraocular Pressure ; Male ; Middle Aged ; Outpatients ; Postoperative Complications ; Retinal Detachment* ; Retinal Perforations ; Retinaldehyde* ; Sex Characteristics

A 47-years old korean farmer was first visited our department in Nov. 19, 1969 with complaining of proptosis, lateral deviation of eye ball and visual disturbance of 5 years duration. The onset was insidious. Past and family history were not contributory. On examination, right eye was within normal limit. The left eye was markedly proptotic (aoout 10 mm of exophthalmos) and displaced out-and downward. The vision of the left eye was L.P.. The ocular motility was slightly limited to all direction. Pupil was normal size and poorly reacted to light. Funduscopic examination revealed pale and slightly excavated in disc. X-ray of chest, skull and optic foramen showed normal. On Nov. 22. 1969 author adopted the Kronlein's approach and exceed well capsulated oval mass situated within the muscle cone, which attached to optic nerve. The tumor mass showed soft, dark reddish color of surface measuring 2 X 2 X 15 cm and its cut surface disclosed sponge like appearance. Histologically the section from tumorous mass showed many large cavernous spaces separated by connective tissue. The newly formed cavernouus space was for the most part lined by a single layer of endothelium and in part contained with red cell. We confirmed adiagnosis of cavernous hemangioma of the orbit in pathologic study. It was suggested that early loss of vision was caused by optic atrophy due to direct pressure of optic nerve by the tumor mass. A review of literature of recent years related to cavernous hemangioma of orbit was added.
Connective Tissue ; Endothelium ; Exophthalmos ; Hemangioma, Cavernous* ; Humans ; Middle Aged ; Optic Atrophy ; Optic Nerve ; Orbit* ; Porifera ; Pupil ; Skull ; Thorax

A 12 years old Korean girl was seen on 10 Oct. 1969 with chief complaint of a large fleshy mass extruded out of the orbit associated with ocular pain of mild degree for several months. Her parents were first noticed that the girl's right eye had a peculiar reflex from the pupillary zone in 2 years of her age. She was advised by a local clinician to correct surgicaIly someday later in her childhood. At the age of four, the pupillary margin of the affected eye had become distorted and they became aware of the eyeball was a little protruded and the grade of protrusion had slowly advanced as she had grown up. About a year ago the patient suffered from sudden attack of severe ocular pain associated with vomiting. Having experienced the recurrences of similar attack several times, she at last in Sept. 1969 met a spontaneous outburst of the extruded mass from which the purulent and bloody contents flowed out. It was to be regretted that the history could not reveal when and how the globe had been disorganized as completely as such that no trace of configuration of the anterior segment could be recognized. Familial and past history were not contributory except measle with good recovery at 2 years of age. On examination, the left eye had good vision and no structural changes, wherease the right side showed a marked extrurusion of fleshy mass out of the lid aperture. The mass had a relatively smooth and congested coverage of the conjunctiva except it had the fistulae through which a small amount of the purulent and bloody discharge flowed out under the digital pressure. It was felt somewhat elastic and movable with a broad base into the orbit. On its surface no trace of the cornea or the other global structures could be found. Physical examinations of the whole body including regional lymphnodes revealed normal X-ray Was of chest, skuIl and optic foramina were normal. On 14 Oct. 1969 under general anesthesia an orbital exentration was undertaken because of either probability of a malignant tumor or a long standing intraocular inflammation. In the way of procedure necrotic contents bursted out by mechanical pressure through the weak point, i.e. the fistulae, and correspondingly the tumorous mass became softened. Confirming no hard mass palpable into the orbit, the operating procedure shifted to do partial exentration. The extirpated mass was subjected to the histological study. Grossly, the dissected area revealed that it contained a well preserved structure of sclera on the one side and completly necrotised material on the other, but it did not contain any remnants of the ordinary global structures such as cornea, iris, lens, vitreous and choroid. The hollowed space partially surrounded by scleral structure was filled with the dark and gelatinous materia. The mass was as a whole rather soft Histological examination showed numerous gland like proliferations composed of poorly differentiated and unpigment columner cells having relatively large nuclei, some of which showed a mitotic figure. These were conceivable to be of an embryonic retina. The lumina of the gland like structures with the various sizes and shapes were filled with a pink staining coagulum and an extremly delicate and regularly arranged fibrillar structure. In some parts the tumor consisted of solid cellular conglomeration with rosett like arrangement and in the other necrotic masses containing tumor cells in all stages of degeneration. For the most part and the surrounding structure of the tumor cells, the picture showed likely to be a diffuse inflammation with an infiltration of polymorphonuclear cells, partly vessels being mostly of capillaries and recent hemorrhages, but the cartilage was not found.
Anesthesia, General ; Capillaries ; Cartilage ; Child ; Choroid ; Conjunctiva ; Cornea ; Estrogens, Conjugated (USP) ; Female ; Fistula ; Gelatin ; Hemorrhage ; Humans ; Inflammation ; Iris ; Orbit ; Parents ; Physical Examination ; Recurrence ; Reflex ; Retina ; Sclera ; Thorax ; Vomiting

In patients with the sequele of poliomyelitis, pyogenic or tuberculous arthritis, or trauma, flexion contracture of the knee could be developed and many difficult problems would be met in treating them. Ilizarov suggested the method of gradual correction of deformities of bone after corticotomy-osteo- clasis, combined with gradual elongation of the shortened soft tissues, and the flexion contracture of knee & limb length discrepancy could be corrected simultaneously or sequentially following a sigle operative procedure. The authors have treated 25 patients with flexion contracture of the knee joint by the principle of Ilizarov treatment at the Sang Gye Paik Hospital between September 1991 and March 1994, The average preoperative flexion contracture of the knee joint, 25° (range, 10°
Arthritis ; Congenital Abnormalities ; Contracture ; Extremities ; Fractures, Stress ; Hip Joint ; Humans ; Ilizarov Technique ; Knee Joint ; Knee ; Leg ; Methods ; Osteotomy ; Poliomyelitis ; Surgical Procedures, Operative ; Tibia

No abstract available.
Female ; Pregnancy ; Pregnancy, Ectopic*

By the concept that IDDM (insulin-dependent diabetes mellitus) is one of the autoimmune diseases, several immune suppressive drugs and immune modulators including BCG have been used to suppress the occurrence of IDDM. A data reported that BCG has different effects for prevention of diabetes according to the timing of drug administration. This study was performed to examine the preventive effect of diabetes development and insulitis by administering BCG at breast-fed period. NOD (non-obese diabetic) mice were divided into three groups: Group I, II, III were injected by BCG on the first day, eighth day, and twenty second day of life respectively. The later BCG was injected, the smaller occurrence of diabetes and the lower severity of insulitis were.
Animals ; Autoimmune Diseases ; Diabetes Mellitus, Type 1 ; Mice ; Mice, Inbred NOD* ; Mycobacterium bovis*

PURPOSE: To describe the clinical efficacy of arthroscopic management followed by manipulation under anesthesia in chronic idiopathic adhesive capsulitis of the shoulder. MATERIALS AND METHODS: We evaluated nineteen patients who had a mean follow-up period of 3 years 1 month using the UCLA shoulder rating score. Arthroscopic management included an arthroscopic examination and debridement of the glenohumeral joint and the subacromial space, as well as the release of the rotator interval, the capsule, the glenohumeral ligaments and the inferior recess. Manipulation was performed after the arthroscopic procedures. RESULTS: Thirteen patients (68%) were completely free from pain. The forward elevation was im-proved from 97 degrees to 175 degrees, the abduction from 69 degrees to 170 degrees, the external rotation from 8 degrees to 51 degrees, and the internal rotation from the range of the buttock and the 3rd-4th lumbar spinous process to the level of the 7th-9th thoracic spinous process. The average UCLA shoulder rating score was 9 points before the operation and 34 points after the operation. CONCLUSION: Our clinical findings suggest that arthroscopic management followed by manipulation is an effective method for the treatment of chronic idiopathic adhesive capsulitis of the shoulder.
Adhesives* ; Anesthesia ; Bursitis* ; Buttocks ; Debridement ; Follow-Up Studies ; Humans ; Ligaments ; Shoulder Joint ; Shoulder*

BACKGROUND: Several studies have reported that cholecystokinin (CCK), a short-term meal related satiety signal, and leptin, long-term signal for controlling feeding behaviour and body weight, act synergistically to inhibit food intake. However the mechanism and neuroanatomical basis for this response remain unclear. To clarify the neuronal mechanisms underlying the synergistic interaction between leptin and CCK, we examined the neuron activated by single or combined injection of leptin and CCK in fasted rats using immunohistochemistry for Fos. The expression of Fos can be used to trace neuronal activation pathways. METHODS: The rats were divided into 4 groups; Tris solution-saline, Tris solution-CCK, leptin-saline, leptin-CCK. Rats were received a single intracerebroventricular injection of either 3mul Tris solution or 3microgram leptin, and a single intraperitoneal injection of either 2mul saline or 2microgram/kg sulfated CCK-8. The changes of the Fos expression were investigated in the paraventricular nucleus (Pa), retrochiasmatic area (RCh), lateral hypothalamic nucleus (LH), central nucleus of amygdala(Ce), supraoptic nucleus (SO), arcuate nucleus (Arc), ventromedial hypothalamic nucleus(VMH),dorsomedial hypothalamic nucleus (DM), ventral premammillary nucleus (PMV), superior lateral subdivision of parabrachial nucleus (LPBS), external lateral subdivision of parabrachial nucleus (LPBE), supragenual nucleus (SGe), area postrema (AP), medial area (SolM) and commissural area (SolC) of nucleus of the solitary tract nuclei. RESULTS: CCK increased the Fos expression in the Pa, RCh, LH, Ce, SO, Arc, VMH, DM, PMV, LPBS, LPBE and SolM. Leptin increased the Fos expression in the Pa, RCh, LH, SO, Arc, VMH, DM, PMV, LPBS, LPBE, SGe, AP and SolM. Injections of leptin and CCK significantly enhanced the Fos expression in the Pa, RCh, VMH, DM, LPBS, and SolM compared with those induced by leptin or CCK alone. CONCLUSION: Our results suggest that the Pa, RCh, VMH, DM, LPBS and SolM may be essential sites mediating the synergistic effect of leptin and CCK to regulate food intake.
Animals ; Arcuate Nucleus ; Area Postrema ; Body Weight ; Brain* ; Cholecystokinin* ; Eating ; Hypothalamic Area, Lateral ; Immunohistochemistry ; Injections, Intraperitoneal ; Leptin* ; Meals ; Negotiating ; Neurons ; Paraventricular Hypothalamic Nucleus ; Rats* ; Sincalide ; Solitary Nucleus ; Supraoptic Nucleus