Nevus Lipomatous cutaneous superficialis (Hoffman-Zurhelle) is distinct clinical entity. A case is reported in which the lesions appeared in childhood and were elevated plaques and nodules in distribution on the tight side of the buttock.
Buttocks ; Nevus*

A clinical study was done on 43 patients witb basal cell carcinoma encountered in the Department of Dermatology, Busan National University Hospital during the past 10-years period frorn January 1968 to December 1977. Tbe results were summarized as follows: 1) Of 43 patients, 15 ceses were male and 28 cases were female with ratio of 1: 1.87. 2) Age incidence ranged frorn 15 years to 87 years with the highest incidence rate in the age group 40-49 years and incidence rate increased remarkbly in numlxr after over 40 years of age. Average age was 55 years. 3) The most common site was face occuring in 39 casts(90.7%), comprising 18 cases on nose, 12 cases on eyelids, 6 cases on cheeks, each 1 case on forehead, upper lip and auricle. 4) Noduloulc rative lesion was most common, otscrved in 29 cases(67.4%), nodular lesion in 9 cascs(20.9%), and pigmented lesion in 5 csses(11.6%). 5. The ratio of basal cell carcinoma was 1:1.2. 6) Three cases of precancerous states including 2 cases of xeroderma pigmentosa and 1 case of irradiated skin lesion were observed.
Busan ; Carcinoma, Basal Cell ; Cheek ; Dermatology ; Eyelids ; Female ; Forehead ; Humans ; Ichthyosis ; Incidence ; Lip ; Male ; Nose ; Skin

Three cases of linear scleroderma with typical clinical and histopathological findings were presented. Case 1: A 10 year old female had a "coupe de sabre" type of linear scleroderma on the right side of the frontal scalp and face and hemiatrophy of the right side of the face. Case 2: A 10 year old female had a type of scleroderma en bande on the palm and dorsum of the left hand and clubbed finger of the left third finger. Case 3: A 21 year old male had a linear type of skin atrophy and sclerosis of the right lower exteremity and mild walking disturbance.
Atrophy ; Child ; Female ; Fingers ; Hand ; Humans ; Male ; Osteoarthropathy, Secondary Hypertrophic ; Scalp ; Scleroderma, Localized ; Sclerosis ; Skin ; Walking ; Young Adult

Three cases of linear scleroderma with typical clinical and histopathological findings were presented. Case 1: A 10 year old female had a "coupe de sabre" type of linear scleroderma on the right side of the frontal scalp and face and hemiatrophy of the right side of the face. Case 2: A 10 year old female had a type of scleroderma en bande on the palm and dorsum of the left hand and clubbed finger of the left third finger. Case 3: A 21 year old male had a linear type of skin atrophy and sclerosis of the right lower exteremity and mild walking disturbance.
Atrophy ; Child ; Female ; Fingers ; Hand ; Humans ; Male ; Osteoarthropathy, Secondary Hypertrophic ; Scalp ; Scleroderma, Localized ; Sclerosis ; Skin ; Walking ; Young Adult

BACKGROUND: Neovascular glaucoma is common secondary glaucoma at high risk for failure of glaucoma filtering surgery. Recently, trabeculectomy with adjunctive mitomycin C trabeculectomy has been tried to improve the surgical success rate of conventional trabeculectomy. But, the long-term effects of mitomycin C trabeculectomy for neovascular glaucoma are unknown. Thus, we evaluated the long-term effects of mitomycin C trabeculectomy and its prognostic factors influencing the outcome. MATERIALS AND METHODS: Medical records of 62 eyes of 55 neovascular glaucoma who had undergone mitomycin C trabeculectomy were retrospectively reviewed. Surgical success was defined as intraocular pressures of 21 mmHg or less with or without glaucoma medications and no loss of light perception. Surgical failure was defined as postoperative loss of light perception in patients with preoperative vision better than light perception, additional glaucoma surgery, or phthisis bulbi in patients with preoperative vision of no light perception. RESULTS: Postoperative success was obtained in 37 (60%) out of 62 eyes after mean follow- up period of 23.9+/-16.2 months. Using Kaplan-Meier survival analysis, cumulative success rate at the 6-, 12-, 24- and 36-month intervals were 85%, 71%, 57% and 52%, respectively. Success rate was greater in eyes with diabetic retinopathy than other causes(p=0.005) and in eyes with preoperative panretinal photocoagulation(PRP) than without PRP(p=0.015). However, Cox proportional hazard regression analysis revealed that preoperative PRP was not a significant risk factor for surgical failure. CONCLUSION: Prognosis of neovascular glaucoma caused by diabetic retinopathy was better than that caused by the other disorders following mitomycin C trabeculectomy. The author would suggest that mitomycin C trabeculectomy could be effective and relatively safe as the first procedure of choice before performing glaucoma drainage device implantation or cyclodestructive procedure.
Diabetic Retinopathy ; Drainage ; Filtering Surgery ; Glaucoma ; Glaucoma, Neovascular* ; Humans ; Intraocular Pressure ; Medical Records ; Mitomycin* ; Prognosis ; Retrospective Studies ; Risk Factors ; Trabeculectomy*

No abstract available.

No abstract available.
Receptors, Antigen*

No abstract available.
Brain* ; Child* ; Humans ; Magnetic Resonance Imaging* ; Seizures*

To evaluate the structural characteristics that might be related to the clinical features noted in preeclamptic patients with focal segmental glomerulosclerosis(FSGS), we analyzed post-partum renal biopsies of 8 preeclamptic patients with FSGS (group 1) by morphometry and glomerular studied the structural-functional relationships. These findings were also compared with those from three postpartum cases with minimal change lesion(group 2) and normal age-matched women(group 3). Mean glomerular volume (MGV) in group 1 and group 2 was (2.64 +/- 0.49) x 10(6) micrometer3 and (2.56+/-0.25)x 10(6) micrometer3, respectively. MGV in both groups was significantly increased compared with that of the control group [(1.11+/-0.22)x10(6) micrometer3](p<0.0005). The volume density of the mesangium/glomerulus [Vv(mes/glom)] in the group 1 patients was significantly increased (p<0.0001) when compared with that of the group 2 and the control group patients. The increment of Vv(mes/glom) was related to both the mesangial cell proliferation and expansion of mesangial matrix. The volume density of the capillary lumen/glomerulus [Vv(cap/glom)] in group I was significantly decreased(p<0.0001) when compared with that of group 2 and the control group. Vv(cap/glom) was directly related to Ccr in group l(r=0.70, p=0.05). These results suggest that reduced capillary luminal area caused by mesangial interposition is related to the decreased glomerular filtration rate in preeclamptic FSGS.
Pregnancy ; Female ; Humans ; Biopsy

The cohort study is an observational epidemiological study which selects the specific study population attempting to study the relatiqnship between an exposure to the purported cause and the subsequent risk of developing disease in accordance of time direction. Since Doll and Hill had studied the association between lung cancer and smoking behavior among the British medical doctors in the years of the last fifties, the defined group cohort studies analysing the relationship between an exposure and the occurence of a disease have become very popular. Cohort studies can be classified as either prospective or retrospective, depending on the temporal relationship between the initiation of the study and the occurence of the disease. Cohort studies are admitted as the very valuable studies for demonstrating the association between an exposure and a disease because it is possible to drive relative and attributable risks and often incidence measures. They can even examine multiple effects of a single exposure. However, they are usually expensive to carry out and large cohorts are required for rare diseases in addition to the time consum ing works. There are also very significant problems associated with selection of appropriate groups to be studied as far as complete ascertainment of disease occurence in them. Usually it is necessary that we must compromise to provide the opportunity for various types of bias such as selection bias, follow-up bias, information bias or misclassification, confounding bias and post hoc bias to occur which can result in incorrect conclusions. Only the success of a cohort study would be expected when the investigator pay the deep care in recognizing and correcting for these biases.
Bias (Epidemiology) ; Cohort Studies* ; Humans ; Incidence ; Lung Neoplasms ; Rare Diseases ; Research Personnel ; Selection Bias ; Smoke ; Smoking