Normal albino rats weighing 180-200 gm were used for a series of this investigation on change of skin mast cell under general and local anesthesia. At first, left side abdominal skin was prepared by hair cutting with scissors about 3cm square and eight irritations by mean of biting with tip of forceps mosquito were applied along the prepared skin margin. Skin specimens were submitted from central area which surrounded by irritated points and also from intact contra-lateral area in 15, 30, 60 and l20 minutes invervals. Submiitted skin specimens were fixed in 10% formalin solution, then were stained with 1% toluidine blue. The number of mast cell was counted under 450X of microscopic examination. CONCLUSION l. There were two stages in changes of skin tissue mast cell number on normal saline solution injected area and irritated area by mean of biting with tip of forceps without any types of anesthesia. i) Decreasing stage: Number of skin tissue mast cell was decreascd and reached to the lowest level at 30 minutes after each irritation. ii) Increasing stage: Number of skin tissue mast cell was increased to the highest level at 120 minutes after each irritation. 2. General ether anesthesia could not infIuence on the change of mast cell number after mechanical biting irritation. 3, Local anesthesia with 2% procaine hydrochloride solution revealed slightly suppressing effect to increasing number of mast cell at 60 and 120 minutes after mechanical irritation. Hnwever, it was not evidence at 15 and 30 minutes after mechanical irritation. 4. There was no significant change of rnast cell number in the intact contralateraI skin area within 120 minutes under gencral and local anesthesia. 5. The number of degranulated mast cells did not correlated with counted total number of mast cells.
Anesthesia ; Anesthesia, Local ; Animals ; Cell Count ; Culicidae ; Ether ; Formaldehyde ; Hair ; Mast Cells* ; Procaine ; Rats ; Skin ; Sodium Chloride ; Surgical Instruments ; Tolonium Chloride

No abstract available.
Humans* ; Myelin Basic Protein* ; Myelin Sheath* ; Myelin-Associated Glycoprotein* ; Oligodendroglia*

Ofloxacin, one of the new quinolone derivatives, is found to be highly effective against both PPNG and non-PPNG urethritis. The objective of this trial was to establish the efficacy of two ofloxacin regimens in the treatment of uncomplicated male gonococcal urethritis. A total of 138 patients with uncomplicated gonococcal urethritis seen at the VD Clinic, Choong-Ku Public Health Center, in Seoul in the period of March Jun 1988, were subjected to this study. The patients were divided randomly into two groups and assigned to one of two treatment regimens of afloxacin, 400mg, PO and 200mg, PO, twice a day for 2 days. No failure case was seen in both groups. Both of these ofloxacin regimens were found to be highly effective and safe in the treatment of gonococcal urethrithis. It is suggested that, because of high rate of PPNGs among circulating N. gonorrhoeae, they can be recommended as the first line treatment for gonorrhea in Korea.
Gonorrhea ; Humans ; Korea ; Male* ; Ofloxacin* ; Public Health ; Seoul ; Urethritis*

Marjolin is ulcer may be defined briefly as a cancer arising in a bum scar. A 41-year-old female had a Marjolin is ulcer(12x10x3cm) on her right lower leg. This ulcerated tumor has been present for two and half months and the induction period sinnc her bum was 29 years. The pathologic diagn.osis was squamous cell carcinoma, grade 2. Roentgenograms of her right lower leg revealed several soft tissue masses densities which, in part, horizontally connected with the periosteum of the tibia. So she was treated by above-knee amputation with dissection of several, unenlarged inguinal nodes which showed no evidence of metastases. She developed large, single, fixed metastatic node in right inguinal area one month after amputation and dissection was done.
Adult ; Amputation ; Carcinoma, Squamous Cell ; Cicatrix ; Female ; Humans ; Leg ; Neoplasm Metastasis ; Periosteum ; Tibia ; Ulcer*

A 23 year-old female with skeleto-dentoalveolar protrusion of maxilla, minor broken contact points between anterior teeth, and missing of lower 1st molars, has been treated with multibanded edgewise technique. After treatment of 14 months, she has gained functional overbite-overjet relationship and facial harmony due to the retraction of upper anterior teeth. Root resorption was slight. Especially, us ing the space of missed lower 1st molars instead of extracting lower premolars, expected and favorable results were obtained.
Adult* ; Bicuspid ; Female ; Humans ; Maxilla ; Molar ; Prognathism* ; Root Resorption ; Tooth ; Young Adult

We performed this study to observe the effects of chronic administration of leuprolide acetate(potent synthetic LHRH analog) to the testicular histopathology of prostatic cancer patient and to the spermatogenesis in cryptochism treatment. Ten out of fifty healthy male rats whose body weight ranged 250-300gm were selected as a control group and the other forty as a study group. Two hundred micro-gram of leuprolide acetate was injected daily into the peritoneal cavity of study group, and ten rats were sacrificed at each first, second, third and sixth week, respectively. Then the changes of testicular weight and histopathological readings under light microscope of both control and study group were recorded and analyzed. The results of experimental data can be summarized as follows : 1. The average testicular weight of control group increased progressively until sixth week to 1. 1.43gm from the initial value of 1.26gm, while the weight of study group decreased to 0.96gm which was 67.1 % of age-matched control group. 2. There were almost no remarkable changes between both groups in terms of number, size and cellularity of seminiferous tubules. We observed the degenerative and regenerative changes simultaneously in spermatogonia and spermatocytes. During the first three weeks, degenerative changes took place while the regenerative changes started from the second week and have fully recovered at the sixth week. And, the number of spermatids and spermatozoa slightly decreased at the first week, but have recovered to normal value from the second week. 3. There were noticeable changes neither in the interstitium of testes except the minimal edema nor in terms of size and number of Leydig cell. The results using rats showed the discordance with those of human study of prostatic cancer patient. This conflict can be attributed to the functional differences of leuprolide action between two species, age of sacrificed rats and insufficiency of dose and time of administration. However, we can draw another conclusion that the leuprolide acetate is expected to have no significant adverse effects to the spermatogenesis in cryptorchism treatment.
Animals ; Body Weight ; Cryptorchidism ; Edema ; Gonadotropin-Releasing Hormone ; Humans ; Leuprolide* ; Male* ; Peritoneal Cavity ; Prostatic Neoplasms ; Rats* ; Reading ; Reference Values ; Seminiferous Tubules ; Spermatids ; Spermatocytes ; Spermatogenesis ; Spermatogonia ; Spermatozoa ; Testis

No abstract available.

No abstract available.

BACKGROUND: We compared the clinical outcomes of cardiac valve surgery in adult Jehovah's Witness patients refusing blood transfusion to those in non-Jehovah's Witness patients without any transfusion limitations. METHODS: From 2005 to 2014, 25 Jehovah's Witnesses (JW group) underwent cardiac valve surgery using a blood conservation strategy. Twenty-five matched control patients (non-JW group) were selected according to sex, age, operation date, and surgeon. Both groups were managed according to general guidelines of anticoagulation for valve surgery. RESULTS: The operative mortality rate was 4.0% in the JW group and 0% in the non-JW group (p = 1.000). There was no difference in postoperative major complications between the groups (p = 1.000). The overall survival rate at 5 and 10 years was 85.6% ± 7.9% and 85.6% ± 7.9% in the JW group, respectively, and 100.0% ± 0.0% and 66.7% ± 27.2% in the non-JW group (p = 0.313). The valve-related morbidity-free survival rates (p = 0.625) and late morbidity-free survival rates (p = 0.885) were not significantly different between the groups. CONCLUSIONS: Using a perioperative strategy for blood conservation, cardiac valve surgery without transfusion had comparable clinical outcomes in adult patients. This blood conservation strategy could be broadly applied to major surgeries with careful perioperative care.
Adult ; Blood Transfusion ; Bloodless Medical and Surgical Procedures* ; Heart Valves* ; Humans ; Jehovah's Witnesses* ; Mortality ; Perioperative Care ; Survival Rate

Ureteroscopic removal of stone is now an established technique for the management of ureteral stones and can be done under direct vision using flexible grasping forceps or stone baskets with increased safety and efficacy. A clinical study of our 35 cases of ureteroscopic removal of ureteral calculi was performed. Only one among 4 cases of mid and upper ureteral calculi and 27 among 31 cases of lower ureteral calculi were removed successfully. Therefore the overall success rate was 80 %(28 among 35 cases). Complications occurred in 6 cases : a case of ureteral avulsion, a case of ureteral separation, 2 cases of uncomplicated urinary tract infection and 2 cases of ureteral perforations. We conclude that ureteroscopic removal of ureteral stone under direct vision can be done safely and be the first choice of management for the lower ureteral surgical calculi, but the antegrade removal of stone through percutaneous nephrostomy tract may be preferable for the upper and mid ureteral calculi.
Calculi ; Hand Strength ; Nephrostomy, Percutaneous ; Surgical Instruments ; Ureter* ; Ureteral Calculi ; Urinary Tract Infections