No abstract available.
Aged, 80 and over* ; Humans ; Transurethral Resection of Prostate*

CT was found to be highly accurate in predicting tumor size and assessing invasion of the surroundingstructures and distant metastasis. Also CT played an important role for determination of operability of esophagealcarcinoma. The CT findings with barium esophagogram in 21 patients with histologically proven esophageal carciomawere reviewed from Feb. 1985 to Feb. 1986 at the department of Radiology, Yonsei University ,College of Medicine.The results were as follows: 1. Number of patients in each stages were: 2 in stage 1, 6 in stage 2, 4 in stage 3,and 9 in stage 4. 2. Peak age distribution was in its 6th decasedes as 9 patiens (42.9%). Overall mean age was 60.8 years. Number of male patients were 19 and 2 of female. 3. Histologic types of esohageal carcinoma were 19cases of epidermoid (90.5%) and 2 cases of adenocarcinoma(9.5%). 4. The tumor location was 1 case in upper, 14cases(66.7%) in middle and 6 cases in lower one-third. 5. Various types of esophageal carcinoma were as follows: 3cases of fungating, 4 cases of infiltrating, 5 cases of ulcerofungating, and 9 cases of ulceroinfiltrating type.6. Average length of involvement in each stages were 4cm in stage 1, 5.5cm in stage 2, 8.8cm in stage 3, and 8.3cmin stage 4. The involved length was longer in advanced cases. In 11 cases(52.4%), the involved length was between4 and 8cm. 7. Angle of periaortic fat plane obliteration of the aortic circumference were as follows: Below 45degrees( 7 cases 33.3%), 45degrees-90degrees (3 cases 14.3%), over 90 degrees(11 cases, 52.4%). 8. Method oftreatment of esophageal carcinoma were as follows: Only radiotherapy in 11 cases(52.4%), radiotherapy withoperation in 5 cases, only operation in 1 cases, and no treatment in 4 cases. 9. Distant metastatic sites were:brain in 1, pericardium in 5, liver in 5, trachea in 2, bronchus in 9, and distant lymph node in 5 cases.
Age Distribution ; Barium ; Bronchi ; Female ; Humans ; Liver ; Lymph Nodes ; Male ; Methods ; Neoplasm Metastasis ; Pericardium ; Radiotherapy ; Trachea

A clinical observation was made on the injuries of genitourinary tract of the in-patients in the Department of Urology, Kyung Hee University Hospital during the period from July 1, 1972 to June 30. 1977. The following results were obtained. 1) Of 689 cases hospitalized, 61 cases were injuries of genitourinary tract, giving a rate of 8.9%. 2) The age ranged from 3 to 70 years and most favorable age was in from 20 to 39 years for 47.6%. The sex ratio, male to female, was 11.2 : 1. 3) The urethra was involved most frequently in 39.3 %, the kidney in 32.8 %, the bladder in 14.8 %, the external genitalia in 11.5 % and the ureter in only one case which was caused by grnecologic operation. 4) Traffic accident was most common cause of the injury in 39.3% and the next was kick and blow in 26.2 %, fail in 13.1 %. 5) Operation in renal injuries was performed in 5 of 20 cases. 6) In bladder injuries, the extraperitoneal type was in 5 cases, the intraperitoneal in 2 cases and Contusion in only one case. 7) 66.7 % of urethral injuries were associated with pubic bone fracture.
Accidents, Traffic ; Contusions ; Female ; Genitalia ; Humans ; Kidney ; Male ; Pubic Bone ; Sex Ratio ; Ureter ; Urethra ; Urinary Bladder ; Urology

We analyzed 34 extension contracture of the knee patients after modified Judet's procedure. Male patient was 32 and female was 2. Age ranged from 19 years to 61 years average being 34 years old. Follow-up period ranged from 12 months to 7 years and 8 months average being 3 years 8 months. 1. The extension contracture of the knee were due to not only scarring of the vastus intermedius but contractures of quadriceps muscles, and finally did lead to intraarticular adhesion in all cases. 2. The results of modified Judet's procedure were excellent or good in 97% and we concluded that the modified Judet's procedure of quadricepsplasty was good method of treatment in extension contracture of the knee. 3. The extension lag after modified Judet's procedures was increased initially but overcame by physical therapy, and did not significantly increase even after release of rectus femoris. 4. Modified Judet's procedure was able to permit early physical therapy without any skin problem.
Cicatrix ; Contracture ; Female ; Follow-Up Studies ; Humans ; Knee ; Male ; Methods ; Quadriceps Muscle ; Skin

The Saville's index of the lumbar spine and the Singh's index of the femoral neck is very simple method to measure degree of osteoporosis. Authors compared Singh's index and Savilles index with Dual Photon Absorptiometry(D.P.X.) and studied the reliability and clinical usefulness of two indices. We took the D.P.X. and simple L-spine lateral view in 103 patients in same time and also performed D.P.X. and both hips A-P view in 70 patients, then analyzed and compared each two indices with D.P.X. The Singh's index had less interpersonal difference and intrapersonal difference compared with Saville's spine index. There was some confidence of Singh's index and Saville's spine index compared with the D.P.X., but the relationship between Saville's spine index and D.P.X. was less promising than that of Singh's index. Authors suggest that the Saville's spine index has less clinical usefulness than Singh's index in measurement of osteoporosis.
Femur Neck ; Hip ; Humans ; Methods ; Osteoporosis ; Spine

N,N-Diethylnitrosamine (DEN) has been proved to have carcinogenic potential in the initiation or promotion stage and the transformed cells proliferate to form preneoplastic nodules which are positive for placental form of glutathione S-transferase (GST-P). E-Cadherin, a member of the cadherin family, is expressed in epithelial cells. To evaluate the role of adhesion molecules (E-Cadherin, alpha-catenin, and beta-catenin), which have not been well understood in carcinogenesis, we investigated the changes of E-cadherin, alpha-Catenin and beta-Catenins by immunohistochemistry and immunoblotting in DEN-induced hepatocarcinogenesis of rat liver. In addition, the sequential analysis of histopathology and the expression of GST-P were also examined. Immunoreactive areas for GST-P were gradually increased from early period of carcinogenesis and strong GST-P positive foci were noted in various lesions, especially in the clear cell and eosinophilic cell nodules. Immunohistochemically, the E-Cadherin expression was increased in DEN-treated preneoplastic nodules in 4 and 10 weeks and hepatocellular carcinomas displayed relatively reduced expression compared with the hyperplastic nodules. But alpha- and beta-catenin expression was increased in hyperplastic nodules and hepatocellular carcinomas. Immunoblotting studies revealed that the level of alpha-catenin (cytosol and membranous fraction) was overexpressed in hyperplastic nodules as well as hepatocellular carcinomas, which showed markedly increased expression. The membranous fraction of beta-catenin was markedly increased in 10 weeks of DEN treatment and slightly reduced in hepatocellular carcinomas. These findings suggest that during DEN-induced hepatocarcinogenesis, the clear cell and eosinophilic cell nodules expressing GST-P in their cytoplasm are early transformed cell nodules. The altered expression of E-Cadherin and catenins is closely related with tumor propagation. Loss or reduced expression of E-cadherin may play a role in the progression of late hyperplastic nodule to hepatocellular carcinoma in DEN-induced rat hepato carcinogenesis.
alpha Catenin ; Animals ; beta Catenin ; Cadherins* ; Carcinogenesis ; Carcinoma, Hepatocellular ; Catenins* ; Cytoplasm ; Eosinophils ; Epithelial Cells ; Glutathione Transferase* ; Glutathione* ; Humans ; Immunoblotting ; Immunohistochemistry ; Liver* ; Rats*

The purpose of this study was to analyze the relationship among the health promoting behaviors, self-reported climacteric symptoms and depression on a cross-sectional survey design. The subjects were 108 middle-aged women who were non-hystrectomized and ranged in age from 40 to 60. They were selected in Seoul and Kyoung-ki province, Korea. Data were collected from Oct. 25 to Nov. 10, 1997 by a structured questionnaire. The instrument used for this study was the revised Health Promotion Lifestyle Profile(HPLP) developed by Walker, Sechrist and Pender, revised Climacteric Symptoms Scale developed by Chi, Sung Ai, and the Beck's Depression Inventory(BID). The data were analyzed by the SPSS/PC+ program using t-test, ANOVA and Scheffe test as a post hoc and Pearson Correlation Coefficient. The results of the study were as follows ; 1. The mean score of health promoting behaviors was low(2.42+/-0.35). There were statistically significant difference in the score of health promoting behaviors according to the educational background, family income, marital satisfaction, and whether or not taking a restorative food(t=-2.07, F=2.60~7.57, p<0.05). 2. The mean score of self-reported climacteric symptoms was 1.69 ; 99% of middle-aged women had symptoms. There were statistically significant difference in the score of middle-aged women's self-reported climacteric symptoms according to the age, number of children, educational background, occupation, family income, marital satisfaction, whether or not receiving hormone replacement therapy(HRT) or consultation experience with a professional, and perceived health status(t=-2.04~3.69, F=2.87~11.63, p<0.05). 3. The mean score of depression was 10.84. There were statistically significant differences in the score of the depression according to the age, number of children, educational background, occupation, marital satisfaction, whether or not receiving menopausal treatment of consultation by a professional, and perceived health status(t=-2.25~3.00, F=3.50~9.24, p<0.05). 4. Women's degree of health promoting behaviors was a negative correlation with the degree of climacteric symptoms(r=-0.19, p=0.03) and the degree of depression(r=-0.23, p=0.01). The degree of climacteric symptoms was a positive correlation with the degree of depression(r=0.64, p=0.01). In conclusion, health promoting behavior should be considered when developing nursing strategies for middle-aged women, especially when dealing with climacteric symptoms and depression.
Child ; Climacteric* ; Cross-Sectional Studies ; Depression* ; Female ; Health Promotion ; Humans ; Korea ; Life Style ; Menopause ; Nursing ; Occupations ; Surveys and Questionnaires ; Seoul

Acanthamoeba spp. are single-celled protozoan organisms that are widely distributed in the environment. In this study, to understand functional roles of a mannose-binding protein (MBP), Acanthamoeba castellanii was treated with methyl-alpha-D-mannopyranoside (mannose), and adhesion and cytotoxicity of the amoeba were analyzed. In addition, to understand the association of MBP for amoeba phagocytosis, phagocytosis assay was analyzed using non-pathogenic bacterium, Escherichia coli K12. Amoebae treated with mannose for 20 cycles exhibited larger vacuoles occupying the most area of the amoebic cytoplasm in comparison with the control group amoebae and glucose-treated amoebae. Mannose-selected amoebae exhibited lower levels of binding to Chinese hamster ovary (CHO) cells. Exogenous mannose inhibited >50% inhibition of amoebae (control group) binding to CHO cells. Moreover, exogenous mannose inhibited amoebae (i.e., man-treated) binding to CHO cells by <15%. Mannose-selected amoebae exhibited significantly decreased cytotoxicity to CHO cells compared with the control group amoebae, 25.1% vs 92.1%. In phagocytic assay, mannose-selected amoebae exhibited significant decreases in bacterial uptake in comparison with the control group, 0.019% vs 0.03% (P<0.05). Taken together, it is suggested that mannose-selected A. castellanii trophozoites should be severely damaged and do not well interact with a target cell via a lectin of MBP.
Acanthamoeba castellanii/drug effects/metabolism/*pathogenicity ; Amebiasis/*parasitology ; Animals ; CHO Cells ; Cell Adhesion/drug effects ; Cell Survival ; Cricetinae ; Cricetulus ; Escherichia coli K12/metabolism ; Female ; Mannose/*pharmacology ; Mannose-Binding Lectin/*metabolism ; Phagocytosis ; Protozoan Proteins/metabolism

A clinical observation was made on one thousand and seventeen cases of endoscopy, performed in the Department of Urology, Kyung Hee University Hospital during the period from January 1, 1977 to December 31, 1978. The results are summarized as follows. 1) During the period, of 5,480 patients visited, 987 patients were examined endoscopically, giving a rate of 18%. 2) The age was ranged from 3 to 91 years old and the most favorable age was in 30 to 49 years old in 49.9%. The sex ratio, male to female, was 1 : 1.43) The common diseases, diagnosed endoscopically in male, were bladder neck contracture 126 cases (29.2%), posterior urethritis 109 cases (25.3%), benign prostatic hypertrophy 51 cases (11.8%) but in female, chronic urethritis was the most common disease in 419 cases(71.5%) and the next subacute cystitis 37 cases (6. 3%), bladder tumor 13 cases (2.2). 4) In male, endoscopy was indicated most commonly due to infravesical obstruction symptoms such as hesitancy, forceful urination, small urinary stream in 78 cases (20.6%) but in female most commonly due to bladder irritation such as frequency, tenesmus, urgency in 239 cases (48.4%). 5) Main symptoms in female urethritis were frequency in 197 cases (47.0%), tenesmus in 156 cases (37.2 %), suprapubic discomfort in 59 cases (14 %). 6) The most common cystoscopic finding in female urethritis was trabeculation in 226 cases (53.9%). 7) The panendoscopic findings in female urethritis were classified into 4 groups by Kim's method The most common group was group IV in 189 cases (45.1%) which showed marked inflammatory changes on bladder neck and urethra. 8) The meatal stenosis was observed in 27.8% of 806 female patients, checked endcscopically.
Constriction, Pathologic ; Contracture ; Cystitis ; Endoscopy* ; Female ; Humans ; Male ; Middle Aged ; Neck ; Prostatic Hyperplasia ; Rivers ; Sex Ratio ; Urethra ; Urethritis ; Urinary Bladder ; Urinary Bladder Neoplasms ; Urination ; Urology

No abstract available.
Neurofibromatoses* ; Neurofibromatosis 1*