We report two cases of malignant lymphoma of mucosa-associated lymphoid tissue arising in the conjunctiva. Case 1, an 18-year-old girl, showed her left lower conjunctival swelling for four months and Case 2, a 29-year-old man, showed similar lesions on both his eyes for one year. Histologically, both cases revealed monomorphous dense lymphoid infiltrates invading the overlying conjunctival epithelium with diffuse patterns. The infiltrates were composed of small lymphocytes admixed with centrocyte-like cells within the conjunctival epithelium and stroma in association with B-cell lineage. No relapse was noted during the period of about 1½ years follow-up in case 1 treated by local excision only and in the follow-up period of 2 months in case 2 treated by local excision and subsequent chemotherapy.
Adolescent ; Adult ; B-Lymphocytes ; Conjunctiva* ; Drug Therapy ; Epithelium ; Female ; Follow-Up Studies ; Humans ; Lymphocytes ; Lymphoid Tissue* ; Lymphoma* ; Recurrence

Progressive zosteriform macular pigmented lesion(PZMPL) is a chronic pigmentary dermatosis similar to progressive cribriform and zosteriform hyperpigmentation(PCZH). This dermatosis described by Simoes in 1980 is characterized by a uniformly tanned macular pigmented lesion in a zosteriform distribution preceded by multiple pruritic macular pigmentation in a part of the dermatome for a period. PZMPL is not a fully understood disease entity but it is thought to be a variant of PCZH. It is differentiated from PCZH by accompanying pruritus as a prodromal symptom, a characteristic clinical course, and histological findings such as pigmentary incontinence. We report herein a case of PZMPL in a 17 year-old girl with the pigmentary skin lesion extending from the left forearm to the left chest along the Blaschkos line. The histological findings revealed increased melanin pigments in the basal layer and focal pigmentary incontinence in the upper dermis. To our knowledge, this case is the first report of PZMPL in korea thought to be the same case reported by Simoes.
Adolescent ; Dermis ; Female ; Forearm ; Humans ; Korea ; Melanins ; Pigmentation ; Prodromal Symptoms ; Pruritus ; Skin ; Skin Diseases ; Thorax ; Triacetoneamine-N-Oxyl

No abstract available.
Myocardial Infarction*

Nocturnal penile tumescence has been proposed as a source of objective data in the evaluation of erectile capacity and clinically important in differentiating between psychogenic and organic impotence. However, the absence of sleep information and difficult differentiation of movement artifact leads to false positive or false negative reaction when portable home monitor is used. This can be overcome by polysomnographic monitoring. In addition, sleep disorders affecting nocturnal penile tumescence also could be screened. Herein, we conducted a study to investigate the significance of polysomnographic nocturnal penile tumescence monitoring in 45 men with erectile dysfunction. The nocturnal penile tumescence data from polysomnographic method were compared with those from portable method, based on the results from standard method. The results obtained were summarized 1. Polysomnographic method showed higher sensitivity(82%), lower false positive(20%) and false negative rate(16%) than portable method (71%, 30%, 28%, respectively) in the differential diagnosis of impotence. 2. Among 10 patients, with measuring of air flow monitoring and anterior tibialis EMG one patient had periodic leg movement. 3. Statistically, parameters of total REM time, total tumescence time/total sleep time, number of maximum tumescence episodes, amount of maximum tumescence episodes, T-up and T-max phase in maximum tumescence episodes, circumferential changes in maximum tumescence episodes, and rigidity in maximum tumescence episodes were found to be significantly decreased in organic impotence group. These results reflect that polysomnographic NPTM provides more validity than portable NPTM on the outcome of the differential diagnosis of impotence, and it would contribute to screening of occult sleep disorders and to study for their characteristics in association with impotence.
Artifacts ; Diagnosis* ; Diagnosis, Differential ; Erectile Dysfunction* ; False Negative Reactions ; Humans ; Leg ; Male ; Mass Screening ; Penile Erection* ; Sleep Wake Disorders

To investigate hemodynamic mechanism of penile erection and to establish animal model which permits hemodynamic study, simultaneous measurement of flow rate, pressure of the internal pudendal artery, and intracorporeal pressure during penile erection was performed using canine electroerection models. The results obtained were summarized as followings: 1. Following pelvic nerve stimulation, the erection phenomenon was grossly observed. The intracorporeal pressure began to increase after a latent period of mean 11.3 sec., and increased to the maximum and then maintained plateau state. When the stimulation was terminated, detumescence with gradual decrease of intracorporeal pressure was observed. 2. With stimulation above threshold level, transient drop of intracorporeal pressure was observed immediately after stimulation. The latent period and time to the maximal intracorporeal pressure were shortened. However, the degree of maximal intracorporeal pressure was not changed. 3. Following electric stimulation of the pelvic nerve, immediate decrease in internal pudendal arterial pressure and increase in flow rate of the internal pudendal artery without change in systemic blood pressure were followed by gradual increase in intracorporeal pressure. These indicate that relaxation of the sinusoidal smooth muscles and the arteries supplying the corpus cavernosum by pelvic nerve stimulation results in an increase in arterial inflow to the corpus cavernosum, which would play an important role in induction of penile erection. And it is suggested that this animal model would contribute to further hemodynamic study and development of therapeutics in erectile impotence.
Animals ; Arterial Pressure ; Arteries ; Blood Pressure ; Dogs* ; Electric Stimulation ; Erectile Dysfunction ; Hemodynamics* ; Male ; Models, Animal ; Muscle, Smooth ; Penile Erection* ; Relaxation

To investigate hemodynamic mechanism of penile erection and to establish animal model which permits hemodynamic study, simultaneous measurement of flow rate, pressure of the internal pudendal artery, and intracorporeal pressure during penile erection was performed using canine electroerection models. The results obtained were summarized as followings: 1. Following pelvic nerve stimulation, the erection phenomenon was grossly observed. The intracorporeal pressure began to increase after a latent period of mean 11.3 sec., and increased to the maximum and then maintained plateau state. When the stimulation was terminated, detumescence with gradual decrease of intracorporeal pressure was observed. 2. With stimulation above threshold level, transient drop of intracorporeal pressure was observed immediately after stimulation. The latent period and time to the maximal intracorporeal pressure were shortened. However, the degree of maximal intracorporeal pressure was not changed. 3. Following electric stimulation of the pelvic nerve, immediate decrease in internal pudendal arterial pressure and increase in flow rate of the internal pudendal artery without change in systemic blood pressure were followed by gradual increase in intracorporeal pressure. These indicate that relaxation of the sinusoidal smooth muscles and the arteries supplying the corpus cavernosum by pelvic nerve stimulation results in an increase in arterial inflow to the corpus cavernosum, which would play an important role in induction of penile erection. And it is suggested that this animal model would contribute to further hemodynamic study and development of therapeutics in erectile impotence.
Animals ; Arterial Pressure ; Arteries ; Blood Pressure ; Dogs* ; Electric Stimulation ; Erectile Dysfunction ; Hemodynamics* ; Male ; Models, Animal ; Muscle, Smooth ; Penile Erection* ; Relaxation

No abstract available.
Animals ; Jaundice, Obstructive* ; Liver Regeneration* ; Liver* ; Rats*

No abstract available.
Microvascular Decompression Surgery*

In order to determine the factors affecting the length of stay by pay status, a total of 961 in-patients medical records with appendectomy, cholecystectomy and Cesarean section discharged from the January 1979 to December 1981 from the University hospital were reviewed. Average length of stay showed no statistically significant difference by year between the insured and the non-insured patients, however multiple diagnoses and surgical complication were significantly different from single diagnosis and non-complicated cases. Surgical complication explained the length of stay mostly, and physician in discharge, multiple diagnoses, and accommodation in order for insured patients. Surgical complication, admission route, physician in charge and age in order explained the length of stay for non-insured patients.
Appendectomy ; Cesarean Section ; Cholecystectomy ; Diagnosis ; Female ; Humans ; Length of Stay* ; Medical Records ; Pregnancy

Each diastereomer of 10-thiophenyl- and 10-benzenesulfonyl-dihydroartemisinin was synthesized from artemisinin in three steps, and screened against chloroquine-resistance and chloroquine-sensitive Plasmodium falciparum. Three of the four tested compounds were found to be effective. Especially, 10 beta-benzenesulfonyl-dihydroartemisinin showed stronger antimalarial activity than artemisinin.
Animals ; Antimalarials/chemistry/*pharmacology ; Artemisinins/chemistry/*pharmacology ; Chloroquine/pharmacology ; Drug Resistance ; Plasmodium falciparum/*drug effects ; Research Support, Non-U.S. Gov't