1.Open Reduction of Calcaneal Fracture
Koon Soon KANG ; Jun Seop JAHNG ; Soon Woun KWON ; Hui Wan PARK ; Yun Tae LEE
The Journal of the Korean Orthopaedic Association 1986;21(4):563-569
Calcaneal fractures involving subtalar joint can be associated with prolonged and severe disability. Many different methods have been tried for the treatment in order to search for better results. From March 1983 to December 1985, 8 cases of calcaneal fractures involving subtalar joint were treated by open rcduction and internal fixation. and the results were as follows: 1. Satisfactory results were obtained from 7 cases out of 8. 2. Anatomic reduction was obtained by open reduction and internal fixation. 3. When medial approach failed, combined lateral and medial approaches gave better visualization of articular fecets and ensured anatomic reduction.
Subtalar Joint
2.A Case of Tuberculous Pneumonitis With Continuous High Spiking Fever.
Hee Seung LEE ; Jung Cheol RYU ; Tae Koon PARK ; Tae Joon PARK ; Eun Soo YANG ; Soo Jeon CHOI ; Young Tace KWAK ; Bong Su CHA ; Se Kyu KIM
Tuberculosis and Respiratory Diseases 1994;41(3):299-302
A 33-year old male was admitted due to continuous high spiking fever for 2 months via local clinic. He had been diagnosed pulmonary tuberculosis at local clinic. However, spiking fever had not been controlled by anti-tuberculous medications. Chest PA showed confluent consolidation on right upper & mid-lung field. 5 anti-tuberculous regimens (Streptomycin, Isoniazid, Rifampin, Ethambutol, Pyrazinamaide) were administered initially and steroid therapy was followed for relieving toxic symptoms Very slowly resolved chest X-ray lesion and continuous fever suggested the possibility of misdiagnosis. After 60th hospital day, the chest X-ray lesion was resolved gradually and fever subsided almost completely. He was discharged on 76th hospital day with anti-tuberculous drugs and steroid(prednisolon), without any other problems except sustained mild fever.
Diagnostic Errors
;
Ethambutol
;
Fever*
;
Humans
;
Isoniazid
;
Male
;
Pneumonia*
;
Rifampin
;
Thorax
;
Tuberculosis, Pulmonary
3.Clinicopathological Characteristics in Invasive Ductal Breast Cancer with Low FDG Uptake in (18)F-FDG PET/CT.
Hyung Il SEO ; Young Tae BAE ; Koon Taek HAN ; Seongjang KIM ; Do Youn PARK
Journal of Breast Cancer 2010;13(1):83-89
PURPOSE: The aim of this study is to evaluate whether low FDG uptake would be associated with the biological low-aggressiveness of invasive ductal carcinoma. METHODS: The subjects consisted of 124 female patients with primary invasive ductal carcinoma. All the patients were examined with (18)F-FDG PET/CT before neoadjuvant chemotherapy. RESULTS: With regard to histopathologic grading, 117 were histopathologic grade 1 and 2, and 7 were grade 3. Low FDG uptake correlated with well and moderate histopathologic grade (p=0.003) and low (18)F-FDG uptake in invasive ductal carcinoma depended on the presence of axillary lymph node metastases (p=0.014) and small tumor (<2.0 cm, p=0.022). Ki-67 positivity ranged from 0% to 60% (mean 15%). Sixty seven specimens showed low immunoreactivity to Ki-67 antigen (<10% of tumor cells). This revealed a significant correlation between low FDG uptake and Ki-67 (p=0.003). Logistic regression analysis between these factors showed that lower histologic grade, no axillary lymph nodes metastases and low Ki-67 (<10%) were correlated with low FDG uptake. CONCLUSION: Our results demonstrated that an association exists between low FDG uptake and good prognostic factors such as lower histologic grade (1, 2), no axillary lymph node metastases and low Ki-67 (<10%).
Breast
;
Breast Neoplasms
;
Carcinoma, Ductal
;
Female
;
Humans
;
Ki-67 Antigen
;
Logistic Models
;
Lymph Nodes
;
Neoplasm Metastasis
;
Prognosis
4.Clinicopathological Characteristics in Invasive Ductal Breast Cancer with Low FDG Uptake in (18)F-FDG PET/CT.
Hyung Il SEO ; Young Tae BAE ; Koon Taek HAN ; Seongjang KIM ; Do Youn PARK
Journal of Breast Cancer 2010;13(1):83-89
PURPOSE: The aim of this study is to evaluate whether low FDG uptake would be associated with the biological low-aggressiveness of invasive ductal carcinoma. METHODS: The subjects consisted of 124 female patients with primary invasive ductal carcinoma. All the patients were examined with (18)F-FDG PET/CT before neoadjuvant chemotherapy. RESULTS: With regard to histopathologic grading, 117 were histopathologic grade 1 and 2, and 7 were grade 3. Low FDG uptake correlated with well and moderate histopathologic grade (p=0.003) and low (18)F-FDG uptake in invasive ductal carcinoma depended on the presence of axillary lymph node metastases (p=0.014) and small tumor (<2.0 cm, p=0.022). Ki-67 positivity ranged from 0% to 60% (mean 15%). Sixty seven specimens showed low immunoreactivity to Ki-67 antigen (<10% of tumor cells). This revealed a significant correlation between low FDG uptake and Ki-67 (p=0.003). Logistic regression analysis between these factors showed that lower histologic grade, no axillary lymph nodes metastases and low Ki-67 (<10%) were correlated with low FDG uptake. CONCLUSION: Our results demonstrated that an association exists between low FDG uptake and good prognostic factors such as lower histologic grade (1, 2), no axillary lymph node metastases and low Ki-67 (<10%).
Breast
;
Breast Neoplasms
;
Carcinoma, Ductal
;
Female
;
Humans
;
Ki-67 Antigen
;
Logistic Models
;
Lymph Nodes
;
Neoplasm Metastasis
;
Prognosis
5.Iliac Vein Injury Due to a Damaged Hot Shearstrade mark Tip Cover During Robot Assisted Radical Prostatectomy.
Enrique Ian LORENZO ; Wooju JEONG ; Sangun PARK ; Won Tae KIM ; Sung Joon HONG ; Koon Ho RHA
Yonsei Medical Journal 2011;52(2):365-368
We report a rare case of vascular injury secondary to a damaged Hot Shearstrade mark tip cover. Two 1 mm holes in the tip cover resulted in perforations in the obturator and external iliac veins during pelvic node dissection. Bleeding was controlled with bipolar coagulation and a 5 mm metal clip in the obturator and iliac vein, respectively. The rest of the procedure was completed uneventfully. Frequent integrity assessment of this accessory is necessary. Its function is important in order to carry out safe dissection in proximity to delicate structures. When injuries arise from areas not directly involved in the dissection, immediate inspection of the instruments should be mandatory.
Humans
;
Iliac Vein/*injuries
;
Male
;
Middle Aged
;
Prostatectomy/*adverse effects/instrumentation/methods
;
Prostatic Neoplasms/surgery
;
Robotics/instrumentation
6.Impact of Cerebrovascular Disease on Survival Benefits from Local Treatment in Patients with De Novo Metastatic Hormone-Sensitive Prostate Cancer
Tae Jin KIM ; Young Dong YU ; Dong Soo PARK ; Koon Ho RHA ; Sung Joon HONG ; Kang Su CHO ; Byung Ha CHUNG ; Kyo Chul KOO
Yonsei Medical Journal 2019;60(12):1129-1137
PURPOSE: Local treatment has become a treatment option for patients with de novo metastatic hormone-sensitive prostate cancer (mHSPC). Subgroup analyses based on a history of cerebrovascular disease (CVD) were performed to evaluate the impact thereof on overall survival (OS) after local treatment. MATERIALS AND METHODS: A retrospective analysis was performed for 879 patients with de novo mHSPC between August 2003 and November 2016. Patients were stratified according to prior CVD history and the type of initial treatment: androgen-deprivation therapy (ADT) alone versus local treatment consisting of radical prostatectomy (RP) or radiation therapy (RT) with ADT, with or without metastasis-directed therapy. The primary outcome was OS assessed by Kaplan-Meier analysis and Cox-regression models. RESULTS: Of 879 patients, 660 (75.1%) men underwent ADT alone, and 219 (24.9%) men underwent RP or RT with ADT, with or without metastasis-directed therapy. The median follow-up was 38 months. Multivariable analysis showed CVD history to be associated with a higher risk of overall mortality (p=0.001). In the overall cohort and in patients without a history of CVD, patients who underwent local treatment exhibited higher OS than men who received ADT alone (all p<0.001). However, the survival benefit conferred by local treatment was not seen in patients with a history of CVD (p=0.324). OS was comparable between patients who received RP and RT (p=0.521). CONCLUSION: Local treatment with or without metastasis-directed therapy may provide OS advantages for mHSPC patients without a history of CVD. Further prospective studies are needed to address these important concerns.
Cerebrovascular Disorders
;
Cohort Studies
;
Follow-Up Studies
;
Humans
;
Kaplan-Meier Estimate
;
Male
;
Mortality
;
Neoplasm Metastasis
;
Prospective Studies
;
Prostate
;
Prostatectomy
;
Prostatic Neoplasms
;
Retrospective Studies
7.Comparison of Laparoscopic and Open Partial Nephrectomies in T1a Renal Cell Carcinoma: A Korean Multicenter Experience.
Hongzoo PARK ; Seok Soo BYUN ; Hyeon Hoe KIM ; Seung Bae LEE ; Tae Gyun KWON ; Seung Hyun JEON ; Seok Ho KANG ; Seong Il SEO ; Tae Hee OH ; Youn Soo JEON ; Wan LEE ; Tae Kon HWANG ; Koon Ho RHA ; Ill Young SEO ; Dong Deuk KWON ; Yong June KIM ; Yunhee CHOI ; Sue Kyung PARK
Korean Journal of Urology 2010;51(7):467-471
PURPOSE: We analyzed a series of patients who had undergone laparoscopic partial nephrectomies (LPNs) and open partial nephrectomies (OPNs) to compare outcomes of the two procedures in patients with pathologic T1a renal cell carcinomas (RCCs). MATERIALS AND METHODS: From January 1998 to May 2009, 417 LPNs and 345 OPNs were performed on patients with small renal tumors in 15 institutions in Korea. Of the patients, 273 and 279 patients, respectively, were confirmed to have pT1a RCC. The cohorts were compared with respect to demographics, peri-operative data, and oncologic and functional outcomes. RESULTS: The demographic data were similar between the groups. Although the tumor location was more exophytic (51% vs. 44%, p=0.047) and smaller (2.1 cm vs. 2.3 cm, p=0.026) in the LPN cohort, the OPN cohort demonstrated shorter ischemia times (23.4 min vs. 33.3 min, p<0.001). The LPN cohort was associated with less blood loss than the OPN cohort (293 ml vs. 418 ml, p<0.001). Of note, two patients who underwent LPNs had open conversions and nephrectomies were performed because of intra-operative hemorrhage. The decline in the glomerular filtration rate at the last available follow-up (LPN, 10.9%; and OPN, 10.6%) was similar in both groups (p=0.8). Kaplan-Meier estimates of 5-year local recurrence-free survival (RFS) were 96% after LPN and 94% after OPN (p=0.8). CONCLUSIONS: The LPN group demonstrated similar rates of recurrence-free survival, complications, and postoperative GFR change compared with OPN group. The LPN may be an acceptable surgical option in patients with small RCC in Korea.
Carcinoma, Renal Cell*
;
Cohort Studies
;
Demography
;
Follow-Up Studies
;
Glomerular Filtration Rate
;
Hemorrhage
;
Humans
;
Ischemia
;
Kidney Neoplasms
;
Korea
;
Nephrectomy*
;
Outcome Assessment (Health Care)
8.Comparison of Laparoscopic and Open Partial Nephrectomies in T1a Renal Cell Carcinoma: A Korean Multicenter Experience.
Hongzoo PARK ; Seok Soo BYUN ; Hyeon Hoe KIM ; Seung Bae LEE ; Tae Gyun KWON ; Seung Hyun JEON ; Seok Ho KANG ; Seong Il SEO ; Tae Hee OH ; Youn Soo JEON ; Wan LEE ; Tae Kon HWANG ; Koon Ho RHA ; Ill Young SEO ; Dong Deuk KWON ; Yong June KIM ; Yunhee CHOI ; Sue Kyung PARK
Korean Journal of Urology 2010;51(7):467-471
PURPOSE: We analyzed a series of patients who had undergone laparoscopic partial nephrectomies (LPNs) and open partial nephrectomies (OPNs) to compare outcomes of the two procedures in patients with pathologic T1a renal cell carcinomas (RCCs). MATERIALS AND METHODS: From January 1998 to May 2009, 417 LPNs and 345 OPNs were performed on patients with small renal tumors in 15 institutions in Korea. Of the patients, 273 and 279 patients, respectively, were confirmed to have pT1a RCC. The cohorts were compared with respect to demographics, peri-operative data, and oncologic and functional outcomes. RESULTS: The demographic data were similar between the groups. Although the tumor location was more exophytic (51% vs. 44%, p=0.047) and smaller (2.1 cm vs. 2.3 cm, p=0.026) in the LPN cohort, the OPN cohort demonstrated shorter ischemia times (23.4 min vs. 33.3 min, p<0.001). The LPN cohort was associated with less blood loss than the OPN cohort (293 ml vs. 418 ml, p<0.001). Of note, two patients who underwent LPNs had open conversions and nephrectomies were performed because of intra-operative hemorrhage. The decline in the glomerular filtration rate at the last available follow-up (LPN, 10.9%; and OPN, 10.6%) was similar in both groups (p=0.8). Kaplan-Meier estimates of 5-year local recurrence-free survival (RFS) were 96% after LPN and 94% after OPN (p=0.8). CONCLUSIONS: The LPN group demonstrated similar rates of recurrence-free survival, complications, and postoperative GFR change compared with OPN group. The LPN may be an acceptable surgical option in patients with small RCC in Korea.
Carcinoma, Renal Cell*
;
Cohort Studies
;
Demography
;
Follow-Up Studies
;
Glomerular Filtration Rate
;
Hemorrhage
;
Humans
;
Ischemia
;
Kidney Neoplasms
;
Korea
;
Nephrectomy*
;
Outcome Assessment (Health Care)
9.Conventional Treatments in Patients with Hodgkin's Disease.
Jong Beom PARK ; Chul Won SEO ; Sang Hee KIM ; Kyung No LEE ; Hun Ho SONG ; Soon Seo PARK ; Hyo Jung KIM ; Yung Joo MIN ; Jin Hee PARK ; Sung Joon CHOE ; Jung Koon KIM ; Tae Won KIM ; Dae Yung JANG ; Je Hwan LEE ; Sung Bae KIM ; Sang Wee KIM ; Koo Hyung LEE ; Jung Sin LEE ; Woo Keon KIM
Journal of the Korean Cancer Association 1999;31(4):821-829
PURPOSE: We conducted this study to determine the efficacy of conventional treatments for patients with Hodgkin's disease and identify the patients who have poor prognosis and need high-dose chemotherapy and autologous stem cell transplantation. MATERIALS AND METHODS: Between Jun. 1989 and Dec. 1997, 50 patients were enrolled and 39 patients were evaluable. Patients were treated with radiotherapy (5 patients) or combination chemotherapy (21 patients) or combined chemotherapy and radiotherapy (13 patients) according to their disease stage. Chemotherapy regimens were C-MOPP (cyclo- phosphamide, vincristine, procarbazine, and prednisone), MOPP (mechlorethamine, vin- cristine, procarbazine, and prednisone), ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine), alternating C-MOPP/ABVD, and MOPP/ABV hybrid. Radiation therapy was performed when there was residual tumor after chemotherapy or bulky disease. The response to treatments was analyzed by clinical stage I-II and stage III-IV patients group, respectively. RESULTS: The complete response rate was 76.9% for total patients, 83.3% for stage I-II patients, and 71.4% for stage III-IV patients. Of the 30 patients achieving complete response, four (13.3%) relapsed at 6, 12, 22, and 28 months after complete response, respectively. The median follow-up duration was 24 months. Nine patients died. Four patients died of Hodgkins disease. Three-year overall survival rate was 72.9% for total patients, 72.5% for stage I-II patients, and 70% for stage III-IV patients. Two-year disease- free survival rate was 77.6% for total patients, 79% for stage I-II stage patients, and 73.9% for stage III-IV patients. The prognostic factor analysis showed that performance status affected the disease-free survival rate. CONCLUSION: Conventional treatments in patients with Hodgkins disease showed results comparable to previous studies. But we were unable to identify the patients, who need high-dose chemotherapy and autologous stem cell transplantation, because of small number of study patients and short follow up duration.
Bleomycin
;
Dimethoate
;
Disease-Free Survival
;
Drug Therapy
;
Drug Therapy, Combination
;
Follow-Up Studies
;
Hodgkin Disease*
;
Humans
;
Neoplasm, Residual
;
Procarbazine
;
Prognosis
;
Radiotherapy
;
Stem Cell Transplantation
;
Survival Rate
;
Vinblastine
;
Vincristine