2.A Stable Secondary Gliosarcoma with Extensive Systemic Metastases: A Case Report.
Tae Min CHOI ; Young Jun CHEON ; Tae Young JUNG ; Kyung Hwa LEE
Brain Tumor Research and Treatment 2016;4(2):133-137
A 63-year-old man complained of intermittent motor weakness of his arm. The magnetic resonance image (MRI) of his brain displayed a high signal lesion in right cingulate gyrus on T2 weighted image. One year later, he showed a stuporous mental status with repeated seizures, and the follow-up brain MRI showed heterogeneously enhanced mass associated with bleeding. He was treated with surgery and radiotherapy for secondary glioblastomas in right cingulate gyrus. One year more later, a mass recurred on the left frontal base, and gliosarcoma was diagnosed. After tumor resection, ventriculoperitoneal shunt, chemotherapy, and re-radiation therapy, all brain lesions were stable. Fourteen months after the diagnosis of gliosarcoma, he complained of dyspnea and back pain. Torso positron emission tomography/computed tomography revealed multiple metastatic lesions in both lungs, pericardium, pleura, liver, lymph nodes, and bones, and metastatic gliosarcoma was diagnosed. One month later, the patient died because of the systemic metastases. We present an unusual case of secondary gliosarcoma with stable brain lesions and extensive systemic metastases.
Arm
;
Back Pain
;
Brain
;
Brain Neoplasms
;
Diagnosis
;
Drug Therapy
;
Dyspnea
;
Electrons
;
Follow-Up Studies
;
Glioblastoma
;
Gliosarcoma*
;
Gyrus Cinguli
;
Hemorrhage
;
Humans
;
Liver
;
Lung
;
Lymph Nodes
;
Magnetic Resonance Imaging
;
Middle Aged
;
Neoplasm Metastasis*
;
Pericardium
;
Pleura
;
Radiotherapy
;
Seizures
;
Stupor
;
Torso
;
Ventriculoperitoneal Shunt
3.The predictive value of changes of bone markers for changes of bone mineral density in postmenopausal hormone replacement therapy with or without active vitamin D.
Hyoung Moo PARK ; Tae cheol KIM ; Kue Hyun KANG ; Sung Jun YOON ; Min HUR
Korean Journal of Obstetrics and Gynecology 2000;43(2):268-274
OBJECTIVE: To estimate the long-term skeletal responses to hormone replacement therapy(HRT) with or without active vitamin D(VD) by using short-term changes of bone markers in postmenopausal women (PMW). METHODS: Biochemical markers of bone formation(osteocalcin,OC) and (&) resorption(deoxypyridinoline, Dpd ) at 3 months & lumbar bone mineral density(BMD) at 1 year were measured in 64 natural PMW taking HRT(n=41) & HRT with calcitriol 0.25 microgram/day(n=23). The correlation of percent changes of bone markers after 3 months of Tx with those in lumbar BMD after 1 year was evaluated. RESULTS: 1. serum-OC & urine-Dpd showed decrease of 20.9% & 30.1% at 3months respectively & BMD increase of 3.8% after 1 year of Tx. 2. Among 58 PMW with decreased u-Dpd change, 49 (84.5%) revealed increase in BMD, while 40 (81.6%) among 49 PMW with decreased serum-OC change showed increased BMD. 3. Bone gainers showed significant decrease in changes of serum-OC(18.1% vs 9.2% p<0.05) & urine-Dpd(32.6% vs 20.4%, p<0.05) compared with those of bone losers. 4. No correlations of change of serum-OC (r=-0.174 p>0.05) & urine-Dpd (r=-0.091 p>0.05) at 3month with BMD changes at 1year were seen in total PMW, but urine-Dpd changes in HRT without active VD group revealed significantly inverse correlation(r=-0.376 p<0.05). CONCLUSION: Short-term changes of bone markers did not precisely predict the long-term changes of BMD in total PMW except urine- Dpd in HRT without active VD.
Biomarkers
;
Bone Density*
;
Calcitriol
;
Estrogen Replacement Therapy*
;
Female
;
Humans
;
Osteocalcin
;
Vitamin D*
;
Vitamins*
4.Effect of Esmolol on Cardiovascular Responses to Extubation.
Ju Tae SOHN ; Hyeun Jun CHUN ; Min Gyu WOO
Korean Journal of Anesthesiology 1995;28(4):520-527
Transient increases in blood pressure and heart rate(HR) at the end of anesthesia and during extubation are common. Tomori and Widdicombe observed that mechanical stimulation of four areas of the upper respiratory tract (nose, epipharynx, laryngopharynx, tracheobnchial tree) induced reflex cardiovascular responses associated with enhanced neuronal activity in the cervical sympathetic efferent fibers. In susceptible patients, even this short period of hypertension and tachycardia can result in myocardial ischemia or increased intracranial pressure. The purpose of present study was to evaluate the effect of esmolol in attenuating cardiovascular responses to extubation under general anesthesia with endotracheal intubation. A sixty healthy patients who underwent elective noncardiac operation under general anesthesia (N2O-O2-enflurane) with endotracheal intubation were randomly divided into two groups : one was placebo group that received intravenous injection of 0.1 cc/kg normal saline, the other was esmolol group that received intravenous injection of 1 mg/kg esmolol. Extubation was performed when the patients could breathe spontaneously and open their eyes on command. In practice extubation was done between 2 and 4 minutes after drug(esmolol or saline) injection. The measurement of systolic blood pressure and heart rate was obtained one minute before extubation and every minute for 5 minutes after extubation, then rate-pressure product was calculated. The results were as follows; 1) When compared to pre-extubation systolic blood pressure, systolic blood pressure for 2 minutes after extubation in both groups increased significantly but systolic blood pressure was more rapidly returned to pre-extubation level in the esmolol group than in the placebo group. When compared to pre-extubation systolic blood pressure, after extubation the number of patients in whom systolic blood pressure increased more than 20% was significantly fewer in the esmolol group than in the saline group. 2) When compared to pre-extubation heart rate, heart rate at 1 minute after extubation in the placebo group increased significantly but heart rate after extubation in the esmolol group did not change significantly. 3) When compared to pre-extubation rate-pressure product, rate-pressure product for 2 minutes after extubation in both group increased significantly. At 4 minutes after extubation, rate-pressure product in the saline group increased significantly when compared to rate-pressure product in the esmolol group. These results suggest that intravenous injection of 1 mg/kg esmolol before extubation blocks heart rate elevation following extubation under general anesthesia and is effective for rapid return to the pre-extubation level of systolic blood pressure.
Anesthesia
;
Anesthesia, General
;
Blood Pressure
;
Heart
;
Heart Rate
;
Humans
;
Hypertension
;
Hypopharynx
;
Injections, Intravenous
;
Intracranial Pressure
;
Intubation, Intratracheal
;
Myocardial Ischemia
;
Neurons
;
Reflex
;
Respiratory System
;
Tachycardia
5.Extraskeletal Cervical Epidural Ewing's Sarcoma: Case Report and Review of the Literature .
Jong Tae KIM ; Dong Sup CHUNG ; Young Min HAN ; Young Sup PARK ; Jun Ki KANG
Journal of Korean Neurosurgical Society 2002;32(1):48-51
A patient with extraskeletal cervical epidural Ewing's sarcoma who presented with cervical radiculopathy is reported. A 58-year-old woman presented with right posterolateral neck pain and upper extremity radiculopathy. The computed tomography myelography showed epidural and paravertebral masses on right side, with widening of the ipsilateral neural foramina at the C2-C3 level. On magnetic resonance images, the mass was isointense to soft tissue on T1-weighted images, hyperintense on T2-weighted images, and showed diffuse enhancement on GdTA enhanced T1-weighted images. The staged, combined posterior and anterior approach were done and the tumor mass was subtotally removed. During postoperative adjuvant chemotherapy with Cytoxane, Adriamycin, Vincristine, Prednisolone regimen, the patient died of severe compression of upper cervical cord by recurrent, extended tumor mass in the spinal canal.
Chemotherapy, Adjuvant
;
Cyclophosphamide
;
Doxorubicin
;
Drug Therapy
;
Female
;
Humans
;
Middle Aged
;
Myelography
;
Neck Pain
;
Prednisolone
;
Radiculopathy
;
Sarcoma, Ewing*
;
Spinal Canal
;
Upper Extremity
;
Vincristine
6.An epidemiological evaluation on the sexual partner in sexually transmitted diseases.
Kyung Min JUN ; Jae Hong KIM ; Young Suck RO ; Young Tae KIM
Korean Journal of Infectious Diseases 1992;24(3):153-160
No abstract available.
Humans
;
Sexual Partners*
;
Sexually Transmitted Diseases*
7.Spontaneous Ruptured Subcapsular Liver Hematoma Associated with Pregnancy.
Min Whan KOH ; Sung Jun PARK ; Kang Hyuk LEE ; Young Jin JANG ; Tae Hyung LEE
Korean Journal of Obstetrics and Gynecology 2000;43(1):95-98
Spontaneous rupture of subcapsular liver hematoma in pregnancy is rare but potential life threatening complication of preeclampsia. We experienced a case of spontaneous rupture of subcapsular hematoma of liver that was treated with conservative method. So, we present the case with a brief review of literatures as first report in Korea.
Hematoma*
;
Korea
;
Liver*
;
Pre-Eclampsia
;
Pregnancy*
;
Rupture, Spontaneous
8.BCGitis of scrofuloderma-like lesions.
Kyung Min JUN ; Chang Woo LEE ; Young Tae KIM ; Jae Hong KIM
Korean Journal of Dermatology 1991;29(2):233-236
A 13-year-old male presented with a walnut-size tender swelling of the left supraclavicular area. The lesion developed 4 months after BCG vaccination in a left. upper arm location. The supraclavicular lesion gradually increased in size and became suppurative witii resultant sinus formation. Histopathological examination of the nodular lesion showei3 foci of epithelioid granulomas with caseation necrosis, and several Langhans' type giant cells. After a diagnosis of BCGitis was made, the patient was, treated with isoniazid an l rifampin for two months without much benefits. Surgical excision of the lesion were performed to expedite clinical regression. After six months of antituherculous chemctherapy, a clinical remission was evident. Scrofuloderma-like BCGitis as well as other cutaneous complications of BCG vaecination are not uncommon. Thus, the practicing dermatologist should be aware of these complications, for correct diagnosis and treatment.
Adolescent
;
Arm
;
Diagnosis
;
Giant Cells
;
Granuloma
;
Humans
;
Isoniazid
;
Male
;
Mycobacterium bovis
;
Necrosis
;
Rifampin
;
Vaccination
9.Two Cases of Extrapelvic endometriosis following Laparoscopy-assisted vaginal hysterectomy and Cesarean section.
Jei Jun BAE ; Mi Sun LIM ; Min Whan KOH ; Tae Hyung LEE ; Mi Jin KIM
Yeungnam University Journal of Medicine 2007;24(1):91-96
Extrapelvic endometriosis is a rare disease. The majority of extrapelvic endometriosis cases involve scar tissue following obstetric and gynecologic procedures. We have treated two cases of extrapelvic incisional endometriosis. A 39 year old female patient with cyclic vaginal spotting after laparoscopic assisted vaginal hysterectomy due to uterine myoma and a 35 year old female patient with a painful palpable abdominal mass after cesarean section. Both underwent complete excision and were proven to have endometriosis by pathology. Here we report on both cases and review the medical literatures.
Adult
;
Cesarean Section*
;
Cicatrix
;
Endometriosis*
;
Female
;
Humans
;
Hysterectomy, Vaginal*
;
Leiomyoma
;
Metrorrhagia
;
Pathology
;
Pregnancy
;
Rare Diseases
10.A case of penetrating injury into the ethmoid and skull base by aliner metallic foreign body.
Chul Min PARK ; Wan Suk JUN ; Sung Tae HONG ; Jae Seon LIM
Korean Journal of Otolaryngology - Head and Neck Surgery 1992;35(5):737-740
No abstract available.
Foreign Bodies*
;
Skull Base*
;
Skull*