The pattern of DNCB (2, 4-dinitrochlorobenzene) oral desensitization and its antigenic specificity were investigated in guinea pigs. In search of antigenic specificity of DNCB oral desensitization, animals were fed oxazolone (4-ethoxymethylene-2- phenyl-oxazol-5-one) in a DNCB presensitized group, and conversely, DNCB fed in an oxazolone presensitized group. For the study of the pattern of oral desensitization, guinea pigs were initially sensitized to DNCB and followed by feeding of DNCB for 6 days, and challenged on the 13th, 21st, 29th, 37th and 45th days after sensitization. Oxazolone feeding in DNCB presensitized guinea pigs had no effect on the development of the fully responsive DNCB contact sensitivity (72. 85g), and DNCB feeding in oxazolone pre-primed animal had no effect on the development of oxazolone contact sensitivity (79. 37g). On the contrary, oxazolone feeding in DNCB preprimed guinea pigs and DNCB feeding in oxazolone pre-primed resulted in, respectively, oxazolone and DNCB oral tolerance (44.44% p < 0.01 & 42.06%p<0.01). The effect of desensitization appeared even one day before the completion of 6 days' feeding and the efficacy lasted about 30 days by the natural waning of contact sensitivity.
Animals ; Dermatitis, Contact ; Dinitrochlorobenzene* ; Epitopes ; Guinea Pigs* ; Guinea* ; Oxazolone

Marjolin is ulcer may be defined briefly as a cancer arising in a bum scar. A 41-year-old female had a Marjolin is ulcer(12x10x3cm) on her right lower leg. This ulcerated tumor has been present for two and half months and the induction period sinnc her bum was 29 years. The pathologic diagn.osis was squamous cell carcinoma, grade 2. Roentgenograms of her right lower leg revealed several soft tissue masses densities which, in part, horizontally connected with the periosteum of the tibia. So she was treated by above-knee amputation with dissection of several, unenlarged inguinal nodes which showed no evidence of metastases. She developed large, single, fixed metastatic node in right inguinal area one month after amputation and dissection was done.
Adult ; Amputation ; Carcinoma, Squamous Cell ; Cicatrix ; Female ; Humans ; Leg ; Neoplasm Metastasis ; Periosteum ; Tibia ; Ulcer*

Ofloxacin, one of the new quinolone derivatives, is found to be highly effective against both PPNG and non-PPNG urethritis. The objective of this trial was to establish the efficacy of two ofloxacin regimens in the treatment of uncomplicated male gonococcal urethritis. A total of 138 patients with uncomplicated gonococcal urethritis seen at the VD Clinic, Choong-Ku Public Health Center, in Seoul in the period of March Jun 1988, were subjected to this study. The patients were divided randomly into two groups and assigned to one of two treatment regimens of afloxacin, 400mg, PO and 200mg, PO, twice a day for 2 days. No failure case was seen in both groups. Both of these ofloxacin regimens were found to be highly effective and safe in the treatment of gonococcal urethrithis. It is suggested that, because of high rate of PPNGs among circulating N. gonorrhoeae, they can be recommended as the first line treatment for gonorrhea in Korea.
Gonorrhea ; Humans ; Korea ; Male* ; Ofloxacin* ; Public Health ; Seoul ; Urethritis*

Benzoyl peroxide has been known to have bacteriostatic activity against Corynebacterium acnes and to have comedolytic action in patients with acne vulgaris. The present study was undertaken to evaluate the therapeutic effect of Renoxal, a 5% benzoyl peroxide lotion, in patients with acne vulgaris. A total of 35 patients entered this study at the Department of Dermatology, Seoul National University Hospital during the five months period from March to July, 1978. All patients were instructed to apply Benoxal on their affected sites once or twice daily; and the number of lesions on three fixed areas were counted before and every week for four weeks after the treatrnent. Two female patients stopped the application due to developrnent of contact dermatitis to Benoxal The results observed in the 33 patients were as follows: 1. The percentage decrease in total number of lesions in four weeks after treatment was 51.1% 2. Closed and open comedones were gradually eliminated; and their numbers were decreased in four weeks after treatment by 45. 8% and 55. 3% respectively. The papules were decreased. by 59. 1 @2 after the first week of treatment, but showed. a transient lag around tbe second week and then marked 61. 5% in four weeks after treatment. 3. Observed side effects included burning sensation,(3 cases), tightness (3 cases), itching sensation (2 cases) and scaling (1 case). All were tolerable without any specific measure or discontinuance of the application. The authors concluded througb this experiment that Benoxal (5% benzoyl peroxide lotion) is a very effective local therapeutic agent in the treatment of acne vulgaris patients.
Acne Vulgaris* ; Benzoyl Peroxide ; Burns ; Dermatitis, Contact ; Dermatology ; Female ; Humans ; Propionibacterium acnes ; Pruritus ; Sensation ; Seoul ; Thiram

Bezoyl peroxide, a powerful oxidizing agent, has been uaed topically in the treatment of acne vulgaris as a cream or lotion and has been shown to he effective for this codition. In 1972 Fulton emphaaized the importance of the vehicles used to obtain. maximum potential of benzoyl peroxide and for this, the gel formulation has been examined in many clinical trials. The present study was undertaken to evaluate the therapeutic effect of Fanoxyl 2.5, a 2.5% . benzayl peraxide gel, in patients with acne vulgaris. A total of 31 patients entered this study at the Departrnent of Dermatology, Jeoul National University Hospital rluring 3 rnanths period, from Decemher, 1978 through February, 1979, All patienta were instructed to apply Fanoxyl 2.5' on their affected areas once or twice a day and the nurnber of lesions on two or three t fixed areas were counted before and onee weekly after initation of the treatment. The reaults observed in the 3I patients were as follaws; 1. The percentage decrease in total nurnber of lesions in 4 weeks after treatment was 56.9%. 2. The authors could follow up for 6 weeks in 6 cases. In 6 case, the mean percentage in total number of lesions in 6 weeks after treatment was 81.7%. 3. Clesed and open eomedones were gradually eliminated; and their numbers were decreased in 4 weeks after treatment by 46.5% and 56.8% respeetiveIy. The papules were rapidly eliminated and their numbers were decreased in 4 weeka, after treatment by 79.8%. 4. Although most patients felt a mild burning sensation and tightness at the begining of the treatment, only a minority of the patients complained of discomfort due to pain(l case), erytherna(l case), tightness(2 cases),burning sensation (1 case), scaling(1 case). But all were tolerable without taking any specific measures or discontinuance of application. In one case, contact dermatitis developed after 4 weeks treatment. The authors concluded through this experiment that Panoxyl 2.5' (2.5% benzoyl peroxide gel) is a very effective local therapeutic agent in the treatment of acne vulgaris patients.
Acne Vulgaris* ; Benzoyl Peroxide* ; Burns ; Dermatitis, Contact ; Dermatology ; Follow-Up Studies ; Humans ; Sensation

BACKGROUND: The nevus of Ota is a benign dermal melanocytic lesion that was previously proved difficult to treat. Recently, the Q-switched ruby laser and Q-switched Nd: YAG laser have been reported to by, successful in the treatment of benign pigmented lesions and tattos. OBJECTIVE: Our study evaluates the treatment of 60 patients with nevus of Ota with Q-switched Nd: YAG lase (l064nm). METHOD: Sixty patients with nevus of Ota were treated by the Q-switched Nd: YAG laser with pulse width 10nsec, and energy fluences ranging from 5.8 to 12J/cm and the laser repetition rate was 5 or 10Hz. The response to treatment was assessed by four independent investigators with photographs. RESULTS: 1. Total therapeutic effects of Q-switched Nd: YAG laser showed excellent result in 23.3%, good in 45%, fair in 18,3%, and poor in 13.3%. 2. Therapeutic effects by distribution proposed by Tanino showed excellent or good results in 84.6% at type Ia, 78.6% at, type Ib, 66.7% at type II, 60% at type III and 45.5% at type N. 3. Therapeutic effects by the number of treatments showed excellent or good results in 22.2% of patients after one treatment, 72.7% after two treatments, 93.3% after three treatments and 100% after four treatment. 4. Therapeutic effects by energy showed excellent or good results in 9.2% at energy range of 10 to 12J/arl and 66.6%, at energy range of 5.8-9.5J/cm. 5. Complications included transient hyperpigmentation (6.7% ), secondary bacterial infection (1.7 %), hypopigmentation (1.7%) and atrophic scar (1.7%). However these subsided spontaneously in a year. 6. The recurrence rate was 2.4%. CONCLUSION: The Q-switched Nd: YAG laser is a very effective mode of treatment for nevus of Ota which has provent unresponsive to other therapeutic modalities.
Bacterial Infections ; Cicatrix ; Humans ; Hyperpigmentation ; Hypopigmentation ; Lasers, Solid-State* ; Nevus of Ota* ; Nevus* ; Recurrence ; Research Personnel

An important concern in treatment for gonorrhea is the high frequency of coexisting chlarnydial and gonococcal infections. But there is difficulty in the diagnosing chlamydial infection. And so, CDC recommends epidemiological treatment, of both gonorrhea and non-gonococcal urethritis in the gonorrheal treatment in order to prevent post-gonococcal urethritis(PGU), A total of 140 male patients with uncomplicated gonococcal urethritis at the VD clinic, Choong-ku Publir. Health Center, in Seoul during December, 1987 February, 1988 were subjected to this study. The patients treated with kanamycin(KM), 2g and aqueous penicillin G(ACPG) 8 million units imaccompanied by probenecid(BEN) 1g by mouth. This combination regimen showed good effect in the treatment of gonococcal urethritis (failure rate 4.2% ). After gonorrheal treatment, the patients were divided randomly into group A and group B. In the group A, adminstrated with doxycycline monohydrate, 100mg, by mouth two times daily for 7 days, 44 and 29 patients were followed at 7th and 14th day after gonorrheal treatment. In the group B, administrated with placebo, 1 tablet, by mouth two times daily for 7 days, 49 and 39 patients were followed at 7th and 14th day after gonorrheal treatment. The PGU incidences were 27.3%(12/44), 20.7%(6,'29) in the group A and 55. 1%(27,'49), 53.8(21/39) in the group B at 7th and 14th day after gonorrheal treatment. Conclusively, eoncornitant administration of doxycycline monohydrate, 100mg, by mouth two times daily for 7 days with gonorrheal treatment lowered PGU significantly.
Centers for Disease Control and Prevention (U.S.) ; Doxycycline ; Gonorrhea ; Humans ; Incidence ; Male* ; Mouth ; Penicillins ; Seoul ; Urethritis*

No abstract available.
Acne Vulgaris*

PURPOSE: To analyze the effectiveness of a two-stage revision surgery for an infected total hip arthroplasty. MATERIALS AND METHODS: Between 1988 and 2005, twenty-four patients (24 hips, 18 males, 6 females) with documented infection of total hip arthroplasty were reviewed and followed for at least two years postoperatively. The preoperative and postoperative clinical and radiologic findings and blood laboratory work were compared. Eight arthroplasty cases were performed through retention of the femoral stem and removal of the acetabular cup with cementing by impregnated antibiotics in the first stage of the operation, and subsequent acetabular cup revision in the second stage of the operation. RESULTS: After the first stage of the operation, infectious organisms were cultured in 19 patients, and isolated Staphylococcus aureus was cultured in 14 patients. The mean follow-up period was 8.2 years, and the average Harris hip score improved to 88.4 points at last follow-up. Radiologic osteolysis was noted in 5 cases, and possible loosening was demonstrated in 1 case. The erythrocyte sediment rate (mm/hr) and C-reactive protein (mg/L) were 43.8/14.2 preoperatively and 17.9/8.3 postoperatively. There were 2 recurrences of infection, for an eradication rate of 91.7% (22 of 24). CONCLUSION: Two-stage revision for an infected total hip arthroplasty proved to be an excellent method with a high eradication rate.
Anti-Bacterial Agents ; Arthroplasty ; C-Reactive Protein ; Erythrocytes ; Follow-Up Studies ; Hip ; Humans ; Male ; Osteolysis ; Recurrence ; Retention (Psychology) ; Staphylococcus aureus

PURPOSE: Flavobacterium indologenes is known to cause keratitis very rarely. Authors have experienced 1 case of keratitis from Flavobacterium indologenes with history of diabetes mellitus, thereby reporting it. METHODS: History taking, slit lamp examination, staining and culture, sensitivity test about antibiotics were performed on 1 case of keratitis. RESULTS: Flavobacterium indologenes was detected in staining and culture that was performed on the first visit. Piperacillin was used based on the sensitivity test about antibiotics. Improvement of corneal lesion and symptom was observed with the use of piperacillin. CONCLUSIONS: Flavobacterium indologenes can be considered as a casual pathogen in keratitis with condition susceptible to opportunistic infection such as systemic illness or abnormal ocular immunity.
Anti-Bacterial Agents ; Diabetes Complications ; Diabetes Mellitus ; Flavobacterium* ; Keratitis* ; Opportunistic Infections ; Piperacillin