No abstract available.
Fibronectins* ; Wound Healing* ; Wounds and Injuries*

Lichen planus is a common, usually intensely pruritic papulosquamous dermatosis with unknown etiology, which may involve the skin, mucous membranes, hair follicles, and nails. Its lesions are usually a localized form but generalized ones are an unusual presentation of lichen planus. We report herein three cases of generalized lichen planus in one male and two female patients, which was diagnosed on clinical and histopathological examinations in all cases.
Female ; Hair Follicle ; Humans ; Lichen Planus* ; Lichens* ; Male ; Mucous Membrane ; Skin ; Skin Diseases

No abstract available.
Blepharoptosis* ; Orbit*

Thyroid dysfunction has heen reported as a side effect of alpha-interferon(IFN) therapy. The incidence of thyroid disorders was 1.2-12%' duripg 1FN therapy for chronic active hepatitis. We experienced a case of hypothyroidism developed after IFN therapy in a 48 year-old man with chronic hepatitis B. Baseline thyroid function before IFN therapy was normal and thyroid auioantibodies were also negative. High tiers ol' antimicrosomal antibody and anti-thyroglobulin antibody appeared and severe hypothyroidism followed at 6 months after starting the IFN therapy.
Hepatitis B, Chronic* ; Hepatitis, Chronic* ; Humans ; Hypothyroidism* ; Incidence ; Interferon-alpha* ; Middle Aged ; Thyroid Gland

BACKGROUND: Evaluation of the cell proliferation activity of neoplasm is useful in making a diagnosis and prognosis. Immunohistochemical staining using MIB1 monoclonal antibodies has recently been demonstrated to assess tumor cell proliferation activity easily, because it can be performed on paraffin-embedded specimens and is available in a retrospective study. OBJECTIVE: The purpose of this study to investigate (a) the use of Ki-67 antibodies in distinguising between benign melanocytic nevus and malignant melanoma, and (b) the correlation between the Ki-67 labelling index(positive number per 100cells) and histological parameters such as the Breslow index, Clarks level, mitotic rate(mitoses per 100cells) in malignant melanoma. METHOD: A total of 37 formalin-fixed, paraffin-embedded melanocytic skin lesions(benign melanocytic nevus 21; malignant melanoma 16) were stained with MIB1 using the one hour method. The values of the Ki-67 labelling index were measured in all the lesions. For each case of malignant melanoma, the Breslow index, Clarks level and mitotic rate were quantitatively evaluated. RESULT: The Ki-67 labelling index averaged 2.6 +1.4 in benign melanocytic nevus and 22.4+ 6.2 in malignant melanoma. In malignant melanoma, the values of the Ki-67 labelling index were significantly correlated with Breslow index(r=0.764), Clark's level(r=0.885) and mitotic rate(r=0.754). CONCLUSION: Our findings suggest that Ki-67 may be a useful tool in distinguising between benign melanocytic nevus and malignant melanoma. According as Ki-67 labelling index correlates with well-established prognostic parameters(Breslow index, Clark's level, mitotic rate), it may therefore carry additional prognostic value for patients with malignant melanoma.
Antibodies ; Antibodies, Monoclonal ; Cell Proliferation ; Diagnosis ; Humans ; Ki-67 Antigen* ; Melanoma ; Nevus, Pigmented ; Prognosis ; Retrospective Studies ; Skin*

Malignant melanoma is a relatively rare tumor. It represents 1.4-15.7% of all malignant tumors. Melanin-containing cells are normally found in the pia mater of adult human subjects. A wide variety of disorders ranging from a simple increase in normal leptomeningeal pigmentstion to highly malignant melanoma may be encountered. However, whether benign or malignant, primary melanoma of the nervous system are extremely rare. The diagnosis was confirmed by operation and biopsy. This case, which we have experienced recently, is reported with a review of the literatures.
Adult* ; Biopsy ; Diagnosis ; Humans ; Melanoma ; Nervous System ; Nevus* ; Pia Mater

Objectives: The purpose of this study was to analyze several factors affecting the efficacy of epidural steroid injections as a nonoperative treatment modality in lumbar disc herniation patients.Summary of Literature Review: Despite several studies, the normal course of intervertebral disc herniation is not fully understood, and the optimal timing of surgery is unclear. Methods: From January 2017 to April 2019, among outpatients in our hospital, 64 patients diagnosed with 3-4 or 4-5 single-level lumbar disc herniation and followed up for at least 6 weeks were included. Epidural steroid injection was performed in all patients during their 1-week admission. Symptoms improved in 36 patients (group 1) and persisted or recurred in 28 patients (group 2), who were finally treated surgically. Demographic factors, magnetic resonance imaging findings, and clinical assessments were analyzed. Results: The only demographic factor with a significant difference between groups was symptom duration. In magnetic resonance imaging, significant differences were found in disc sequestration and the degree of the herniated disc. At 6 weeks after the injection, significant differences were found between the 2 groups in visual analog scale scores and the Korean version of the Oswestry Disability Index. Conclusions Several factors must be considered when treating patients with lumbar disc herniation. Of note, longer symptom duration was found to be associated with a lower effectiveness of conservative treatment. The effects of treatment could also be influenced by the disc form and the degree of disc herniation.

We report a case of trichilemmal catcinoma in a 79-year-old woman presentde an atrophic scar remaining after excision of a recurrent nodule on the right mandibular area, Her past history revealed that there had been a painful pea-sized brownish nofule on the same site for two years. Eleven months before presentation, it had been excised but recurred 9 months later. Histopathologic findings showed a clear cell neoplasm with trichilemmal keratinization. The tumor cells showed PAS-positive cytoplasm and cytologic atypia with a few mitoitic figures. Immunohistochemical staining for high molecular weight cytokeratin was positive but carcinoembryonic antigens and epithelial membrane antigens were all negative. To our knowledge this is the first report of trichilemmal carcinoma in Korea.
Aged ; Carcinoembryonic Antigen ; Cicatrix ; Cytoplasm ; Female ; Humans ; Keratins ; Korea ; Molecular Weight ; Mucin-1

Some intracranial masses are usually treated following a presumptive diagnosis based on the clinical picture and neurological studies but in some instances a proven histological diagnosis might alter the method of treatment as well as affect the prognosis. Open surgical biopsy however might cause serious neurological deficit in many of these patients however a stereotaxic approach might avoid such problems. For the correct three dimensional target localization on CT scan we developed nearly artifact free simplified CT interface frame that accurately interface between the CT scanner and the stereotasic instrument makes it possible to take biopsies at exact and with low risk. In 10 patients CT interfaced stereotaxic biopsy of brain lesions were performed. 100% accurate histological diagnosis was obtained and helped considerably in planning further therapy. The localization error was less than 0.04mm and no significant complications occured in these patients.
Artifacts ; Biopsy* ; Brain* ; Diagnosis ; Diagnosis, Differential* ; Humans ; Prognosis ; Tomography, X-Ray Computed

The tethered cord syndrome is a clinical entity manifested by progressive motor and sensory changes in the legs, incontinence, back or leg pain, and scoliosis in young children. Based on remarkable neurological improvement after release of cord tension by sectioning the filum, it might be concluded that the neurological deficit was effected by cord tethering. The main objective of this experiments was to elucidate the pathophysiology involved in the tethered cord by observing the effect of tethered cord on regional spinal cord blood flow(rSCBF) and somatosensory evoked potentials(SEPs) and define a threshold relationship between SEP and rSCBF. Thirty adult cats, weighing 2.7 to 4.2kg were used in this study. The cats were divided into three groups as follows: Control group=non-tethered(10 cats), 5g-traction group=cord traction with 5g weight(10 cats). 10g-traction group=cord traction with 10g weight(10 cats). The rSCBF and SEP measurements were performed immediately after cord traction in each animal, at 30, 60, 90, 120 minutes and the final rSCBF at 3 hours by the hydrogen clearance technique. The results obtained were as follows: 1. Traction and resulted in a reduction of flow to 30%(6.0+/-1.4ml/100g/min) of normal control spinal cord flow(18.2+/-1.6ml/100g/min) at adjacent area of traction(L1) in 5g-traction group and 18%(3.5+/-0.7ml/100g/min) of normal control flow in 10g-traction group during the cord traction for 3 hours. 2. From 30 minutes to 3 hours following the cord traction, there was a tendency toward marked reduction of the blood flow at the adjacent area(L1, T10) in 10-traction group. 3. The rostral area of spinal cord away from traction was less influenced in a reduction of blood flow following the cord traction. 4. A close correlation was found between spinal evoked potentials and flow suggesting a threshold relationship. 1) The SEP was present shortly after traction though marked by altered in shape and suppressed. 2) The SEP responses progressively decreased in latency at the adjacent distal area of the cord during traction, however less changed in shape at the rostral area of the cord. 3) The SEP suppressed in shape if the blood flow in spinal cord was below 14ml/100g/min. 4) The neuronal dysfunction caused by tethered cord could be due to impairment of blood flow. It is assumed that prolonged neuronal dysfunction may lead to structural damage of the neuron.
Adult ; Animals ; Cats* ; Child ; Evoked Potentials ; Humans ; Hydrogen ; Leg ; Neural Tube Defects ; Neurons ; Scoliosis ; Spinal Cord* ; Traction