Astrocytes are the most numerous cellular elements in the cerebrum, and they normally have a very slow turnover rate. But during regeneration after injury, they proliferate markedly resulting in astrogliosis. The extracellular matrix in the central nervous system is present in the vessel walls and in the external glia limitans as a basal lamina. The presence of an intact extracellular matrix framework is important in regeneration after injury. Understanding the properties of astrocytic proliferation will be helpful to find out new treatment for functional recovery in the central nervous system. In this study, after cryogenic injury was performed on the cerebral cortex in rats, changes in astrocytes and the extracellular matrix were observed using light microscopy, immunohistochemical stain for glial fibrillary acidic protein(GFAP), proliferating cell nuclear antigen(PCNA), fibronectin, laminin, and type IV collagen, autoradiography and electron microscopy. The results were as follows; 1) The coagulative necrosis, which followed cryogenic injury on the cerebral cortex was healed, forming a new pia mater above the lesion. 2) Some of the PCNA positive cells were astrocytes and some of the GFAP positive cells showed a positive reaction to PCNA. 3) Proliferating astrocytes labelled by autoradiography or immunohistochemical stain for PCNA reached maximal numbers 3days after the injury and they were no longer found 2 weeks after injury. 4) In autoradiography with immunohistochemical stain for GFAP, about 1% of GFAP positive astrocytes were labelled by autoradiography and in double immunohistochemical stain for PCNA and GFAP, about 8-16% of GFAP positive astrocytes were also stained by PCNA. 5) In immunohistochemical stain for fibronectin, laminin and type IV collagen, laminin and type IV collagen were present in the newly formed blood vessel walls and fibronectin showed a diffuse positive reaction within the lesion. The new pia mater was formed within 2 weeks after the injury. 6) On electron microscopic examination, basal lamina material was found in the vessel wall 1 week after the injury and at 2 weeks, a nearly complete and continuous basal lamina was formed although the thickness was uneven. According to these findings, astrocytes in the cerebral cortex of adult rats proliferate very early in the regenerative period after cryogenic injury. At 2 weeks after the injury, this regeneration ceases and the damaged basal lamina of pia mater and vessel wall were reconstituted.
Adult ; Male ; Female ; Humans ; Rats ; Animals

A 66 year old man with history of dizziness and occasional headache for a month was found to have right subclavian steal syndrome confirmed by angiogram. Right radial pulse is very weak. Blood pressure on left is 130/70mmHg and on right 70/50. Marked Bruits are audible on right side of neck and shoulder area.
Aged ; Blood Pressure ; Dizziness ; Headache ; Humans ; Neck ; Shoulder ; Subclavian Steal Syndrome*

A 66 year old man with history of dizziness and occasional headache for a month was found to have right subclavian steal syndrome confirmed by angiogram. Right radial pulse is very weak. Blood pressure on left is 130/70mmHg and on right 70/50. Marked Bruits are audible on right side of neck and shoulder area.
Aged ; Blood Pressure ; Dizziness ; Headache ; Humans ; Neck ; Shoulder ; Subclavian Steal Syndrome*

The purpose of this study was to evaluate the prevalence rate of low back pain (LBP) in the high school students and to analyze the differences and correlations with the spinal-pelvic structural variations and disability index with LBP. The subjects are 499 high school students (236 males, 263 females: mean age, 16.38 years). They were assessed for LBP with the numerical rating scale (NRS) and for disability with the Korean version Oswestry disability index (KODI). All subjects were to take the plain radiographic examination for spinal-pelvic structural variations including thoracic, lumbar, thoracolumbar Cobb's angle, lumbar lordotic curve, sacral slope, pelvic tilt and pelvic incidence. All subjects were divided into two groups by NRS scores (0, 1=no/minimum pain group [NMP group], 2-10=low back pain group [LBP group]). The prevalence rate of LBP of all subjects was 56.7% (n=283). NRS and total KODI scores were higher in the LBP group (3.38 cm/11.83%) than NMP group (0.07 cm/2.74%) (p<0.001). In the spinal-pelvic structural variations analysis, the thoracic Cobb's angle was significantly high in LBP group (p<0.05), but others were shown no differences between the both groups (p>0.05). NRS had significantly positive correlation with KODI (p<0.001). NRS and KODI did not demonstrate any correlations with spinal-pelvic structural variations (p>0.05). In conclusion, this study showed high prevalence rate of LBP in the high school students, but did not show significant correlations with the spinal-pelvic structural variations and disability index.
Back Pain ; Female ; Humans ; Incidence ; Low Back Pain* ; Male ; Prevalence

The aim of this study was to analyze long-term survivals in patients with stage IB to IIA cervical cancer treated by neoadjuvant chemotherapy setting. Between February 1989 and January 1998, 94 women with previously untreated stage IB to IIA carcinoma of the uterine cervix who received cisplatin based neoadjuvant chemotherapy were enrolled in this study. All of patients with chemoresponse (complete response, n=15; partial response, n=47) and 16 patients with chemoresistance received radical surgery (RS group). The other 16 patients with chemoresistance received radiotherapy for definite treatment (RT group). In the RS group, the 10 yr survival estimation in patients with bulky tumors (diameter > or =4 cm, n=26) was similar to that with non-bulky tumors (83.3% vs. 89.3%, p=NS). In selected patients with chemoresistance, those treated by radiotherapy (n=16) showed significantly poorer survivals than those treated by radical surgery (n=16) [10 yr survival rates of RT (25%) vs. RS (76.4%), p=0.0111]. Our results support that a possible therapeutic benefit of neoadjuvant chemotherapy plus radical surgery is only in patients with bulky stage IB to IIA cervical cancer. In cases of chemoresistance, radical surgery might be a better definite treatment option.
Uterine Cervical Neoplasms/drug therapy/*radiotherapy/*surgery ; Treatment Outcome ; Survival Analysis ; Retrospective Studies ; Prognosis ; Neoplasm Staging ; Multivariate Analysis ; Middle Aged ; Humans ; Follow-Up Studies ; Fluorouracil/administration & dosage ; Female ; Drug Resistance, Neoplasm ; Combined Modality Therapy ; Cisplatin/administration & dosage ; Chemotherapy, Adjuvant ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Adult

PURPOSE: The purpose of this study is to analyze the intervention studies for married immigrant women. METHODS: Based on inclusion criteria, 45 articles published from 2006 to 2011 were reviewed and analyzed. RESULTS: Among the total amount of studies, 77.8% have been conducted since 2009; and 46.7% of them were for a master's thesis, 11.1% were for a doctoral thesis, and 42.2% were journal articles. Most of them were quantitative research (77.8%) and 71.1% were conducted in urban areas. The most frequently conducted intervention was art therapy (35.6%), whereas 6.7% was health education. In total, 104 outcome indicators were used with 57 (54.8%) in the mental health domain, 29 (27.9%) in the social health domain, and 18 (17.3%) in the physical health domain. The most commonly used outcome indicator was self-esteem (23.2%), and the next, in the order of frequency, included self-efficacy (23.2%), acculturative stress (21.4%), and depression (10.7%). CONCLUSION: Most intervention studies were conducted to support the sociocultural adaptation of married immigrant women, while few intervention studies were conducted to support the health of married immigrant women. To promote the health and quality of life of married immigrant women, many health related intervention programs should be undertaken.
Art Therapy ; Depression ; Emigrants and Immigrants ; Female ; Health Education ; Humans ; Clinical Trial ; Mental Health ; Quality of Life

PURPOSE: To assess the performance of the dynamic contour tonometer (DCT) in eyes undergoing excimer laser photorefractive keratectomy (PRK). METHODS: Intraocular pressure (IOP) was measured in 30 eyes after first time excimer laser PRK pre and three months post operatively using Goldmann applanation tonometer (GAT), noncontact air tonometer (NCT), and the DCT. RESULTS: There was significant correlation between central corneal thickness (CCT) and IOP measurements by GAT and NCT (CCT vs GAT: r2=0.31, p<0.01, CCT vs NCT: r2=0.39, p<0.01). However, the correlation between CCT and IOP measurements by DCT was not significant (CCT vs DCT: r2=0.14, p=0.32). After PRK, the mean change in CCT and IOP measurements using GAT, NCT, DCT were 73.70+/-26.92 micrometer (mean+/-SD), 2.43+/-2.86 mmHg (p<0.01), 3.83+/-2.34 mmHg (p<0.01) and 0.44+/-1.51 mmHg (p=0.125), respectively. The preoperative and postoperative DCT measurements did not differ significantly. CONCLUSIONS: The reduction in CCT induced by PRK doesn't appear to influence DCT measurements; therefore, DCT may be better suited over GAT or NCT for monitoring IOP in eyes that underwent refractive surgery.
Eye ; Intraocular Pressure ; Lasers, Excimer ; Peptides ; Photorefractive Keratectomy ; Refractive Surgical Procedures

PURPOSE: This study was conducted to investigate nursing students' knowledge and beliefs about Kangaroo care (KC). METHODS: A cross-sectional descriptive design was used. Undergraduate students enrolled in departments of nursing (n=322) from three universities in D city participated. Knowledge and beliefs about KC were measured using the Kangaroo Care Questionnaire (KCQ). RESULTS: The overall level of nursing students' knowledge about KC was very low with a mean score of 6.9 out of 17. The mean score for nursing students' beliefs about KC was 87.4 out of 100, indicating relatively positive beliefs. The students who had both education and exposure to KC had higher scores for knowledge and more positive beliefs about KC compared to students with no experience or exposure to KC. There was a positive correlation between knowledge and beliefs about KC (r=.371, p<.001). CONCLUSION: The results suggest that there is a need to develop educational programs for nursing students in order to increase their knowledge and develop positive beliefs about KC.
Education ; Humans ; Infant, Newborn ; Infant, Premature ; Kangaroo-Mother Care Method ; Macropodidae* ; Nursing* ; Students, Nursing*

PURPOSE: To compare the aberration change in the pseudophakia with three types of acrylic intraocular lenses (IOL) as well as with normal phakic eyes METHODS: This single-center prospective study comprised of 51 cataract patients who underwent cataract surgery and 12 phakic eyes. Fourteen eyes received an Acrysof(R) MA60BM, 18 eyes, a Sensar(R) AR40, and 19 eyes, an Corneal(R) ACR6D. One month after cataract surgery, the aberration of the eyes was measured using a Hartmann-Shack type aberrometer. The same test was performed for 12 normal phakic eyes. The individual Zernike polynomials, and the root mean square (RMS) values of the third and the fourth order aberration among the groups were compared. The total RMS value of each group was also compared. RESULTS: The RMS value of the third and the fourth order aberration was similar in each group. In addition, there was no significant difference in the total RMS value among the groups. An individual Zernike coefficient (Z3(3); triangular astigmatism with a base on the y axis) showed a significant difference in all the IOL implanted groups compared to the normal phakic eyes. CONCLUSIONS: An ocular higher-order aberration after these 3 acrylic IOL implantations in cataract surgery is similar to that of the normal phakic eyes, but can differ in the local aberration.
Astigmatism ; Cataract ; Humans ; Lenses, Intraocular* ; Prospective Studies ; Pseudophakia*

PURPOSE: To evaluate the effect on postoperative pain of the application of 20% ethanol before debridement of the corneal epithelium METHODS: During photorefractive keratectomy (PRK), performed on 44 eyes of 22 patients with mild to moderate myopia, 20% ethanol was applied on the eyes for 30 seconds just before debridement of the corneal epithelium. Meanwhile, conventional debridement of the epithelium was done on the fellow eyes. Patients were asked to evaluate their subjective postoperative pain after 3 hours, 1 day and 3 days. We measured epithelial healing time by the time of bandage contact lens removal. We also measured visual acuity and manifested refraction at 1 month after surgery. RESULTS: Significantly less postoperative pain was reported at 3 hours and 1 day after surgery in the eyes with ethanol applied. However, postoperative pain did not differ between the two groups at 3 days after surgery, nor did uncorrected visual acuity, manifested refraction at 1 month after surgery, or epithelial healing time. CONCLUSIONS: Application of 20% ethanol as pre-treatment in debridement of the corneal epithelium is beneficial in reducing postoperative pain in PRK.
Bandages ; Debridement* ; Epithelium ; Epithelium, Corneal* ; Ethanol ; Humans ; Myopia ; Pain, Postoperative ; Photorefractive Keratectomy ; Visual Acuity