1.Disseminated Superficial ACtinic Porokeratosis Occuring in 3 Generations.
Eun Jung CHUNG ; Tae Yoon KIM ; Hyung Ok KIM ; Chung Won KIM ; Won HOUH
Korean Journal of Dermatology 1981;19(6):963-967
Disseminated superficial actinic porokeratosis (DSAP) has an autosomal dominant mode of inheritance with reduced penetration at young age, characterized by multiple superficial keratotic lesions surrounded by a slightly raised border. The aggrevation of the lesion by exposing UV light indicates that phenotypic expression of gene regluating DSAP is related to sun light. We observed a family of which 13 members had DSAP in 3 successive generations. They were grandrnother, two sons of her 3 offsprings, 2 grandsons and 8 granddaughters. Lesions of all cases were found on the sun exposed areas, especially, face, extremities and upper trunk but exceptionally one had a lesion on the unex posed area, abdomen below the iliac crest. The number of lesions of the individual patient were 12-116, and there appeared to be increasing number of lesions with age.
Abdomen
;
Extremities
;
Family Characteristics*
;
Humans
;
Porokeratosis*
;
Solar System
;
Ultraviolet Rays
;
Wills
2.Radiologic evaluation of globus symptom
Tae Sub CHUNG ; Jong Tae LEE ; Hyung Sik YOO ; Jung Ho SUH ; Ki Whang KIM ; Tae Young JANG ; In Yong PARK
Journal of the Korean Radiological Society 1986;22(6):999-1004
The globus symptom is a condition in which a patient, often middle aged women, complains of a lump andchocking sensation in the throat, Functional disturbance of the cricopharyngeal muscle, rendering it incapable ofrelaxing during swallowing, has long been recognized as a cause of globus symptom and dysphagia. We wanted to findout how often and to what extent distrubed relaxation of the cricopharyngeal muscle can be seen in patients withglobus symptom with routine examination and video esophagogram. The results were as follows: 1. Male : femaleratio was 1:2.4. 2. Globus symptom was most frequent in the age group between 30-39 of female. 3. Organic lesionswere seen in 43.6%(24 Pts) of globus patients. 4. Cricopharyngeal muscle was visualized in 29.1%(16Pts), esophageal diverticulum in 3.6%(2 Pts) and degenerative spondylosis in 3.6%(2 Pts). 5. Incidence of visualizationof cricopharyngeal muscle were higher in male group (50%) than female one (20.5%). 6. Cricopharyngeal muscle wasmost frequently visualized on early swallowing phase(12/16 Pts).
Deglutition
;
Deglutition Disorders
;
Diverticulum, Esophageal
;
Female
;
Humans
;
Incidence
;
Male
;
Middle Aged
;
Pharynx
;
Relaxation
;
Sensation
;
Spondylosis
3.A Study on the Influence of Serum IgE Level on T cell Function in Atopic Dermatitis.
Chung Won KIM ; Chun Wook PARK ; Tae Yoon KIM ; Hyung Ok KIM
Korean Journal of Dermatology 1984;22(6):593-598
The influence of serum IgE level on T cell function and number in atopic dermatitis was performed. For the study we selected 2 groups of atopic derrnatitis patients which were 10 cases of atopic dermatitis patients with more than 400 IU/ml of serum 1gE level and 1(l cases with less than 400 IU/ml, The lymphocyte transformation test with phytohernagglutinin and E-rosette test with AET treated sheep cell were perforrned in each group and compare the result of each group with each other and al'o with those of control group. The reults are as follows; l. The mean serum level of IgE in AD(538. 8 407.42 IU/ml) was higher than in normal control(126. 5 133, R8 IU/ml) (p<0.01). 2 The mean LTT S.I. in AD(8.83 -3.85) was lower than in nomnal control (13.99 5.55) (p<0.01). 3. The mean percentage of E-rosette in AD(68,65+6.6g) was lower than 4pp IU/ml(mean+2x SD of serum IgE of control groups), 1) The LTT S, I. was decreased in both groups according to increment of serum IgE, The higher IgE group(8.64+3,9p) had statistical significance compared to normal control(13.gg+5.55) (p<0.01) but not in low IgE group(9.08:4.11).2) The percentage of E-rosette was decreased in both groups according to increment of serum IgE. The both groups of low IgE(71.08.-6,24) and high IgE(66. 22 6. R7) had statistical significance compared to normal control(77.65+4.39 %) (p 0.01).
beta-Aminoethyl Isothiourea
;
Dermatitis, Atopic*
;
Humans
;
Immunoglobulin E*
;
Lymphocyte Activation
;
Sheep
4.A Case of Malignant Acanthosis Nigricans Associated with Gastric Adenocarcinoma.
Hyung Geun PARK ; Seong Min PARK ; Doo Chan MOON ; Kyung Sool KWON ; Tae Ahn CHUNG
Korean Journal of Dermatology 1989;27(3):316-319
A 51-year-old female had disseminated, symmetrically distributed, brownish black pigmentation and papillary hypertrophy on the intertriginous and flexural areas for 6 months, and gastric adenocarcinoma was confirmed during the evaluation of internal malignancy, The cutaneous finding of acanthosis nigricans was a significant cutaneous marker of internal malignancy in this case.
Acanthosis Nigricans*
;
Adenocarcinoma*
;
Female
;
Humans
;
Hypertrophy
;
Middle Aged
;
Pigmentation
5.A Case of Generalized Granuloma Annulare.
Hyung Geun PARK ; Doo Chan MOON ; Kyung Sool KWON ; Tae Ahn CHUNG
Korean Journal of Dermatology 1989;27(3):299-303
We experienced a case of generalized granuloma annular e in a 68-year-old man. Many factors have been implicated in the genesis of this disease, but in this case no etiologic factors were identified. He was treated successfully with systemic corticosteroid for about l year.
Aged
;
Granuloma Annulare*
;
Granuloma*
;
Humans
6.Significance of Peanut Agglutinin in the Differentiation between Basal Cell Carcinoma and Trichoepithelioma.
Hyung Geun PARK ; Doo Chan MOON ; Kyung Sool KOWN ; Tae Ahn CHUNG
Korean Journal of Dermatology 1989;27(3):241-247
Great difficulty may be encountered in the differentiation of basal cell carcinoma from trichoepithelioma snd, in some cases, it may even be irnpossible. Immunohistochemical methods using peanut agglutinin(PNA) which is glycoprotein of non-immune origin selectively binding to galactose-N-acetyl-galactosa-mine are increasingly used in dermatopathology to improve the diagnosis and differential diagnosis. Using PNA, anti-PNA antibody, and peroxidase antiperoxi-dase(PAP) technique, normal skin specimens, basal cell carcinomas, trichoepitheliiomas, and a variety of different skin tumors were studied, and different PNA Ibinding sites between basal cell carcinomas and trichoepitheliomas were observed. The results were as follows : l. In normal skin, except the basement membrane, epidermis and hair follicle epithelium showed a cell membrane staining of PNA, which stained weakly in the Ibssal cell layer. Sebaceous glands revealed membranous and cytoplasmic staining of PNA, but sweat ducts and duct coi1s were mostly negative. 2. 34 of 36(94.4%) basal cell carcinoma sections demonstrated peritumorous PNA-positive bands, and none of 5 trichoepithelioma sections showed peritumorous PNA-binding. 3. Peritumorous PNA-positive bands were strongly positive in solid and keratotic basal cell carcinomas, but decreased or absent in the vicinity of the ulceration or the dense inflammatory infiltration. 4. None of the other skin tumors(squamous cell carcinoms, keratoscanthoma, Bowens disesse and actinic keratosis} showed a periturnorous PNA-positive band. Therefore, we believe that the PNA staining on paraffin-embedded sections using PAP technique can be a useful probe for the differentiation of basal cell carcinoma from trichoepithelioma.
Actins
;
Basement Membrane
;
Carcinoma, Basal Cell*
;
Cell Membrane
;
Cytoplasm
;
Diagnosis
;
Diagnosis, Differential
;
Epidermis
;
Epithelium
;
Glycoproteins
;
Hair Follicle
;
Peanut Agglutinin*
;
Peroxidase
;
Sebaceous Glands
;
Skin
;
Sweat
;
Ulcer
7.A comparison study of Pharmacia CAP system, fluoroallergosorbent test and radioimmunoassay for serum lgE and eosinophil cationic protein measurement.
Hyung Ok KIM ; Chung Won KIM ; Tae Yoon KIM ; Dou Hee YOON ; Ho Pyo LEE
Korean Journal of Allergy 1997;17(1):58-66
Results from two in vitro assays, Pharmacia CAP system(CAP) and fluoroallergosorbent test(FAST), for detecting serum specific IgE to three allergens, mugwort, Derraatophagoides pteronyssinus, and eat epithelium, were compared with skin prick test(SPT) results in 53 atopie dermatitis patients with positive SPT and 25 non-atopic controls. Using SPT results as the reference standards, CAP achieved higher sensitivity than FAST in determination of three allergens. CAP for measuring total IgE and eosinophil cationic protein(ECP) was also compared with FAST and ECP radioimmunoassay(RIA), respectively. In comparison of two assays for total serum IgE, the values obtained with CAP were significantly higher than those with FAST. In comparison of CAP and RIA for measuring ECP, the values obrained with CAP were significantly higher than those with RIA and the differences between ECP values of two assays were significant in high ECP group(>8.3 micro gram/1). These results suggest that CAP is the preferred test and seems to be more appropriate method for detection of specific IgE and ECP in patients with allergic digeases.
Allergens
;
Artemisia
;
Dermatitis
;
Eosinophil Cationic Protein*
;
Eosinophils*
;
Epithelium
;
Humans
;
Immunoglobulin E
;
Radioimmunoassay*
;
Skin
8.Three Cases of Letterer - Siwe Disease.
Hyung Gi CHA ; Doo Chan MOON ; Kyung Soll KWON ; Tae Ahn CHUNG
Korean Journal of Dermatology 1994;32(1):186-192
Letterer-Siwe disease is one of Langerhans cell histiocytosis, with Hand-Schuller-Christian disease and eosinophilic granuloma, characterized by proliferation of Langevha is cell. The clinical course of Letterer-Siwe disease is acute fulmunant of casionally fatal, involving skin and many other internal organs, such as the lymph node, liver, spleen, ung and bone. We present 3 cases of Letterer-Siwe disease with characteristic cutaneous findings and revealed Langerhans granules by imrriunohistochemical stain and electronmicrc scopic examination. All patients died in spite of combined chernotherapy.
Eosinophilic Granuloma
;
Histiocytosis, Langerhans-Cell
;
Humans
;
Liver
;
Lymph Nodes
;
Skin
;
Spleen
9.Secondary Biliary Cirrhosis in A Case with Intraductal Growth of Hepatocellular Carcinoma.
Hyung Geun SONG ; Yong Il KIM ; Chung Yong KIM ; Soo Tae KIM
Korean Journal of Pathology 1987;21(3):185-191
A case of hepatocellular carcinoma (HCC) complicating with secondary biliary cirrhosis due to intrahepatic bile duct growth of the tumor is presented. The patient was 34 years-old male who had been suffered from right upper quadrant pain with intermittent fluctuating jaundice for 4 months. Left lobectomy specimen contained a single, 4 cm sized, relatively well circumscribed and partly protruding nodular HCC in the medial seqment of left lobe. It compressed the left hepatic duct, and the intra and extra-hepatic ducts were completely plugged with tumor casts (extending to the common bile duct at the operating table). Remaining hepatic parenclyma was the seat of advanced secondary biliary cirrhosis in which were abundance of HBsAg-containing hepatocytes possibily representing a HBsAg carrier status. Biliary cirrhosis in HCC is an extremely rare manifestation, reflecting the delayed adequate clinical procedure by unusual pattern of obstructive jaundice. In such a case presenting as persisting and fluctuating obstructive jaundice in HCC, an intrabile duct tumor growth should be suspected.
Male
;
Humans
;
Carcinoma, Hepatocellular
10.A Case of Fetal Nuchal Cystic Hygroma.
Yung Ha CHOI ; Chung Ok PARK ; Wan Seok PARK ; Tae Hyung LEE ; Sung Ho LEE
Yeungnam University Journal of Medicine 1989;6(1):165-169
Fetal cystic hygroma is a rare congenital malformation of the lymphatic system appearing as a single or multiloculated fluid-filled cavity, most often in the neck. A case of fetal nuchal cystic hygroma was diagnosed by Ultrasonography at 22 weeks of gestation and the diagnosis was confirmed at autopsy. We present the case with a brief review of literature.
Autopsy
;
Diagnosis
;
Lymphangioma, Cystic*
;
Lymphatic System
;
Neck
;
Pregnancy
;
Ultrasonography