No abstract available.
Animals ; Hyperbaric Oxygenation* ; Osteomyelitis* ; Rats*

BACKGROUND: Gonorrhea is one of the most common venereal diseases in the world. Antibioticresistance development has been an issue with the penicillinase-producing Neisseria gonorrhoeae(PPNG) development. It is possible for PPNG to be resistant to other medications. Therefore, it is significant to determine its frequency rate and its disposition. OBJECTIVES: In this surveillance, we examined overall development frequency of PPNG from 1981 ti 1998. Comparing current five years' frequency rate with that of previous five year, we predicted possible development rate and described the procedures the physicians must take into account in gonorrhea treatment. METHODS: We examined the development frequency of PPNG in male patients of the venereal disease clinic of Jung-gu Community Health Center in Seoul from 1981 to 1998. Also, we analyzed the overall tendency with time series analysis using statistics package, SPSS 7.5.Grouping the years in five-year units, development frequency of PPNG of current five years (1994-1998) was compared with that of previous years. RESULTS: For the result of monthly analysis of frequency rate of PPNG development from 1981 to 1998, the rate tendency came out with a sligh rise (slope : 0.15). And for the result of comparison of grouped years, in current five years, its rate was 51.6%, marking a significant decline from that of the previous five years, which was 57.2% (p-value : <0.0001). CONCLUSION: The rate of current five years was reported to have declined from the previous years. However, the rate is still over 50%. Therefore, the government should continue the PPNG surveillance with test of sensitivity of the medications in use. Moreover, to eliminate gonorrhea, the education on high risk groups should continue and physicians should use a dose of adequate antibiotics in treatment.
Anti-Bacterial Agents ; Community Health Centers* ; Education ; Gonorrhea ; Humans ; Male ; Neisseria gonorrhoeae* ; Neisseria* ; Seoul* ; Sexually Transmitted Diseases

5 alpha-reductase deficiency resulting in male pseudohermaphroditism is a rare disease characterized by clitoral-like phallus, bifid scrotum, urogenital sinus, testis cited in labioscrotal folds. Evaluation of plasma T/DHT ratios in infancy, particularly after hCG stimulation of the testes and elevated urinary tetrahydrocortisol (THF) to 5 alpha-tetrahydrocortisol(5 alpha-THF) ratios provide a valuable dianostic test for 5 alpha-reductase deficiency. We report one case of 5 alpha-reductase deficiency who were presented with ambiguous genitalia and elevated T/DHT ratio before and after hCG stimulation.
46, XY Disorders of Sex Development ; Cholestenone 5 alpha-Reductase* ; Disorders of Sex Development ; Plasma ; Rare Diseases ; Scrotum ; Testis ; Tetrahydrocortisol

No abstract available.
Arthroplasty ; Femoral Fractures ; Hip

BACKGROUND: "Rebuild-up" phenomenon, induced by hyperventilation, is a characteristic finding on EEG in children with Moyamoya disease. Its mechanism, however, remains obscure. In this study, we examined the relationship between cerebral lesions on MRI, stenosis or occlusion of cerebral vessel on cerebral angiography, and EEG findings in children with Moyamoya disease. METHODS: We have reviewed medical records of 33 patients, who were confirmed as Moyamoya disease by cerebral angiography at Asan Medical Center. EEG and brain MRI were carried out in all subjects. RESULTS: 1) Epidemiologic data were : the male to female ratio was 1:1.1; highest rate(90.7%) of onset in age group below 10 years; mean age at clinical onset was 7.4 years; average diagnostic interval from clinical onset to diagnosis was 1.9 years. 2) The most common initial and recurrent or residual symptoms were motor deficit. 3) The most common site of occlusion or stenosis of cerebral vessel on cerebral angiography was anterior cerebral area(>97%) and the most common cerebral infarction area on brain MRI was anterior cerebral area, too. 4) The hyperventilation(for 3 minutes) on EEG were carried out in 25 patients and the prolonged build-up or rebuild-up phenomenon was observed in 13 patients(52%). 5) The prolonged build-up or rebuild-up phenomenon on EEG was observed in 6 of 15 patients who were occlusion of cerebral vessel, and in 7 of 10 patients who were stenosis of cerebral vessel on angiography. CONCLUSION: 1) The background slowings on EEG maybe suggestive of the infarction stage of Moyamoya disease in children. 2) The prolonged build-up or rebuild-up phenomenon might indicate the preinfarction stage of Moyamoya disease in children.
Angiography ; Brain ; Cerebral Angiography ; Cerebral Infarction ; Child ; Chungcheongnam-do ; Constriction, Pathologic ; Diagnosis ; Electroencephalography ; Female ; Humans ; Hyperventilation ; Infarction ; Magnetic Resonance Imaging ; Male ; Medical Records ; Moyamoya Disease*

Nesidioblastosis, also known as persistent hyperinsulinemic hypoglycemia of infancy(PHHI) or familial hyperinsulinsm, is the most common cause of recurrent severe hypoglycemia in infancy. It is an autosomal recessive disorder characterized by irregular insulin secretion leading to inappropriately raised plasma insulin concentration compared to blood glucose levels. Recently, mutations in the sulfonylurea receptor(SUR) have been described in association with PHHI. The mainstay of medical treatment is glucose infusion and diazoxide or long acting somatostatin. If medical treatment fails in preventing hypoglycemia, near total pancreatectomy is recommended. We report one case of nesidioblastosis cured by near total pancreatectomy with brief review of literatures.
Blood Glucose ; Congenital Hyperinsulinism* ; Diazoxide ; Glucose ; Humans ; Hypoglycemia ; Infant, Newborn* ; Insulin ; Nesidioblastosis* ; Pancreatectomy ; Plasma ; Somatostatin

No abstract available.
Humans* ; Membranes*

Stereotactic radiosurgery, including gamma knife radiosurgery (GKS), can in rare cases result in de novo cavernous malformations (CMs). Here, we present a case of de novo CM induced by GKS following treatment of a cerebellar arteriovenous malformation (AVM). A 48-year-old woman was diagnosed with left unilateral Moyamoya disease. Conventional cerebral angiography also revealed an AVM in the left cerebellum. The patient underwent GKS using a 50% isodose of 15 Gy at the margin of the left cerebellar AVM. Magnetic resonance imaging (MRI) taken 3 years after GKS revealed small chronic hemorrhages with perilesional edema in the left cerebellum. Five years later, the lesions became aggravated, but were asymptomatic. Eight years following GKS, the patient was admitted complaining of headache and dizziness. Brain MRI revealed a 1.3cm hemosiderin deposit with an inner hyperintense nodular portion that was enhanced in the left cerebellum. An open craniotomy was performed and the mass was removed, from which pathological findings were compatible with those for CM. The patient recovered to the prehemorrhagic state. This case shows that De novo CMs can rarely develop after radiosurgery. Most CMs have been reported to develop following radiosurgery for brain tumors. As shown in this patient, CMs can also develop after radiosurgery for cerebellar AVM in adults.
Radiosurgery

Ewing's sarcoma had never been described as a primary tumor outside bone, although other malignant skeletal tumors, such as osteogenic sarcoma & chondrosarcoma, are known to arise from extraskeletal soft tissues. In 1975, Angervall & F.M. Enzinger reported 39 cases of small, round or oval cell sarcomas occuring in the soft tissues and considered histologically indistinguishable from Ewing's sarcoma of bone. Recently, We experienced one case of extraskeletal neoplasm resembling Ewing's sarcoma of bone which it was located deeply in the calf area of young female patient and the case review has been followed until the death, approxlmately 10.5 months after removal.
Chondrosarcoma ; Female ; Humans ; Osteosarcoma ; Sarcoma ; Sarcoma, Ewing

No abstract available.
Granuloma, Lethal Midline*