No abstract available.
Calcium* ; T-Lymphocytes*

BACKGROUND: The number of nongonococcal urethritis(NGU) cases is exceeding more and more that of Gonorrhea in developeing nations and some of the developing countr es such as Korea. The best evidence for an etiologic role for Trichomonas Vaginalis is in nongonococcal urethritis. OBJECTIVE: We compared the effects of Tetracycline to Tetracycine and Metronidazole in the treatment of male patients with nongonococcal urethritis and wished to find out the incidence of Trichomon-as Vaginalis in male patients with nongonocaccal urethritis indirectly. METHOD: From January, ],989 to December, 1992, three hundred male patients with nongococcal urethritis(NGU) at the Venreal Disease Clinic of Choong-Ku Publi Health Center in Seoul were allocated randomly into one of two treatment regimens. and one hundred sixty eight patients were followed. RESULTS: Eighty(83.4%) of ninty six patients treated with Tetrac; cline, 500mg, PO, q.i.d. for 14 days were cured. Sixty two(86.2%) of seventy two patients treatec with Tetracycline, 500mg, PO, q.i. d. for 14 days and Metronidaole. 2.0gm, PO, for 1 day were cured. There is no significant different between the 2 groups in treated rates(P<0.05). CONCLUSION: It suggests that male patients with nongonococcal ure1hritis due to trichomoniasis are rare in Korea. This may be die to the fact that the incidence of trichorioniasis has been declining since the 1960s. It also suggests not only the need for further studies on tool is disease but also more studies on other causes of nongonocoqeal urethritis, its treatment and epidernio.ogical study.
Gonorrhea ; Humans ; Incidence ; Korea ; Male* ; Metronidazole* ; Seoul ; Tetracycline* ; Trichomonas vaginalis ; Urethritis

A 26 year old female presented complaining of a pea-sized nodule on her left lower eyelid for 10 years duration. Histopathological study showed several cysts in the dermis surrounded by secretory cells. The cysts were filled with decapitatory secretions. Positive staining with carcinoembrynic an tigen(CEA) was detected by immunoperoxidase technique. These clinical and histopathological findings suggest apocrine hidrocystoma developed on the left lower eyelid.
Adult ; Dermis ; Eyelids ; Female ; Hidrocystoma* ; Humans ; Immunoenzyme Techniques

There are some effective methods for removing layers of skin to improve aging face and dermatologic defects : chemabrasion (chemical peeling), dermabrasion(surgical removal), laserabrasion. Chemabrasion, generally performed with a chemical solution, is most useful for removal of fine facial wrinkles and abnormal pigmentation. The application of chemical caustics, especially TCA (trichloroacetic acid), is known to be an effective and is now commonly practiced to improve the surface of the facial skin that has been blemished by pigmentation, wrinkles, solar damage and certain scars. Trichloroacetic acid is a colorless melting crystal and derivatives of acetic acid which das protein precipitating properties. It has specific odor but there is not systemic toxic effect like a phenol. It has heavy caustic effect on skin and mucosa and cause the coagulation necrosis of the skin and therefore, it must be handled carefully and stored in the proper condition. Especially, moderate to high concentrated TCA solution must be treated by well-trained persons. A 46-year-old woman visited a private clinic for removal of fine wrinkles around the lip. She was refered to our department because of acute upper lip coagulation necrosis which was caused by injection of 35% TCA solution mistaken for lidocaine, which was supposed to be used for anesthesia. At her arrival, cental half of upper lip showed severe coagulation necrosis. The lesion was well discriminated in a few days, then debridement and immediate reconstruction was done using an Abbe flap. Chemical peeling is a relatively effective procedure for improvement of aging skin lesion in a lower cost with a short time operation, if the practitioner has much experience and optimal indication is properly selected. But not so as, side effect and complication may be often ocurred in a mistake and as a result irreversible scars are remained. We experienced a rare case of upper lip necrosis which was caused by TCA injection mistaked for lidocaine in a private clinic and so, We report this case with the results of experiment of rabbit model which was observation of macroscopic and microscopic changes of the abdominal skin of the rabbit injected with serially diluted TCA solution.
Acetic Acid ; Aging ; Anesthesia ; Caustics ; Cicatrix ; Debridement ; Female ; Freezing ; Humans ; Lidocaine ; Lip* ; Middle Aged ; Mucous Membrane ; Necrosis* ; Odors ; Phenol ; Pigmentation ; Skin ; Trichloroacetic Acid

Angiogenesis is a crucial step in tumor growth and progression. Scarce data is available on angiogensis in gastrointestinal tumors. We studied 16 normal colon, 44 adenomas and 29 carcinomas to evaluate angiogenesis in colorectal tumors and to assess the correlation among p53 protein, proliferative activity and other clinical prognostic parameters. Endothelial cells were immunostained with an anti-Factor VIII mAb; in each case three microscopic fields(x 200) were counted: average number of the three fields was defined as microvessel density (MVD). p53 protein expression was 45.5%(20/44) in adenomas, and 79.3%(23/29) in carcinomas (p<0.01). p53 protein expression of carcinomas was 57.1%(4/7) in diploid tumors, 100%(8/8) in aneuploid tumors (p=0.07), 100%(8/8) in well differentiated tumors, and 50%(2/4) in poorly differentiated tumors (p=0.09). MIB-1 score was 2.3+/-0.7(38) in adenomas, 3.4+/-0.5(29) in carcinomas (p<0.01). There was no significant correlation between p53 protein and MIB-1 score. MVD was 10.4+/-4.1(16) in the normal mucosa, 21.5+/-7.9(39) in the adenomas, 35.3+/-9.7(26) in carcinomas (normal versus adenomas, p<0.01; adenomas versus carcinomas, p<0.01). MVD was 25.8+/-5.4(2) in carcinomas confined to mucosa, and 36.1+/-9.6(24) in carcinomas with transmural invasion. The higher MIB-1 score was in carcinomas the more MVD increased but there was no statistical significance (r=0.38, p=0.055). MVD of carcinomas was not associated with nodal metastasis, p53 expression, and DNA ploidy. p53 protein and MIB-1 expression are useful methods for the evaluation of malignancy, and tumor angiogenesis is an early event in a colorectal tumor but MVD does not correlate with prognostic parameters except for the tumor depth.
Adenoma* ; Aneuploidy ; Colon ; Colorectal Neoplasms ; Diploidy ; DNA ; Endothelial Cells ; Microvessels* ; Mucous Membrane ; Neoplasm Metastasis ; Ploidies

Ureteroscopic removal of stone is now an established technique for the management of ureteral stones and can be done under direct vision using flexible grasping forceps or stone baskets with increased safety and efficacy. A clinical study of our 35 cases of ureteroscopic removal of ureteral calculi was performed. Only one among 4 cases of mid and upper ureteral calculi and 27 among 31 cases of lower ureteral calculi were removed successfully. Therefore the overall success rate was 80 %(28 among 35 cases). Complications occurred in 6 cases : a case of ureteral avulsion, a case of ureteral separation, 2 cases of uncomplicated urinary tract infection and 2 cases of ureteral perforations. We conclude that ureteroscopic removal of ureteral stone under direct vision can be done safely and be the first choice of management for the lower ureteral surgical calculi, but the antegrade removal of stone through percutaneous nephrostomy tract may be preferable for the upper and mid ureteral calculi.
Calculi ; Hand Strength ; Nephrostomy, Percutaneous ; Surgical Instruments ; Ureter* ; Ureteral Calculi ; Urinary Tract Infections

No abstract available.
Humans ; Multivariate Analysis* ; Stomach Neoplasms*

Nesidioblastosis, also known as persistent hyperinsulinemic hypoglycemia of infancy(PHHI) or familial hyperinsulinsm, is the most common cause of recurrent severe hypoglycemia in infancy. It is an autosomal recessive disorder characterized by irregular insulin secretion leading to inappropriately raised plasma insulin concentration compared to blood glucose levels. Recently, mutations in the sulfonylurea receptor(SUR) have been described in association with PHHI. The mainstay of medical treatment is glucose infusion and diazoxide or long acting somatostatin. If medical treatment fails in preventing hypoglycemia, near total pancreatectomy is recommended. We report one case of nesidioblastosis cured by near total pancreatectomy with brief review of literatures.
Blood Glucose ; Congenital Hyperinsulinism* ; Diazoxide ; Glucose ; Humans ; Hypoglycemia ; Infant, Newborn* ; Insulin ; Nesidioblastosis* ; Pancreatectomy ; Plasma ; Somatostatin

We performed this study to observe the effects of chronic administration of leuprolide acetate(potent synthetic LHRH analog) to the testicular histopathology of prostatic cancer patient and to the spermatogenesis in cryptochism treatment. Ten out of fifty healthy male rats whose body weight ranged 250-300gm were selected as a control group and the other forty as a study group. Two hundred micro-gram of leuprolide acetate was injected daily into the peritoneal cavity of study group, and ten rats were sacrificed at each first, second, third and sixth week, respectively. Then the changes of testicular weight and histopathological readings under light microscope of both control and study group were recorded and analyzed. The results of experimental data can be summarized as follows : 1. The average testicular weight of control group increased progressively until sixth week to 1. 1.43gm from the initial value of 1.26gm, while the weight of study group decreased to 0.96gm which was 67.1 % of age-matched control group. 2. There were almost no remarkable changes between both groups in terms of number, size and cellularity of seminiferous tubules. We observed the degenerative and regenerative changes simultaneously in spermatogonia and spermatocytes. During the first three weeks, degenerative changes took place while the regenerative changes started from the second week and have fully recovered at the sixth week. And, the number of spermatids and spermatozoa slightly decreased at the first week, but have recovered to normal value from the second week. 3. There were noticeable changes neither in the interstitium of testes except the minimal edema nor in terms of size and number of Leydig cell. The results using rats showed the discordance with those of human study of prostatic cancer patient. This conflict can be attributed to the functional differences of leuprolide action between two species, age of sacrificed rats and insufficiency of dose and time of administration. However, we can draw another conclusion that the leuprolide acetate is expected to have no significant adverse effects to the spermatogenesis in cryptorchism treatment.
Animals ; Body Weight ; Cryptorchidism ; Edema ; Gonadotropin-Releasing Hormone ; Humans ; Leuprolide* ; Male* ; Peritoneal Cavity ; Prostatic Neoplasms ; Rats* ; Reading ; Reference Values ; Seminiferous Tubules ; Spermatids ; Spermatocytes ; Spermatogenesis ; Spermatogonia ; Spermatozoa ; Testis

No abstract available.
Classification* ; Humans ; Stomach Neoplasms*