No abstract available.
Diagnosis* ; Ossification, Heterotopic* ; Risk Factors* ; Spinal Cord Injuries* ; Spinal Cord*

The authors studied the formation of giant mitochondria in liver cell. The Sprague Dawley rats were sacrificed following intervals; 5, 10, 20, 30, and 60 minutes after intraperitoneal injection of hydrazine in the amount of 200 microliter/kg. And the extracted liver tissues were examined with light and electron microscopes. The results obtained were summarized as follow; Light microscopically, there is little difference between control and experimental groups. Electron microscopically, elongated, bizzare shaped mitochondria are appears 5 minutes after hydrazine injection. Those show attenuated portion, Y, U, or C shaped feature suggesting fusion or budding mitochondria. The number of giant mitochondria is decreased after 10 minutes group and rarely present in 60 minutes group. The results suggest in this experiment that the formation of giant mitochondria is kind of reversible change and it is different from the mitochondrial swelling of cellular injury. Intermitochondrial fusion and mitochondrial budding may be related with the formation of giant mitochondria.
Rats ; Animals

It is the most important to select optimal culture conditions to promote safe embryo growth in the technique of human in vitro fertilization and embryo transfer. It has been shown that the addition of biologic fluids, such as blood serum, of various origins, improved fertilization and early cleavage rates in numerous species. The purpose- of this study is to attempt to measure developmental potential of mouse eggs fertilized and cleaved in Ham's F10 culture medium containing a chelating agent, EDTA and fetal cord serum. hi this study, we selected 40 female mice and 20 male mice, and investigated optimal serum concentration' for mouse embryo growth. Two cell stage mouse embryos were cultured in Ham's F-10 medium, Ham's F-10 medium with various concentrations of EDTA, or Ham's F-10 medium with EDTA and 10% human cord serum. Developmental ratios to morula in Ham's F-10 medium containing various concentrations of EDTA and/or 10% fetal cord serum were significantly higher than in unsupplemented Ham's F-10 medium (p<0.05). Developmental ratios to blastocyst in Ham's F-10 containing 10% fetal cord serum and 5011M or 100pM EDTA were significanldy higher than in unsupplemented Ham's F-10 medium (p<0.05). Developmental ratios to morula in Ham's F-10 containing 10% fetal cord serum and 100,uM EDTA were significanitly higher than in Ham's F-10 with 10% fetal cord serum used commonly in many human IVF centers(p<0.05). Developmental ratio to blastocyst in Ham's F-10 containing 10% fetal cord serum and 100pM EDTA was significanity higher than in Ham's F-10 with 200pM EDTA(p<0.05).
Animals ; Blastocyst ; Edetic Acid* ; Eggs ; Embryo Transfer ; Embryonic Structures* ; Female ; Fertilization ; Fertilization in Vitro ; Humans ; Male ; Mice* ; Morula ; Ovum ; Serum

No abstract available.
Epidermal Cyst*

No abstract available.
Trichothiodystrophy Syndromes*

No abstract available.

BACKGROUND: Lupus erythematosus panniculitis (LEP), (or lupus erythematosus profundus), is an unusual variant of lupus erythematosus which primarily affects subcutaneous fat. LEP may occur with or without other manifestations of cutaneous or systemic lupus erythematosus. Only a few studies on the clinical and histopathologic manifestation of LEP have been conducted in Korea. OBJECTIVE: The purpose of this study was to investigate clinical, laboratory, and histopathologic features of LEP in Korean patients. METHOD: A total of 30 patients confirmed as having LEP at the Chungbuk National University Hospital between 1 July 1994 and 31 June 2004 were included in this study. The medical records and histopathologic findings were reviewed. RESULTS AND CONCLUSION: 1. LEP occurred predominantly in females, with the female to male ratio being 4: 1. The mean age at diagnosis was 38.5 years. 2. The most common clinical features were nodules or plaques, and 60% of the patients had pain or tenderness. Skin lesions affected the proximal arm area, face, trunk, scalp, and buttocks. In 26% of cases, LEP was associated with discoid lupus erythematosus (DLE), and 13% had evidence of mild systemic lupus erythematosus (SLE). The antinuclear antibody (ANA) was positive in 30% of cases. 3. The main histopathologic characteristics of LEP were predominant lymphocytic lobular panniculitis, hyaline necrosis, mucin deposit, and lymphoid aggregates. 4. Treatments included antimalarial drugs, systemic corticosteroids, intralesional corticosteroids, or topical potent corticosteroids under occlusion. They produced some improvement in most cases, however LEP exhibited a chronic nature with a high relapse rate.
Adrenal Cortex Hormones ; Antibodies, Antinuclear ; Antimalarials ; Arm ; Buttocks ; Chungcheongbuk-do ; Diagnosis ; Female ; Humans ; Hyalin ; Korea* ; Lupus Erythematosus, Discoid ; Lupus Erythematosus, Systemic ; Male ; Medical Records ; Mucins ; Necrosis ; Panniculitis ; Panniculitis, Lupus Erythematosus* ; Recurrence ; Scalp ; Skin ; Subcutaneous Fat

No abstract available.
Pregnancy*

Endovascular stenting is accepted as an effective treatment for patients with Budd-Chiari syndrome (BCS). We herein present a case of successful endovascular treatment. A 46-year-old woman, who was followed up for 10 years after a diagnosis of BCS, showed progression progressive of liver cirrhosis and deterioration deteriorated of liver function. Three main hepatic veins were thrombosed with complete occlusion of the suprahepatic of the inferior vena cava (IVC); thus, hepatic venous blood flow was draining into the inferior right hepatic veins through the intrahepatic collaterals and passed passing through the subcutaneous venous collaterals. She underwent endovascular stenting of the IVC for palliation. A septoplasty needle was passed through the occluded IVC through into the internal jugular vein access and then to access the femoral vein using a snare wire. Severe elastic recoiling was observed after balloon dilatation; thus, a 28x80 mm stenting was done inserted across the occlusion, and repeat double ballooning was performed. The final venogram shows showed restored IVC inflow. The patient began to lose body weight 1 day after stenting, and edema disappeared within 1 week. She is was doing well at the 6 month follow-up visit with nearly normal liver function and marked resolution of cutaneous venous engorgement. In conclusion, endovascular stenting appeared to be an effective treatment to alleviate portal pressure and to prevent BCS-associated complications; thus, endovascular stenting should be considered before marked hepatic vein stenosis or complete occlusion occurs in patients with BCS.
Body Weight ; Budd-Chiari Syndrome* ; Constriction, Pathologic ; Diagnosis ; Dilatation ; Edema ; Female ; Femoral Vein ; Follow-Up Studies ; Hepatic Veins ; Humans ; Hyperemia ; Jugular Veins ; Liver ; Liver Cirrhosis ; Middle Aged ; Needles ; Portal Pressure ; SNARE Proteins ; Stents* ; Vena Cava, Inferior*

Nevus sebaceus is a hamartoma of both epithelial and non-epithelial components, which that undergoes age-related change. It commonly affects the head and neck, particularly the scalp. In 10-20% of nevus sebaceus cases, secondary benign or malignant neoplasms such as syringocystadenoma papilliferum, trichoblastoma or basal cell carcinoma occur between 40-80 years of age. In only rare instances does a sebaceous carcinoma develop within a nevus sebaceus. To our knowledge, only 3 cases of sebaceous carcinoma in nevus sebaceus have been reported in the Korean dermatologic literature. We present a case of a sebaceous carcinoma arising from nevus sebaceus in a 46-year-old Korean man.
Carcinoma, Basal Cell ; Hamartoma ; Head ; Humans ; Middle Aged ; Neck ; Nevus* ; Scalp