The purpose of the study was to determine factors influencing compliance with anti-tuberculosis therapy. The study subjects were 104 tuberculosis patients who have received the initial treatment in 3 health centers of Kyongju-city, Dalseong-Gun in Teagu and Kumi-city. Data were collected between september and october 1995. The patients were classified into the improved group and the non-improved group according to outcomes of 3 month treatment with short-term therapeutic regimen. To find factors influencing compliance with anti-tuberculosis therapy, multiple logistic regression was made. There was no significant differences between the improved group and the non-improved group in sex, age, education level, occupation, family pattern, and habitual change regarding smoking and drinking. The level of knowledge about anti-tuberculosis therapy in the improved group was significantly higher than the non-improved group(p<0.01). Multiple logistic regression analysis revealed that family support for not forgetting medication(p<0.05) was a predictor of improvement and knowledge about anti-tuberculosis therapy (p=0.054), regularity of medication(p=0.062), and consultation to family, doctor and nurse(p=0.075)were marginal predictors of improvement. Treatment must be given to every patient confirmed as having tuberculosis and must be given free of charge to the patients. The requirements for adequate chemotherapy are prescribed in the correct dosage and taken regularly by the patient for a sufficient period to prevent relapse of the disease after cure. It is suggested that education to the patients should be reinforced and connectedness between patients and tuberculosis control workers and family should be solidated.
Compliance* ; Drinking ; Drug Therapy ; Education ; Humans ; Logistic Models ; Occupations ; Recurrence ; Smoke ; Smoking ; Tuberculosis

A survey was conducted to study perception and attitudes of health workers towards health centers activities and organization of health services, from August 15 to September 30, 1994. The study population was 310 health workers engaged in seven urban health centers in Taegu City area. A questionnaire method was used to collect data and response rate was 81.3 percent or 252 respondents. The following are summaries of findings: Profiles of study population: Health workers were predomina1itly female(62.3%); had college education(60. 3%); 'and held medical and nursing positions(39.6%), technicians(30.6%) and. public health/administrativc positions(29.8%). Perceptions on health center's resources: Slightly more than a half(51.1%) of respondents expressed that physical facilities of the centers are inadequate; equipments needed are short(39.0%); human resource is inadequate(44.8%); and health budget allocated is insufficient(38.5%) to support the performance of health center's activities. Decentralization and health services: The majority revealed that the decentralization of government system would affect the future activities of health centers(51.9%) which may have to change. However, only one quarter of respondents(25.4%) seemed to view the decentralization positively as they expect that it would help perform health activities more effectively. The majority of the respondents(78.6%) insisted that the function and organization of the urban health centers should be changed. Target workload and job satisfaction: A large proportion (43.3%) of respondents felt that present target setting systems for various health activities are unrealistic in terms of community needs and health center's situation while only 11.1 percent responded it positively; the majority(57.5%) revealed that they need further training in professional fields to perform their job more effectively; more than one third(35.7%) expressed that they enjoy their professional autonomy in their job performance; and a considerable proportion (39.3%) said they are satisfied with their present work. Regarding the personnel management, more worker (47.3%) perceived it negatively than positive(11.5%) as most of workers seemed to think the personnel management practiced at the health centers is not fair or justly done. Health services rendered: Among health services rendered, health workers perceived the following services are most successfully delivered; they are, in order of importance, Th controi, curative services, and maternal and child health care. Such areas as health education, oral health, environmental sanitation, and integrated health services are needed to be strengthening. Regarding the community attitudes towards health workers, 41.3 percent of respondents think they are trusted by the community they serve. New areas of concern identified which must be included in future activities of health centers are, in order of priority, health care of elderly population, home health care, rehabilitation services, and such chronic diseases control programs as diabetes, hypertension, school health and mental health care. In conclusion, the study revealed that health workers seemed to have more negative perceptions and attitudes than positive ones towards organization and management of health services and activities performed by the .urban health centers where they are engaged. More specifically, the majority of health workers studied revealed to have the following areas of health center's organization and management inadequate or insufficient to support effective performance of their health activities: Namely, physical facilities and equipments required are inadequate; human and financial resources are insufficient; pefsonnel management is unsatisfactory; setting of service target system is unrealistic in terms of the community needs. However, respondents displayed a number of positive 'perceptions, particularly' to those areas as further training needs 'and implementation of decentralization of government system which will bring more autonomy of local government as they perceived these change would bring the necessary changes to future activities of the health center. They also displayed positive perceptions in their job autonomy and have job satisfactions.
Aged ; Budgets ; Child ; Child Health ; Chronic Disease ; Daegu ; Surveys and Questionnaires ; Delivery of Health Care ; Health Education ; Health Priorities ; Health Services ; Humans ; Hypertension ; Job Satisfaction ; Local Government ; Mental Health ; Nursing ; Oral Health ; Personnel Management ; Politics ; Professional Autonomy ; Rehabilitation ; Sanitation ; School Health Services ; Urban Health*

In human reproduction, fertilization is the first step for successful pregnancy. From the perspective of sperm physiology, the progressive motility and capacitation, including hyperactivation and acrosome reaction, are the most important factors in the fertilization of oocytes. Numerous studies have demonstrated the roles of calcium ions, cyclic nucleotides, and bicarbonate in the acquisition of progressive motility and capacitation. Among these factors, calcium ion plays the most important role. Sperm possess several calcium channels, including voltage-gated calcium channel, cyclic nucleotide-gated calcium channel, transient receptor potential channel, and channels of the CatSper family The CatSper family is a newly-identified group of four sperm-specific cation channels. CatSper1 and CatSper2 proteins localize on the sperm tail and play a critical role in sperm motility and fertilization. In contrast, CatSper3 and CatSper4 proteinsare expressed only in the acrosomal region of sperm head, which implies that they may have a role in the acrosome reaction. Taken together, the CatSper family is the most important group of calcium channels for regulating sperm physiology and appear to be an attractive target for non-hormonal male contraceptives.
Acrosome Reaction ; Calcium ; Calcium Channels ; Contraceptive Agents, Male ; Fertilization ; Humans ; Ions ; Nucleotides, Cyclic ; Oocytes ; Physiology ; Pregnancy ; Reproduction ; Sperm Head ; Sperm Motility ; Sperm Tail ; Spermatozoa

PURPOSE: In advanced prostate cancer, malignant cells generally tend to spread into the bone, and metastasis into nonregional lymph nodes (NRLNs) at the time of initial diagnosis is relatively rare. We investigated the prognostic significance of NRLN metastasis in patients receiving hormonal therapy and chemotherapy. MATERIALS AND METHODS: From February 2005 to August 2011, we identified 105 patients who had metastatic prostate cancer. First, we assessed the prognostic effect of NRLN metastasis on the prostate-specific antigen response through logistic regression and the progression-free time to castration-resistant prostate cancer (CRPC) by using the Cox proportional hazard regression model. Second, we investigated the prognostic influence of NRLN metastasis on the chemotherapy response through logistic regression and on cancer-specific survival of CRPC patients receiving chemotherapy by using Cox proportional analysis. RESULTS: Of these 105 patients, 12 patients (11.4%) had only NRLN metastases without bone metastases. Progression-free time to CRPC was significantly less in patients with NRLN metastases by Cox proportional hazard regression multivariate analysis (p=0.020). However, NRLN metastasis was not an independent factor for predicting the response to chemotherapy in CRPC patients, and NRLN metastasis did not reduce cancer-specific survival in the multivariate analysis. CONCLUSIONS: Twelve (11.4%) of 105 patients with NRLN metastases had lymph node metastases without bone metastases. In addition, NRLN metastasis was a significant prognostic factor for predicting reduced progression-free time to CRPC. Thus, although we speculate that prostate cancer with NRLN metastasis exhibits unique tumor biology, additional molecular and genetic studies are needed.
Biology ; Humans ; Logistic Models ; Lymph Nodes ; Lymphatic Metastasis ; Multivariate Analysis ; Neoplasm Metastasis ; Prognosis ; Prostate ; Prostate-Specific Antigen ; Prostatic Neoplasms

No abstract available.

No abstract available.
Aortic Aneurysm* ; Humans ; Rupture*

No abstract available.
Humans ; Pregnancy, Twin*

No abstract available.
Abscess* ; Drainage*

Voglibose, an α-glucosidase inhibitor, inhibits breakdown of complex carbohydrates into simple sugar units in intestine. Studies showed that voglibose metabolism in the liver might be negligible due to its poor intestinal absorption. Numerous microorganisms live in intestine and have several roles in metabolism and detoxification of various xenobiotics. Due to the limited information, the possible metabolism of voglibose by intestinal microbiota was investigated in vitro and in vivo.

BACKGROUND/AIMS: Recurrence of peptic ulcer after successful eradication of Helicobacter pylori is closely associated with reinfection. The aim of this study was to measure the rate and related factors of H. pylori reinfection through a 4-year follow-up excluding recrudescence. METHODS: Triple therapy was administered to H. pylori-positive 204 people in April 1998 in Gyeongju, Korea. The urea breath test was performed in April 1999. Eighty-seven subjects were regarded as negative for H. pylori, and they were followed up for 4 years to analyze the trends of reinfection rate and its related factors. Sixty-seven subjects completed the 4-year follow-up. During the follow-up period the urea breath test and questionnaire surveys were performed in April 2000, October 2001, and April 2003. RESULTS: The cumulative reinfection rate was 16.4% for 4 years, and the yearly reinfection rate was 4.1%. The reinfection rate of subjects having postprandial fullness and epigastric bloating was significantly high (p<0.05), and that of the subjects with high dyspepsia symptom scores (4 or 5) was also significantly higher than those with low dyspepsia symptom scores (3 or below)(p=0.016). According to the multiple logistic regression analysis to predict the factors related with H. pylori reinfection, the dyspepsia symptom score was the only significant variable with the odds ratio of 1.688. CONCLUSIONS: The cumulative reinfection rate for 4 years was 16.4% in a Korean rural community. The dyspepsia symptom score can be used to predict H. pylori reinfection in community population.
Adult ; Aged ; Breath Tests ; Drug Therapy, Combination ; Female ; Follow-Up Studies ; Helicobacter Infections/diagnosis/*drug therapy ; *Helicobacter pylori ; Humans ; Korea ; Male ; Middle Aged ; Recurrence ; Rural Health