We presented a case of Reiters syndrome consisting of conjunctivitis, arthritis, and skin lesions, occurring in 20-year-o1d male. He had neither an episode of dysentery nor a history of sexual exposure before onset of syndrome. The skin lesions had begun with erythernatous scaly patches on the inguinal region and scalp, and later followed by generalized pustular, psoriasiform and/or hyperkeratotic crusted lesions on the erythematous base. Yellowish discoloration and onycholysis of nails and shallow ulcer of glans penis were observed. Arthritis of the knee and shoulder joints were developed, accompanied by pain, swelling, limited motion, wasting and weakness of both lower extremities. In laboratory investigation, urinalysis, stool examination for parasites and occult blood, renal function test, blood VDRL, and X-ray of chest, both knee. joints, shoulder joint and thoracolumbar spine were within normal limit or negative except for leukocytosis(24, 500/mm), increased ESR(90 mm/hr) and hypoalbuminemia(2.6 g/dl), and he was associated with HLA-A3, A 9, B5, and Rw 49 Histopathologically skin biopsy specimen showed extensive hyperkeratosis, paralceratosis, elongated rete ridges, spongiform macropustule of Kogoj. He was treated effectively with antibiotics, corticosteroid, and methotrexate for two months without recurrence till now.
Anti-Bacterial Agents ; Arthritis ; Biopsy ; Conjunctivitis ; Dysentery ; Hematologic Tests ; HLA-A3 Antigen ; Humans ; Joints ; Knee ; Lower Extremity ; Male ; Methotrexate ; Occult Blood ; Onycholysis ; Parasites ; Penis ; Recurrence ; Scalp ; Shoulder Joint ; Skin ; Spine ; Thorax ; Ulcer ; Urinalysis

A 51-year-old man had small, tender, skin colored firm nodule on the helix of the both ears for eight months. He was found to have classic features of chondrodermatitis nodularis chronica helicis, namely, tender nodule less than 1 cm in length with central crusting, localization to helix, age, men, and histologic findings. The histologic examination of the biopsy specimen showed the presence of thinned epiderrnis on center. acanthosis on the adjacent epidermis, with hyperkeratosis and parakeratosis, and cleft between epidermis and dermis. In the dermis, highly vascularized connective tissue and chronic inflarnmatory infiltrate were visible with perichondrial fibrosis. Elastic tissue stain showed degeneration of elastic fibers. After complete excision, no recurrence was obsered until now.
Biopsy ; Connective Tissue ; Dermis ; Ear ; Elastic Tissue ; Epidermis ; Fibrosis ; Humans ; Hypertrichosis ; Male ; Middle Aged ; Parakeratosis ; Recurrence ; Skin

BACKGROUND: A presumptive diagnosis of cutaneous tuberculosis can be made on the basis of patients' history, clinical and histologic findings. However, isolation of Mycobacerum tuberculosis is required for a definitive diagnosis and confirmation can be difficult with traditional techniques, including the direct visualization in tissue and growth in culture. OBJECTIVE: We used polymerase chain reaction(PCR) for the detection of mycobacterial DNA from routinely prepared formalin-fixed, paraffin-embedded skin specimens to evaluate its usefulness as a diagnostic tool. METHOD: We studied typical cases of localized cutaneous tuberculosis. Ten paraffin-embedded biopsy samples obtained from 2 patients with scrofuloderma, lupus vulgaris and tuberculosis verrucosa cutis were analyzed by PCR, respectively. RESULTS: M. tuerculosis DNA was demonstrated in all 10 specimens. CONCLUSION: This study shows that the PCR will be a useful method for the confirmation of the diagnosis in localized cutaneous tuberculosis and many skin lesions thought to be related to M. tuberculosis infection.
Biopsy* ; Diagnosis ; DNA* ; Humans ; Lupus Vulgaris ; Mycobacterium tuberculosis* ; Mycobacterium* ; Paraffin* ; Polymerase Chain Reaction* ; Skin* ; Tuberculosis ; Tuberculosis, Cutaneous*

A 22-year-old male has had multiple, grouped, asymptomatic, yellowish flat papules, nodules, and plaques on the knees, elbows, butteeks, hands, and feet. Yellowish nodules first appeared on the heels after birth, and gradually increased in size and number and spread to the knees, elbows, buttocks, and hands. Physical examination revealed normaI except for the skin lesions. Gross finding of the serum was clear and paper electrophoresis revealed marked increase in betalipo-protein and mild increase in prebetalipoprotein, suggesting type II hyperlipoproteinemia Serum cholesterol was 510 mg%, and serum triglyceride was 190mg%. Histopathology showed many aggregates of foam cells on H-E stain and many lipid droplets in the dermis on oil red O stain.
Buttocks ; Cholesterol ; Dermis ; Elbow ; Electrophoresis, Paper ; Foam Cells ; Foot ; Hand ; Heel ; Humans ; Hyperlipoproteinemia Type II* ; Knee ; Male ; Parturition ; Physical Examination ; Skin ; Triglycerides ; Xanthomatosis* ; Young Adult

Acute Febrile Neetrophilic Dermatosis(AFND, Sweet's syndrome) ia characterixed by painful erythematous plaquea aaaociatcd with arthralgia, fever and leukocytoeis, We preagented a case of acute febrice neutrophilie denmatoeis in acutemyelogenous leukemia which occurred in a 55-year-old man. After 10 days of treatment with prednisolone, the skin lesion disapceared, but he die of pneumonia in spite of anticancer therapy.
Arthralgia ; Fever ; Humans ; Leukemia ; Leukemia, Myeloid, Acute* ; Middle Aged ; Pneumonia ; Prednisolone ; Skin ; Sweet Syndrome*

Cutis marmorata telangiectatica congenita, which was first described by Van Lehuizen in 1922, is characterized by the presence at birth of a persistent cut;is marmorata pattern, phlebectasia, spider nevus-like telangiectasia, and areas of ulceration and steady improvernent with time. We reported a case of cutis mar.morata telangiectatica. congenita occuring in a 70 days old female infant showing the reticulated mottling and atrophy of the skin on the both lower extremites, right upper extremity, abdomen and buttock muscle weakening of right upper extremity and left lower extremity compare with the opposite side. Skin lesions were much improved during the observation period of 10 months without any other specific treatment except hermiatrophy of right upper extremity.
Abdomen ; Atrophy ; Buttocks ; Female ; Humans ; Infant ; Lower Extremity ; Parturition ; Skin ; Spiders ; Telangiectasis ; Ulcer ; Upper Extremity

The idiopathic calcinosis of the scrotum which was first described by Shapiro et al. in 1970 is usually multiple, asymptomatic nodules of the scrotal skin and is easily misdiagnosed clinically as calcified epidermal inclusion cyst or pilar cyst. We present three cases of the idiopathic calcinosis of the scrotum. Clinically these three patients showed slightly yellowish papules or nodules in the scrotum without any other cutaneous disorders and subjective symptoms except mild itching sensation in one case. Histopathologically calcium deposits were found in the dermis without any evidence of residual cysts, and partial foreign body reaction was seen around the calcified area in one case. Laboratory findings including serum calcium, phosphorous and potassium level were within normal limits.
Calcinosis* ; Calcium ; Dermis ; Epidermal Cyst ; Foreign-Body Reaction ; Humans ; Potassium ; Pruritus ; Scrotum* ; Sensation ; Skin

A 56-year- old man showed millet seed to egg sized, yellowish tender papules, subcutaneous mass on the both elbows, dorsa of both hands & feet, and lateral malleoli and helix of right ear for 6 years. the significant laboratory findings were leukocytosis, increased erythrocyte sedimentation rate, glycosuria, hyperuricemia and increased blood glucose level. X-ray findings of both hands & feet demonstrated gouty arthritic patterns. Histopathologic findings of the left lateral malleolar lesion revealed the typical patterns. Histopathologic findings of the left lateral malleolar lesion revealed the typical pattern of gout with needle-shaped urate crystal. Therapy was begun with colchicine & allopurinol but the patient died of renal failure three weeks after the start of therapy.
Allopurinol ; Blood Glucose ; Blood Sedimentation ; Colchicine ; Ear ; Elbow ; Foot ; Glycosuria ; Gout* ; Hand ; Humans ; Hyperuricemia ; Leukocytosis ; Ovum ; Panicum ; Renal Insufficiency ; Uric Acid

Kaposis sarcoma(KS) is a multicentrically developing vascular neoplasm with four types of clinical manifestation. One of these, classic KS is clinically carmcterized by late onset, chronic course and radiosensitive. We report a case of classic KS in a 72-year-old male. This pateint complainted of purple patches and dark purple nxluk. on slightly edematous lower legs. The histopathologic sections from the lesional sites showed infiltration of spindle cells with newly formed vascular slits, dilated blood vessels and aggregated hemosiderins in the dermis.
Aged ; Blood Vessels ; Dermis ; Hemosiderin ; Humans ; Leg ; Male ; Sarcoma* ; Vascular Neoplasms

We report a typical case of Hunters syndrr me in a 9 year old boy, who presented with firm skin colored nodules that coalesce to form a reticular pattern on a symmetrical rea between the angles of the scapulas, which is regarded as the pathognornonic cutaneous rnarker, for Hunters syndrome. He also showed growth retardation, clear corneas, hepatomegaly, attertich deficit and mild mental deterioration. The skin biopsy specimen taken frorn a typical nodule shows loosely arranged collagen fibers with massive mucinous material which stains positively with aliar blue at both pH 2.5 and 0.5, metachromatic granules within fibroblast stained with toluidine blue.
Biopsy ; Child ; Collagen ; Coloring Agents ; Cornea ; Fibroblasts ; Hepatomegaly ; Humans ; Hydrogen-Ion Concentration ; Male ; Mucins ; Mucopolysaccharidosis II* ; Scapula ; Skin* ; Tolonium Chloride