1.A System for Medical Students to Evaluate the Teaching Skills of Medical Staff
Tadashi KITAHARA ; Takeshi KUBO
Medical Education 2008;39(6):433-436
1) We report on a system implemented in 2007 in the Department of Otolaryngology, Osaka University School of Medicine, to allow medical students to evaluate the teaching skills of medical staff and report on the effects of interventions, based on the evaluations, to improve the teaching skills of the staff.
2) The scores for teaching skills in clinical training as evaluated by medical students were significantly increased after the staff had checked their scores to improve their teaching skills.
3) The number of students choosing to do clinical clerkships in the Department of Otolaryngology was higher in 2008, when students evaluated the staff s teaching skills, than in 2007, when they did not.
2.Low Ki-67 labeling index is a clinically useful predictive factor for recurrence-free survival in patients with papillary thyroid carcinoma
Takashi MASUI ; Katsunari YANE ; Ichiro OTA ; Kennichi KAKUDO ; Tomoko WAKASA ; Satoru KOIKE ; Hirotaka KINUGAWA ; Ryuji YASUMATSU ; Tadashi KITAHARA
Journal of Pathology and Translational Medicine 2025;59(2):115-124
We report a new risk stratification of invasive stage papillary thyroid carcinomas (PTCs) by combining invasive status, using extrathyroid invasion (Ex) status, and tumor growth speed using the Ki-67 labeling index (LI). Methods: We examined tumor recurrence in 167 patients with PTC who were surgically treated at the Kindai University Nara Hospital between 2010 and 2022. The patients were classified according to the degree of invasion [negative (Ex0) or positive (Ex1, Ex2, and Ex3)] and tumor growth speed expressed with Ki-67 LI, as low (<5%) or high (>5%). This study confirmed previous findings that the disease-free survival (DFS) rate in PTCs significantly differed between patients with a high and low Ki-67 index. Results: When combining Ex status (negative or positive) and Ki-67 proliferation status (low or high), the DFS rate of invasion in the negative, low Ki-67 LI group was only 1.1%, while that of invasion in the positive, high Ki-67 LI was 44.1%. This study reports for the first time that recurrence risks can be stratified accurately when combining carcinoma’s essential two features of extrathyroid invasion status and tumor growth speed. Conclusions: We believe the evidence for low tumor recurrence risk may contribute to use of more conservative treatment options for invasive-stage PTCs and help alleviate patient anxiety about tumor recurrence and death.
3.Low Ki-67 labeling index is a clinically useful predictive factor for recurrence-free survival in patients with papillary thyroid carcinoma
Takashi MASUI ; Katsunari YANE ; Ichiro OTA ; Kennichi KAKUDO ; Tomoko WAKASA ; Satoru KOIKE ; Hirotaka KINUGAWA ; Ryuji YASUMATSU ; Tadashi KITAHARA
Journal of Pathology and Translational Medicine 2025;59(2):115-124
We report a new risk stratification of invasive stage papillary thyroid carcinomas (PTCs) by combining invasive status, using extrathyroid invasion (Ex) status, and tumor growth speed using the Ki-67 labeling index (LI). Methods: We examined tumor recurrence in 167 patients with PTC who were surgically treated at the Kindai University Nara Hospital between 2010 and 2022. The patients were classified according to the degree of invasion [negative (Ex0) or positive (Ex1, Ex2, and Ex3)] and tumor growth speed expressed with Ki-67 LI, as low (<5%) or high (>5%). This study confirmed previous findings that the disease-free survival (DFS) rate in PTCs significantly differed between patients with a high and low Ki-67 index. Results: When combining Ex status (negative or positive) and Ki-67 proliferation status (low or high), the DFS rate of invasion in the negative, low Ki-67 LI group was only 1.1%, while that of invasion in the positive, high Ki-67 LI was 44.1%. This study reports for the first time that recurrence risks can be stratified accurately when combining carcinoma’s essential two features of extrathyroid invasion status and tumor growth speed. Conclusions: We believe the evidence for low tumor recurrence risk may contribute to use of more conservative treatment options for invasive-stage PTCs and help alleviate patient anxiety about tumor recurrence and death.
4.Low Ki-67 labeling index is a clinically useful predictive factor for recurrence-free survival in patients with papillary thyroid carcinoma
Takashi MASUI ; Katsunari YANE ; Ichiro OTA ; Kennichi KAKUDO ; Tomoko WAKASA ; Satoru KOIKE ; Hirotaka KINUGAWA ; Ryuji YASUMATSU ; Tadashi KITAHARA
Journal of Pathology and Translational Medicine 2025;59(2):115-124
We report a new risk stratification of invasive stage papillary thyroid carcinomas (PTCs) by combining invasive status, using extrathyroid invasion (Ex) status, and tumor growth speed using the Ki-67 labeling index (LI). Methods: We examined tumor recurrence in 167 patients with PTC who were surgically treated at the Kindai University Nara Hospital between 2010 and 2022. The patients were classified according to the degree of invasion [negative (Ex0) or positive (Ex1, Ex2, and Ex3)] and tumor growth speed expressed with Ki-67 LI, as low (<5%) or high (>5%). This study confirmed previous findings that the disease-free survival (DFS) rate in PTCs significantly differed between patients with a high and low Ki-67 index. Results: When combining Ex status (negative or positive) and Ki-67 proliferation status (low or high), the DFS rate of invasion in the negative, low Ki-67 LI group was only 1.1%, while that of invasion in the positive, high Ki-67 LI was 44.1%. This study reports for the first time that recurrence risks can be stratified accurately when combining carcinoma’s essential two features of extrathyroid invasion status and tumor growth speed. Conclusions: We believe the evidence for low tumor recurrence risk may contribute to use of more conservative treatment options for invasive-stage PTCs and help alleviate patient anxiety about tumor recurrence and death.
5.Indications of Kampo Medicine for Neuro-Otologic Disease
Tadao OKAYASU ; Hiroki OHYAMA ; Koichi KITANO ; Kazuo MITANI ; Tadashi KITAHARA
Kampo Medicine 2021;72(1):1-8
Kampo medicine is widely used in Japan for neuro-otologic disease (e.g. tinnitus, dizziness, hearing loss). Some patients with these diseases suffer from comorbidity of other non-otologic symptoms. We reviewed typical Kampo medicine formulations for neuro-otologic disease. Kampo extracts have indications not only the neuro-otologic but also other systemic diseases. Kampo medicine would facilitate the care of patients with both neuro-otologic diseases and comorbid symptoms.