Kampo medicine is widely used in Japan for neuro-otologic disease (e.g. tinnitus, dizziness, hearing loss). Some patients with these diseases suffer from comorbidity of other non-otologic symptoms. We reviewed typical Kampo medicine formulations for neuro-otologic disease. Kampo extracts have indications not only the neuro-otologic but also other systemic diseases. Kampo medicine would facilitate the care of patients with both neuro-otologic diseases and comorbid symptoms.