No abstract available.
Cicatrix* ; Contracture*

No abstract available.
Breast* ; Child* ; Humans

A case of Epidermolysis Bullosa Dystrophica is reported with review of pathogenesis with literatures. Epidermolysis Bulloaa Dystrophica is a rare genetic disease which is characterized by the formation of blister upon the minor trauma or friction to the skin. A 7-year old boy was referred to our dept. in Aug. 1976 because of a severe bullous eruption primarily on his hands and feet. On admission tense bullae were noted on the dorsa of hands and feet which is usually serous but may be hermorhagic tendency. Soon thereafter tbis bullous lesion tend to break down into painful shallow denudation which may leave depigmented scars and milia after healing. Family history was negative for skin disorders.
Blister ; Child ; Cicatrix ; Epidermolysis Bullosa Dystrophica* ; Epidermolysis Bullosa* ; Foot ; Friction ; Hand ; Humans ; Male ; Skin ; Transcutaneous Electric Nerve Stimulation

We report the implantation of a balloon-expandable intravascular stent at proximal left anterior decending artery in a patients suffered from Canakian functional class III angina for 8 years. The patient received 3 times percutaneous transluminal coronary angioplasty at proximal left anterior descending and circumflex artery without benefits. Repeated angiography revealed restenosis at proximal left anterior descending artery. Atherectomy was tried with transluminal extraction catheter(TEC) with luminal dissection and coronary bypass graft followed. occluded vein grafts were defined by follow-up angiography and chest pain recurred. No residual stenosis or thrombosis was documented in 24 hour follow-up angiography and the patient was discharged without symptom at 10 days after stenting.
Angiography ; Angioplasty, Balloon, Coronary ; Arteries ; Atherectomy ; Chest Pain ; Constriction, Pathologic ; Follow-Up Studies ; Humans ; Phenobarbital ; Stents* ; Thrombosis ; Transplants ; Veins

No abstract available.
Female ; Humans

Esperson(R), a new topical steroid ointment containing 0. 05% 17-Desoxymethasone,. was used in several kinds of dermatoses. Framycetin which was isolated and uientified by the research organisation of Roussel Laboratories (SOFRAPEN) in 1950 from culture broths of a strain of Streptomyces species is a wide spectrum antibiotics on various bacterial infectious diseases. Total 50 patients including 10 cases of 2ndary infected Atopic dermatitis, 10 of infected Contact dermatitis, 6 of infected Seborrheic dermatitis, 7 of infected Neurodermatitis, 3 of infected Chronic dermatitis, 5 of lmpetigo, 2 of infected Nummular eczema, 2 of infected Infantile ecze;na, 1 of infected Intertrigo, 1 of Eczematoid Otitis extema, 1 of 2nd degree Bum, 1 of infected Pruritis ani, 1 of infeeted 1nsect bite. were treated with Frason(R) (0.05% 17-desoxymethasone & 0.5% Framycetin combination). Among these 50 patiants, we observed excellent effects in 7 patients (14%), good effect in 29 patients (58%), fair effect in 10 patients (20%), Totally 36 patients (72%) revealed excellent to good therapeutic effects on their skin conditione after unoccluded application of Frason(R). 3 times daily for about 14 days. There was no sid ffect in all subjects after application of Esperson-F.
Anti-Bacterial Agents ; Communicable Diseases ; Dermatitis ; Dermatitis, Atopic ; Dermatitis, Contact ; Dermatitis, Seborrheic ; Desoximetasone ; Eczema ; Framycetin ; Humans ; Intertrigo ; Neurodermatitis ; Otitis ; Pruritus ; Skin ; Skin Diseases* ; Streptomyces ; Sudden Infant Death

No abstract available.
Catheters*

Various methods of treatment, other than antibiotic therapy, have been proposed for the treatment of female urethral syndrome; however, the results of these treatment methods are disappointing, due perhaps to the use of the wrong treatment approach. The aim of this study was to evaluate the effectiveness of external sphincter relaxant and biofeedback (BFB) with electrical stimulation therapy (EST) in patients who do not respond well to antibiotics. One hundred and five patients with a diagnosis of female urethral syndrome were entered into this study. Antibiotics were given as a first-line therapy for about 3 months. In cases of recurrent or incurable urethral syndrome, antibiotic therapy combined with external sphincter relaxant or BFB with EST were performed. External sphincter relaxant group was composed of 31 patients (29.5%) who showed functional urethral obstruction. Biofeedback group was composed of 41 patients (39.0%) who had severe pain or discomfort with irritative voiding symptoms. Subjective symptom was measured before and after therapy using the Bristol Female Lower Urinary Tract Symptoms questionnaire. Thirty-three patients (31.4%) were treated with antibiotic therapy alone and 7 (21.2%) of these patients recurred. The symptom score of this group changed from 10.51 to 2.85. In the antibiotics plus external sphincter relaxant group (N=31), the symptom score changed from 12.39 to 3.96. Five (16.1%) of these patients recurred and 3 of these 5 underwent urethral dilatation. In the antibiotics plus biofeedback group (N=41), the average urinary frequency changed from 12.2 to 7.7 times a day and nocturia changed from 2.4 to 0.6 times a night. The symptom score improved from 15.22 to 4.69 and the overall satisfaction rate was 87.8% (41.5%: very satisfied, 46.3%: satisfied, 12.2%: no response). Female urethral syndrome is not due to a single factor but is a complex disease due to various combined symptoms and mechanisms. This condition needs to be treated with an appropriate treatment protocol. We believe that satisfactory results could be obtained in female urethral syndrome, which has shown poor prognosis until now, by appropriately combining treatment methods, which include the use of external sphincter relaxants, biofeedback therapy and bladder training, according to indication, and depending on whether symptoms continue after initial antibiotic therapy.
Adult ; Aged ; Antibiotics/*therapeutic use ; Biofeedback (Psychology) ; Electric Stimulation Therapy ; Female ; Human ; Middle Age ; Parasympatholytics/therapeutic use ; Urethral Diseases/etiology/*therapy

No abstract available.
Prostate*

Matrix metalloproteinases (MMPs), which is a kind of Zn-dependent enzyme, are a family of proteolytic enzymes that can degrade the extracellular matrix and then play important roles in the pathophysiology of ischemia/reperfusion, especially MMP-2 and MMP-9. This study was aimed to demonstrate how heat treatment and Hsp70 regulate expression of MMP-2 and MMP-9. The expression and regulation of MMPs after ischemic-like injury with and without heat treatment were investigated in the astrocytes expressing Hsp70 or LacZ and mock infected cells. Primary astrocyte cultures were prepared from ICR mice and infected with retroviral vectors overexpressed Hsp70 or LacZ. After heat treatment, expression of MMP-2 mRNAs was not remarkably changed in heat moc cells. Otherwise, expression of MMP-9 mRNAs was significantly reduced by heat treatment. Expression of MMP-2 and MMP-9 in astrocytes, which were treated with ischemic injury after heat treatment, was obviously decreased than in untreated Moc cells. Moreover, Hsp70s were significantly synthesized in response to heat treatment. Compared to amount of protein expression of MMP-2 and MMP-9, the expression of MMP-2 in astrocytes expressing Hsp70, LacZ and mock infected were decreased after heat treatment, especially pro-form of protein expression of MMP-2. However, the expression of MMP-9 were decreased only in the astrocytes expressing Hsp70 by heat treatment and OGD injury after heat treatment, not shown a big change in the LacZ cells and mock infected cells. The results of activity study with MMPs protein were that MMP-2 protein activity was reduced but not in condition of ischemic injury after heat treatment. On the other hand, the activity of MMP-9 after heat treatment was similar to the results of activity of MMP-9 adding ischemic injury. In this study, we shown that Hsp70 overexpression following heat treatment reduced the expression of proMMP-2, proMMP-9 and processed MMP-2, especially. This findings can suggest a possible role of Hsp70 induced by heat treatment for regulation of MMPs and neuroprotection in ischemic injury.
Animals ; Astrocytes* ; Extracellular Matrix ; Hand ; Hot Temperature* ; Humans ; Matrix Metalloproteinases* ; Mice ; Mice, Inbred ICR ; Peptide Hydrolases ; RNA, Messenger ; Zidovudine