Theophylline tablets with release action (Theo KD) was tested in dosage 100mg x 2 tablets a time each 12 hours for asthma patients, and was compared to 100mg THEOSTAT tablet with release action of Laboratoiries INAVA (France). Results: Theo KD was suitable in the treatment of 2 0r 3 degree asthma. ADRs were minor and temporary. No one stopped treatment due to ADRs
Theophylline ; Tablets ; Chemistry

The study for modernization of traditional prescriptions with the help of new technology of extration and chemistry of natural compounds. With the help of new technologies, 3 traditional prescriptions – Luc Vi, Dai Bo Am, Cam Cum were modernizied. The newly prepraed product – tablets, capsules coated tablet had got pharmacopia criteria and had assured the therapentic effects, the safety thestability, the quality and the utility as the heritage of traditional medicines
Medicine, Traditional ; Chemistry ; Tablets

The study conducted on bronchial asthmatic patients treated at Allergic Clinic in Bach Mai Hospital. The patients treated by theophylline pill acting within 12 hours, manufactured by Hanoi College of Pharmacy combined with Central Pharmaceutical Factory No. 2, used single-blind, controlled method. The patients used 200mg dose, twice in day (8 a.m and 8 p.m), separated from each other 12 hours. Results: The change of respiratory functions are good, both groups are more than 15 percentage
Theophylline ; Clinical Chemistry Tests ; Tablets

To combine fingerprint and drug release rate in vitro, in order to study in vitro release of complex components of Chuanping sustained tablets, compound traditional Chinese medicine preparation. A qualitative determination of the characteristic peaks of the compound preparations were conducted by the fingerprint. The results of the dissolution rate determination under different release conditions showed that the release of three index components (methamphetamine, pseudoephedrine and scopolamine) of Chuanping sustained tablets was less affected by gastrointestinal factors, with similarity factors being more than 80 with unknown component release curves of three major characteristic peaks in the fingerprint. The qualitative determination proved that multiple components of the compound traditional Chinese medicine preparation was dissolved in vitro at similar rates, realizing the balanced release of complex components of the compound traditional Chinese medicine preparation. This study layed a theoretical and experimental basis for quality evaluation for the compound traditional Chinese medicine preparation.
Drugs, Chinese Herbal ; chemistry ; Tablets

Based on the fact that glycyrrhizic acid can form micelles in aqueous solution and play a role in solubilization, the optimal compatibility ratio between puerarin and glycyrrhizic acid was screened to prepare puerarin-glycyrrhizic acid dispersible tablets and investigate the dissolution of puerarin. The particle size, Zate potential and puerarin dissolution were compared among the micellar solutions with mass ratio of 7∶1, 6∶1, 5∶1, 4∶1, 3∶1 and 2∶1(puerarin to glycyrrhizic acid), and it was found that when the mass ratio of puerarin and glycyrrhizic acid was 5∶1, the micelle showed smallest particle size, uniform distribution, and largest puerarin dissolution, so mass ratio of 5∶1 was determined as the optimal condition. The formulation of puerarin-glycyrrhizic acid dispersible tablets was optimized by single factor and orthogonal test: puerarin 100.0 mg, glycyrrhizin 20.0 mg, polyvinylpolypyrrolidone 24.0 mg as disintegrating agent, microcrystalline cellulose 135.0 mg as stuffing bulking agent, hydroxypropyl methyl cellulose 18.0 mg as adhesive agent, magnesium stearate 2.7 mg as lubricant, and tablet weight of 300.0 mg. High-performance liquid chromatography(HPLC) method was used to determine the content of puerarin in dispersible tablets. Puerarin showed a good linear relationship(r=0.999 8) in the range of 15.5-248 g·L~(-1), with high precision(RSD<2.0%) and good repeatability(RSD<2.0%), and the recovery rate was 101.1%, RSD 0.89%. There was no significant difference in the quantity of puerarin in different batches of puerarin-glycyrrhizic acid dispersible tablets. When the artificial gastric juice was used as the dissolution medium, the dissolution of puerarin in puerarin-glycyrrhizic acid dispersible tablets could reach over 85% within 15 min. When phosphate buffer(pH 6.8) was used as the dissolution medium, the dissolution of puerarin in the puerarin-glycyrrhizic acid dispersible tablets had a faster dissolution rate in vitro, 99.8% in 30 min. Therefore, puerarin-glycyrrhizic acid dispersible tablets could improve the dissolution of puerarin in vitro due to the solubilization effect of glycyrrhizic acid.
Glycyrrhizic Acid ; chemistry ; Isoflavones ; chemistry ; Solubility ; Tablets

OBJECTIVETo establish a new method using AOTF-Near infrared spectroscopy for fast identifying Fufang Danshen tablets.

METHODNear-infrared spectroscopy of Fufang Danshen tablets from different factories and different bacth numbers were collected and the discriminant analysis model (FFDS-C) was established with principal component analysis. This model was applied to predict the the different samples of Fufang Danshn tablets.

RESULTThe model can be used to precisely identify Fufang Danshen tablets from other samples.

CONCLUSIONThe method with low consumption is simple and quick and can be applied to the identification of the Fufang Danshen tablets.

Drugs, Chinese Herbal ; chemistry ; Spectroscopy, Near-Infrared ; methods ; Tablets ; chemistry

The formulation for sustained release tablet of Epinedium component was selected and the evaluation equation of in vitro release was established. The liquidity of component was improved with the help of colloidal silica aided by spray drying, which would be the main drug in the sustained release tablets. Dissolution was selected as an evaluation index to investigate skeletal material type, fillers, impact porogen, lubricants and other materials on the quality of sustained release tablet. The sustained release tablets were prepared by dry compression. Formulation of sustained release preparations was main drug 35%, HPMC K(4M) 20% and HPMC K(15M) 10% as skeleton material, MCC 31% as filler, PEG6000 2% as porogen and magnesium stearate 2% as lubricant. The sustained release tablets released up to 80% in 8 h. The zero order equation, primary equation and Higuchi equation could simulate the release characteristics of sustained release tablets in vitro, the correlation coefficients r were larger than 0.96. The primary equation was most similar in vitro release characteristics and its correlation coefficient r was 0.9950. The preparation method is simple and the results of formulation selection are reliable. It can be used to guide the production of Epimedium component sustained release preparations.
Chemistry, Pharmaceutical ; methods ; Delayed-Action Preparations ; chemistry ; Drugs, Chinese Herbal ; chemistry ; Epimedium ; chemistry ; Kinetics ; Tablets ; chemistry

Co-processed excipients withgelatinized or non-gelatinized starch were prepared by spray drying. Powder and tablet properties of corocessed excipients prepared were compared with those of physical mixtures and spray-dried lactose. Their applicability in traditional Chinese medicine (TCM) powder tableting was tested on two TCM extracts, i.e., the gardenia extract and the Herba Sedi extract. It was shown that gelatinizing starch before co-spray drying with lactose could improve the performance and efficiency of starch as a binder, resulting in remarkable improvement in physicomechanical properties of co-processed excipients prepared. Conpared to self-made and commercially available spray-dried lactose, co-processed excipients achieved better compactability and higher drug loading for TCM extracts. In conclusion, the lactose-gelatinized starch co-processed excipient, with excellent physicomechanical properties, is promising to be explored as a new excipient for direct tableting.
Excipients ; chemistry ; Lactose ; chemistry ; Medicine, Chinese Traditional ; methods ; Powders ; chemistry ; Starch ; chemistry ; Tablets ; chemistry

OBJECTIVETo prepare controlled porosity osmotic-pump tablets of total paeony glycosides (TPG) and establish the relationship between formulation factors of membrane and drug release rate.

METHODUniform design was used to achieve the quantitative relationship between the release rate and formulation factors of membrane. Optimized prescription was calculated from the regression equation.

RESULTA significant correlation and a fine precision of the regession equation were obtained. Controlled porosity osmotic-pump tablets of TPG were prepared based on the calculations, and the drug release profile was in accord with zero-order kinetics (r = 0.9902).

CONCLUSIONUniform design is a convenient and efficient approach for formulation optimization of controlled porosity osmotic-pump tablets.

Chemistry, Pharmaceutical ; methods ; Drugs, Chinese Herbal ; chemistry ; Glycosides ; chemistry ; Osmotic Pressure ; Paeonia ; chemistry ; Porosity ; Tablets ; chemistry

Sustained-release tablet has become one of the hottest research spots in the area of sustained release preparations with its unique advantages. At present, a series of shortcomings were exited in the ordinary ginkgo preparations, which were used for the treatment of cardiovascular and cerebrovascular diseases. In order to avoid these shortcomings, ginkgo flavonoids matrix tablets were prepared in this paper. Furthermore, the amount and varieties of matrix material, adhesives and fillers were investigated. Meanwhile, the formulation was optimized by using the method of orthogonal design, and Zero-order, First-order, Higuchi, Ritger-peppas equation were used for the model fitting and mechanism discussing of drug release.
Chemistry, Pharmaceutical ; methods ; Flavonoids ; chemistry ; pharmacology ; Ginkgo biloba ; chemistry ; Kinetics ; Tablets ; chemistry