Quantitation of Metronidazole by reversed phase liquid chromatography using Supelco LC-ABZ column and a mobile phase containing an acid aqueous phase (pH Metronidazole ; Tablets

Study on some methods used to quantify berberine chloride showed that the UV measuring and volumetric titration methods did not express only amount of berberine chloride itself. It is necessary to apply high- performance liquid chromatography (HPLC) to achieve the optimal conditions for better splitting, higher accuracy…in order to apply more widely in testing products commonly in market with many components combined to berberine chloride. To find out optimal methods, which are suitable with condition of present some pharmaceutical units, it is necessary to experiment continuously methods such as UV measuring and volumetric titration,… using HPLC method to compare.
Berberine ; Tablets

Sustained release film coated tablets containing dexchlorpheniramine maleate were prepared in such a structure as two-third of drug were dispersed in Eudragit RS 100 to form insoluble matrix that gradually releases drug by diffusional mechanism, the rest was dispersed in the immediate release part. The core tablets were compressed by a wet granulation process and the film coated tablets by a routine film coating process with Eudragit E suspension. The formed coated tablets have suitable technical characteristics. The third formulation with Eudragit RS- drug ratio 2:1 has got the dissolution extent and the release rate in vitro similar to those of Polaramine 6mg repetabs. They also meet the requirements invitro release rate versus time for sustained release capsules containing Chlorpheniramine maleate by USP XXIII. Therefore, these film coated tablets with dexchlorpheniramine maleate may be candidates for a sustained release dosage form
dexchlorpheniramine ; Tablets

Chronic prostatitis has various symptoms and many problems in management. Recently a lipidosterolic extract of Serenoa Repens, Permixon has been reported to reveal potential antiandrogenic and anti inflammatory activities on prostate. Then we used Permixon on chronic prostatitis and following results were obtained. Permixon is administered orally in dose of 160mg., b.i.d. for 60 days in 31 cases of chronic prostatitis in 1st group, Permixon 160mg, with Cipro-floxacin 500mg, b.i.d. in 35 cases in 2nd group and Placebo 2 tablets, b.i.d. in 30 cases in 3rd group. In 1st group 36 cases(77.4%) were improved, 29 cases(82.8%) in 2nd group and 7 cases (23.3 %) of 3rd group were improved. Permixon is an effective drug in chronic prostatitis and there was no changes in laboratory findings and negligible side effects were noticed
Prostate ; Prostatitis* ; Serenoa* ; Tablets

Study on 2 drugs of combined components: The drug number 1: combined tablets of Ethambutol/Isoniazide 400/150mg; The drug number 2: combined tablets of Rifampicine/Isoniazide 150/100mg and Pyrazinamide 500mg. These drugs delivered from India to Vietnam by the airway or shipment during April 2001 to September 2003. The results showed that: delivering time was approximately 10 days in airway and estimated time of 32 days in shipment. The time for issuing Vinacontrol's cerfiticate on drug quality was approximately 348 days, the time for issuing certificate on drug quality was longer than delivering time both the airway and the shipment. The results of testing drug quality before and after delivering pharmaceutical drugs from India to Vietnam found that testing indicators excepted assays were as same in certificate of manufacturer, SGS International and Vinacontrol and assay of imported drugs was in rank of registered standards
Pharmaceutical Preparations ; Tablets ; Vietnam

The study for modernization of traditional prescriptions with the help of new technology of extration and chemistry of natural compounds. With the help of new technologies, 3 traditional prescriptions – Luc Vi, Dai Bo Am, Cam Cum were modernizied. The newly prepraed product – tablets, capsules coated tablet had got pharmacopia criteria and had assured the therapentic effects, the safety thestability, the quality and the utility as the heritage of traditional medicines
Medicine, Traditional ; Chemistry ; Tablets

The HPLC method described herein has sufficient sensitivity to determine the pharmacokinetic parameters of nifedipine in plasma. A single dose cross study was carried out in volunteers comparing the test sustained release nifedipine formulation to Adalat retard tablets. Pharmacokenetic variables were calculated from the nifedipine plasma concentration data and evaluated statistically. The results showed the test formulation to be bioequivalent to the reference tablets.
Nifedipine ; Biological Availability ; tablets

Since 1975, lidocaine has been made up in Friendship hospital with the name rythmocardyl as a dissoluble tablet in the bowels. The magistral formula and processing procedures have been studied and tested to reach the VNP II - 1994 and BP-1993 standards. The lethal dosage (LD50), the anti - ventricular fibrillation and anti-arrhythmic effects, the blood concentration of lidocaine taken orally at different times as well as the dissolution of rythmocardyl in the human body have been tested experimentally. The research have proven that lidocaine, taken orally has few side effects and is safe and effective to treat the cardiac arrhythmia, notably the ventricular extrasystoles
Lidocaine ; Arrhythmia ; tablets ; therapeutics

To stabilize vitamin B12 in tablets containing Vitamin B1+B6+B12, Kollidon Cl-M was used as stabililizer combining with the dispersion of vitamin B12 in dry state before compression. Applying accelerated stability testing with storage condition of t0 = 570C, RH = 80% in 72 hours, the preliminary results showed that the use of Kollidon CL-M 2% in the formulation can improved effect on the stabilization of vitamin B12.
Vitamins ; Pharmaceutical Preparations ; tablets

Testing of pharmaceutical dosage forms for in vitro drug release and dissolution characteristics is very important for ensuring batch-to-batch quality control and to optimize formulations during product development. The ideal system for evaluating the drug release characteristics of poorly water-soluble drug formulations (as nifedipine tablets) is to maintain “sink conditions”. Flow-through dissolution systems (e.g. USP XXIV apparatus 4) can be used to over come solubility limitations. In this study, a flow-through dissolution system was installed to evaluate two sustained release nifedipine tablets (Adalat retard 20 mg and Nifedipine retard 20 mg- Life Pharma). The dissolution profiles prove that this system with the pump rate of 14-16 ml/min offers a method to evaluate nifedipine tablets, especially sustained release formulations.
Nifedipine ; tablets ; Pharmaceutical Preparations