1.Preliminary evaluation of the role of biomarkers in diagnosing dementia
Luc Viet Tran ; Thang Pham ; Hung Trong Nguyen ; Binh Thanh Nguyen ; Huong Van Nguyen ; Ngoc Bich Nguyen ; Van Thanh Ta
Journal of Medical Research 2008;56(4):87-91
Background: Dementia is a common pathological condition that affects older people. Most causes of dementia are Alzheimer\u2019s disease and vascular dementia. Diagnosing these conditions mostly relied on clinical patterns, but some biomarkers have been mentioned as the indicators of this condition. Objectives: 1) To evaluate the alteration of some biomarkers in cerebrospinal fluid (CSF) samples from Alzheimer\u2019s patients. 2) To compare the concentration of biomarkers in CSF samples from patients with vascular dementia and Alzheimer\u2019s disease. Subjects and method: Case group involved 41 patients who were diagnosed as AD and vascular dementia based on DSM-IV criteria. 31 matched healthy people were included in control group. All subjects were given neuro-psychological tests and thorough clinical examination. Brain CT scan and MRI were done for both groups. CSF samples were taken from patients in the study group to measure levels of some biomarkers. Results. The levels of total taurine (T-tau) and phosphorylated taurine (P-tau) 181 proteins are higher in the dementia group. The concentration of Abeta-42 is significantly different between case and control groups, but similar between vascular dementia and Alzheimer\u2019s disease patients. Conclusion: Changes in biomarkers are valuable in different diagnosis of Alzheimer\u2019s disease and other types of dementia. However, findings of CSF studies have to be considered with findings from imaging studies and clinical examination.
Biomarker
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Dementia
;
Alzheimer\u2019s disease
2.The role of matrix metalloproteinase (MMP \u2013 9) in metastasis of nasopharyngeal carcinoma
Ha Thi Ngoc Nguyen ; To Van Ta ; Binh Hoa Do ; Phi Thi Phi Pham
Journal of Medical Research 2008;58(5):1-7
Background: Identifying the factors which affect the invasion and metastasis process takes a vital role in the treatment of cancer. This is the first study on the relationship between the expression of matrix metalloproteinase (MMP \u2013 9), invasion and metastasis of nasopharyngeal carcinoma (NPC) in Vietnam. Objectives: To evaluate the significance of matrix metalloproteinase \u2013 9 in predicting the metastasis potential of NPC. Subject and Method: The expression of MMP \u2013 9 was studied by immunohistochemical analysis in 33 nasopharyngeal carcinoma sections and the associations of MMP-9 with lymph nodes metastasis and clinical features. Results: Positive immunostaining for MMP-9 was observed in 94.94% of the NPCs, 39.4% of the cases being extensively positive (+++). The expression of MMP-9 correlated significantly with cervical lymph nodes metastasis (p<0.05). 5/16 cases (31.25% of the cases) without cervical lymph nodes metastasis expressed MMP-9 with 2+ or 3+ level, non-significant of MMP-9 expression with T classification and clinical stage. Conclusions: The expression of MMP-9 often goes along with lymph nodes metastasis in nasopharyngeal carcinoma.
MMP-9
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Nasopharyngeal carcinoma
3.The factual status of diabetes mellitus – glucoza tolerant declining, related factors and hospital management status in Hanoi city
Journal of Practical Medicine 2004;471(1):51-54
A survery was conducted on 1069 subjects aged 20- 74 years old(male 47%, female 53%) living in Ha Noi, concerning the diabetes status. Results showed no difference in term of genders but geographically, in urban areas the prevalence was 2 times higher than in the suburb. The number of diabetes patients of under secondary level were 21 times higher than the higher level. Among the hand worker, the prevalence was lower than in sedentary workers. The prevalence was also low in the intellectuals.
Diabetes Mellitus
;
Glucose
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Epidemiology
4.Blood biochemical parameters and anthropometric indexes among people with risk factors for type 2 diabetes
Phong -- Le ; Binh and colleagues Van Ta
Journal of Medical and Pharmaceutical Information 2003;0(11):26-29
Background: Diabetes is a common chronic glucide metabolic disorder affecting hundreds of millions of people around the world. In Vietnam, the number of people with risk of type 2 diabetes is approximately 5 million. \r\n', u'Objectives: To discover the changes of blood biochemical parameters and mean body mass index (SMIJ waist circumference in individuals with diabetic risk factors). \r\n', u'Method: 95 people with diabetic risk factors were selected by screening. One group was in Ngoc Trao or Phu Son wards (n=52) and other group was in Sa Dinh ward (n=43). \r\n', u'Results: In Ngoc Trao and Phu Son wards: the prevalence of blood glucose, cholesterol triglyceride, HDL, LDL disorders and SMI>23 were 65.3%, 32.7%, 46.2%, 1.9%, 36.5%, 61.5%, respectively. In Sa Dinh ward: those were 62.8%, 29.7%, 44.2%, 2.3%, 34.9% and 67.4%, respectively. \r\n', u'Conclusion: Disorders of blood biochemical parameters accounted for very high rate in individuals with diabetic risk factors and could be considered main risk factors. \r\n', u'
Blood biochemical parameters
;
anthropometric indexes
;
type 2 diabetes
5.The effects of Luu Hoang (sulphur)
Journal Reasearch of Vietnam Traditional Medicine and Pharmacy 2003;0(9):11-12
Luu Hoang with its yellow colour, spongy consistency, sour taste, toxicity, can infultrate inward through the medians of kidney and large bowel. Oral use of Luu Hoang can tossify the “fire”, assiste the “yang”. Topic use can detoxicate, kill the parasite, treat the pimples, Luu Hoang abates the itch in cases of scale, fungi on skin, eczema. Luu Hoang is used in the conditions of boil, the cold in kidney, coldish impaired “yang”, coldish secretion, difficulty in faces exerete and urinate. Oral use of 1-3 g in powder and pill, topic use with powder spreaded in the wound… are the most common methods. Counter indications are in the cases of impaired “iin”, exceeded “fire”, pregnancy, and incompatible with Phac Tieu
Medicine, Traditional
;
Therapeutics
;
Pharmaceutical Preparations
6.Influence of nutrition al habit and physical activities on the disturbance of sugar metabolism
Journal of Practical Medicine 2003;463(10):56-59
Research on 1060 people who from 20 to 74 years old live in Hanoi. 47% of them was man and 53% was woman. Result: eating and drinking habit has importance effect to the development of diabetes disease. People who eat much fat, drink much beer and eat little vegetable have higher risk of suffering diabetes to use little fat, don’t drink beer and smoke tobacco, and eat more vegetable. People who live in city eat vegetable, fruit and smoke less than suburban but they drink beer much than suburban. Body activity has close relation to the disease condition
metabolism
;
Nutrition Therapy
;
Motor Activity
7.Study on the eddects of "Tru ngua B" tablets in the model of allergic contact dermatitis
Journal Reasearch of Vietnam Traditional Medicine and Pharmacy 2003;0(11):25-26
“Antiitchy B” tablets were processed from herbal medicines including prepared Rchmannia glutinosa, Angelica sinensis, Paeonia lactiflora, Salvia miltiorrhiza, Glycyrrhiza uralensis, and Sophora flavescens, plus shells of Ostrea gigas and Ketotifen. Experimental study carried on mice with allergic contact dermatitis showed that “antiitchy B” tablets significantly inhibited dinitrofluobenzene induced allergic inflammation in mice ears epidermis
Medicine, Traditional
;
Dermatitis, Allergic Contact
;
Medicine, Herbal
;
drugs
8.A More evidence confirming the state of iodine deficiency in Mekong Delta.
Journal of Practical Medicine 2003;445(3):23-26
Iodine concentrations of water samples, vegetable samples and soil samples in Kien Thanh commune (KT) – Cho Moi district – An Giang province were compared with those of Duyen Ha commune (DH) – Thanh Tri district – Ha Noi city. Iodine intake of KT people was about 60 mg daily. 70.1% of urine samples had low iodine concentration. Iodine concentration in water, soil and vegetable in both communes were in the low range and had statistically significant differences. In ND, mean iodine concentration in the soil was lower than in DH (2.63530 mg/kg vs 3.0360 mg/kg). In the water iodine mean concentration was lower in KT than in DH (0.00127 mg/kg vs 0.00173 mg/kg) and in vegetable 0.96100 mg/kg vs 1.15770 mg/kg respectively
A More evidence confirming the state of iodine deficie
9.Obesity - risk and our attitude
Journal of Practical Medicine 2002;435(11):16-19
The obesity is growing in the Western Pacific Region. Currently, is have been not the major health problem in viet nam; however, the experts anticipated a rapid rise in prevalence in viet Nam during coming years, with high prevalence will be found in youngsters. The prevalence of obesity is highest in people aged 20 - 50 years. Women are more susceptible than men. The prevalence is increasing with the growth of the socioeconomic and different according to geographic, race and ethnic characteristics. Studies demonstrated that the criteria for obese classification applied for Europeans and Americans could not be used for Asians, especially for people from ASEAN countries. WHO introduced new criteria for this condition that can apply to this region since year 2000. To prevent effectively this condition, Viet Nam must implement active and appropriate measures right now.
Obesity
;
Attitude
10.Role of preventive therapy for solid lesions of normothyroidic single-nodular goiter.
Journal of Practical Medicine 2002;435(11):53-56
Normothyroidic single-nodular goiter is a common disease. Now it can be detected and intervented early so that its prognosis is improving significantly. The effectiveness of preventive therapy for nodular goiter by TST releasing inhibition with levothyroxin was examined in 110 patients. The results showed that levothyroxin therapy to inhibit the release of TST is needed for solid lesions. In younger patients with less than 1cm goiter, the result of treatment is more likely to be maximized, the lesions regress completely and the thyroid functions are normalized. For more than 45-year patients with more than 2-cm goiter, the result of treatment is poor. Use levothyroxin with cautions in over 60-year patients who have cardiovascular diseases and multiple nodular goiter.
Goiter, Nodular
;
Prevention & control
Result Analysis
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