Objective: To explore the effectiveness of exercise combined with nutrition intervention on body mass index (BMI), blood glucose and blood lipid in obese adolescents. Methods: Eighty obese adolescents who participated in a weight-loss training camp were selected as the intervention group, and 50 healthy adolescents were selected as the control group. Adolescents in the intervention group received 8-week weight-loss training and nutritional intervention, while those in the control group maintained their original lifestyle. The changes in body weight, body fat percentage, blood glucose, lipid and inflammatory indicators were compared before and after intervention in both groups. Results: After intervention, weight, BMI, body fat percentage and waisthip ratio of the intervention group were significantly lower than those before intervention (P<0.05). The levels of insulin, HOMA-IR, TG and LDL in the intervention group before intervention were significantly higher than those in the control group (P<0.05). There was no significant difference in blood glucose after intervention (P>0.05). The levels of insulin, HOMA-IR, TG and LDL after intervention were significantly lower than those before intervention (P<0.05). There was no significant difference in HOMA-IR, TG and LDL levels between the intervention and the control group (P>0.05). The levels of TNF-α and hs-CRP in the intervention group before intervention were significantly higher than those in the control group (P<0.05); the levels of TNF-α and hs-CRP in the study group after intervention were significantly lower than those before intervention(P<0.05); the levels of TNF-α and hs-CRP in the control group before and after intervention had no significant changes (P>0.05). Conclusion Exercise combined with nutrition intervention can effectively reduce body fat and body weight, improve insulin resistance, regulate glycolipid metabolism and reduce inflammation in adolescent obese patients.